Tag: 100-200

《Transition-metal-free, meta-selective arene CH direct α-aryl cyanomethylation of naphthalimide using a trifluoromethyl directing group》 was published in Dyes and Pigments in 2020. These research results belong to Li, Zheyao; Rao, Caihui; Chen, Lu; Fu, Chao; Zhu, Tingting; Chen, Xi; Liu, Chuanxiang. Safety of 2-(3-Bromophenyl)acetonitrile The article mentions the following:

A method for introducing a substituted aryl acetonitrile group at the C2 position of naphthalimide using trifluoromethyl as the directing group was reported. The transformation was operationally simple, requires mild conditions and was highly regioselective, without the need for a transition metal catalyst. This work provided a novel route for preparing α-diaryl nitrile derivatives I [R = Ph, 3-BrC6H4, 4-MeOC6H4, etc.]. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Safety of 2-(3-Bromophenyl)acetonitrile)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Safety of 2-(3-Bromophenyl)acetonitrile

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In 2013,Li, Meiling; Woods, Philip A.; Smith, Martin D. published 《Cation-directed enantioselective synthesis of quaternary-substituted indolenines》.Chemical Science published the findings.Formula: C8H6BrN The information in the text is summarized as follows:

An asym. method for the synthesis of quaternary-substituted indolenines via a 5-endo-dig cyclization of an α-cyanocarbanion onto an isonitrile was developed. This transformation relies on Broensted acid activation of the isonitrile functional group under asym. phase transfer conditions in the presence of a Broensted base. Good to excellent levels of enantioselectivity were obtained (85 : 15 to 96 : 4 e r., 18 examples) using a bespoke bifunctional catalyst. Enantioenriched indolenines produced in this process can be intercepted by nucleophilic species with high levels of diastereoselectivity to generate complex indoline frameworks. This process offers a general asym. approach to reactions involving the isonitrile functional group. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Formula: C8H6BrN)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Formula: C8H6BrN

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《Synthesis, ellipsometry and non-linear optical features of substituted 1,3,5-triphenylpyrazolines》 was written by Gondek, Ewa; Niziol, Jacek; Danel, Andrzej; Kucharek, Mateusz; Jedryka, Jaroslaw; Karasinski, Pawel; Nosidlak, Natalia; Fedorchuk, Andrij A.. Safety of 3-Oxo-3-phenylpropanenitrileThis research focused ontriphenylpyrazoline dye synthesis ellipsometry nonlinear optical property. The article conveys some information:

Ellipsometric and nonlinear optical properties of new, differently substituted, 1,3,5-triphenylpyrazolines dyes, were studied. Results of theor. calculation within a framework of d. functional theory (DFT) technique were verified by spectroscopic ellipsometry and optical second harmonic generation (SHG) experiment at fundamental laser wavelength 1064 nm. Absorption bands and complex refractive indexes were determined Principal role of 2-thienyl substituent for first order nonlinear optical properties was demonstrated. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Safety of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Safety of 3-Oxo-3-phenylpropanenitrile

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Name: 4-FluorobenzonitrileIn 2021 ,《4,4′-(Pyridin-4-ylmethylene)dibenzonitrile》 appeared in Molbank. The author of the article were Lancaster, Ben M. J.; Nicholls, Alexander J.; Baxendale, Ian R.. The article conveys some information:

This communication described an unprecedented substitution cascade, in which 4-methylpyridine, following deprotonation with LDA, twice acted as a carbon nucleophile in an unusual SNAr process, to form a novel triarylmethane structure I. A proposed mechanism for this sequence was presented that was supported by single crystal X-ray anal. of the resulting product. This unique transformation was of note as it highlighted a neat and efficient entry as a single step to complex triarylmethane architectures containing both substituted Ph and pyridyl aromatics The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Name: 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Name: 4-Fluorobenzonitrile

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In 2022,Nakamura, Momoko; Yoshida, Kazuhiro; Togo, Hideo published an article in Tetrahedron. The title of the article was 《Novel preparation of 2,5-diarylpyrroles from aromatic nitriles with 3-arylpropylmagnesium bromides, 1,3-diiodo-5,5-dimethylhydantoin, and tBuOK》.Application In Synthesis of 4-Fluorobenzonitrile The author mentioned the following in the article:

Treatment of aromatic nitriles ArCN (Ar = 4-Me, 3-Me, 2-Me, 4-t-Bu, 4-Cl, 3,5-dichloro, 2-naphthyl, etc.) with 3-arylpropylmagnesium bromides (Ar'(CH2)3MgBr = H, Me, Cl) under warming conditions and then with water, followed by the reaction with DIH at room temperature under irradiation with a LED lamp and then with tBuOK gave 2,5-diarylpyrroles in moderate yields. The key step of the present method is the formation of N-iodo-2,5-diaryl-4,5-dihydropyrroles by the reaction of the formed imines with DIH, which proceeds through the 1,5-H shift of iminyl radical, 5-exo-tet cyclization by the imine group, and N-iodination of the formed 2,5-diaryldihydropyrroles.4-Fluorobenzonitrile(cas: 1194-02-1Application In Synthesis of 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Application In Synthesis of 4-Fluorobenzonitrile

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In 2022,Zhang, Xiuqi; Zhang, Fukuan; Li, Xiaolan; Lu, Ming-Zhu; Meng, Xin; Huang, Lei; Luo, Haiqing published an article in Organic Letters. The title of the article was 《Direct Synthesis of Biphenyl-2-carbonitriles by Rh(III)-Catalyzed C-H Hiyama Cross-Coupling in Water》.COA of Formula: C7H4FN The author mentioned the following in the article:

This method represents an efficient rhodium(III)-catalyzed O-C-H arylation of readily available benzimidate derivatives 2-R-3-R1-4-R2C6H2C(=NH)OR3 (R = H, F, MeO; R1 = H, Me, Br, MeO, F; R2 = H, CF3, I, etc.; R3 = Et, t-Bu, i-Pr, Me) with diverse arylsilanes ArSi(OEt)3 (Ar = 4-methoxyphenyl, 1-naphthyl, thiophen-2-yl, benzodioxol-5-yl, etc.) in water as a sustainable solvent, enabling the straightforward synthesis of potentially useful biphenyl-2-carbonitrile derivatives I. This silicon-based protocol employs benzimidates as both an efficacious directing group and the source of a nitrile group. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1COA of Formula: C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.COA of Formula: C7H4FN

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Kwon, Ye-Mi; Kim, Sou Hyun; Jung, Young-Suk; Kwak, Jae-Hwan published their research in Pharmaceuticals in 2021. The article was titled 《Synthesis and Biological Evaluation of (S)-2-(Substituted arylmethyl)-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide Analogs and Their Synergistic Effect against PTEN-Deficient MDA-MB-468 Cells》.Recommanded Product: 17201-43-3 The article contains the following contents:

A series of twenty-six compounds of furfuryl or benzyl tetrahydropyrazino[1,2-a]indole analogs were synthesized and evaluated for cytotoxic activity against the estrogen receptor (ER)-pos. breast cancer cell line (MCF-7) and the epidermal growth factor receptor (EGFR) over-expressed triple-neg. breast cancer cell line (MDA-MB-468). Among them, compounds 2b, 2f and 2i showed more potent activity and selectivity against MDA-MB-468 cells than gefitinib, as an EGFR- tyrosine kinase inhibitor. In addition, it was confirmed by means of isobologram anal. of combinational treatment with gefitinib that they have a synergistic effect, especially compounds 2b and 2f, which inhibit Akt T308 phosphorylation. Moreover, it was confirmed that 2-benzyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide analogs (2b, 2f, and Ref 2) tend to selectively inhibit PI3Kβ, which is involved in the phosphorylation of Akt. In addition to this study using 4-Cyanobenzyl bromide, there are many other studies that have used 4-Cyanobenzyl bromide(cas: 17201-43-3Recommanded Product: 17201-43-3) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Recommanded Product: 17201-43-3

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Sallio, Romain; Payard, Pierre-Adrien; Pakulski, Pawel; Diachenko, Iryna; Fabre, Indira; Berteina-Raboin, Sabine; Colas, Cyril; Ciofini, Ilaria; Grimaud, Laurence; Gillaizeau, Isabelle published their research in RSC Advances in 2021. The article was titled 《Copper-catalyzed transformation of alkyl nitriles to N-arylacetamide using diaryliodonium salts》.Recommanded Product: 2-(3-Bromophenyl)acetonitrile The article contains the following contents:

This work reports a simple and efficient method for the copper-catalyzed redox-neutral transformation of alkyl nitriles e.g., PhCH(Me)CN using eco-friendly diaryliodonium salts as diphenyliodonium triflate, (4-bromophenyl)(2,4,6-trimethylphenyl)iodonium triflate, 2-thienyl-(phenyl)iodonium triflate, etc. and leading to N-arylacetamides e.g., PhCH(Me)C(O)NHPh. The method features high efficiency, broad substrate scope and good functional group tolerance. In addition to this study using 2-(3-Bromophenyl)acetonitrile, there are many other studies that have used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 2-(3-Bromophenyl)acetonitrile) was used in this study.

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Recommanded Product: 2-(3-Bromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
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Cardenas, Jorge; Gavino, Ruben; Garcia-Rios, Erendira; Rios-Ruiz, Lucero; Puello-Cruz, Ana C.; Morales-Serna, Francisco Neptali; Gomez, Samuel; Lopez-Torres, Adolfo; Morales-Serna, Jose Antonio published their research in RSC Advances in 2021. The article was titled 《The Heck reaction of allylic alcohols catalysed by an N-heterocyclic carbene-Pd(II) complex and toxicity of the ligand precursor for the marine benthic copepod Amphiascoides atopus》.Synthetic Route of C7H4BrN The article contains the following contents:

The palladium-catalyzed reaction of aryl halides and allylic alcs. was an attractive method for obtaining α,β-unsaturated aldehydes and ketones, which represent key intermediates in organic synthesis. In this context, a 1,2,3-triazol-5-ylidene (aNHC)-based palladium(II) complex formed in situ was found to be a selective catalyst for the syntheses of building blocks from the corresponding aryl halides and allylic alcs., with yields ranging from 50% to 90%. The lack of toxic effects of the ligand precursor (1,2,3-triazolium salt) of the palladium(II) complex for the harpacticoid copepod Amphiascoides atopus allowed to contrast the efficiency of the catalytic system with the potential impact of the principal waste chem. in global aquatic ecosystems, which has not been previously addressed. In the experiment, the researchers used 2-Bromobenzonitrile(cas: 2042-37-7Synthetic Route of C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Synthetic Route of C7H4BrN

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《A hydrophilic heterogeneous cobalt catalyst for fluoride-free Hiyama, Suzuki, Heck and Hirao cross-coupling reactions in water》 was written by Sobhani, Sara; Hosseini Moghadam, Hadis; Skibsted, Joergen; Sansano, Jose Miguel. SDS of cas: 623-00-7 And the article was included in Green Chemistry in 2020. The article conveys some information:

A hydrophilic heterogeneous cobalt catalyst of chitosan, denoted as mTEG-CS-Co-Schiff-base, has been successfully prepared This newly synthesized catalyst was characterized by different methods such as XRD, FE-SEM, TEM, TGA, FT-IR, 13C{1H} CP/MAS NMR, XPS and ICP analyses. The catalyst displayed excellent activity for the palladium and fluoride-free Hiyama, Suzuki, Heck and Hirao reactions of various aryl iodides 4-RC6H4I (R = H, OMe, Cl, I), bromides 4-R1C6H4Br (R1 = H, OMe, NO2, CN, Cl, Me, Br)/(2-bromoethenyl)benzene and chlorides 4-R2C6H4Cl (R2 = H, NO2, CN, Me) (i.e., the most challenging aryl halides which are cheaper and more widely available than aryl iodides and bromides) in water. The presence of triethylene glycol tags with hydrophilic character on the Co-complex supported on chitosan provides dispersion of the catalyst particles in water, which leads to higher catalytic performance and also facile catalyst recovery by successive extraction The catalyst was reused for at least six successive runs without any discernible decrease in its catalytic activity or any remarkable changes in catalyst structure. The use of water as a green solvent, without requiring any additive or organic solvent, as well as use of a low cost and abundant cobalt catalyst instead of expensive Pd catalysts along with the catalyst recovery and scalability, make this method favorable from environmental and economic points of view for the C-C and C(sp2)-P coupling reactions. Notably, this is the first report on the application of a cobalt catalyst in Hiyama reactions. In the experiment, the researchers used many compounds, for example, 4-Bromobenzonitrile(cas: 623-00-7SDS of cas: 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,SDS of cas: 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

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