Chen, Xinhui’s team published research in Inorganic Chemistry in 2022 | CAS: 17201-43-3

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Quality Control of 4-Cyanobenzyl bromide

In 2022,Chen, Xinhui; Yang, Fan; Han, Congcong; Han, Licong; Wang, Fubo; Jin, Guoxia; Wang, Haiying; Ma, Jianping published an article in Inorganic Chemistry. The title of the article was 《[Fe2S2-Agx]-Hydrogenase Active-Site-Containing Coordination Polymers and Their Photocatalytic H2 Evolution Reaction Properties》.Quality Control of 4-Cyanobenzyl bromide The author mentioned the following in the article:

Three [Fe2S2-Agx]-hydrogenase active-site-containing coordination polymers (CPs), {[Fe2S2-Ag1](4-cpmt)2(CO)6(ClO4-)}n (1), {[Fe2S2-Ag2](4-cpmt)2(CO)6(OTf-)2(benzene)}n (2), and {[Fe2S2-Ag2](3-cpmt)2(CO)6(ClO4-)2}n (3), were obtained by a direct synthesis method from ligands [FeFe](4-cpmt)2(CO)6 [L1; 4-cpmt = (4-cyanophenyl)methanethiolate] and [FeFe](3-cpmt)2(CO)6 [L2; 3-cpmt = (3-cyanophenyl)methanethiolate] with silver salts. 1-3 Represent the first examples of [FeFe]-hydrogenase-based CPs. It was worth noting that the Ag-S bonding between the Ag centers and S atoms of a [Fe2S2] cluster produced a novel [Fe2S2-Agx] (x = 1 or 2) catalytic site in all three polymers. The results of photochem. H2 generation experiments indicated that 2 and 3 containing [Fe2S2-Ag2] active sites showed obviously improved catalytic performances compared with ligands L1 and L2 and [Fe2S2-Ag1]-containing 1. This work provides a pioneering strategy for the direct synthesis of [Fe2S2]-based CPs or metal-organic frameworks. The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Quality Control of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Quality Control of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Alizadeh, Abdolali’s team published research in ChemistrySelect in 2022 | CAS: 614-16-4

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Safety of 3-Oxo-3-phenylpropanenitrile

In 2022,Alizadeh, Abdolali; Rostampoor, Azar published an article in ChemistrySelect. The title of the article was 《Efficient One Pot and Chemoselective Synthesis of Polysubstituted Dihydro-6H-chromeno[4,3-d]pyrazolo[1,5-a]pyrimidin-6-ones via a Four-Component Reaction》.Safety of 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:

In this research, a simple and chemoselective synthesis of highly fluorescent polysubstituted dihydro-6H-chromeno[4,3-d]pyrazolo[1,5-a]pyrimidin-6-ones containing one chiral stereocenter was presented by a sequential four-component reaction of 4-chloro-3-formylcoumarin, 1-phenyl-2-(1,1,1-triphenyl-λ5-phosphanylidene)ethan-1-ones (Wittig reagent), benzoylacetonitriles and hydrazine hydrate as readily available starting materials, which includes base-mediated 1,4-addition/aza-Michael addition/formation of two C-N bonds. The desired products were obtained with short reaction times, easy purification (products can be purified by washing with EtOH), and medium to high yields (up to 92%) under relatively mild reaction conditions. Mol. structures were determined by IR spectrophotometry, mass spectrometry, NMR spectroscopy, and single-crystal X-ray anal. In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Safety of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Safety of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Polites, Viktor C.’s team published research in Organic Letters in 2021 | CAS: 623-00-7

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Related Products of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Polites, Viktor C.; Badir, Shorouk O.; Keess, Sebastian; Jolit, Anais; Molander, Gary A. published their research in Organic Letters in 2021. The article was titled 《Nickel-Catalyzed Decarboxylative Cross-Coupling of Bicyclo[1.1.1]pentyl Radicals Enabled by Electron Donor-Acceptor Complex Photoactivation》.Related Products of 623-00-7 The article contains the following contents:

The synthesis and Ni-catalyzed functionalization of BCP redox-active esters with (hetero)aryl bromides via the action of a photoactive electron donor-acceptor complex were reported. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzonitrile(cas: 623-00-7Related Products of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Related Products of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chatterjee, Basujit’s team published research in ACS Catalysis in 2021 | CAS: 2042-37-7

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.COA of Formula: C7H4BrN

Chatterjee, Basujit; Jena, Soumyashree; Chugh, Vishal; Weyhermueller, Thomas; Werle, Christophe published their research in ACS Catalysis in 2021. The article was titled 《A Molecular Iron-Based System for Divergent Bond Activation: Controlling the Reactivity of Aldehydes》.COA of Formula: C7H4BrN The article contains the following contents:

The direct synthesis of amides and nitriles from readily available aldehyde precursors provides access to functional groups of major synthetic utility. To date, most reliable catalytic methods have typically been optimized to supply one product exclusively. Herein the authors describe an approach centered on an operationally simple iron-based system that-depending on the reaction conditions-selectively addresses either the C=O or C-H bond of aldehydes. This way, two divergent reaction pathways can be opened to furnish both products in high yields and selectivities under mild reaction conditions. The catalyst system takes advantage of iron’s dual reactivity capable of acting as (1) a Lewis acid and (2) a nitrene transfer platform to govern the aldehyde building block. The present transformation offers a rare control over the selectivity based on the iron system’s ionic nature. This approach expands the repertoire of protocols for amide and nitrile synthesis and shows that fine adjustments of the catalyst system’s mol. environment can supply control over bond activation processes; thus, providing easy access to various products from primary building blocks. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7COA of Formula: C7H4BrN)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.COA of Formula: C7H4BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Baran, Talat’s team published research in Carbohydrate Polymers in 2020 | CAS: 623-00-7

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Recommanded Product: 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

《Pd NPs@Fe3O4/chitosan/pumice hybrid beads: A highly active, magnetically retrievable, and reusable nanocatalyst for cyanation of aryl halides》 was written by Baran, Talat. Recommanded Product: 623-00-7 And the article was included in Carbohydrate Polymers in 2020. The article conveys some information:

In this study, Fe3O4/chitosan/pumice hybrid beads were developed as a new stabilizer agent, and palladium nanoparticles (Pd NPs) were successfully decorated on the designed stabilizer without adding any toxic reducing resource. Then, the potential use of Pd NPs@Fe3O4/chitosan/pumice hybrid beads as a heterogeneous catalyst against different aryl halide cyanations was investigated with K4[Fe(CN)6]. In these reactions, Pd NPs@ Fe3O4/chitosan /pumice hybrid beads showed high catalytic activity by converting aryl halides to the desired benzonitriles with high product yields (80%-98%). Due to the magnetically separable nature of Pd NPs@Fe3O4/chitosan/pumice hybrid beads, they were reused several times, and 86% yield was obtained even after six successive runs. This paper reveals that Pd NPs@Fe3O4/chitosan/pumice hybrid beads have a high potential to synthesis a broad range of nitriles due to their excellent catalytic and retrievable capability. After reading the article, we found that the author used 4-Bromobenzonitrile(cas: 623-00-7Recommanded Product: 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Recommanded Product: 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sanagawa, Atsushi’s team published research in Organic Letters in 2019 | CAS: 1194-02-1

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Product Details of 1194-02-1

The author of 《Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts》 were Sanagawa, Atsushi; Nagashima, Hideo. And the article was published in Organic Letters in 2019. Product Details of 1194-02-1 The author mentioned the following in the article:

Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPiv)2 (Piv = COtBu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Product Details of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Product Details of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Wei David’s team published research in Molecular Catalysis in 2021 | CAS: 1194-02-1

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Related Products of 1194-02-1

Wang, Wei David; Wang, Fushan; Chang, Youcai; Dong, Zhengping published an article in 2021. The article was titled 《Biomass chitosan-derived nitrogen-doped carbon modified with iron oxide for the catalytic ammoxidation of aromatic aldehydes to aromatic nitriles》, and you may find the article in Molecular Catalysis.Related Products of 1194-02-1 The information in the text is summarized as follows:

Herein, cost-effective, renewable biomass chitosan was used to prepare a N-doped carbon modified with iron oxide catalyst (Fe2O3@NC) for nitrile synthesis. The iron oxide nanoparticles were uniformly wrapped in the N-doped carbon matrix to prevent their aggregation and leaching. Fe2O3@NC-800, which was subjected to carbonization at 800 C, exhibited excellent activity, selectivity and stability in the catalytic ammoxidation of aromatic aldehydes to aromatic nitriles. This study was provided a new method for the fabrication of an efficient and cost-effective catalyst system for synthesizing nitriles.4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yavari, Issa’s team published research in Monatshefte fuer Chemie in 2020 | CAS: 614-16-4

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Formula: C9H7NO

《Synthesis and structure of dialkyl (Z)-3-amino-2-cyano-4-diazopent-2-enedioates》 was published in Monatshefte fuer Chemie in 2020. These research results belong to Yavari, Issa; Mohsenzadeh, Ramin; Kayanian, Jasmine. Formula: C9H7NO The article mentions the following:

Diazo-transfer reaction of tosyl azide and alkyl 2-cyanoacetates in the presence of pyridine at 0° gives the corresponding alkyl 2-cyano-2-diazoacetates. This material readily underwent nucleophilic attack by pyridinium 1-cyano-2-alkoxy-2-oxoethan-1-ide to form dialkyl (Z)-3-amino-2-cyano-4-diazopent-2-enedioates. The X-ray structure of a typical product is reported, as well as DFT computational studies that illuminate the structural features of these stable diazo compounds The results came from multiple reactions, including the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Formula: C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Formula: C9H7NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Puetz, Alexander M.’s team published research in Chemical Science in 2020 | CAS: 623-00-7

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,HPLC of Formula: 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

《Total scattering reveals the hidden stacking disorder in a 2D covalent organic framework》 was published in Chemical Science in 2020. These research results belong to Puetz, Alexander M.; Terban, Maxwell W.; Bette, Sebastian; Haase, Frederik; Dinnebier, Robert E.; Lotsch, Bettina V.. HPLC of Formula: 623-00-7 The article mentions the following:

Interactions between extended π-systems are often invoked as the main driving force for stacking and crystallization of 2D organic polymers. In covalent organic frameworks (COFs), the stacking strongly influences properties such as the accessibility of functional sites, pore geometry, and surface states, but the exact nature of the interlayer interactions is mostly elusive. The stacking mode is often identified as eclipsed based on observed high symmetry diffraction patterns. However, as pointed out by various studies, the energetics of eclipsed stacking are not favorable and offset stacking is preferred. This work presents lower and higher apparent symmetry modifications of the imine-linked TTI-COF prepared through high- and low-temperature reactions. Through local structure investigation by pair distribution function anal. and simulations of stacking disorder, we observe random local layer offsets in the low temperature modification. We show that while stacking disorder can be easily overlooked due to the apparent crystallog. symmetry of these materials, total scattering methods can help clarify this information and suggest that defective local structures could be much more prevalent in COFs than previously thought. A detailed anal. of the local structure helps to improve the search for and design of highly porous tailor-made materials. The results came from multiple reactions, including the reaction of 4-Bromobenzonitrile(cas: 623-00-7HPLC of Formula: 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,HPLC of Formula: 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Hengwei’s team published research in Nature Communications in 2019 | CAS: 1194-02-1

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Reference of 4-Fluorobenzonitrile

The author of 《Quasi Pd1Ni single-atom surface alloy catalyst enables hydrogenation of nitriles to secondary amines》 were Wang, Hengwei; Luo, Qiquan; Liu, Wei; Lin, Yue; Guan, Qiaoqiao; Zheng, Xusheng; Pan, Haibin; Zhu, Junfa; Sun, Zhihu; Wei, Shiqiang; Yang, Jinlong; Lu, Junling. And the article was published in Nature Communications in 2019. Reference of 4-Fluorobenzonitrile The author mentioned the following in the article:

Hydrogenation of nitriles represents as an atom-economic route to synthesize amines, crucial building blocks in fine chems. However, high redox potentials of nitriles render this approach to produce a mixture of amines, imines and low-value hydrogenolysis byproducts in general. Here we show that quasi at.-dispersion of Pd within the outermost layer of Ni nanoparticles to form a Pd1Ni single-atom surface alloy structure maximizes the Pd utilization and breaks the strong metal-selectivity relations in benzonitrile hydrogenation, by prompting the yield of dibenzylamine drastically from ∼5 to 97% under mild conditions (80°C; 0.6 MPa), and boosting an activity to about eight and four times higher than Pd and Pt standard catalysts, resp. More importantly, the undesired carcinogenic toluene byproduct is completely prohibited, rendering its practical applications, especially in pharmaceutical industry. Such strategy can be extended to a broad scope of nitriles with high yields of secondary amines under mild conditions. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Reference of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Reference of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts