Tag: 100-200

In 2017,Sonyanaik, Banoth; Sakram, Boda published 《Design and synthesis of novel substituted 1,8-naphthyridin-2-yl-amide derivatives at ambient temperature and evaluation of their antimicrobial activity》.Heterocyclic Letters published the findings.Application In Synthesis of 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

A new series of substituted 1,8-naphthyridin-2-yl-amide derivatives I (R1 = H, 3-NO2, 4-Br, etc.; R2 = H, 4-Cl) have been successfully synthesized in good yields at ambient temperature by reaction of various substituted 3-phenyl-1,8-naphthyridin-2-amines with aryl benzoic acids. All the newly synthesized compounds were evaluated for their in vitro antimicrobial activity. All these compounds exhibit good antibacterial and excellent antifungal activity. Among them, compound I (R1 = H, 4-Br, 4-NO2; R2 = 4-Cl) showed remarkable inhibition of antimicrobial activity. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Application In Synthesis of 2-(3-Bromophenyl)acetonitrile)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Application In Synthesis of 2-(3-Bromophenyl)acetonitrile

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In 2010,Liu, Yang; Huang, Liping; Xie, Fuchun; Hu, Youhong published 《Base-Promoted One-Pot Tandem Reaction of 3-(1-Alkynyl)chromones under Microwave Irradiation to Functionalized Amino-Substituted Xanthones》.Journal of Organic Chemistry published the findings.Synthetic Route of C8H6BrN The information in the text is summarized as follows:

A base-promoted one-pot tandem reaction has been developed from 3-(1-alkynyl)chromones, e.g., I, with various acetonitriles to afford functionalized amino-substituted xanthones, e.g., II, under microwave irradiation This tandem process involves multiple reactions, such as Michael addition/cyclization/1,2-addition, without a transition metal catalyst. This method provides an efficient approach to build up natural product-like diversified amino-substituted xanthone scaffolds rapidly.2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN) was used in this study.

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Synthetic Route of C8H6BrN

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Safety of 2-(3-Bromophenyl)acetonitrileIn 2019 ,《A conventional and solid-state synthesis, biological activity, and molecular docking studies of 6-arylbenzo[4,5]imidazo[1,2-a] [1,8]naphthyridin-10-ols》 was published in Synthetic Communications. The article was written by Boda, Sakram; Dharavath, Ravi; Madhavaram, Madhavi; Adem, Kurumanna; Palithapu, Madhu; Maloth, Govan; T, Parthasarathy. The article contains the following contents:

An effective, practical, and simple approach toward the preparation of highly-substituted 6-arylbenzo[4, 5]imidazo[1,2-a][1,8]naphthyridin-10-ols I (R = H, 3-NO2, 2-CF3, etc.) by the reaction of 3-aryl-1,8-naphthyridin-2-amines with benzoquinone in acid catalyzed cyclization under solid-state method, as well as conventional conditions, has been described. The products are obtained in good yields and in a solid of high purity. The major advantages of solid states are easy workup, low costs, short reaction time, good efficacy, and environment-friendly procedure. The newly synthesized compounds were thoroughly characterized using spectral data and elemental analyses. All compounds were screened for their biol. evaluation. Predominantly and compounds showed the highest antibacterial activity. Moreover, all the synthesized compounds were docked against topoisomerase II DNA gyrase enzyme. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Safety of 2-(3-Bromophenyl)acetonitrile)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Safety of 2-(3-Bromophenyl)acetonitrile

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Recommanded Product: 17201-43-3In 2019 ,《Quinoline-1,2,3-triazole Hybrids: Design and Synthesis through Click Reaction, Evaluation of Anti-Tubercular Activity, Molecular Docking and In Silico ADME Studies》 appeared in ChemistrySelect. The author of the article were Reddyrajula, Rajkumar; Dalimba, Udayakumar. The article conveys some information:

A new series of quinoline-1,2,3-triazole derivatives I (R = benzyl, phenacyl, 4-methoxy phenacyl, etc.), II were designed based on the mol. hybridization concept and the mols. were synthesized by employing a click chem. approach. The pharmacophoric units (quinoline and 1,2,3-triazole) are linked through either an ether or an amide functionality; such a simple structural modification of the linker group significantly enhanced the anti-tubercular activity of the mols. and all the amide derivatives showed better inhibition activity as compared to their ether analogs. However, these compounds did not inhibit significantly the growth of tested bacterial strains: the activity profile is similar to that observed for standard anti-TB drugs indicating the specificity of these compounds towards the M.tuberculosis strain. The mol. docking studies of the active compounds with two target enzymes (Inh A and CYP121) of M.tuberculosis revealed the strong binding interactions, mainly through hydrogen bonding, between the mols. and the target receptors. Furthermore, prediction of in silico-ADME (A: absorption, D: distribution, M: metabolism and E: excretion) parameters indicated that these compounds have an excellent oral bioavailability. The results suggest that these quinoline-1,2,3-triazole hybrids are a promising class of mol. entities for the development of new anti-tubercular leads.4-Cyanobenzyl bromide(cas: 17201-43-3Recommanded Product: 17201-43-3) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Recommanded Product: 17201-43-3

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Shen, Cong; Zhu, Yuhang; Jin, Shuqi; Xu, Kejie; Luo, Shuxin; Xu, Lixia; Zhong, Guofu; Zhong, Liangjun; Zhang, Jian published an article in 2022. The article was titled 《Regio- and stereo-selective olefinic C-H functionalization of aryl alkenes in ethanol》, and you may find the article in Organic Chemistry Frontiers.Application of 2042-37-7 The information in the text is summarized as follows:

N,N-bidentate-chelation-assisted α- and β-olefinic C-H alkenylation of aryl alkenes in ethanol to afford aryl dienes/trienes with excellent regio- and stereo-selectivities was reported. The reaction of 2-alkenyl benzylamine and benzoic acid derived substrates proceeded through six-membered exo-cyclometallation and seven-membered endo-cyclometallation. The aerobic protocols feature wide functionality tolerance, high selectivities and yields, mild conditions and scalable preparation, and the directing group can be easily removed to afford Boc-protected amine by simple reduction The experimental part of the paper was very detailed, including the reaction process of 2-Bromobenzonitrile(cas: 2042-37-7Application of 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Application of 2042-37-7

Referemce:
Nitrile – Wikipedia,
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Xing, Ai-Ping; Shen, Zhenpeng; Zhao, Zhe; Tian, Xinzhe; Ren, Yun-Lai published their research in Catalysis Communications in 2021. The article was titled 《CuO-catalyzed conversion of arylacetic acids into aromatic nitriles with K4Fe(CN)6 as the nitrogen source》.Application of 1194-02-1 The article contains the following contents:

CuO was demonstrated to be effective as the catalyst for the conversion of arylacetic acids to aromatic nitriles ArCN [Ar = Ph, 2-MeC6H4, 1-naphthyl, etc.] with non-toxic and inexpensive K4Fe(CN)6 as the nitrogen source via the complete cleavage of the C≡N triple bond. The present method allowed a series of arylacetic acids including phenylacetic acids, naphthaleneacetic acids, 2-thiopheneacetic acid and 2-furanacetic acid to be converted into the targeted products in low to high yields. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Application of 1194-02-1

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Nitrile – Wikipedia,
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《Planochromism of cyanoxime anions: Computational and mechanistic studies in solid state and solutions》 was published in Inorganica Chimica Acta in 2020. These research results belong to Morton, Jeffrey; Dennison, Richard; Nemykin, Victor; Gerasimchuk, Nikolay. Application In Synthesis of 3-Oxo-3-phenylpropanenitrile The article mentions the following:

The benzoylcyanoxime, NC-C(=N-OH)-C(O)-C6H5 (later H(BCO)), represents a new ampolydentate ligand that received attention in the light of useful biol. properties of its coordination compounds Colorless H(BCO), upon deprotonation, gains color that depends on the counter-cation and the system in general. Five derivatives of H(BCO), with colorless organic and inorganic mono-cations – Cs, Tl, Ag, N(CH3)4 and As(C6H5)4 – were synthesized and characterized by the X-ray anal., vibrational and electronic spectroscopy. Compounds exhibited unexpected and significant differences in color, both in solid state and in solutions, that were challenging to explain, thereby warranting detailed investigation including high-level DFT/TDFT computations. It was found that the BCO- anion demonstrates neg. solvatochromic in polar protic ROH (R=H, CH3, C2H5, C3H7, C4H9) solvents, and appears yellow in color, as tetraalkylammonium or alkali metal salts. In polar aprotic solvents, such as CH3CN, DMF, and DMSO, solutions of the BCO- anion are red. The color originates from n → π * transition in the anion. Solid state structures evidenced a considerable dependence on planarity of the BCO- anion on its color, as well as on the character of bonding in the C-N-O fragment: yellow color is associated with an oxime (bond length C-N is shorter than N-O), while red color is due to the nitroso character (bond length C-N is longer than the N-O). An addition of ethanol to red solutions of the BCO-containing salts leads to the color change to yellow, which is the result of the formation of an H-bond between the C-N-O fragment of cyanoxime and the solvent, also leading to the flattening of the structure. An explanation for this new color-changing effect was offered, based on exptl. evidence and TD/DFT calculations In the experiment, the researchers used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Application In Synthesis of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Application In Synthesis of 3-Oxo-3-phenylpropanenitrile

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《The direct C4-arylation of 3,5-dimethylisoxazole with aryl bromides catalyzed by imidazolidin-2-ylidene based palladium-PEPPSI complexes》 was published in Inorganica Chimica Acta in 2020. These research results belong to Kaloglu, Murat; Ozdemir, Ismail. HPLC of Formula: 2042-37-7 The article mentions the following:

In this study, the synthesis and characterization of four new imidazolinium salts as carbene precursors and their corresponding four new PEPPSI-type (PEPPSI = Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation) palladium complexes I (R = 4-Me, 2,4,6-tri-Me, 2,3,4,5,6-pentamethyl, 4-tert-butyl) were reported. The catalytic activities of all palladium complexes I were evaluated in the direct C4-arylation of 3,5-dimethylisoxazole with para-substituted aryl bromides 4-R1C6H4Br (R1 = H, Me, CHO, F, etc.), ortho-substituted aryl bromides 2-R2C6H4Br (R2 = Me, CN) and heteroaryl bromides R3Br (R3 = quinolin-3-yl, thiophen-2-yl). A range of functional groups such as methoxy, acetyl, formyl, fluoro, trifluoromethyl, nitrile or tert-Bu on the aryl bromides were successfully tolerated, and good yields were generally obtained in presence of 1 mol% catalyst loading at 120°C. In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7HPLC of Formula: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.HPLC of Formula: 2042-37-7

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Nitrile – Wikipedia,
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The author of 《Indium(III)chloride catalyzed synthesis of novel 1H-pyrazolo[1,2-b]phthalazine-5,10-diones and 1H-pyrazolo[1,2-a]pyridazine-5,8-diones under solvent-free condition》 were Jadhav, Amol Maruti; Balwe, Sandip Gangadhar; Kim, Jong Su; Lim, Kwon Taek; Jeong, Yeon Tae. And the article was published in Tetrahedron Letters in 2019. Name: 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:

An efficient, inexpensive and environmentally friendly synthesis of novel 3-amino-2-benzoyl-1-aryl-1H-pyrazolo[1,2-b]phthalazine-5,10-dione and 3-amino-2-benzoyl-1-aryl-1H-pyrazolo[1,2-a]pyridazine-5,8-dione derivatives were developed via one-pot three-component reaction of phthalhydrazide or maleic hydrazide, aryl aldehydes and substituted benzoylacetonitriles in the presence of catalytic amount of InCl3 as a Lewis acid catalyst under solvent-free conditions. A mild reaction conditions, short reaction times, high yields and a wide range of functional group tolerance were the most important features of this protocol. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Name: 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Name: 3-Oxo-3-phenylpropanenitrile

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The author of 《Bis-salophen palladium complex immobilized on Fe3O4@SiO2 nanoparticles as a highly active and durable phosphine-free catalyst for Heck and copper-free Sonogashira coupling reactions》 were Sardarian, Ali Reza; Kazemnejadi, Milad; Esmaeilpour, Mohsen. And the article was published in Dalton Transactions in 2019. Related Products of 623-00-7 The author mentioned the following in the article:

New Fe3O4@SiO2 core-shell superparamagnetic nanoparticles functionalized by a bis-salophen Schiff base Pd complex were synthesized and employed as an efficient magnetic nanocatalyst in the Heck and Sonogashira cross coupling reactions. The synthesized nanostructures were characterized by FTIR spectroscopy (FTIR), XRD, dynamic light scattering (DLS), energy dispersive X-ray anal. (EDX), XPS, elemental anal. (CHN), cyclic voltammetry (CV), Brunauer-Emmett-Teller anal. (BET), and UV-visible spectroscopy. The morphol. and size of the nanoparticles were studied by FE-SEM and TEM analyses. The magnetic properties of the catalyst were studied by VSM anal. The loading content and leaching amounts of Pd on the catalyst were measured by inductively coupled plasma (ICP) anal. The thermal behavior of this magnetic heterogeneous catalyst was studied using a TGA instrument. This heterogeneous catalytic system showed a good performance in the coupling of aryl halides with alkynes (Sonogashira reaction) as well as aryl halides with alkene derivatives (Heck reaction). High to excellent yields were achieved for these C-C coupling reactions. The catalyst can be simply separated from the reaction media by an external magnet and reused for 8 consecutive runs without any significant loss of activity. The kinetics of the reactions were studied. After reading the article, we found that the author used 4-Bromobenzonitrile(cas: 623-00-7Related Products of 623-00-7)

4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Related Products of 623-00-7 It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Referemce:
Nitrile – Wikipedia,
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