Tag: 100-200

On May 5, 2016, Franconetti, A.; Dominguez-Rodriguez, P.; Lara-Garcia, D.; Prado-Gotor, R.; Cabrera-Escribano, F. published an article.Formula: C12H7N3 The title of the article was Native and modified chitosan-based hydrogels as green heterogeneous organocatalysts for imine-mediated Knoevenagel condensation. And the article contained the following:

A variety of methylenemalononitriles and Et cyanoacrylates derived from both aromatic and heteroaromatic aldehydes were synthesized by Knoevenagel condensation catalyzed with native and modified chitosan-based heterogeneous catalysts. The efficiency of our hydrogel organocatalysts, chitosan hydrogel beads and ureidyl-chitosan derivative hydrogel disks, was evaluated as function of pH, temperature and catalyst concentration by considering reaction rates, conversions, E/Z stereoselectivities, and kinetic studies of a model reaction between 4-nitrobenzaldehyde and Et cyanoacetate. An unprecedented study by solid state 13C CP MAS NMR of the employed catalyst when reaction was quenched after a 50% of conversion, has demonstrated that an imine-chitosan intermediate is formed during this process. Anal. of E/Z Et cyanoacrylate isomer mixtures for determining the corresponding stereoselectivity was carried out by NMR measuring carbon-proton coupling constants (3JC,H) using a novel CLIP-HSQMCB experiment Addnl., DFT calculations let us rationalize the observed E/Z stereoselectivities as well as to evaluate the role of ureidyl moiety on interaction with aldehydes and imine intermediate formation with chitosan derivative The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to aromatic aldehyde knoevenagel condensation chitosan hydrogel organocatalyst, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Darmanin, Thierry; Godeau, Guihem; Guittard, Frederic; Klimareva, Elena L.; Schewtschenko, Irina; Perepichka, Igor F. published an article in 2018, the title of the article was A Templateless Electropolymerization Approach to Porous Hydrophobic Nanostructures Using 3,4-Phenylenedioxythiophene Monomers with Electron-Withdrawing Groups.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile And the article contains the following content:

Controlling the surface structures of conducting polymers is extremely important for various applications not only because of their unique optoelectronic properties but also owing to the wetting properties of these materials. Using a templateless electropolymerization approach, we report the formation of porous polymer nanostructures from a series of 3,4-(1,2-phenylenedioxy)(PheDOT) derivatives with electron-withdrawing side groups (Cl, CN, CF, SOCH). In this templateless electropolymerization, trace water present in solution is sufficient to produce gas bubbles (O2 and H2) and, as a consequence, to form the porous nanostructures with a tendency to form nanotubes on the surface. We show that the substituents in PheDOT play an important role to control the porous nanostructures and, as a consequence, the surface hydrophobicity. Using 3,4-(1,3-propylenedioxy)type (ProDOT) derivative F4-BnDOT, the formation of densely packed nanofibers was demonstrated, and these are not a result of the presence of trace water. In this case, the surfaces are even more hydrophobic than for PheDOT-based polymers, displaying extremely high apparent water contact angles (θw = 138-144 °) and strong water adhesion. Such surfaces from electropolymerized conducting polymers could be used in a number of technol. applications, e.g. self-cleaning surfaces, micropatterning, water harvesting and microfluid systems. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

The Article related to phenylenedioxythiophene monomer derivative electron withdrawing group templateless electropolymerization property, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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On April 30, 2003, Ali, Gameel A. M. El-Hag published an article.Name: 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Studies on Thiazolopyridines. Part 3: Reactivity of Thiazolo[3,2-a]-3-aza[1,8]naphthyridine Towards Some Nucleophiles. And the article contained the following:

A variety of new thiazolo[3,2-a]pyridine derivatives having 3-indolyl group were produced by refluxing thiazolinone derivative with different benzylidenemalononitrile derivatives Reactivity of Thiazolo[3,2-a]-3-aza[1,8]naphthyridine (I) toward some nitrogen nucleophiles was investigated. Thus, the novel pyrazoles were obtained when I was allowed to react with hydrazine and Ph hydrazine in ethanol under reflux. On the other hand, pyrazolo[3′,4′:4,5]thiazolo[3,2-a]-3-aza[1,8]naphthyridine was formed by condensation of I with benzoyl hydrazine. Finally, condensed heterocyclic compounds containing pyran rings were obtained by treatment I with active ethylene compounds Antimicrobial activity of some of the product was also evaluated. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Name: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to thiazolopyridine derivative preparation reactivity nucleophile antimicrobial activity, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Name: 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 20, 2014, Han, Shiqing; Tong, Yao; Pan, Qiang; Jiang, Zengqiang; Miao, Dazhuang published a patent.COA of Formula: C7H3ClN2O2 The title of the patent was A synthetic method for 2-substituted benzothiazole derivatives. And the patent contained the following:

The invention relates to a process for the preparation of 2-substituted benzothiazole derivatives via heterocyclization of 2-halogenated nitrobenzene with elemental sulfur and aliphatic amines. For instance, 2-phenyl-benzothiazole was prepared from 1-chloro-2-nitrobenzene, sulfur, and benzylamine in 76% yield as a white solid. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).COA of Formula: C7H3ClN2O2

The Article related to benzothiazole preparation heterocyclization halonitrobenzene benzylamine sulfur, heterocyclization and other aspects.COA of Formula: C7H3ClN2O2

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Nitrile – Wikipedia,
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On October 30, 2008, Delisser, Vern; Hedberg, Martin; Jansson, Annette; Raadevik, Andreas; Ryberg, Per; Thiering, Swantje published a patent.Category: nitriles-buliding-blocks The title of the patent was Process for preparation of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile. And the patent contained the following:

The present invention pertains to a process for the preparation of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile as a free base and pharmaceutically acceptable salts thereof, particularly the citrate salt. For example, Et 2-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]acetate was reacted with 3-fluoro-4-nitrobenzonitrile in THF at -20 °C in presence of lithium tert-butoxide to afford an intermediate, which was treated with Degussa heterogeneous catalyst (platinum and vanadium on active carbon) under hydrogen for selective reduction of nitro group to amino group. The reduction product obtained above was treated with citric acid monohydrate at 60-75 °C for 2 h in Bu acetate, DMF, and iso-propanol, cooled to 5 °C over 10 h, and held overnight at 5 °C to gave 75 % yield of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile citrate as an orange solid. Advantageously, the new process is suitable for large scale industrial manufacturing The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Category: nitriles-buliding-blocks

The Article related to preparation morpholin indole citrate, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 24, 2012, Delisser, Vern; Hedberg, Martin; Jansson, Annette; Raadevik, Andreas; Ryberg, Per; Thiering, Swantje published a patent.Synthetic Route of 34662-29-8 The title of the patent was Process for the manufacturing of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1h-indole-5-carbonitrile 701. And the patent contained the following:

The present invention relates to a new process for the manufacture of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile as a free base and pharmaceutically acceptable salts thereof, particularly the 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, and to new intermediates prepared in said process suitable for large scale manufacturing of said compound The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Synthetic Route of 34662-29-8

The Article related to preparation morpholin indole citrate, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Synthetic Route of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 7, 2015, Saidalimu, Ibrayim; Tokunaga, Etsuko; Shibata, Norio published an article.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Carbene-Induced Intra- vs Intermolecular Transfer-Fluoromethylation of Aryl Fluoromethylthio Compounds under Rhodium Catalysis. And the article contained the following:

The intra- vs intermol. transfer-fluoromethylation of aryl fluoromethylthio compounds is proposed. Finely designed ArSCF3 I [X = CF3] nicely releases its trifluoromethyl (CF3) group intermolecularly under rhodium catalysis, whereas a difluoromethylated analog, ArSCF2H I [X = CF2H] shows intramol. reaction. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to carbene induced transfer fluoromethylation aryl fluoromethylthio compound rhodium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Quality Control of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qin, Wenbing; Lin, Weifeng; Li, Xin; Xiong, Wei; Liu, Guokai published an article in 2020, the title of the article was Difluoromethylation of dicyanoalkylidenes by electrophilic S-(difluoromethyl)sulfonium salt: efficient construction of difluoromethylated all-carbon-substituted centers.HPLC of Formula: 2510-01-2 And the article contains the following content:

An efficient approach for difluoromethylation of dicyanoalkylidenes by electrophilic S-(difluoromethyl)sulfonium salt under organic base was described. A wide range of structurally and functionally diverse dicyanoalkylidenes was readily transferred into corresponding desirable difluoromethylated compounds bearing difluoromethylated all-carbon-substituted centers in good to excellent yields under standard reaction conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).HPLC of Formula: 2510-01-2

The Article related to difluoromethylation dicyanoalkylidene difluoromethyl sulfonium, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.HPLC of Formula: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 27, 2021, Fu, Jiya; Zhang, Chuanbao; Zhao, Lili; Li, Ran; Deng, Yihang; Yuan, Jinfang; Wang, Yanbo; Zhu, Junyan published a patent.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Preparation of spiro dihydrofluorene derivatives. And the patent contained the following:

The invention discloses a preparation of spiro dihydrofluorene derivative, which has the advantages of high efficiency, low cost and good application prospect. Spiro dihydrofluorene derivatives are shown in formula I, wherein R1 is selected from: CN or CO2 Me; R2 is selected from substituted Ph, substituted pyridyl, substituted furanyl, substituted thiophene or substituted naphthyl; R3 is selected from one of hydrogen, halogen, alkyl, trifluoromethyl, hydroxyl, alkoxy, nitro, ester, amino, acylamino, alkacyloxy, cyano, aryl, alkenyl, halobenzyloxy, halobenzylamine or halophenoxy; R4 is selected from one of hydrogen, halogen, alkyl, trifluoromethyl, alkoxy, nitro, ester, amino, cyano, aryl, alkenyl, halobenzyloxy, halobenzylamine or halophenoxy. Spiro dihydrofluorene derivatives were prepared via cyclization of 2-benzofuranone derivatives and 1-indene methylene malononitrile. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to spiro dihydrofluorene preparation cyclization, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 31, 2009, Liang, Jing; Zhang, Meimei; Wei, Xianyong; Zong, Zhimin; Wang, Xiangshan published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was One-step synthesis of fluorene or phenanthrene derivatives via the reaction of arylaldehyde and malononitrile with 2-(1,2-dihydroinden-3-ylidene)malononitrile or 2-(2,3-dihydronaphthalen-4(1H)-ylidene)-malononitrile catalyzed by KF/Al2O3 in ethyl alcohol. And the article contained the following:

A method for the synthesis of the title compounds [i.e., 3-amino-1-(phenyl)-9H-fluorene-2,4-dicarbonitrile derivatives and 3-amino-1-(phenyl)-9,10-dihydro-2,4-phenanthrenedicarbonitrile derivatives] is reported here. A series of fluorene or phenanthrene derivatives was synthesized from aryl aldehyde derivatives, malononitrile and 2-(1,2-dihydro-3-indenylidene)malononitrile or 2-(2,3-dihydro-4-naphthalenylidene)malononitrile catalyzed by KF/Al2O3 at 80° in ethanol. This method has the advantages, such as mild reaction conditions, high yields (72-88%) and easy operation. The structures of the products were characterized by IR, NMR, elemental anal. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to phenanthrene amino phenyl phenanthrenedicarbonitrile preparation, fluorene amino phenyl fluorenedicarbonitrile preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Anthracenes and Phenanthrenes and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts