Tag: 100-200

Koeckritz, P.; Schmidt, L.; Liebscher, J. published an article in 1987, the title of the article was Iminoformylation reaction of substituted crotononitriles. II. The reaction of ylidenemalonitriles with formamide acetals in the presence of acetic acid.Formula: C12H8N2 And the article contains the following content:

Iminoformylation of ylidenemalononitrile with formamide acetals in the presence of AcOH gave good yields of 1,1-dicyano-4-aminobuta-1,3-dienes, building blocks to heterocycles. Thus, condensation of H2CRCR1:C(CN)2 (R = H, Me, Et, R1 = Me, Et, Me2CHCH2, Ph, PhCH:CH, etc.) with R2R3NCH(OMe)2 [R2,R3 = Me; R2R3 = CH2CH2OCH2CH2), (CH2)4] gave 34-99% R2R3NCH:CRCR1:C(CN)2. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Formula: C12H8N2

The Article related to crotononitrile iminoformylation, ylidenemalonitrile iminoformylation formamide acetal, cyanoaminobutadiene, butadiene cyano amino, Aliphatic Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Formula: C12H8N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 31, 2000, Abdelhamid, Abdou O.; Zohdi, Hussein F.; Ziada, Mahmoud M. published an article.Recommanded Product: 75629-62-8 The title of the article was A facile synthesis of [1,2,4]triazino[4,5-a]benzimidazoles, pyrazolo[5,1-c]triazines, triazolo[5,1-c]triazines and pyrido[1,2-a]benzimidazoles. And the article contained the following:

Triazino[4,5-a]benzimidazoles have been obtained by coupling of arenediazonium chlorides with Et (1-ethoxycarbonyl)benzimidazole-2-acetate. Pyrazolo[5,1-c]triazines and triazolo[5,1-c]triazines have been synthesized via coupling of diazotized heterocyclic amines with Et benzimidazole-2-acetate. Et benzimidazole-2-acetate reacts with 1,1-dicyano-2-substituted ethenes and 1-cyano-1-ethoxycarbonyl-2-substituted ethenes to give pyrido[1,2-a]benzimidazoles, resp. Structures of the newly synthesized compounds are confirmed on the basis of elemental analyses, spectral data and alternative methods whenever possible. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 75629-62-8

The Article related to triazinobenzimidazole preparation, pyrazolotriazine preparation, triazolotriazine preparation, pyridobenzimidazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Recommanded Product: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Alizadeh, Abdolali; Hosseini, Seyed Yasub; Vahabi, Amir Hossein published an article in 2014, the title of the article was Substituent effects and structural features of α,α-dicyanoolefins and ketene dithioacetals on directing polyfunctionalized 2,6-dicyanoanilines or pyrazolo[1,5-a]pyridines.Recommanded Product: 2510-01-2 And the article contains the following content:

An efficient and facile synthesis of pyrazolo[1,5-a]pyridine derivatives, e.g., I, and polyfunctionalized 2,6-dicyanoaniline derivatives, e.g., II, via vinylogous Michael addition of cyclic or acyclic α,α-dicyanoolefins to electron-deficient ketene dithioacetals in the presence of hydrazine at room temperature was described. The prominent feature of this one-pot procedure is an apparent dichotomy in the nature of products, which was dictated by the structure and functionality of substrates. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2510-01-2

The Article related to pyrazolopyridine dicyanoaniline preparation substituent structure effect, dicyanoolefin ketene dithioacetal michael addition, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Recommanded Product: 2510-01-2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bertini, Simone; Saccomanni, Giuseppe; DelCarlo, Sara; Digiacomo, Maria; Gargini, Claudia; Piano, Ilaria; Campisi, Giuseppe Matteo; Ghidoni, Riccardo; Macchia, Marco; Manera, Clementina published an article in 2017, the title of the article was Application of an improved HPLC-FL method to screen serine palmitoyl transferase inhibitors.Product Details of 34662-29-8 And the article contains the following content:

In this work, we reported the application and validation of an improved high-performance liquid chromatog. method coupled with a fluorimetric detector (HPLC-FL) to screen the activity of two heterocyclic derivatives reported as serine palmitoyl transferase (SPT) inhibitors. The anal. conditions were optimized in terms of the derivatization procedure, chromatog. condition, extraction procedure, and method validation according to EMEA guidelines. Once fully optimized, the method was applied to assess the SPT-inhibitory activity of the above-mentioned derivatives and of the reference inhibitor myriocin. The obtained results, expressed as a percentage of residual SPT activity, were compared to those obtained with the reference radio immune assay (RIA). The good correlation between the two types of assay demonstrated that the improved HPLC-FL method is suitable for a preliminary and rapid screening of potential SPT-inhibitors. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Product Details of 34662-29-8

The Article related to serine palmitoyl transferase inhibitor hplcfl method, hplc, spt, enzymatic assay, screening, serine palmitoyl transferase, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Product Details of 34662-29-8

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Koeckritz, Peter; Sattler, Ruth; Liebscher, Juergen published an article in 1985, the title of the article was Iminoformylation reaction of substituted crotononitriles. I. Synthesis of new N,N-disubstituted 4-amino-1,1-dicyanobuta-1,3-dienes.Product Details of 2510-01-2 And the article contains the following content:

Condensation of H2CRCR1:C(CN)2 [R = H, Me; R1 = e.g. Et, Ph, 2-thienyl; RR1 = e.g. (CH2)4] with R2R3NH [R2 = alkyl, Ph; R3 = R2, PhCH2, cyclohexyl; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH2)2] and (EtO)3CH in the presence of carboxylic acids as catalysts gave ∼70 title compounds R2R3NCH:CRCR1:C(CN)2 in moderate to good yields depending on steric conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Product Details of 2510-01-2

The Article related to crotononitrile iminoformylation orthoformate amine, carboxylic acid iminoformylation catalyst, butadiene aminodicyano, Aliphatic Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Product Details of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 31, 1988, Hiremath, Shivayogi P.; Ullagaddi, Ashok; Sekhar, K. Raja; Purohit, Muralidhar G. published an article.Application of 75629-62-8 The title of the article was Synthesis of various pyrazole-1-carbonylindoles. And the article contained the following:

2-Indolecarbohydrazides were treated with MeCOCH2CO2Et to give pyrazolinones I (R1 = H, Me; R2 = OMe, Me, Cl, Br H, OEt; R3 = H Me; R4 = Me, Ph, H). Pyrazoles II were prepared from hydrazides and MeCOCH2COMe. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application of 75629-62-8

The Article related to pyrazole indolecarbonyl, indole pyrazolecarbonyl, indolecarbohydrazide cyclocondensation acetoacetate acetylacetone, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 31, 1997, Ram, Vishnu Ji; Nath, Mahendra published an article.SDS of cas: 75629-62-8 The title of the article was Synthesis of diheteroarylmethanes from activated nitriles. And the article contained the following:

Novel procedures for the preparation of diheteroarylmethanes, e.g., the pyrimidinylindolylmethanes I (R = H, benzyl; R1 = amino, Me, Ph, pyridyl, morpholino), were developed from the base-catalyzed condensation-cyclization of indolylmethylmalononitrile II (R = H, R1 = H, benzyl) with amidine, dicyandiamide, hydroxylamine, hydrazine, and thioglycolic acid. The acid catalyzed reaction of II (R2 = bond) with thiosemicarbazide affords thiadiazole III. Base-catalyzed reaction of 3-indolylacetonitrile with dicyandiamide gives sym. triazine IV. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).SDS of cas: 75629-62-8

The Article related to diheteroarylmethane preparation, methane diheteroaryl preparation, nitrile condensation cyclization, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.SDS of cas: 75629-62-8

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 5, 2005, Basurto, Sara; Garcia, Susana; Neo, Ana G.; Torroba, Tomas; Marcos, Carlos F.; Miguel, Daniel; Barbera, Joaquin; Ros, M. Blanca; de la Fuente, M. Rosario published an article.Application of 2510-01-2 The title of the article was Indene and pseudoazulene discotic liquid crystals: A synthetic and structural study. And the article contained the following:

Several new liquid-crystalline indene and pseudoazulene systems are reported. These mols. give rise to either columnar hexagonal mesophases and/or columnar plastic phases. The unique nature of these compounds stems from their nonclassical discotic structure. Although the mols. have rigid aromatic cores, they lack terminal tails and instead the polarizable atoms (S, halogens) or polar groups (CN, CO) act as unusual soft parts. From many structurally related materials, for this type of compound mol. stacking in the solid state is a prerequisite for the appearance of a columnar mesophase, although other intermol. interactions within the layers are also important in establishing liquid-crystalline order. The behavior reported for these mesomorphic mols. opens up new possibilities in the search for related mol. interactions that might be useful for the construction of supramol. architectures with particular properties. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to indene pseudoazulene discotic liquid crystal structure property, Crystallography and Liquid Crystals: Liquid Crystals, Plastic Crystals and other aspects.Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
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On January 7, 1999, Konstantinova, Lidia S.; Rakitin, Oleg A.; Souvorova, Ljudmila I.; Rees, Charles W.; White, Andrew J. P.; Williams, David J.; Torroba, Tomas published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was One-pot synthesis of new liquid crystalline indeno heterocyclic materials. And the article contained the following:

Disulfur dichloride converts 1-(dicyanomethylene)indane into 2,3-dichloro-1-(dicyanomethylene)indene and dichlorocyanoindeno-1,2-thiazine (I); it also converts inden-3-ylacetic acid into 2,3-dichloro-1-(dichloromethylene)indene and α,2,3-trichloro-1-indenylideneacetylchloride, dichloroindeno[2,1-c]-1,2-dithiolone (II) and dichloroindenothiophenone; upon melting crystals of the 2,3-dichloro-1-(dichloromethylene)indene and dichloroindenothiophenone are strongly birefringent and I exhibits thermochromicity; mechanisms are outlined for the novel transformations and x-ray crystal structures for I and II are analyzed. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to one pot synthesis liquid crystal indeno heterocyclic compound, Crystallography and Liquid Crystals: Liquid Crystals, Plastic Crystals and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 30, 2012, Gabrielli, Serena; Palmieri, Alessandro; Panmand, Deepak S.; Lanari, Daniela; Vaccaro, Luigi; Ballini, Roberto published an article.SDS of cas: 2510-01-2 The title of the article was β-Nitroacrylates as key starting materials for the one-pot synthesis of densely functionalized penta-substituted anilines. And the article contained the following:

The reaction of ylidene malononitriles with β-nitroacrylates, in Et3N/MeCN, affords the one-pot synthesis of a new class of penta-substituted, densely-functionalized anilines in satisfactory to good overall yields. The method represents a very important improvement of the recent strategy for the preparation of anilines from conjugated nitro alkenes. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to nitroacrylate ylidene malononitrile conjugate addition, aniline substituted preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: General and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts