Tag: 100-200

On December 23, 2013, Ranise, Angelo; Lucchesini, Francesco; Caviglia, Matteo; Alfei, Silvana; Spallarossa, Andrea; Caneva, Chiara published an article.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Unconventional stereoselective one-pot synthesis of Knoevenagel-type indoles via in situ condensation of iminium salts with active methylene reagents. And the article contained the following:

A simple one-pot procedure for the stereoselective synthesis of Knoevenagel-type indoles is described. The method is based on the in situ reaction of indole iminium salts (four of them are fully characterized) with acyclic sym. and unsym. active methylene reagents in the presence of triethylamine. In general, the overall yields are moderate to good. Some of relevant reaction parameters and steric effects affecting stereoselectivity are discussed. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to stereoselective knoevenagel condensation iminium methylene, indole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 23, 2006, Clayton, Joshua; Ma, Fupeng; Van Wagenen, Bradford; Ukkiramapandian, Radhakrishnan; Egle, Ian; Empfield, James; Isaac, Methvin; Slassi, Abdelmalik; Steelman, Gary; Urbanek, Rebecca; Walsh, Sally published a patent.COA of Formula: C10H8FNO2 The title of the patent was Preparation of isoindolones as metabotropic glutamate receptor potentiators. And the patent contained the following:

The title compounds I [R1 = (un)substituted 3-7 membered ring that may contain one or more heteroatoms selected from N, O and S; R2, R3 = H, alkyl, aryl, etc.; R4, R6 = H, OH, halo, etc.; R5 = H, halo, NO2, etc.; R7 = H, halo, NO2, etc.; R8, R9 = H, halo, NO2, etc.; or, where n is greater than 1, two or more R8 and/or R9 on adjacent carbons may be absent to form an alkenyl or alkynyl moiety], useful as metabotropic glutamate receptor modulators, particularly in neurol. and psychiatric disorders, were prepared E.g., a multi-step synthesis of II, was given. Generally, compounds I were active in assays described (e.g., mGluR2 assay) at concentrations (or with EC50 values) less than 10 μM. The pharmaceutical composition comprising the compound I is disclosed. The experimental process involved the reaction of Methyl 2-cyano-4-fluoro-6-methylbenzoate(cas: 877151-43-4).COA of Formula: C10H8FNO2

The Article related to isoindolone preparation metabotropic glutamate receptor potentiator mglur2, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C10H8FNO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 31, 2018, Honarmand, M.; Givzad, M. published an article.Recommanded Product: 75629-62-8 The title of the article was An efficient and eco-friendly process for the Knoevenagel reaction using nano organosalt catalyst. And the article contained the following:

A novel nano organosalt was synthesized easily by the reaction of sulfuric acid with 1,3-diaminopropane in water. The morphol. and structure of the synthesized organosalt were determined by various techniques. The catalytic application of organosalt was investigated in the Knoevenagel reaction of aryl/heteroaryl/alkyl aldehydes with activated methylene compounds under solvent-free conditions. The Knoevenagel products were obtained in high to excellent yields in the short reaction times. No toxic solvents and byproducts were involved, and in most cases no tedious purifications were needed. The catalyst was also recovered and reused after the five reaction cycles without a significant decrease in catalytic activity. The TEM image and elemental anal. of the recovered catalyst were confirmed the high stability and durability of nano organosalt under the applied reaction conditions. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 75629-62-8

The Article related to knoevenagel reaction nano organosalt catalyst eco friendly process, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Recommanded Product: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 25, 2018, Cao, Dongdong; Yang, Jianguo; Ying, Anguo; Mo, Hanjie; Chen, Dingben; Chen, Gang published a patent.Category: nitriles-buliding-blocks The title of the patent was Method for preparing trisubstituted 4-aminocarbazole and disubstituted 1-aminodibenzo[b,d]thiophene compound from 3-nitroindole compound or 3-nitrobenzothiophene and 2-(1-arylethylidene)malononitrile. And the patent contained the following:

The title method for preparing trisubstituted 4-aminocarbazole and disubstituted 1-aminodibenzo[b,d]thiophene compound includes adopting 3-nitroindole compound or 3-nitrobenzothiophene and 2-(1-arylethylidene)malononitrile as raw materials, reacting at 50°C for 6-24 h in solvent acetonitrile under the catalysis of triethylamine under the protection of nitrogen gas to obtain the final product. For instance, 1-amino-3-phenyl-2-dibenzothiophenecarbonitrile was prepared from 3-nitro-benzo[b]thiophene and 2-(1-phenylethylidene)-propanedinitrile in 52% yield. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks

The Article related to aminocarbazole aminodibenzothiophene preparation cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 31, 2018, Dyachenko, V. D.; Matusov, I. O.; Dyachenko, I. V.; Nenajdenko, V. G. published an article.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Knoevenagel Reactions of Indole-3-carbaldehyde. Synthesis of 3-Substituted Indole Derivatives. And the article contained the following:

The Knoevenagel condensations of 1H-indole-3-carbaldehyde with various CH acids gave a number of substituted 3-(1H-indol-3-yl)acrylonitriles and acrylamides which were alkylated to afford the corresponding N-alkyl derivatives I [R = CN, CO2(CH2)6CH3, C(O)NHc-Pr; R1 = Me, allyl, Bn, etc.]. The latter were used as Michael acceptors in the synthesis of 4H-pyran, pyridine, 5,6,7,8-tetrahydroquinoline and [1,3]thiazolo[3,2-a]pyridine derivatives containing an indole fragment. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Reference of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indole preparation, nitrile indole knoevenagel condensation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 31, 2009, Li, Xiaochuan; Kim, Sung-Hoon; Kun, Jun; Son, Young-A. published an article.Electric Literature of 2510-01-2 The title of the article was Synthesis and Optical Properties of (A)n-π-(Ph)3N Type Dyes. And the article contained the following:

Two new (A)n-π-(Ph)3N type dyes were designed, synthesized and characterized. The optical properties and structures of them were studied, including UV-visible spectroscopy, photo-luminescence spectroscopy. The geometric structures of them were calculated theor. based on the DFT level using BLYP/GGA basis set, the HOMO/LOMO levels were also measured and calculated The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Electric Literature of 2510-01-2

The Article related to dye synthesis optical property, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Optical Properties (Linear) and other aspects.Electric Literature of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 17, 2020, Feng, Jiaxu; Chen, Yingying; Qin, Wenhui; Huang, You published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Phosphine-Catalyzed (3 + 2)/(3 + 2) Sequential Annulation of γ-Vinyl Allenoates: Access to Fused Carbocycles. And the article contained the following:

The first (3 + 2)/(3 + 2) sequential annulation of γ-vinyl allenoates with alkylidenemalononitriles enabled by phosphine catalysis has been reported. A broad range of structurally dense tetra- and penta-substituted bicyclic[3,3,0]octene derivatives, containing a quaternary center and three sequential stereogenic center, were synthesized in good to excellent yields. In this approach, three new C-C bonds are formed in one pot, and εC and αC of γ-vinyl allenoate are two electrophilic centers, whereas its γC exhibits nucleophilic reactivity. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to alkylidenemalononitrile vinyl allenoate phosphine catalyst sequential diastereoselective annulation, fused carbocycle one pot preparation, Alicyclic Compounds: Tricyclic Compounds and Higher Analogs, Including Adamantanes, Fullerenes and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 31, 2003, Elinson, M. N.; Fedukovich, S. K.; Zaimovskaya, T. A.; Vereshchagin, A. N.; Nikishin, G. I. published an article.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Electrocatalytic transformation of malononitrile and cycloalkylidenemalononitriles into spirotricyclic and spirotetracyclic compounds containing cyclopropane and pyrroline fragments. And the article contained the following:

Electrolysis of cycloalkylidenemalononitriles and malononitrile in MeOH in an undivided cell in the presence of the NaBr-NaOMe mediator system gives spirotricyclic compounds containing cyclopropane and pyrroline fragments in 50-77% yields. Spirobicyclic and spirotricyclic tetracyanocyclopropanes undergo electrolysis in alcs. to afford spirotricyclic and spirotetracyclic products containing cyclopropane and pyrroline fragments in 50-93% yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to electrocatalytic spirocyclization malononitrile cycloalkylidenemalononitrile spirotricyclic spirotetracyclic cyclopropane pyrroline, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 14, 2004, Ando, Kazuo; Kawai, Makoto; Kawamura, Mitsuhiro; Matsumizu, Miyako; Morita, Asato; Sakurada, Isao published a patent.Reference of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of heterocyclic bicyclic compounds as NR2B receptor antagonists. And the patent contained the following:

Title compounds I [R1-2 = H, halo, alkyl, alkoxy, etc.; X = bond, alkylene, etc.; A = bicyclic, aromatic, (un)saturated heterocyclic ring, etc.; B = Ph, heteroaryl, etc.] are prepared For instance, N-[(2-benzyl-1H-indol-5-yl)methyl]-4-hydroxybenzamide (II)is prepared in 2 steps from (2-benzyl-1H-indol-5-yl)carbonitrile. II has Ki = 2 nM for the NR2B receptor. I is useful for the treatment of disease conditions caused by over activation of NMDA NR2B receptor, e.g., pain. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to bicyclic benzimidazole benzoxazole quinazoline nr2b receptor antagonist preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
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On February 28, 2019, Chen, Yiyang; Peng, Zhixing; Tao, Yuhan; Wang, Zaibin; Lu, Ping; Wang, Yanguang published an article.Formula: C12H8N2 The title of the article was Polymorphism-dependent emissions of two phenoxazine derivatives. And the article contained the following:

Two phenoxazine derivatives 1 and 2 were synthesized and their photoluminescent properties were systematically investigated. These two compounds presented crystallization-induced emission (CIE) with polymorphism-dependent emission (PDE). Compound 1 presented two single crystal structures with maximum emission wavelengths of 540 nm and 560 nm, while compound 2 possessed three single crystal structures with maximum emission wavelengths of 516 nm, 547 nm, and 556 nm, resp. Moreover, compound 1 showed reversible mechanochromic luminescence by grinding/heating or solvent fuming processes. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Formula: C12H8N2

The Article related to polymorphism emission phenoxazine derivative, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Formula: C12H8N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts