Tag: 100-200

Liu, Yingtian; Dang, Xinxin; He, Yu; Bai, Hudong; Chen, Xuehong; Li, Jun-Long; Fan, Junting; Jiang, Hezhong; Li, Jiahong published an article in 2019, the title of the article was Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile And the article contains the following content:

A straightforward and efficient method was developed for the synthesis of 2-cyanoacrylamides R1R2C:C(CN)CONH2 [R1 = n-Pr, Ph, 4-MeOC6H4, PhCH:CH, 2-furyl, etc., R2 = H; R1 = Ph, R2 = Me, Ph; R1R2 = (CH2)5, o-C6H4CH2CH2, etc.] from 2-methylenemalononitriles R1R2C:C(CN)2 in good to excellent yields through monohydration under mild and simple reaction conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to methylene malononitrile preparation diastereoselective monohydration palladium catalyst, cyano acrylamide preparation, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 27, 2021, Shen, Chunli; Sun, Guanglong; Wu, Chengde; Chen, Shuhui published a patent.Reference of 5-Bromo-3-hydroxypicolinonitrile The title of the patent was Bicyclic compound used as selective androgen receptor modulator. And the patent contained the following:

Disclosed are a bicyclic compound used as a non-steroidal selective androgen receptor modulator and the use thereof in the preparation of a drug for treating related diseases which are mediated by an androgen receptor. Specifically, the present invention discloses a compound as shown in formula I or a pharmaceutically acceptable salt thereof. The experimental process involved the reaction of 5-Bromo-3-hydroxypicolinonitrile(cas: 1160936-51-5).Reference of 5-Bromo-3-hydroxypicolinonitrile

The Article related to bicyclic compound preparation androgen receptor modulator treatment disease, Alicyclic Compounds: Bicyclic Compounds, Including Azulenes, Heptalenes, and Pentalenes and other aspects.Reference of 5-Bromo-3-hydroxypicolinonitrile

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Nitrile – Wikipedia,
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On April 12, 2004, Blazej, Sylwia; Kwast, Andrzej; Makosza, Mieczyslaw published an article.Reference of 3-Chloro-4-nitrobenzonitrile The title of the article was cine-Substitution of the nitro group in 2,4-disubstituted nitroarenes with carbanions of aryl alkyl sulfones. And the article contained the following:

Rapid protonation of short lived σH adducts, e.g., I, derived from the nucleophilic addition of aryl alkyl sulfones to 2,4-disubstituted nitrobenzenes, resulted in elimination of nitrous acid giving 1,3,5-trisubstituted benzenes, e.g., II, as products of cine-substitution of the nitro group. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to nitrobenzene aryl alkyl sulfone cine substitution, aryl arylalkyl sulfone preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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Chen, Hui; Zhao, Sihan; Cheng, Shaobing; Dai, Xingjie; Xu, Xiaoying; Yuan, Weicheng; Zhang, Xiaomei published an article in 2019, the title of the article was Synthesis of Novel Pterocarpen Analogues via [3 + 2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines.Related Products of 2510-01-2 And the article contains the following content:

By employing triethylamine as a catalyst, [3+2]-coupling-elimination cascade of α,α-dicyano-olefins, e.g., I, with quinone monoimines, e.g., II, was realized. The reactions afforded various novel pterocarpen analogs, e.g., III, with generally moderate yields (up to 75%). In addition, a plausible reaction mechanism was proposed. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

The Article related to pterocarpen analog preparation coupling elimination cascade triethylamine catalyst, Biomolecules and Their Synthetic Analogs: Flavonoids and Natural and Fused Coumarins and other aspects.Related Products of 2510-01-2

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Nitrile – Wikipedia,
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Lega, D. A.; Chernykh, V. P.; Shemchuk, L. A. published an article in 2016, the title of the article was The study of the three-component interaction between 1-ethyl-1H-2,1-benzothiazin-4(3H)-one 2,2 dioxide, hetarylcarbaldehydes and active methylene nitriles.HPLC of Formula: 75629-62-8 And the article contains the following content:

Some peculiarities of the three-component reaction of 1-ethyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide with active methylene nitriles and hetarylcarbaldehydes have been described in this article. It has been found that if malononitrile is used, the products of the three-component reaction are 2-amino-4-hetaryl-3-cyano-6-ethyl-4,6- dihydropyrano[3,2-c][2,1]benzothiazine 5,5-dioxides irresp. of the hetaryl fragment nature in the initial aldehyde. When using Et cyanoacetate as an active methylene nitrile instead of malononitrile the reaction lost its selectivity. In this case, depending on the hetarylcabaldehyde, three different types of products were obtained, namely, 2-amino-3-alkoxycarbonyl-4-hetaryl-4H-pyrans (for pyridine-3-, pyridine-4-carbaldehydes, and furan-2-carbaldehyde), triethylammonium salt of bis(1-ethyl-1H-2,1-benzothiazin-2,2- dioxo-4-ol-3-yl)(2-thienyl)methane (for thiophen-2-carbaldehyde) or Et 2-cyano-3-(1H-indol-3-yl)acrylate (for indole-3-carbaldehyde). Formation of a stable triethylammonium salts was considered as the process competitive with formation of 2-amino-4H-pyrans. This has allowed us to propose the modified mechanism of 2-amino-4H-pyran formation. This mechanism includes formation of triethylammonium salts of bis-adducts. According to this mechanism 2-amino-3-ethoxycarbonyl-4-(2-thienyl)-4H-pyran without any impurity of bis-adduct could be selectively obtained using the three-component reaction. Triethylammonium salts of bis-adducts were obtained by direct reaction of 1-ethyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide with hetarylcarbaldehydes in the presence of equimolar amounts of triethylamine. It has been shown that the three-component reaction of 1-ethyl-1H-2,1-benzothiazM(3H)-one 2,2-dioxide with active methylene nitriles and hetarylcarbaldehydes is a more effective tool for obtaining fused 2-amino-4-hetaryl-4H-pyrans compared to the stepwise approach. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).HPLC of Formula: 75629-62-8

The Article related to three component reaction ethylbenzothiazinone dioxide hetarylcarbaldehyde nitrile, Physical Organic Chemistry: Ring Formation, Cleavage, Enlargement, and Contraction and other aspects.HPLC of Formula: 75629-62-8

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Nitrile – Wikipedia,
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Elslager, Edward F.; Jacob, Patricia; Werbel, Leslie M. published an article in 1972, the title of the article was Antimalarial drugs. 28. Folate antagonists. 6. Synthesis and antimalarial effects of fused 2,4-diaminothieno [2,3-d] pyrimidines.Category: nitriles-buliding-blocks And the article contains the following content:

2,4-Diamino-5,7 – dihydro – 6H – thiopyrano[4 ,3 :4,5]thieno[2,3-d]pyrimidine, 2,4-diamino-9H-indeno[1 ,2 :4,5]thieno[2,3-d]-pyrimidine, 2,4-diamino – 5H – indeno[2 ,1 :4,5]thieno[2,3 – d]-pyrimidine, 9,11-diamino-5,6-dihydronaphtho[1 ,2 :4,5]thieno-[2,3-d]pyrimidine, 7,9-diamino-5,6-dihydronaphtho[2 ,1 :4,5]-thieno[2,3-d]pyrimidine, 2,4-diamino – 7 – benzyl – 5,6,7,8 – tetrahydropyrido[4 ,3 :4,5]thieno[2,3-d]pyrimidine, and various 2,4-diamino – 5,6,7,8 – tetrahydro – [1]benzothieno[2,3 – d]pyrimidines were prepared by cyclization of the requisite fused 2-aminothiophene-3-carbonitriles with ClC(:NH)Nh2.HCl. Several compounds exhibited strong inhibitory effects against Streptococcus faecalis (MGH-2), Staphylococcus aureus (UC-76), Streptococcus faecalis (ATCC 8043), Lactobacillus casei (ATCC 7469), and Pediococcus cerevisiae (ATCC 8081) in vitro, and three compounds displayed slight antimalarial activity against Plasmodium berghei in mice and Plasmodium falciparum (Uganda I) in vitro. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks

The Article related to thienopyrimidine diamino fused, antimalarial fused diaminothienopyrimidine, antibacterial fused diaminothienopyrimidine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
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Jain, Shubha; Reddy, B. Nagi; Rao, K. Sambasiva; Neeliah, G. published an article in 2010, the title of the article was Microwave assisted synthesis of indole substituted alkenes using Knoevenagel condensation reaction and their antibacterial activity study.Computed Properties of 75629-62-8 And the article contains the following content:

The reaction rate of the Knoevenagel condensation can be dramatically enhanced by irradiating the reaction mixture containing an 3-indolealdehyde, active methylene compound, L-proline and PhCl using a com. microwave oven. Several Knoevenagel condensation products were synthesized within 5-17 min in good yields. The new compounds were also screened for antibacterial activity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Computed Properties of 75629-62-8

The Article related to indole active methylene knoevenagel condensation microwave, indolyl alkene preparation antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 75629-62-8

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On June 30, 2007, Abd El-Latif, Nehad A.; Amr, Abd El-Galil E.; Ibrahiem, Alhusain A. published an article.Formula: C12H7N3 The title of the article was Synthesis, reactions, and pharmacological screening of heterocyclic derivatives using nicotinic acid as a natural synthon. And the article contained the following:

A series of substituted pyridine derivatives were prepared from 3-acetylpyridine, which was prepared from the corresponding nicotinic acid as a natural starting material. Reaction of 3-acetylpyridine with indole-3-carboxaldehyde afforded the corresponding 3-β-(3-indolyl)(acryloyl)pyridine, which was treated with hydroxylamine hydrochloride in pyridine or acetic acid in the presence of sodium acetate to afford 3-β-(3-indolyl)(acryloyl)pyridine oxime and oxazole derivatives The oxime was treated with Et isothiocyanate or toluene-3,5-diisocyanate in refluxing dioxane to give the corresponding Et thiosemicarbazide and 3,5-bis(semicarbazide) derivative 3-β-(3-Indolyl)(acryloyl)pyridine was condensed with malononitrile in refluxing ethanol in the presence of piperidine as a catalyst to give a cyano(amino)pyran derivative, while it was condensed with Et cyanoacetate or malononitrile in the presence of ammonium acetate to yield (cyano)pyridone and cyano(amino)pyridine derivatives Cyclization of (acryloyl)pyridine with o-phenylenediamine in refluxing butanol led to the formation of the corresponding benzodiazepine via the intermediate A. Finally, cycloaddition reaction of (acryloyl)pyridine with thiourea yielded thioxopyrimidine, which was treated with chloroacetic acid to yield thiazolopyrimidine. An arylmethylene derivative was prepared by reacting thiazolopyrimidine with indole-3-carboxaldehyde or by treating thioxopyrimidine with indole-3-carboxaldehyde and chloroacetic acid in one step. The pharmacol. screening showed that many of the compounds thus prepared have good analgesic and anticonvulsant activities comparable to valdecoxib [i.e, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide] and carbamazepine as reference drugs. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

The Article related to nicotinic acid indolecarboxaldehyde thioxopyrimidine preparation analgesic anticonvulsant, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C12H7N3

Referemce:
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On June 30, 1994, Mahboobi, Siavosh; Grothus, Goetz published an article.Category: nitriles-buliding-blocks The title of the article was 1,3-Dinitropropanes: intermediates to 1,3-diaminopropanes. And the article contained the following:

Reduction of malodinitriles RCH(CN)2 (R = di-p-anisylmethyl, 3-indolylmethyl) to the corresponding diamines does not work. Reduction of dinitro-2-(indol-3-yl)propanes and subsequent reaction with K2PtCl4 afforded dichloroplatinum(II) complexes I [R1 = H, Me, Et; R2 = H, Me, Ph; R3 = H (17); R1 = Et, R2 = 4-HOC6H4, R3 = 5- or 6-HOC6H4]. Complexes 17 show weak binding affinities to the estrogen receptor and no antitumor activity towards MCF-7- and MDA-MB-2231-cell lines. Two-fold addition of nitromethane to the aldehyde function is possible. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Category: nitriles-buliding-blocks

The Article related to indolylpropanediamine preparation reaction, propanediamine indolyl, platinum indolylpropanediamine preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
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On May 1, 2014, Papeo, Gianluca Mariano Enrico; Krasavin, Mikhail Yurievitch; Orsini, Paolo; Scolaro, Alessandra published a patent.Recommanded Product: 877151-43-4 The title of the patent was Preparation of carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors. And the patent contained the following:

Provided are substituted 4-carboxamido-isoindolinone derivatives of formula I which selectively inhibit the activity of poly (ADP-ribose) polymerase (PARP-1) useful in the treatment of cancer, cardiovascular disease, central nervous system injury, and inflammation. I [wherein R is H or fluorine, when (a) n is 0 and m is 0, 1, 2, or 3 then R1 is 3- to 6-membered cycloalkyl or 4- to 6-membered heterocyclyl; and R2 is 3-, 5-, or 6-membered cycloalkyl, 4- to 6-membered heterocyclyl, or (hetero)aryl; (b) n is 1 and m is 0 then R1 is 3- to 6-membered cycloalkyl or aryl each which is optionally substituted; and R2 is null, 3- to 6-membered cycloalkyl, 4- to 6-membered heterocyclyl, (hetero)aryl, each which is optionally substituted; (c) n is 2 or 3 and m is 0 then R1 is 3- to 6-membered cycloalkyl, 4-to 6-membered heterocyclyl, or (hetero)aryl, each which is optionally substituted; and R2 is null, 3- to 6-membered cycloalkyl, 4- to 6-membered heterocyclyl, (hetero)aryl, each which is optionally substituted; (d) n and m are each independently 1, 2, or 3; R1 and R2 are independently 3- to 6-membered cycloalkyl, 4- to 6-membered heterocyclyl, or (hetero)aryl] or pharmaceutically acceptable salts thereof are claimed and exemplified. II was prepared in a multistep procedure (preparation given). I were assayed for antitumor activity in Capan-1 BRCA-2 mutated mouse model from which it was determined III exhibited tumor growth inhibition of 54% with no evidence of toxicity. The present invention also provides processes for preparing I and pharmaceutical compositions comprising I. The experimental process involved the reaction of Methyl 2-cyano-4-fluoro-6-methylbenzoate(cas: 877151-43-4).Recommanded Product: 877151-43-4

The Article related to carboxamidoisoindolinone derivative preparation parp inhibitor cancer inflammation cardiovascular disease, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 877151-43-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts