Tag: 100-200

On June 22, 2017, Mobashery, Shahriar; Speri, Enrico; Chang, Mayland published a patent.Formula: C12H7N3 The title of the patent was Potentiators of beta-lactam antibiotics and combination therapy. And the patent contained the following:

Proteins of methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic sensor/signal transducer, are phosphorylated on exposure to β-lactam antibiotics. This event is critical for the onset of the biochem. events that unleash induction of antibiotic resistance. The phosphorylation and the antibiotic-resistance phenotype can be abrogated in the presence of phenylpropanenitrile derivatives, eg. I, (X= O, CH2, S, SO2, or a direct bond; R1= CN, SO2Me, CONH2, CO2H, etc.; m= 1,2,3,4; n= 1,2,3,4,5; R2= H, halo, alkyl, alkoxy, heteroaryl, etc.; R3= halo, alkyl, alkoxy, heteroaryl, etc.), that restore susceptibility of the organism to β- lactam antibiotics. The invention thus provides compounds and methods for abrogating antibiotic resistance to β-lactam antibiotics and for treating infections causes by antibiotics prone to developing resistance by potentiating β-lactam antibiotics. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to phenylpropanenitrile derivative betalactam antibiotic resistance mrsa, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Formula: C12H7N3

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On December 30, 2021, Nuellen, Max Peter; Schulze, Benjamin; Wudarczyk, Jakob Jacek published a patent.Related Products of 337965-61-4 The title of the patent was Organic compounds for use in organic electronic devices (OLED), semiconductor layer and display device. And the patent contained the following:

The present invention relates to a compound of formula I and an organic electronic device comprising a semiconductor layer which comprises a compound of formula I. The experimental process involved the reaction of 2-(6-Fluoropyridin-3-yl)acetonitrile(cas: 337965-61-4).Related Products of 337965-61-4

The Article related to organic compound electronic device oled semiconductor layer display device, Electric Phenomena: Semiconductor Junctions and Devices and other aspects.Related Products of 337965-61-4

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Goud, S. Banuprakash; Guin, Soumitra; Prakash, Meher; Samanta, Sampak published an article in 2022, the title of the article was Cu(OAc)2/DABCO-mediated domino reaction of vinyl malononitriles with cyclic sulfamidate imines: access to 6-hydroxyaryl-2-aminonicotinonitriles.Category: nitriles-buliding-blocks And the article contains the following content:

A novel Cu(II)-salt/DABCO-mediated one-pot access to a myriad of highly substituted biol. relevant 2-aminonicotinonitriles possessing a resourceful phenolic moiety, e.g., I with satisfactory yields is reported. This method involves cyclic sulfamidate imines, e.g., benzo[e][1,2,3]oxathiazine 2,2-dioxide as 1C1N sources and different kinds of acyclic/cyclic vinyl malononitriles, e.g., 2-(1-phenylethylidene)malononitrile as 4C sources for pyridine synthesis via a vinylogous Mannich-cycloaromatization sequence process, creating two new C-N bonds under mild conditions. Importantly, this de novo strategy is applicable to gram-scale syntheses, underlining the method’s practicability and allowing for a wide range of substrates with excellent functional group tolerance. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks

The Article related to hydroxyaryl aminonicotinonitrile preparation, cyclic sulfamidate imine vinyl malononitrile domino vinylogous mannich cycloaromatization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: nitriles-buliding-blocks

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On January 31, 2006, Zahouily, Mohamed; Bahlaouan, Bouchaib; Abrouki, Younes; Salah, Mohamed; Bahlaouan, Ouafa; Rayadh, Ahmed; Aadil, Mina; Sebti, Said published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Natural phosphate and potassium fluoride doped natural phosphate as new catalysts for the Vilsmeier-Haack type reaction. And the article contained the following:

The catalytic activity of the inexpensive natural- or potassium fluoride doped- phosphates as bases was evaluated in a Vilsmeier-Haack type reaction. High efficiency, in term of chem. yields and reaction rates was found in the preparation of 2-chlor-3-cyanopyridines starting from 2-propylidene-malononitriles. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to propylidene malononitrile vilsmeier haack reaction natural phosphate catalyst, pyridine chlor cyano preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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On September 8, 2016, Rajkumar, Vadla; Babu, Srinivasarao Arulananda; Padmavathi, Rayavarapu published an article.HPLC of Formula: 75629-62-8 The title of the article was Regio- and diastereoselective construction of a new set of functionalized pyrrolidine, spiropyrrolidine and spiropyrrolizidine scaffolds appended with aryl- and heteroaryl moieties via the azomethine ylide cycloadditions. And the article contained the following:

Highly regio- and diastereoselective syntheses of a new set of functionalized pyrrolidines, spiro-pyrrolidine/pyrrolizidine oxindoles, spiroacenaphthylenolyl-pyrrolidines/pyrrolizidines and spiro-1,3-indandionolyl-pyrrolidines/pyrrolizidines appended with various aryl- and heteroaryl moieties via the azomethine ylide cycloaddition reaction are reported. The Ag-catalyzed [3+2] cycloaddition of azomethine ylides derived from N-benzylideneiminoglycinates with various arylidene/heteroarylidenemalononitriles gave C-3,C-5-aryl/heteroaryl substituted C-4,C-4-dicyanopyrrolidine-2-carboxylate scaffolds with good regio- and diastereoselectivity. Further, the [3+2] cycloaddition of azomethine ylides derived from the decarboxylative reactions of different 1,2-dicarbonyls and α-amino acids with the indole/pyrrole-based dipolarophiles were studied. In the context of enriching the library of functionalized spiropyrrolidine- and spiropyrrolizidine scaffolds, these reactions led to the assembling of various spiro-pyrrolidine/pyrrolizidine oxindoles, spiroacenaphthylenolyl-pyrrolidines/pyrrolizidines and spiro-1,3-indandionolyl-pyrrolidines/pyrrolizidines appended with the indolyl- and pyrrolyl moieties at the C-3 position of the spiro-pyrrolidine/pyrrolizidine rings. The stereochem. of the cycloadducts was assigned based on the single crystal x-ray structures of representative major diastereomers obtained from the azomethine ylide cycloaddition reactions. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).HPLC of Formula: 75629-62-8

The Article related to spiropyrrolidine spiropyrrolizidine aryl azomethine ylide cycloaddition regio diastereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 75629-62-8

Referemce:
Nitrile – Wikipedia,
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Srour, Aladdin M.; Dawood, Dina H.; Saleh, Dalia O. published an article in 2021, the title of the article was Synthesis, 3D-pharmacophore modelling and 2D-QSAR study of new pyridine-3-carbonitriles as vasorelaxant active agents.Related Products of 75629-62-8 And the article contains the following content:

A new set of pyridine-3-carbonitriles conjugated with various five-membered ring systems at pyridinyl C-6 were designed and synthesized as vasorelaxant active agents. The majority of the new target derivatives exhibited noteworthy vasodilation efficacy and nine compounds were the most potent analogs with IC50 values = 220.7, 256.7, 164.1, 252.2, 229.8, 265.2, 247.9, 239.1 and 159.8μM, resp., which were superior to that of prazosin hydrochloride (IC50 = 272.8μM). Moreover, four compounds displayed significant α1-adrenergic receptor (α1-AR) blocking efficiency ranging from 65.38 to 87.86% compared with 89.34% for prazosin hydrochloride. Furthermore, a 2D-QSAR study and 3D-pharmacophore model were introduced to carry out compare-fit study for the designed mols. with the generated hypothesis and creating a statistically significant model. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Related Products of 75629-62-8

The Article related to pyridine carbonitrile preparation pharmacophore modeling vasorelaxant active agent hypertension, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 75629-62-8

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On September 30, 2018, Hebishy, Ali M. S.; Abdelhamid, Ismail A.; Elwahy, Ahmed H. M. published an article.Product Details of 75629-62-8 The title of the article was Synthesis of novel bis(dihydropyridine) and terpyridine derivatives. And the article contained the following:

A synthesis of novel bis(cyanopyridones) by the reaction of the appropriate bis(cyanoacetamide) with the corresponding arylidenemalononitrile in the presence of basic catalysts was reported. In some cases, the corresponding bis(2-cyano-3-arylacrylamide) derivatives were isolated from these reactions as single products. The multicomponent strategy for the synthesis of the target compounds was also investigated. The utility of bis(cyanoacetamides) as building blocks for novel bisquinolinones was also studied. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Product Details of 75629-62-8

The Article related to cyanopyridone preparation, cyanoacetamide arylidenemalonitrile michael addition cyclization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 75629-62-8

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On May 31, 1987, Morales-Rios, M. S.; Espineira, J.; Joseph-Nathan, P. published an article.Related Products of 75629-62-8 The title of the article was Carbon-13 NMR spectroscopy of indole derivatives. And the article contained the following:

The chem. shifts of 298 naturally occurring and synthetic compounds containing the indole chromophoric group are listed. Substituent effects on 13C chem. shifts (SCS) induced by substitution on the heteroaromatic five-membered ring are discussed. The data provide a reference set for future 13C NMR investigations and highlight the need for unambiguous exptl. evidence to resolve controversial assignments for differently substituted representative indole derivatives Many original assignments have been changed, and values not considered to be unambiguously assigned are delineated. The 1J(CH) values for the parent indole were measured. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Related Products of 75629-62-8

The Article related to carbon nmr indole derivative, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.Related Products of 75629-62-8

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On December 3, 2003, Suga, A.; Kubota, H.; Miura, M.; Sasuga, D.; Moritani, H. published a patent.SDS of cas: 34662-29-8 The title of the patent was Preparation of tetrahydropyranalkyl carboxamide derivatives as inhibitors of apo β-related lipoprotein secretion. And the patent contained the following:

A novel tetrahydropyran derivative which has an excellent apo B-related lipoprotein secretion-inhibiting activity of the following general formula (I) or a salt thereof are prepared wherein R1 and R3 are the same or different and each represents H or lower alkyl; R2 is H, halogen, Ra-lower alkyl, or R20O-CO-; Ra is H, R21O-CO-, R22R23N-, R24R25N-CO-, R26O-cyano, or optionally-substituted hetero ring; R4, R5, R6 and R7 are the same or different and each is H, halogen, haloalkyl, cyano, lower alkyl, lower alkyl-O-, R21O-CO-lower alkyl-, R27-CO-, or R28R29N-S(O)2-; R8 and R9 are the same or different and each is H, lower alkyl, R30-lower alkyl-, R31R32N-, optionally- substituted hetero ring, or R33R34R35C-; R8 and R9 may together form optionally-substituted hetero ring-; X is N or CR36; R20, R22 to R26, R28, R29, R32 and R36 are the same or different and each is H or lower alkyl; R21 is H, lower alkyl, or aryl-lower alkyl-; R27 is HO-, lower alkyl-O-, or optionally-substituted hetero ring-, or lower alkyl-O-; R30 represents optionally-substituted aryl, optionally-substituted hetero ring-, or lower alkyl-O-; R31 represents optionally-substituted aryl, or optionally-substituted hetero ring-; R33 represents HO-lower alkyl-, or optionally-substituted hetero ring-lower alkyl-; R34 represents optionally-substituted aryl-. Thus, e.g., II was prepared by hydrolysis of corresponding Et ester (preparation given). In assays to evaluate apo β-related lipoprotein secretion-inhibiting activity, selected compounds of I possessed IC50 values ranging from 1.7-40 nM. As inhibitors of apo β-related lipoprotein secretion, I have excellent blood cholesterol and triglyceride-lowering effect, and are useful as remedies for hyperlipemia, arteriosclerosis, obesity and pancreatitis. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).SDS of cas: 34662-29-8

The Article related to pyran tetrahydro derivative preparation lipoprotein secretion inhibitor, pyranalkylcarboxamide derivative preparation hyperlipemia arteriosclerosis obesity pancreatitis, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.SDS of cas: 34662-29-8

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On January 24, 2020, Zhuo, Junrui; Yuan, Weicheng; Zhao, Jianqiang; Quan, Baoxue; Du, Anni; Wang, Keke published a patent.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Polycyclic heterocyclic compound synthesized using water as medium, its preparation method, and application. And the patent contained the following:

A simple and environmentally-friendly method of preparing a polycyclic heterocyclic compound having improved air-stability, suitability for wide application in photoluminescence materials, drug screening and pharmaceutical industry, and mild reaction conditions is provided. The polycyclic heterocyclic compound is represented by Formula I, where X is O, S, and N-R, Y is H, CH2, OCH2, (CH2)2, (CH2)3, and Ar is alkyl, halogen or aryl-substituted benzene ring, furan ring, thiophene ring, and R1 is hydrogen, alkyl, halogen, and aryl group. The preparation method of the polycyclic heterocyclic compound comprises: using water as a reaction medium and under the regulation of a base, adding dicyanoolefin synthesizer and 2-nitroheteroarom. or 3-nitroheteroarom. hydrocarbon and performing alkali-promoted [4+2] olefin cyclization reaction to obtain the final product. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to polycyclic heterocyclic compound synthesis water medium, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
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