Tag: 100-200

In 2015,Chen, Jinju; Liu, Chuanxiang; Guan, Fengjie; Zhang, Chuanxiu; Ji, Kai; Wang, Xinyu; Xu, Min; Wu, Fanhong published 《Derivatives of α,α-Aryl Naphthalimide Nitriles as Fluoride Ion Sensors: Convenient Precursors for the Synthesis of Aryl Naphthalimide Ketones》.Synlett published the findings.Synthetic Route of C8H6BrN The information in the text is summarized as follows:

A facile and efficient SnAr procedure involving the displacement of activated naphthalimide bromides with the anions of substituted aryl acetonitriles was developed for the preparation of α,α-aryl naphthalimide nitrile derivatives, which can be used as fluoride ion sensors and convenient precursors for the synthesis of aryl naphthalimide ketones based on fluoride-induced deprotonation followed by autoxidative decyanation. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Synthetic Route of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Surpassing Robeson Upper Limit for CO2/N2 Separation with Fluorinated Carbon Molecular Sieve Membranes》 was written by Yang, Zhenzhen; Guo, Wei; Mahurin, Shannon Mark; Wang, Song; Chen, Hao; Cheng, Long; Jie, Kecheng; Meyer, Harry M. III; Jiang, De-en; Liu, Gongping; Jin, Wanqin; Popovs, Ilja; Dai, Sheng. Application of 1194-02-1 And the article was included in Chem in 2020. The article conveys some information:

The CO2-philic properties of powd. fluorinated triazine frameworks make them promising candidates for fabrication of porous CO2 separation membranes. This is rarely reported because of lack of suitable synthetic approaches. Here, fluorinated membranes based on covalent triazine frameworks are prepared through a rational design of aromatic nitrile monomers containing fluorine and ether groups via a sol-gel polymerization process. The CO2 separation performance rises significantly with the fluorine content in the membrane. With functionalized triazine units, fluorine, and ether groups, these carbon mol. sieve membranes obtained after pyrolysis exhibit intrinsic ultra-micropores, high surface areas and excellent thermal stability under air. Excellent CO2 permeability and CO2 to N2 selectivity surpassing the Robeson upper bound are achieved. Our general design and synthesis protocol allow an easy access to fluorinated porous membranes, thus significantly expanding the currently limited library of CO2-philic and chem. stable membranes for highly efficient CO2 separation The results came from multiple reactions, including the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Application of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Merging Photoredox PCET with Ni-Catalyzed Cross-Coupling: Cascade Amidoarylation of Unactivated Olefins》 were Zheng, Shuai; Gutierrez-Bonet, Alvaro; Molander, Gary A.. And the article was published in Chem in 2019. Category: nitriles-buliding-blocks The author mentioned the following in the article:

Herein, the amidoarylation of unactivated olefins by a cascade process from non-functionalized amides is reported by merging, for the first time, photoredox proton-coupled electron transfer (PCET) with nickel catalysis. This new technol. grants access to an array of complex mols. containing a privileged pyrrolidinone core from alkenyl amides and aryl- and heteroaryl halides in the presence of a visible light photocatalyst and a nickel catalyst. Notably, the reaction is not restricted to amides-carbamates and ureas can also be used. Mechanistic studies, including hydrogen-bond affinity constants, cyclization rate measurements, quenching studies, and cyclic voltammetry, were central to comprehend the subtleties contributing to the integration of the two catalytic cycles. In addition to this study using 4-Bromobenzonitrile, there are many other studies that have used 4-Bromobenzonitrile(cas: 623-00-7Category: nitriles-buliding-blocks) was used in this study.

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Category: nitriles-buliding-blocks It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Chem included an article by Li, Jiesheng; Luo, Yixin; Cheo, Han Wen; Lan, Yu; Wu, Jie. Name: 4-Bromobenzonitrile. The article was titled 《Photoredox-Catalysis-Modulated, Nickel-Catalyzed Divergent Difunctionalization of Ethylene》. The information in the text is summarized as follows:

Herein, the use of ethylene feedstock and com. available aryl halides was demonstrated to accomplish the divergent synthesis of 1,2-diarylethanes, 1,4-diarylbutanes, or 2,3-diarylbutanes in a highly selective fashion through the synergistic combination of nickel and photoredox catalysis. Mechanistic studies suggested that the observed selectivity was due to different active states of Ni(I) and Ni(0) modulated by Ru- and Ir-based photoredox catalysts, resp. The ability to access different organometallic oxidation states via photoredox catalysis promises to inspire new perspectives for synergistic transition-metal-catalyzed divergent synthesis. In the experimental materials used by the author, we found 4-Bromobenzonitrile(cas: 623-00-7Name: 4-Bromobenzonitrile)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Name: 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Chem included an article by Zhao, Da; Xu, Peng; Ritter, Tobias. Category: nitriles-buliding-blocks. The article was titled 《Palladium-Catalyzed Late-Stage Direct Arene Cyanation》. The information in the text is summarized as follows:

The first general late-stage aryl C-H cyanation with broad substrate scope and functional-group tolerance was reported. The reaction was enabled by a dual-ligand combination of quinoxaline and an amino acid-derived ligand. The method was applicable to direct cyanation of several marketed small-mol. drugs, common pharmacophores and organic dyes.4-Fluorobenzonitrile(cas: 1194-02-1Category: nitriles-buliding-blocks) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Tuning the porosity and photocatalytic performance of triazine-based graphdiyne polymers through polymorphism》 were Schwarz, Dana; Acharjya, Amitava; Ichangi, Arun; Kochergin, Yaroslav S.; Lyu, Pengbo; Opanasenko, Maksym V.; Tarabek, Jan; Vacek Chocholousova, Jana; Vacek, Jaroslav; Schmidt, Johannes; Cejka, Jiri; Nachtigall, Petr; Thomas, Arne; Bojdys, Michael J.. And the article was published in ChemSusChem in 2019. Application of 623-00-7 The author mentioned the following in the article:

Crystalline and amorphous organic materials are an emergent class of heterogeneous photocatalysts for the generation of hydrogen from water, but a direct correlation between their structures and the resulting properties has not been achieved so far. To make a meaningful comparison between structurally different, yet chem. similar porous polymers, two porous polymorphs of a triazine-based graphdiyne (TzG) framework are synthesized by a simple, one-pot homocoupling polymerization reaction using as catalysts CuI for TzGCu and PdII/CuI for TzGPd/Cu. The polymers form through irreversible coupling reactions and give rise to a crystalline (TzGCu) and an amorphous (TzGPd/Cu) polymorph. Notably, the crystalline and amorphous polymorphs are narrow-gap semiconductors with permanent surface areas of 660 m2 g-1 and 392 m2 g-1, resp. Hence, both polymers are ideal heterogeneous photocatalysts for water splitting with some of the highest hydrogen evolution rates reported to date (up to 972 μmol h-1 g-1 with and 276 μmol h-1 g-1 without Pt cocatalyst). Crystalline order is found to improve delocalization, whereas the amorphous polymorph requires a cocatalyst for efficient charge transfer. This will need to be considered in future rational design of polymer catalysts and organic electronics. After reading the article, we found that the author used 4-Bromobenzonitrile(cas: 623-00-7Application of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Application of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Organometallics included an article by Ding, Yi; Ma, Xiaoli; Liu, Yashuai; Liu, Wenqing; Yang, Zhi; Roesky, Herbert W.. Synthetic Route of C7H4FN. The article was titled 《Alkylaluminum Complexes as Precatalysts in Hydroboration of Nitriles and Carbodiimides》. The information in the text is summarized as follows:

The metathesis reaction of aluminum(III) dihydride β-diketiminate LAlH2 (1, L = (DippN:CMe)2CH, Ar = 2,6-iPr2C6H3) with BuLi and Bu2Mg, resp., resulted in di-Bu aluminum complex LAlBu2 (2). Meanwhile 1 reacted with MeLi producing di-Me aluminum LAlMe2 (3). Complexes 2 and 3 were characterized by NMR and elemental anal., and 2 was addnl. studied by single-crystal X-ray diffraction. The reported synthesis allows for access of dialkylaluminum complexes from aluminum(III) dihydride compound (1) with excellent yields. The chemoselective double hydroboration of nitriles or single hydroboration of carbodiimides was studied with pinacolborane (HBpin) using LAl(n-Bu)2 (2) as the precatalyst to afford bis(boryl)amines (4a-4m) and N-borylamines (6a-6d) under solvent-free and mild conditions (60 °C). The records show that the catalytic reactions proceed in quant. yields and short time. Moreover, nearly quant. yield of di(boryl)(silyl)amine (5) was obtained, when cyanobenzene was reacted with equal amounts of HBpin and phenylsilane in the presence of precatalyst 2. A comparison of the previously reported hydroboration reactions with nitriles in the literature and our results in the presence of the precatalyst LAl(n-Bu)2 show convincingly the better results of short reaction time, mild reaction conditions, and quant. yields. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2014,Wu, Hai-Qiu; Pannecouque, Christophe; Yan, Zi-Hong; Chen, Wen-Xue; He, Qiu-Qin; Chen, Fen-Er; Balzarini, Jan; Daelemans, Dirk; De Clercq, Erik published 《Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase》.MedChemComm published the findings.Computed Properties of C8H6BrN The information in the text is summarized as follows:

A series of conformationally restricted dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) hybrids, e.g., I, which combined the structural features of C6-α-methylbenzyl-thio-DABOs (α-methyl-S-DABOs) and C6-α-cyanobenzyl-thio-DABOs (CN-S-DABOs), has been synthesized and biol. evaluated for their anti-HIV activity against wild-type HIV-1 strain IIIB, double RT mutant (K103N + Y181C) strain RES056 and HIV-2 strain ROD in MT-4 cell cultures. Most of these compounds exhibited inhibitory activity (wild-type) within the range of EC50 values from micromolar to nanomolar. Among them, compound I displayed the highest anti-HIV-1 activity with an EC50 value of 91 nM and a selectivity index (SI) of 548, which was more potent than zalcitabine and comparable to nevirapine and delavirdine in the same assay. The preliminary structure-activity relationship (SAR) and mol. docking anal. of this new series of conformationally constrained CN-S-DABO hybrids were also investigated. In the experiment, the researchers used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Computed Properties of C8H6BrN)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Computed Properties of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Regioselective C-H chlorination: towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds》 were Gao, Chao; Li, Hongchen; Liu, Miaochang; Ding, Jinchang; Huang, Xiaobo; Wu, Huayue; Gao, Wenxia; Wu, Ge. And the article was published in RSC Advances in 2017. Recommanded Product: 6-Phenoxynicotinonitrile The author mentioned the following in the article:

A protocol for the auxillary directed C-H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and estrone was developed. The 2-pyridine group allows for a highly efficient palladium-catalyzed chlorination and sequential ortho C-H functionalization reaction of phenol derivatives to produce a variety of sym. and unsym. 2,4,6-trisubstituted phenols. In the experimental materials used by the author, we found 6-Phenoxynicotinonitrile(cas: 99902-72-4Recommanded Product: 6-Phenoxynicotinonitrile)

6-Phenoxynicotinonitrile(cas: 99902-72-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Recommanded Product: 6-Phenoxynicotinonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C9H7NOIn 2022 ,《Efficient synthesis of novel spiro[indoline-3,5′-pyrano-[2,3-d]pyrimidin]-2-one derivatives and antitumor activity evaluation》 was published in Heterocycles. The article was written by Li, Zhenhua; Huang, Guoqing; Rong, Dayou; Cao, Yingyan; Hu, Ronghui. The article contains the following contents:

An efficient method for synthesis of the spiro[indoline-3,5′-pyrano[2,3-d]pyrimidin]-2-one derivatives I [R1 = H, 7-Me, 5-Cl, etc.; R2 = H, Me; R3 = CN, C(O)Me, CO2Et; R4 = Me, Ph] from 2′-amino-2-oxospiro[indoline-3,4;-pyran]-3′-carbonitriles using bis(trichloromethyl) carbonate (BTC) and triphenylphosphine oxide (TPPO) was developed. A series of target compounds I with broad substrate scope were synthesized in moderate to good yields. Some of the compounds I were evaluated for antitumor activities against four cancer cell lines A549, HepG-2, MCF-7 and HeLa using 5-FU and cisplatin as reference and showed good antitumor activity when compared with the standard drugs. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Computed Properties of C9H7NO) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Computed Properties of C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts