Tag: 100-200

《Tris(triazolo)triazine-based emitters for solution-processed blue thermally activated delayed fluorescence organic light-emitting diodes》 was written by Hundemer, Fabian; Crovini, Ettore; Wada, Yoshimasa; Kaji, Hironori; Braese, Stefan; Zysman-Colman, Eli. Quality Control of 4-FluorobenzonitrileThis research focused onTristriazolotriazine emitters processed blue thermally fluorescence organic lightemitting diodes. The article conveys some information:

We report a new emitter 3,4,5-3TCz-TTT based on a tris(triazolo)triazine acceptor that shows thermally activated delayed fluorescence and cross-compare its performance with the recently reported analog, 3DMAC-TTT. These compounds show blue emission and delayed fluorescence with delayed lifetimes on the order of milliseconds. Solution-processed organic light-emitting diodes achieving maximum external quantum efficiencies, EQEmax, of 5.8% for 3,4,5-3TCz-TTT and 11.0% for 3DMAC-TTT.4-Fluorobenzonitrile(cas: 1194-02-1Quality Control of 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Quality Control of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Access to pyridines via cascade nucleophilic addition reaction of 1,2,3-triazines with activated ketones or acetonitriles》 was written by Zhang, Yuan; Luo, Han; Lu, Qixing; An, Qiaoyu; Li, You; Li, Shanshan; Tang, Zongyuan; Li, Baosheng. HPLC of Formula: 614-16-4This research focused ontriazine acetonitrile tandem regioselective cycloaddition nucleophilic addition; ketone triazine tandem regioselective cycloaddition nucleophilic addition; pyridine preparation. The article conveys some information:

The cascade nucleophilic addition reactions of 1,2,3-triazines with activated acetonitriles or ketones, which were used to construct highly substituted pyridines that were not easily accessed by conventional methods was reported. The strategy addressed some structural diversity issues currently facing medicinal chem., and the resulting pyridines was used as convenient precursors for the synthesis of related pharmaceuticals. This method was applied to the syntheses of the marketed drug etoricoxib and several biol. important mols. in a few steps. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4HPLC of Formula: 614-16-4) was used in this study.

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.HPLC of Formula: 614-16-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

SDS of cas: 1194-02-1In 2019 ,《Cyanation of Aryl and Heteroaryl Aldehydes Using In-Situ-Synthesized Ag Nanoparticles in Crocus sativus L. Extract》 was published in ChemistrySelect. The article was written by Sajadi, S. Mohammad; Nasrollahzadeh, Mahmoud; Akbari, Reza. The article contains the following contents:

An efficient, inexpensive and simple methodol. was reported for the cyanation of aryl and heteroaryl aldehydes using in situ synthesized silver nanoparticles (Ag NPs) with the use of Crocus sativus L. aqueous extract as a reducing and stabilizing biomedia. Furthermore, stable and cheap silver precursor (AgNO3) along with the non-toxic, efficient and inexpensive cyanide source K4[Fe(CN)6] were used for this reaction. This system provided an alternative protocol to the existing methods for the synthesis of aryl and heteroaryl nitriles. All products were obtained in good to excellent yields under ligand- and organic solvent-free conditions. The fourier-transform IR spectroscopy (FT-IR), UV-visible spectroscopy (UV-Vis), X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) techniques were used for the characterization of the biosynthesized Ag NPs. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1SDS of cas: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.SDS of cas: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

COA of Formula: C8H6BrNIn 2019 ,《Synthesis of N-benzyl substituted 1,4-imino-L-lyxitols with a basic functional group as selective inhibitors of Golgi α-mannosidase IIb》 appeared in Bioorganic Chemistry. The author of the article were Klunda, Tomas; Sestak, Sergej; Kona, Juraj; Polakova, Monika. The article conveys some information:

Inhibition of the biosynthesis of complex N-glycans in the Golgi apparatus is one of alternative ways to suppress growth of tumor tissue. Eight N-benzyl substituted 1,4-imino-L-lyxitols with basic functional groups (amine, amidine, guanidine), hydroxyl and fluoro groups were prepared, optimized their syntheses and tested for their ability to inhibit several α-mannosides from the GH family 38 (GMIIb, LManII and JBMan) as models for human Golgi and lysosomal α-mannoside II. All compounds were found to be selective inhibitors of GMIIb. The most potent structure bearing guanidine group, inhibited GMIIb at the micromolar level (Ki = 19 ± 2 μM) while no significant inhibition (>2 mM) of LManII and JBMan was observed Based on mol. docking and pKa calculations this structure may form two salt bridges with aspartate dyad of the target enzyme improving its inhibitory potency compared with other N-benzyl substituted derivatives published in this and previous studies. The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3COA of Formula: C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.COA of Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Jacob, Raquel G.; Hartwig, Daniela; Nascimento, Jose Edmilson R.; Abib, Paola B.; Ebersol, Camila P.; Nunes, Pamela P. P.; Birmann, Paloma T.; Casaril, Angela M.; Savegnago, Lucielli; Schumacher, Ricardo F. published an article in Tetrahedron Letters. The title of the article was 《Sequential one-pot synthesis and antioxidant evaluation of 5-amino-4-(arylselanyl)-1H-pyrazoles》.Name: 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:

A simple and efficient method for the sequential one-pot synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles catalyzed by CuI/bpy under mild conditions was described. The starting materials were easily available benzoylacetonitriles, substituted hydrazines and diaryl diselenides. A range of substituted 5-amino-4-(arylselanyl)-1H-pyrazoles was obtained in moderate to good yields (49% to 90%). Moreover, the antioxidant effect of the 5-amino-4-(arylselanyl)-1H-pyrazoles were reported in several in-vitro trials, which is extremely important, because oxidative stress is a crucial role in the development of various human diseases. This data revealed that all compounds demonstrated promising effects in scavenging the synthetic radical ABTS+, presented reducing power in ferric ion reducing antioxidant power (FRAP) assay, and ability to inhibit linoleic acid peroxidation Thus, these compounds can be interesting synthetic mols. in the protection from oxidative diseases. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Name: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Name: 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Akunuri, Ravikumar; Vadakattu, Manasa; Kaul, Grace; Akhir, Abdul; Saxena, Deepanshi; Ahmad, Mohammad Naiyaz; Bujji, Sushmitha; Joshi, Swanand Vinayak; Dasgupta, Arunava; Yaddanapudi, Venkata Madhavi; Chopra, Sidharth; Nanduri, Srinivas published an article in ChemistrySelect. The title of the article was 《Synthesis and Antibacterial Evaluation of 3,4-Dihydro-1H-benzo[b]azepine-2,5-dione Derivatives》.COA of Formula: C8H6BrN The author mentioned the following in the article:

Fused-azepinones are interesting heterocyclic scaffolds present in various natural products and synthetic derivatives with potent kinase inhibition, anti-cancer, anti-inflammatory, anti-HIV, neuroprotective, anti-fouling and other biol. activities. These fused-azepinones are also known for their antimicrobial activity against the Plasmodium falciparum, Leishmania, Escherichia coli, and Streptococcus pneumonia. In the present work, author synthesized a library of 3,4-dihydro-1H-benzo[b]azepine-2,5-dione derivatives and evaluated them for their antibacterial potential against a panel of bacterial pathogens. The Structure-activity relationship studies revealed the essential structural features for the promising antibacterial properties against Staphylococcus aureus and Mycobacterium tuberculosis with MIC 4-64μg/mL. In addition, these compounds exhibited favorable selectivity index (SI≥10) in cytotoxicity studies. With the interesting antibacterial properties exhibited and good selectivity index, these compounds have emerged as promising candidates for further development. In the experiment, the researchers used many compounds, for example, 4-Cyanobenzyl bromide(cas: 17201-43-3COA of Formula: C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.COA of Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gao, Na; Liu, Xiaoyu; Yuan, Xu; Hu, Bingwei; Jiang, Peiyun; Lin, Jun; Jin, Yi published an article in 2022. The article was titled 《Oxidative [2 + 1 + 1 + 1] Annulation of Aldehydes and Methylene Nitriles: Synthesis of Diastereoselective Polysubstituted Cyclopentenes》, and you may find the article in Journal of Organic Chemistry.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile The information in the text is summarized as follows:

Herein, a green cascade approach to prepare a variety of diastereoselective polysubstituted cyclopentene derivatives through metal-free oxidative [2 + 1 + 1 + 1] annulation of aldehydes and methylene nitriles were reported. Mechanistic studies demonstrated that the reaction underwent a four-step cascade reaction including air oxidation and Michael addition to obtain the final product. This reaction features readily available starting materials, transition metal-free, eco-friendly operations, gram-scale syntheses, and wide functional group tolerance. The methodol. may be useful for the construction of polysubstituted cyano-cyclopentene heterocycles with potential biol. activity. The experimental part of the paper was very detailed, including the reaction process of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application In Synthesis of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Carbohydrate Polymers included an article by Kandathil, Vishal; Kempasiddaiah, Manjunatha; B. S., Sasidhar; Patil, Siddappa A.. Related Products of 623-00-7. The article was titled 《From agriculture residue to catalyst support; A green and sustainable cellulose-based dip catalyst for C-C coupling and direct arylation》. The information in the text is summarized as follows:

In this work, a dip catalyst made of cellulose, isolated from agriculture residue (sugarcane bagasse), in which biogenically synthesized palladium nanoparticles were dispersed. The prepared dip catalyst was characterized by FESEM, EDS, XRD, ATR-IR, TGA, TEM, XPS and ICP-OES anal. Also, the activity of the dip catalyst was studied in the Suzuki-Miyaura cross-coupling between aryl halides and arylboronic acids to get biaryls and was found to gave excellent conversion with 15 recycles. Further, the activity of dip catalyst in C5-arylation of 2-substituted thiophenes was evaluated for which promising yields of aryl-thiphenyls I [R = 4-Me, 4-OMe, 4-CN, etc.; R1 = C(O)H, C(O)Me] were obtained. In the experiment, the researchers used 4-Bromobenzonitrile(cas: 623-00-7Related Products of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Related Products of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Catalysis Communications included an article by Ren, Shishuai; Wang, Yangyang; Yang, Fei; Sun, Hongjian; Li, Xiaoyan. Synthetic Route of C7H4FN. The article was titled 《Dehydration of primary amides to nitriles catalyzed by [CNC]-pincer hydrido cobalt(III) complexes》. The information in the text is summarized as follows:

The dehydration reactions from primary amides to nitriles were catalyzed by the [CNC]-pincer hydrido cobalt(III) complexes [(ortho-F4C6-CH=N-C10H6)Co(III)(H)(PMe3)2], [(2,5-F2C6H2-CH=N-C10H6)Co(III)(H)(PMe3)2] (I) and [(2,4,5-F3C6H-CH=N-C10H6)Co(III)(H)(PMe3)2] as catalysts with (EtO)3SiH as an efficient reducing agent. These hydrido cobalt(III) complexes as catalysts are suitable for many substrates and have good functional group tolerance. Among the three cobalt hydrides, complex I is the best catalyst. This is the first hydrido cobalt complex-catalyzed dehydration of primary amides to nitriles. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Nature Communications included an article by Nambo, Masakazu; Yim, Jacky C.-H.; Freitas, Luiza B. O.; Tahara, Yasuyo; Ariki, Zachary T.; Maekawa, Yuuki; Yokogawa, Daisuke; Crudden, Cathleen M.. Related Products of 17201-43-3. The article was titled 《Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling》. The information in the text is summarized as follows:

Herein, Pd-catalyzed Suzuki-Miyaura cross-coupling of α-fluorinated benzylic triflones with arylboronic acids affording structurally diverse α-fluorinated diarylmethanes Ar1C(X)(F)Ar2 [Ar1 = 4-t-BuC6H4, 4-O2NC6H4, 4-CO2MeC6H4, etc.; Ar2 = Ph, 2-MeC6H4, 1-naphthyl, etc.] was reported. The ease of synthesis of fluorinated triflones as the key starting materials enabled powerful late-stage transformations of known biol. active compounds into fluorinated analogs. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Related Products of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Related Products of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts