Tag: 100-200

Lin, Yamei; Bu, Qingxia; Xu, Jiaxian; Liu, Xiao; Zhang, Xueping; Lu, Guo-Ping; Zhou, Baojing published their research in Molecular Catalysis in 2021. The article was titled 《Hf-MOF catalyzed Meerwein-Ponndorf-Verley (MPV) reduction reaction: Insight into reaction mechanism》.HPLC of Formula: 614-16-4 The article contains the following contents:

Hf-MOF-808 exhibits excellent activity and specific selectivity on the hydrogenation of carbonyl compounds via a hydrogen transfer strategy. Its superior activity than other Hf-MOFs is attributed to its poor crystallinity, defects and large sp. surface area, thereby containing more Lewis acid-base sites which promote this reaction. D. functional theory (DFT) computations are performed to explore the catalytic mechanism. The results indicate that alc. and ketone fill the defects of Hf-MOF to form a six-membered ring transition state (TS) complex, in which Hf as the center of Lewis stearic acid coordinates with the oxygen of the substrate mol., thus effectively promoting hydrogen transfer process. Other reactive groups, such as -NO2, C = C, -CN, of inadequate hardness or large steric hindrance are difficult to coordinate with Hf, thus weakening their catalytic effect, which explains the specific selectivity Hf-MOF-808 for reducing the carbonyl group. The experimental part of the paper was very detailed, including the reaction process of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.HPLC of Formula: 614-16-4

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Nitriles – Chemistry LibreTexts

《Synthesis of Molybdenum Pincer Complexes and Their Application in the Catalytic Hydrogenation of Nitriles》 was written by Leischner, Thomas; Spannenberg, Anke; Junge, Kathrin; Beller, Matthias. Synthetic Route of C7H4FN And the article was included in ChemCatChem in 2020. The article conveys some information:

A series of molybdenum(0), (I) and (II) complexes ligated by different PNP and NNN pincer ligands were synthesized and structurally characterized. Along with previously described Mo-PNP complexes, all prepared compounds were tested in the catalytic hydrogenation of aromatic nitriles to primary amines. Among the applied catalysts, one is particularly well suited for the hydrogenation of electron-rich benzonitriles. Addnl., two aliphatic nitriles were transformed into the desired products in 80 and 86%, resp. Moreover, a catalytic intermediate was isolated and its role in the catalytic cycle was subsequently demonstrated. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Synthetic Route of C7H4FN

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《Transition metal- and solvent-free double hydroboration of nitriles》 was written by Bedi, Deepika; Brar, Aneelman; Findlater, Michael. Recommanded Product: 1194-02-1 And the article was included in Green Chemistry in 2020. The article conveys some information:

A highly efficient, room temperature double hydroboration of nitriles under transition metal-free and solvent-free conditions is reported. Sodium triethylborohydride is used as a catalyst and yields up to 99% are disclosed. Mechanistic studies reveal the reaction proceeds in a stepwise manner with initial formation of a boryl-imine which undergoes a second hydroboration to afford a diborylated amine product.4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 1194-02-1

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Talukder, Poulami; Chen, Shengxi; Roy, Basab; Yakovchuk, Petro; Spiering, Michelle M.; Alam, Mohammad P.; Madathil, Manikandadas M.; Bhattacharya, Chandrabali; Benkovic, Stephen J.; Hecht, Sidney M. published their research in Biochemistry on December 29 ,2015. The article was titled 《Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction》.Application of 83783-33-9 The article contains the following contents:

Described herein are the syntheses and photophys. characterization of three novel cyanotryptophans, and their efficient incorporation into proteins as fluorescent probes. Photophys. characteristics indicated that each was significantly brighter and red-shifted in fluorescence emission relative to tryptophan. Each analog was used to activate a suppressor tRNA transcript and was incorporated with good efficiency into two different positions (Trp22 and Trp74) of Escherichia coli dihydrofolate reductase (ecDHFR). The Trp analogs could be monitored selectively in the presence of multiple native Trp residues in DHFR. 6-CNTrp (A) formed an efficient Förster resonance energy transfer (FRET) pair with L-(7-hydroxycoumarin-4-yl)ethylglycine (HCO, D) at position 17. Further, 6-CNTrp (A) was incorporated into two DNA binding proteins, including the Klenow fragment of DNA polymerase I and an RNA recognition motif (RRM2) of heterogeneous nuclear ribonucleoprotein L-like (hnRNP LL). Using these proteins, we demonstrated the use of FRET involving A as a fluorescence donor and benzo[g]quinazoline-2,4-(1H,3H)-dione 2′-deoxyriboside (Tf) or 4-aminobenzo[g]quinazoline-2-one 2′-deoxyriboside (Cf) as fluorescent acceptors to study the binding interaction of the Klenow fragment with duplex DNA oligomers (labeled with Tf), or the domain-specific association between hnRNP LL and the BCL2 i-motif DNA (labeled with Cf). Thus, the non-natural amino acid could be used as a FRET partner for studying protein-nucleic acid interactions. Together, these findings demonstrate the potential utility of 6-CNTrp (A) as a fluorescence donor for the study of protein conformational events. In the experimental materials used by the author, we found 3-Formyl-1H-indole-6-carbonitrile(cas: 83783-33-9Application of 83783-33-9)

3-Formyl-1H-indole-6-carbonitrile(cas: 83783-33-9) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Application of 83783-33-9

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Category: nitriles-buliding-blocksIn 2019 ,《Sustainable Synthesis of Quinazoline and 2-Aminoquinoline via Dehydrogenative Coupling of 2-Aminobenzyl Alcohol and Nitrile Catalyzed by Phosphine-Free Manganese Pincer Complex》 was published in Organic Letters. The article was written by Das, Kalicharan; Mondal, Avijit; Pal, Debjyoti; Srimani, Dipankar. The article contains the following contents:

A sustainable synthesis of quinazoline and 2-aminoquinoline via acceptorless dehydrogenative annulation is presented. The reaction is catalyzed by earth-abundant well-defined manganese complexes bearing NNS ligands. Furthermore, a one-pot synthetic strategy for the synthesis of 2-alkylaminoquinolines through sequential dehydrogenative annulation and N-alkylation reaction has also been demonstrated. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Category: nitriles-buliding-blocks)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Category: nitriles-buliding-blocks

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Name: 2-BromobenzonitrileIn 2019 ,《Single-molecule photoredox catalysis》 appeared in Chemical Science. The author of the article were Haimerl, Josef; Ghosh, Indrajit; Koenig, Burkhard; Vogelsang, Jan; Lupton, John M.. The article conveys some information:

The chem. of life is founded on light, so is it appropriate to think of light as a chem. substance Planck’s quantization offers a metric analogus to Avogadro’s number to relate the number of particles to an effective reaction of single mols. and photons to form a new compound A rhodamine dye mol. serves as a dehalogenating photocatalyst in a consecutive photoelectron transfer (conPET) process which adds the energy of two photons, with the first photon inducing radical formation and the second photon triggering PET to the substrate mol. Rather than probing catalytic heterogeneity and dynamics on the single-mol. level, single-photon synthesis is demonstrated: the light quantum constitutes a reactant for the single substrate mol. in a dye-driven reaction. The approach illustrates that mol. diffusion and excited-state internal conversion are not limiting factors in conPET reaction kinetics because of catalyst-substrate preassocn. The effect could be common to photoredox catalysis, removing the conventional requirement of long excited-state lifetimes. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Name: 2-Bromobenzonitrile

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Nitriles – Chemistry LibreTexts

Category: nitriles-buliding-blocksIn 2019 ,《Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Petek, Nejc; Stefane, Bogdan; Novinec, Marko; Svete, Jurij. The article conveys some information:

A series of novel 7-aminoalkyl substituted pyrazolo[1,5-a]pyrimidine derivatives were synthesized and tested for inhibition of cathepsin K. The synthetic methodol. comprises cyclization of 5-aminopyrazoles with N-Boc-α-amino acid-derived ynones followed by transformation of the ester and the Boc-amino functions. It allows for easy diversification of the pyrazolo[1,5-a]pyrimidine scaffold at various positions. Mol. docking studies with pyrazolo[1,5-a]pyrimidine derivatives were also performed to elucidate the binding mode in the active site of cathepsin K. The synthesized compounds exhibited moderate inhibition activity (Ki ≥ 77 μM). In the experiment, the researchers used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Category: nitriles-buliding-blocks)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Category: nitriles-buliding-blocks

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In 2022,Li, Yan published an article in Monatshefte fuer Chemie. The title of the article was 《Palladium-catalyzed cross-coupling of benzyltitanium(IV) reagents with aryl fluorides》.Recommanded Product: 1194-02-1 The author mentioned the following in the article:

The first palladium-catalyzed cross-coupling between benzyltitanium(IV) reagents with aryl fluorides is reported. A variety of diarylmethanes can be prepared in good to excellent yields by the catalyst system of PdCl2(dppf)2 associated with 1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxypiperidine. This reaction offered a highly efficient approach to diarylmethanes that are commonly found in life-changing drug mols. The experimental part of the paper was very detailed, including the reaction process of 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Chang-Sheng; Yu, Yongqi; Sunada, Yusuke; Wang, Chen; Yoshikai, Naohiko published an article in 2022. The article was titled 《Cobalt-Catalyzed Carbo- and Hydrocyanation of Alkynes via C-CN Bond Activation》, and you may find the article in ACS Catalysis.Related Products of 1194-02-1 The information in the text is summarized as follows:

Cobalt-catalyzed carbo- and hydrocyanation reactions of alkynes via C-CN bond cleavage of organic cyanides are reported. A low-valent cobalt-diphosphine catalyst generated by reduction with Zn promotes the arylcyanation of alkynes with trans-selectivity. By contrast, the addition of Zn(OTf)2 to this catalytic system not only accelerates the transformation but also switches the stereoselectivity, affording cis-arylcyanation products. The present catalytic systems prove to be effective for alkenylcyanation using alkenyl cyanides as well as for transfer hydrocyanation using propionitrile as the HCN surrogate. Exptl. and computational studies on arylcyanation have been performed to gain insight into the reaction pathways, including the possible origin of the stereodivergence under cobalt and cobalt/zinc catalysis. In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Related Products of 1194-02-1

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Zhu, Chen; Yue, Huifeng; Rueping, Magnus published an article in 2022. The article was titled 《Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry》, and you may find the article in Nature Communications.Name: 2-Bromobenzonitrile The information in the text is summarized as follows:

A three-component, reductive cascade, cross-coupling reaction for the arylalkylation of alkynes was reported. A wide range of trisubstituted alkenes were obtained in good to high yields with excellent chemo- and stereoselectivity by switching between electrochem. and photocatalysis. The E isomer of the product was obtained exclusively when the reaction was conducted with electricity and nickel, while the Z isomer was generated with high stereoselectivity when photo- and nickel dual catalysts were used. Moreover, photo-assisted electrochem. enabled nickel catalyzed protocol was demonstrated to selectively deliver Z-trisubstituted alkenes without the addition of photocatalysts. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Name: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts