Tag: 100-200

《Electrochemical Synthesis of 1-Naphthols by Intermolecular Annulation of Alkynes with 1,3-Dicarbonyl Compounds》 was published in Organic Letters in 2020. These research results belong to He, Mu-Xue; Mo, Zu-Yu; Wang, Zi-Qiang; Cheng, Shi-Yan; Xie, Ren-Ren; Tang, Hai-Tao; Pan, Ying-Ming. SDS of cas: 614-16-4 The article mentions the following:

C-centered radical cyclization under electrochem. conditions is a feasible strategy for constructing cyclic structures. Reported herein is the electrochem. synthesis of highly functionalized 1-naphthols using alkynes and 1,3-dicarbonyl compounds by (4 + 2) annulation of C-centered radical. Electrolysis was conducted with Cp2Fe as redox catalyst, thereby eliminating the use of oxidants and transition-metal catalysts. The synthesized 1-naphthol compounds showed good antitumor activity in vitro, and further studies indicated that compound I induced tumor cell apoptosis. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4SDS of cas: 614-16-4) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.SDS of cas: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Blockage detection and diagnosis of externally parallelized monolithic microreactors》 were Tonomura, Osamu; Taniguchi, Satoshi; Nishi, Kazuki; Nagaki, Aiichiro; Yoshida, Jun-ichi; Hirose, Katsuyuki; Ishizuka, Norio; Hasebe, Shinji. And the article was published in Catalysts in 2019. Recommanded Product: 2-Bromobenzonitrile The author mentioned the following in the article:

To realize stable operation of a microchem. system, it is necessary to develop a process monitoring method that can detect and diagnose blocked microreactors. In this study, a system composed of five monolithic microreactors and a split-and-recombine-type flow distributor (SRFD) was developed for Suzuki-Miyaura coupling. Firstly, the effects of operating conditions on the yield was examined by using a single microreactor. After that, an optimal design problem was formulated to maximize the blockage detection performance by adjusting the channel resistances of the SRFD and the sensor locations in the SRFD under the design constraints. To efficiently solve the problem, a pressure drop compartment model, which is analogous to elec. resistance networks, was used. The optimally designed system was exptl. evaluated from the viewpoint of the capability of continuous operation and the blockage detection and diagnosis performance. The evaluation results show that continuous operation was successfully carried out for one hour, and that the artificially generated blockage of each microreactor was accurately identified. The developed system minimized the process performance degradation due to blockage. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Recommanded Product: 2-Bromobenzonitrile

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Nitrile – Wikipedia,
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The author of 《Sequential C-H and C-C Bond Cleavage: Divergent Constructions of Fused N-Heterocycles via Tunable Cascade》 were Li, Xianwei; Rao, Jianhang; Ouyang, Wensen; Chen, Qian; Cai, Ning; Lu, Yu-Jing; Huo, Yanping. And the article was published in ACS Catalysis in 2019. Quality Control of 4-Fluorobenzonitrile The author mentioned the following in the article:

Streamlining the generation of diverse highly functionalized mols. from abundant feedstocks holds great synthetic promises and challenges in pharmaceutical and material discovery. Herein, we report a tunable selectivity in multiple cascade reactions for the divergent assembly of fused N-heterocycles, comprising sequential activation of C-H and C-C bonds. Isolatable indene-type intermediates might be responsible for the generation of densely substituted fused pyridines, azepines, and azafluorenones products. The tolerance of strongly coordinating N-heterocycles, and those readily applicable for the late-stage modifications of pharmaceuticals and material mols. precursors, further demonstrated the synthetic robustness of this transformation. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Quality Control of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Quality Control of 4-Fluorobenzonitrile

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,ChemistrySelect included an article by Chen, Jing; Ding, Yuxin; Gao, Yejun; Zhou, Dongheng; Hider, Robert; Ma, Yongmin Dr. Application of 614-16-4. The article was titled 《Selectfluor-promoted Synthesis of 2,4- and 2,6-Diarylpyridines Through Annulation of Aromatic Ketones with an Ammonium Source in DMF》. The information in the text is summarized as follows:

An efficient one-pot four-component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4-diarylsubstituted pyridines promoted by Selectfluor has been achieved. Sym. pyridines were obtained selectively when non-Me ketones were used as the starting materials. Two C-C and C-N bonds are formed during the oxidative cyclization process. In the experimental materials used by the author, we found 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application of 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Application of 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Nature Catalysis included an article by Zhu, Chen; Yue, Huifeng; Maity, Bholanath; Atodiresei, Iuliana; Cavallo, Luigi; Rueping, Magnus. Computed Properties of C7H4BrN. The article was titled 《A multicomponent synthesis of stereodefined olefins via nickel catalysis and single electron/triplet energy transfer》. The information in the text is summarized as follows:

Herein, a one-pot difunctionalization of alkynes via a photoredox/nickel dual-catalyzed three-component cross-coupling reaction under mild conditions, providing access to a series of highly important tri-substituted alkenes. Notably, in contrast to traditional methods that are based on the steric hindrance of the substrates to control the reaction selectivity, both E- and Z-isomers of tri-substituted alkenes, which are often energetically close, can be obtained by choosing an appropriate photocatalyst with a suitable triplet state energy. Beyond the immediate practicality of this transformation, this newly developed methodol. might inspire the development of diverse and important one-pot functionalizations of carbon-carbon multiple bonds via photoredox and transition-metal dual-catalyzed multicomponent reactions. In the experimental materials used by the author, we found 4-Bromobenzonitrile(cas: 623-00-7Computed Properties of C7H4BrN)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Computed Properties of C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Green Chemistry included an article by Liu, Yaxu; He, Shaopo; Quan, Ziyi; Cai, Huizhuo; Zhao, Yang; Wang, Bo. Application of 1194-02-1. The article was titled 《Mild palladium-catalysed highly efficient hydrogenation of CN, C-NO2, and C=O bonds using H2 of 1 atm in H2O》. The information in the text is summarized as follows:

The first example of a mild and high-efficiency protocol enabling a process in water using 1 atm of H2 for the efficient and selective hydrogenation of nitriles RCN [R = CH3(CH2)2, 4-FC6H4, naphthalen-1-yl, etc.], nitro compounds 4-R1C6H4NO2 (R1 = H, F, Cl, Br, OH, Me, MeO, NH2), ketones R2C(O)R3 [R2 = CH3(CH2)2, 3-FC6H4, 2-H3CC6H4, etc.; R3 = Me, CF3] and aldehydes R4CHO [R4 = 4-(H3C)2CHC6H4, 3,4,5-(H3CO)3C6H2, naphthalen-1-yl, etc.], to yield primary amines RCH2NH2, 4-R1C6H4NH2 and alcs. R2CH(OH)CH3, R4CH2OH with satisfactory yields of up to >99% has been presented. Several palladium-based nanoparticle catalysts were prepared from K2PdCl4 and ligands, and one of them was found to be the best and most suitable for the hydrogenation of CN, C-NO2 and C=O bonds. In addition, the catalyst Pd-NPs can be easily recycled and reused without losing their activity and selectivity. A plausible mechanism for the hydrogenation of a CN bond was also proposed, representing the first example that possesses great potential for sustainable industrial purposes. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Application of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2015,Sugiura, Y.; Tachikawa, Y.; Nagasawa, Y.; Tada, N.; Itoh, A. published 《Synthesis of benzoyl cyanide through aerobic photooxidation of benzyl cyanide using carbon tetrabromide as a catalyst》.RSC Advances published the findings.Related Products of 31938-07-5 The information in the text is summarized as follows:

A synthetic method towards benzoyl cyanide through aerobic photooxidation of benzyl cyanide in the presence of carbon tetrabromide under visible light irradiation with fluorescent lamps have been developed. The experimental part of the paper was very detailed, including the reaction process of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Related Products of 31938-07-5

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Formula: C9H7NOIn 2020 ,《Transition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N-Propargyl Enamines》 appeared in Synthesis. The author of the article were Chikayuki, Yuya; Miyashige, Takakane; Yonekawa, Shiori; Kirita, Akiko; Matsuo, Natsuko; Teramoto, Hiroyoshi; Sasaki, Shigeru; Higashiyama, Kimio; Yamauchi, Takayasu. The article conveys some information:

A transition-metal-free synthesis of pyridine derivatives by 6-endo-dig cyclization of N-propargyl enamines was developed. This method is environmentally friendly and is a high atom economy reaction that is easily accessed to provide pyridine derivatives in moderate to good yield by heating N-propargyl enamines in solvent without additives. The total synthesis of onychine was achieved in 51% yield in only two steps by using this method. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Formula: C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Formula: C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Kaya, Meltem; Demir, Sevde; Arici, Mursel; Wriedt, Mario; Yesilel, Okan Zafer published an article in Polyhedron. The title of the article was 《Synthesis, characterization, and optical properties of four coordination polymers with 3,5-dicarboxy-1-(4-cyanobenzyl)pyridin-1-ium bromide》.Safety of 4-Cyanobenzyl bromide The author mentioned the following in the article:

Four coordination polymers based on a new 3,5-dicarboxy-1-(4-cyanobenzyl)pyridin-1-ium bromide (H2cbpyBr), formulated as {[Mn(μ-cbpy)2]·2H2O}n (1), {[Co(μ-cbpy)2]·2H2O}n (2), {[Cu(μ-cbpy)2]·H2O}n (3) and {[Zn3(μ-cbpy)6]·6H2O}n (4) were synthesized and characterized by x-ray single-crystal, IR spectroscopy, powder diffraction, and elemental anal. X-ray diffraction anal. revealed that isostructural complexes 1, 2, and 4 displayed 1D structures while complex 3 exhibited 3D coordination polymer with 66-dia topol. In complexes 1, 2, and 4, the adjacent 1D chains were further assembled by π···π and C:N, π interactions into the 3D supramol. framework. Furthermore, optical properties for the compounds were calculated and thermal behaviors of all the complexes were studied at 30-1000°. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Safety of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Safety of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Long, Yang; Zheng, Yanling; Xia, Ying; Qu, Lang; Yang, Yuhe; Xiang, Haifeng; Zhou, Xiangge published an article in 2022. The article was titled 《Nickel-Catalyzed Synthesis of an Aryl Nitrile via Aryl Exchange between an Aromatic Amide and a Simple Nitrile》, and you may find the article in ACS Catalysis.Recommanded Product: 1194-02-1 The information in the text is summarized as follows:

A nickel-catalyzed synthesis of an aryl nitrile via aryl exchange between an aromatic amide and a simple nitrile was developed. By using cheap, easy-to-handle, and low-toxic 4-cyanopyridine as the cyanating source, cyanation of various aromatic amides afforded an assortment of aryl nitriles including bioactive drugs and organic luminescent mols. in good yields. The reaction exhibited wide substrate scope, good functional group tolerance, and unique selectivity that were complementary to traditional methods. Moreover, two key nickel complexes formed by oxidative addition to each substrate are obtained and determined by X-ray crystallog., which gave strong support for the mechanism elucidations. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Recommanded Product: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts