Tag: 100-200

Martin, Nazario; Quinteiro, Margarita; Seoane, Carlos; Soto, Jose L. published an article in 1987, the title of the article was Synthesis of some polyheterocyclic systems with isolated nuclei.SDS of cas: 75629-62-8 And the article contains the following content:

Knoevenagel-type condensation reactions of heterocyclic aldehydes were carried out. Thus, treatment of RCHO (R = pyridyl, pyrrolyl, furyl, etc.) with active methylene compounds PhCOCH2R1 (R1 = CN, CO2Et) in EtOH containing piperidine afforded benzoylheteroarylacrylonitrile and -acrylates RCH:CR1COPh (I). The I underwent cyclization with malononitrile to give 4H-pyrans II. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).SDS of cas: 75629-62-8

The Article related to pyrancarbonitrile heteroaryl, pyridineacrylonitrile benzoyl, furanacrylonitrile benzoyl, pyrroleacrylonitrile benzoyl, thiopheneacrylonitrile benzoyl, indoleacrylonitrile benzoyl, aldehyde knoevenagel condensation benzoylacetonitrile, acetonitrile benzoyl condensation aldehyde, acetate benzoyl condensation aldehyde and other aspects.SDS of cas: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 25, 2022, Zhu, Lixiang; Peng, Heling; Guo, Yan; Che, Jixing; Wu, Jia-Hong; Su, Zhishan; Wang, Tianli published an article.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Enantioselective Synthesis of Atropisomeric Biaryl Phosphorus Compounds by Chiral-Phosphonium-Salt-Enabled Cascade Arene Formation. And the article contained the following:

Axially chiral biaryl monophosphorus mols., exemplified by atropisomeric 1,1′-biaryl aminophosphines, are significant motifs in numerous chiral ligands/catalysts. Developing efficient methods for preparing P compounds with these privileged motifs is an important endeavor in synthetic chem. Herein, the authors develop an effective, modular method by a chiral-phosphonium-salt-catalyzed novel cascade between P-containing nitroolefins and α,α-dicyanoolefins, leading to a great diversity of atropisomeric biaryls bearing P groups in high yields with excellent stereoselectivities. The reaction features include a Thorpe-type cycloaddition/oxidative hydroxylation/aromatization cascade pathway with a central-to-axial chirality transfer process. Insight gained from the authors’ studies is expected to advance general efforts towards the catalytic synthesis of atropisomeric biaryl P compounds, offering a platform for developing new efficient chiral ligands and catalysts. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to naphthyl nitroolefin cycloaddition cyanoolefin chiral phosphonium salt catalyst, aminophosphorylnaphthalenylnitro dihydrophenanthrene carbonitrile derivative preparation crystal structure, mol structure aminophosphorylnaphthalenylnitro dihydrophenanthrene carbonitrile derivative, atropisomerism, biaryl phosphines and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 29, 2005, Xue, Dong; Chen, Ying-Chun; Cui, Xin; Wang, Qi-Wei; Zhu, Jin; Deng, Jin-Gen published an article.Electric Literature of 2510-01-2 The title of the article was Transfer Hydrogenation of Activated C:C Bonds Catalyzed by Ruthenium Amido Complexes: Reaction Scope, Limitation, and Enantioselectivity. And the article contained the following:

It was found that the chemoselectivity could be completely switched from C:O to C:C bonds in the transfer hydrogenation of activated α,β-unsaturated ketones R1CH:CR2COR3 (R1 = Ph, 4-MeOC6H4, 4-O2NC6H4; R2 = H, Me, MeCO, EtO2C; R3 = Me, Ph) catalyzed by diamine-ruthenium complex. Moreover, this addition via metal hydride had been applied to the reduction of various activated olefins R4R5C:CR6R7 (R4 = H, Me; R5 = H, n-C5H11, Ph, 4-MeOC6H4, 4-O2NC6H4; R6 = CN, EtO2C, Ph, O2N, etc.; R7 = H, CN, O2N, HO2C, etc.). The electron-withdrawing ability of functional groups substituted on C:C bonds at the α- or β-position had strong influence on the reactivity. In addition, a wide variety of chiral diamine-Ru(II)(arene) systems was investigated to explore the asym. transfer hydrogenation of prochiral α,α-dicyanoolefins. Two parameters had been systematically studied: (i) the structure of the N-sulfonylated chiral diamine ligands and (ii) the structure of the metal precursors. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Electric Literature of 2510-01-2

The Article related to ketone unsaturated stereoselective chemoselective transfer hydrogenation ruthenium amido complex, dinitrile enantioselective transfer hydrogenation ruthenium amido complex, alkene activated transfer hydrogenation ruthenium amido complex, sulfonamide amino preparation chiral ligand asym transfer hydrogenation and other aspects.Electric Literature of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 18, 2015, Spallarossa, Andrea; Caneva, Chiara; Caviglia, Matteo; Alfei, Silvana; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra; Brindisi, Margherita; Zisterer, Daniela M.; Bright, Sandra A.; Williams, Clive D.; Crespan, Emmanuele; Maga, Giovanni; Sanna, Giuseppina; Delogu, Ilenia; Collu, Gabriella; Loddo, Roberta published an article.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents. And the article contained the following:

A new series of indole-based analogs were recently identified as potential anticancer agents. The Knoevenagel-type indoles herein presented were prepared via a one-pot condensation of iminium salts with active methylene reagents and were isolated as single geometric isomers. Biol. evaluation in different cell-based assays revealed an antiproliferative activity for some analogs already in the nanomolar range against leukemia, breast and renal cancer cell lines. To explain these effects, the most promising analogs of the series were engaged in further cell-based studies. Compounds I [R1 = R3 = H, R2 = Ph, X = CN, Y = thien-2-yl-(E), SO2Ph-(E); R1 = R3 = H, R2 = Ph, X = C(:O)Me, Y = SO2Ph-(E); R1 = R3 = H, R2 = C6H4OMe-4, X = CN, Y = CN, SO2Ph-(E)] highlighted a pro-apoptotic potential being able to induce apoptosis in HL60, K562 and MCF-7 cell lines in a dose and time-dependent manner. The ability of these compounds to arrest cell cycle at the G2/M phase inspired the immunofluorescence studies which allowed us to identify tubulin as a potential target for compounds (E)-I [R1 = R3 = H, R2 = Ph, X = CN, Y = SO2Ph; R1 = R3 = H, R2 = C6H4OMe-4, X = CN, Y = SO2Ph]. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to unconventional knoevenagel type indole preparation cell based proapoptotic agent, structure activity relationship unconventional knoevenagel type antiproliferative, leukemia proapoptotic agent unconventional knoevenagel type indole, breast cancer proapoptotic agent unconventional knoevenagel type indole and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 24, 2020, Zhuo, Jun-Rui; Quan, Bao-Xue; Zhao, Jian-Qiang; Zhang, Ming-Liang; Chen, Yong-Zheng; Zhang, Xiao-Mei; Yuan, Wei-Cheng published an article.SDS of cas: 2510-01-2 The title of the article was Base-mediated [4+2] annulation of electron-deficient nitrobenzoheterocycles and α,α-dicyanoalkenes in water: Facile access to structurally diverse functionalized dibenzoheterocyclic compounds. And the article contained the following:

A base-mediated [4 + 2] annulation of electron-deficient nitrobenzoheterocycles with α,α-dicyanoalkenes for the synthesis of structurally diverse dibenzoheterocyclic compounds was reported. Reaction of 2-nitrobenzofurans/2-nitrobenzothiophenes with α,α-dicyanoalkenes afforded fused-benzofuran-carbonitrile derivatives and fused-benzothiophene-carbonitrile derivatives I [R1 = H, 10-Me, 10-Cl, etc.; R2 = H, 3-Me, 2-OMe, 4-Br, etc.; R3R4 = H, (CH2)2, OCH2, etc.; X = O, S]. Reaction between 3-nitrobenzothiophenes and α,α-dicyanoalkenes was developed to give fused-benzothiophene-carbonitrile derivatives II [R5 = H, 10-Me, 10-F, 10-Cl, 10-Ph; R6R7 = H, (CH2)2, OCH2, etc.]. Synthesis of fused-indole derivatives III [R8 = H, 10-F, 10-Cl, 11-Br; R9 = acetyl, tert-butyloxycarbonyl, tosyl; R10R11 = H, OCH2, (CH2)2, (CH2)3] by reaction of 3-nitroindoles and α,α-dicyanoalkenes was reported. Preparation of polycyclic heteroaromatic compounds IV [R12 = H, 10-OMe, 10-F, etc.] via oxidative dehydrogenation of some of the fused-benzofuran-carbonitrile derivatives I was reported. The reaction proceeded smoothly via a tandem vinylogous Michael addition/cyclization/tautomerization/elimination process in water with cesium carbonate as base, affording a wide range of dibenzofurans, dibenzothiophenes and carbazoles in good to high yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

The Article related to dibenzoheterocyclic compound green preparation, nitrobenzoheterocycle dicyanoalkene tandem annulation base mediated, polycyclic heteroaromatic compound preparation, fused benzofuran carbonitrile derivative oxidative dehydrogenation, amino phenyl dihydrophenanthrobenzofuran carbonitrile preparation and other aspects.SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 21, 2007, Liu, Tian-Yu; Cui, Hai-Lei; Long, Jun; Li, Bang-Jing; Wu, Yong; Ding, Li-Sheng; Chen, Ying-Chun published an article.Application of 2510-01-2 The title of the article was Organocatalytic and Highly Stereoselective Direct Vinylogous Mannich Reaction. And the article contained the following:

The first direct asym. vinylogous Mannich (AVM) reaction of α,α-dicyanoolefins and N-Boc aldimines was described promoted by a simple chiral bifunctional thiourea-tertiary amine organocatalyst. The reaction was highly efficient (S/C up to 1000) and regio-, stereoselective (generally >99% de, >96% ee) at room temperature for a broad array of substrates. Enantiomerically pure δ-amino acid and subsequential δ-lactam could be smoothly prepared from the adduct. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

The Article related to dicyanoolefin aldimine chiral thiourea tertiary amine asym vinylogous mannich, dicyanovinyl amine stereoselective preparation reduction hydrolysis, amino acid stereoselective preparation amidation, lactam stereoselective preparation, asym vinylogous mannich catalyst chiral thiourea tertiary amine and other aspects.Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 15, 2005, Nishiyabu, Ryuhei; Anzenbacher, Pavel Jr. published an article.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Sensing of Antipyretic Carboxylates by Simple Chromogenic Calix[4]pyrroles. And the article contained the following:

A simple, two- or three-step method for the synthesis of chromogenic octamethyl calix[4]pyrrole-based (OMCP) sensors for anions was presented. Electrophilic aromatic substitution allows for converting the pyrrole moieties of OMCP into a dye. The formation of a sensor-anion complex results in partial charge transfer and a dramatic change in color. The absorption (UV-vis) and NMR titration experiments show that the chromogenic OMCPs sense anions administered as aqueous solutions, even at high ionic strength (∼0.1 M NaCl), while displaying selectivity for pyrophosphate and carboxylate anions. The experiments with polyurethane sensor films show a strong response for aqueous carboxylates, such as antipyretics naproxen ≈ ibuprofen > salicylate, without being biased by bicarbonate or carboxy termini of blood plasma proteins. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to antipyretic ibuprofen salicylate naproxen carboxylate chromogenic calixpyrrole preparation, chromogenic calix pyrrole sensor anion preparation, sensor anion complex chromogenic calixpyrrole preparation color change, polyurethane sensor film anion complex chromogenic calixpyrrole color change and other aspects.Recommanded Product: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Matsnev, Andrej; Noritake, Shun; Nomura, Yoshinori; Tokunaga, Etsuko; Nakamura, Shuichi; Shibata, Norio published an article in 2010, the title of the article was Efficient Access to Extended Yagupolskii-Umemoto-Type Reagents: Triflic Acid Catalyzed Intramolecular Cyclization of ortho-Ethynylaryltrifluoromethylsulfanes.Computed Properties of 2510-01-2 And the article contains the following content:

S-(trifluoromethyl)benzo[b]thiophenium salts, as analogs of Yagupolskii-Umemoto type reagents, were synthesized by novel triflic acid mediated intramol. cyclization of ortho-ethynylaryltrifluoromethylsulfanes. Cyclopropyl analog I is especially useful for the electrophilic trifluoromethylation of β-ketoesters and dicyanoalkylidenes. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Computed Properties of 2510-01-2

The Article related to ortho ethynylaryltrifluoromethylsulfane preparation triflic acid intramol cyclization, benzothiophenium salt trifluoromethyl derivative preparation yagupolskii umemoto reagent analog, beta keto ester sulfur trifluoromethyl benzothiophenium salt electrophilic trifluoromethylation and other aspects.Computed Properties of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Wu, Mei; Huang, Sheng; Hou, Huiqing; Lin, Jie; Lin, Mei; Zhou, Sunying; Zheng, Zhiqiang; Sun, Weiming; Ke, Fang published an article in RSC Advances. The title of the article was 《DIPEA-induced activation of OH- for the synthesis of amides via photocatalysis》.Computed Properties of C7H4BrN The author mentioned the following in the article:

Herein, an efficient light-mediated strategy for the synthesis of amides in which a weak organic base acts as a reductant to induce the formation of OH- from water under metal-free conditions was reported. A mechanistic study revealed that the generation of an N,N-diisopropylethylamine (DIPEA) radical via single electron transfer (SET), with the assistance of photocatalyst, that increased the nucleophilicity of the water mols. with respect to the cyanides was essential. Moreover, the removal rate of nitrile in wastewater can be as high as 83%, indicating that this strategy had excellent potential for nitrile degradation In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7Computed Properties of C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Computed Properties of C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《SO2F2-Promoted Dehydration of Aldoximes: A Rapid and Simple Access to Nitriles》 were Zhao, Yiyong; Mei, Guangyao; Wang, Haibo; Zhang, Guofu; Ding, Chengrong. And the article was published in Synlett in 2019. Related Products of 1194-02-1 The author mentioned the following in the article:

A rapid, simple and mild process for the dehydration of aldoximes RCH=NOH (R = benzyl, 4-fluorophenyl, naphth-1-yl, pyridin-2-yl, etc.) to give the corresponding nitriles RCN, which utilizes SO2F2 as an efficient reagent, has been developed. A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes proceeded with high efficiency to afford nitriles in excellent to quant. yields with great functional group compatibilities in acetonitrile under ambient conditions. Moreover, the eco-friendly conditions of SO2F2/Na2CO3/aqueous methanol were suitable for converting nitrobenzaldoximes R1C6H4CH=NOH (R1 = 2-nitro, 3-nitro, 4-nitro) into nitrobenzonitriles R1C6H4CN. In addition, a one-pot synthetic strategy of obtaining nitrobenzonitriles R1C6H4CN from nitrobenzaldehydes R1C6H4CHO has been confirmed to be feasible.4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts