Tag: 100-200

The author of 《Multi-component reaction to access a library of polyfunctionally substituted 4,7-dihydropyrazolo[3,4-b]pyridines》 were Aggarwal, Ranjana; Kumar, Suresh; Singh, Gulshan. And the article was published in Synthetic Communications in 2019. Formula: C9H7NO The author mentioned the following in the article:

A practical approach to polyfunctionally substituted 4,7-dihydropyrazolo[3,4-b]pyridine derivatives from heteroaryl hydrazine, 3-aryl-3-oxopropanenitriles and aldehydes have been described in the report. The present catalyst-free protocol involves the intermediacy of 5-aminopyrazole and α-cyanochalcone, which undergoes in situ Michael addition to afford title compounds in moderate to good yields. All the steps were conducted concomitantly to render the procedure as practical and straightforward as possible. The expeditious synthetic protocol experiment takes less than one hour and shows broad substrate scope. In the part of experimental materials, we found many familiar compounds, such as 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Formula: C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Formula: C9H7NO

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Su, Ting; Naughton, Mary Ann H.; Smyth, Mark S.; Rose, Jack W.; Arfsten, Ann E.; McCowan, Jefferson R.; Jakubowski, Joseph A.; Wyss, Virginia L.; Ruterbories, Kenneth J.; Sall, Daniel J.; Scarborough, Robert M. published their research in Journal of Medicinal Chemistry on December 19 ,1997. The article was titled 《Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors》.Synthetic Route of C10H6N2O The article contains the following contents:

A series of highly potent and specific fibrinogen receptor antagonists have been discovered and optimized through structural modification of novel amidinoindole and benzofuran compounds Systematic linker optimization afforded the amidinobenzofuran-containing inhibitor 3-[[3-(5-amidino-2-benzofurancarboxamido)propionyl]amino]-3-phenylpropionic acid (I), which displayed an IC50 value of 250 nM in platelet aggregation assays. Attempts to enhance activity by modifying the β-position of β-alaninate of inhibitor I had only a modest effect on inhibitory activity in aggregation assays. Analogs prepared to enhance the activity by conformational restriction were also found to be equally or less potent. In contrast, modification at the α-position of β-alaninate resulted in the identification of extremely potent and novel amidinobenzofuran-containing derivatives Reexamination of 5,6-bicyclic aromatic nucleus led to the further identification of amidinoindole- and amidinoindazole-containing derivatives These analogs exhibited potent in vitro activity with IC50 values of 25-65 nM in platelet aggregation assays and an IC50 value of 2 nM in fibrinogen binding assays and demonstrated a selectivity of >50,000-fold for GPIIb-IIIa vs. the most closely related integrin, the vitronectin receptor, αvβ3. In the experiment, the researchers used 3-Formyl-1H-indole-6-carbonitrile(cas: 83783-33-9Synthetic Route of C10H6N2O)

3-Formyl-1H-indole-6-carbonitrile(cas: 83783-33-9) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Synthetic Route of C10H6N2O

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Shen, Yan-Ming; Song, Lin-Lin; Qian, Xu-Hong; Yang, You-Jun published an article on January 31 ,2013. The article was titled 《A scalable synthesis of 1-amino-5-cyanonaphthalene, a precursor for a nitric oxide probe (NO550) designed via the dye assembly principle》, and you may find the article in Chinese Chemical Letters.Application of 72016-73-0 The information in the text is summarized as follows:

A convenient and scalable synthesis of 1-amino-5-cyanonaphthalene was described. In the experimental materials used by the author, we found 5-Amino-1-naphthonitrile(cas: 72016-73-0Application of 72016-73-0)

5-Amino-1-naphthonitrile(cas: 72016-73-0) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Application of 72016-73-0

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Computed Properties of C9H13NO2On May 31, 2020, de Azambuja, Francisco; Yang, Ming-Hsiu; Feoktistova, Taisiia; Selvaraju, Manikandan; Brueckner, Alexander C.; Grove, Markas A.; Koley, Suvajit; Cheong, Paul Ha-Yeon; Altman, Ryan A. published an article in Nature Chemistry. The article was 《Connecting remote C-H bond functionalization and decarboxylative coupling using simple amines》. The article mentions the following:

Transition metal-catalyzed C-H functionalization and decarboxylative coupling are two of the most notable synthetic strategies developed in the past 30 years. Here, we connect these two reaction pathways using bases and a simple Pd-based catalyst system to promote a para-selective C-H functionalization reaction from benzylic electrophiles [e.g., I → II (82%, 75% isolated) in presence of Pd(PPh3)4 and Et3N in toluene at 110°]. Exptl. and computational mechanistic studies suggest a pathway that involves an uncommon Pd-catalyzed dearomatization of the benzyl moiety followed by a base-enabled rearomatization through a formal 1,5-hydrogen migration. This reaction complements ‘C-H activation’ strategies that convert inert C-H bonds into C-metal bonds prior to C-C bond formation. Instead, this reaction exploits an inverted sequence and promotes C-C bond formation prior to deprotonation. These studies provide an opportunity to develop general para-selective C-H functionalization reactions from benzylic electrophiles and show how new reactive modalities may be accessed with careful control of the reaction conditions. The experimental part of the paper was very detailed, including the reaction process of Ethyl 1-cyanocyclopentane-1-carboxylate(cas: 28247-14-5Computed Properties of C9H13NO2)

Ethyl 1-cyanocyclopentane-1-carboxylate(cas: 28247-14-5) is a member of cyclopentanes. Although cyclopentane itself doesn’t have a single highly favoured conformation, a substituent on the cyclopentane ring can upset the balance of strains thereby favouring either the envelope or the half-chair.Computed Properties of C9H13NO2

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HPLC of Formula: 1194-02-1In 2019 ,《A BEt3-Base Catalyst for Amide Reduction with Silane》 appeared in Journal of Organic Chemistry. The author of the article were Yao, Wubing; Fang, Huaquan; He, Qiaoxing; Peng, Dongjie; Liu, Guixia; Huang, Zheng. The article conveys some information:

Reported herein is the development of a simple but practical catalytic system for the selective reduction of amides with hydrosilane or hydrosiloxane. Low-cost and readily available triethylborane (1.0 M in THF), in combination with a catalytic amount of an alkali metal base, was found to catalyze the reduction of all three amide classes (tertiary, secondary, and primary amides) to form amines under mild conditions. In addition, the selective transformation of secondary amides to aldimines and primary amides to nitriles can also be achieved by using a proper combination of BEt3 and base. The scope of these BEt3-base-catalyzed amide hydrosilylation reactions has been explored in depth. Preliminary results of mechanistic studies suggest a modified Piers’ silane Si-H···B activation mode wherein the hydride abstraction by BEt3 is promoted by the coordination of an alkoxide or hydroxide anion to the Si center. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.HPLC of Formula: 1194-02-1

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Reference of 4-Cyanobenzyl bromideIn 2022 ,《Photocatalytic activity of ultrathin 2DPNs for enzymatically generating formic acid from CO2 and C-S/C-N bond formation》 appeared in Sustainable Energy & Fuels. The author of the article were Singh, Pooja; Yadav, Rajesh K.; Singh, Chandani; Chaubey, Surabhi; Singh, Satyam; Singh, Atul P.; Baeg, Jin-OoK.; Kim, Tae Wu; Gulzhian, Dzhardimalieva. The article conveys some information:

The exploration of efficient and cheap photocatalysts for the transformation of CO2 into value-added chems. is a cornerstone challenge in organic chem. Two-dimensional covalent organic frameworks (2D-COFs) have attracted a great deal of increasing demand in the field of photocatalysis. Here, we report the design and development of two-dimensional porphyrin nanoplates (2DPNs) as low-cost and highly efficient photocatalysts. The construction of 2DPNs was achieved by the reaction of 5,10,15,20-tetraphenylporphyrin (TPP) building block units via a one-pot Friedel-Crafts reaction. The study revealed that the resultant photocatalyst has many useful properties of a better catalyst such as the superb solar light-harvesting ability, suitability of the optical band-gap, and highly ordered π-electron channels facilitating efficient charge migrations. Further study provides the better utility of 2DPN photocatalysts in the generation of solar fine chems. via the formation of C-S and C-N bonds under solar light irradiation with excellent reusability property. Furthermore, the 2DPN photocatalysts have been efficiently used as catalysts in the CO2 fixation and generation of formic acid as a green energy source under metal-free conditions. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Reference of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Reference of 4-Cyanobenzyl bromide

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In 2022,Lai, Nang Duy; Nguyen, Thu Trang; Nguyen, Nhu Ngan Ha; Retailleau, Pascal; Mac, Dinh Hung; Nguyen, Thanh Binh published an article in Organic Chemistry Frontiers. The title of the article was 《Direct access to 2-aryl-3-cyanothiophenes by a base-catalyzed one-pot two-step three-component reaction of chalcones with benzoylacetonitriles and elemental sulfur》.Quality Control of 3-Oxo-3-phenylpropanenitrile The author mentioned the following in the article:

Herein, unexpected results on the formation of 3-cyanothiophene derivatives as the major products via a three-component reaction of chalcones, benzoylacetonitriles and elemental sulfur along with the minor products 2-aminothiophenes was reported. The ratios between these two thiophene products is 4 : 3 and could be varied by simply changing the promoting base as well as its stoichiometric ratio. The method was successfully extended to benzoylacetate in place of benzoylacetonitrile to provide thiophene-3-carboxylates. In the experimental materials used by the author, we found 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Quality Control of 3-Oxo-3-phenylpropanenitrile)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Quality Control of 3-Oxo-3-phenylpropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Hui; Yan, Yingkun; Li, Min; Zhang, Xiaomei published an article in 2021. The article was titled 《An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines》, and you may find the article in Organic & Biomolecular Chemistry.Electric Literature of C9H7NO The information in the text is summarized as follows:

By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles I (R1 = C6H5, 4-OMeC6H4, 4-FC6H4, etc.; R2 = Me, Et, Bn, Allyl; R3 = H, 5-Me, 5-Cl, etc.; R4 = H, Me, Et, Bn, Boc) with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural anal. and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity. The experimental process involved the reaction of 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Electric Literature of C9H7NO)

3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Electric Literature of C9H7NO

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Nitrile – Wikipedia,
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《One-pot synthesis of bio-supported Pd nanoparticles by using clove leaf and their catalytic performance for Suzuki coupling reaction》 was published in Journal of Molecular Structure in 2020. These research results belong to Wang, Zhen; Bai, Xuefeng. Electric Literature of C7H4BrN The article mentions the following:

Bio-supported palladium nanoparticles (PdNPs/RCL-b) were synthesized by one-pot method without adding any chem. reducing and stabilizing agents. In the preparation process, Clove leaf (CL) was used as carrier, reducing and stabilizing agents. The extraction of reducing compounds from CL, the reduction and stabilization of Pd2+, and palladium nanoparticles (PdNPs) loading on the extraction residue of CL (RCL) were accomplished simultaneously, avoiding the agglomeration of PdNPs and ensuring PdNPs loading evenly on RCL. The prepared PdNPs/RCL-b catalysts were characterized by XRD, UV-Vis, Micro-IR spectroscopy, FT-IR and TEM. The hydroxyl groups and other reductive groups which exist in polyphenols and flavonoids reduced Pd2+ to PdNPs, while the C=O, C-O and other groups containing O served as good protective agents and stabilizers for the formation of PdNPs. The PdNPs had a face-centered cubic structure with a particle size distribution of 1.26-8.78 nm and an average particle size of 4.49 nm, and uniformly dispersed on the surface of RCL. The results of catalytic Suzuki coupling reaction between 4-bromonitrobenzene and phenylboronic acid over PdNPs/RCL-b at 60°C showed that the yield was 96.22% for 20 min and the value of TOF was 5773.2 h-1. After the reaction between 4-bromotoluene and phenylboronic acid repeated for 8 times, the yield remains above 91%. This method provides a more facile, efficient and green approach to the preparation of supported nano-palladium catalysts. After reading the article, we found that the author used 4-Bromobenzonitrile(cas: 623-00-7Electric Literature of C7H4BrN)

4-Bromobenzonitrile(cas: 623-00-7) is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceuticals and other organic chemicals,Electric Literature of C7H4BrN It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

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《Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region》 was published in Bioorganic Chemistry in 2020. These research results belong to Floresta, Giuseppe; Fallica, Antonino N.; Romeo, Giuseppe; Sorrenti, Valeria; Salerno, Loredana; Rescifina, Antonio; Pittala, Valeria. HPLC of Formula: 17201-43-3 The article mentions the following:

The enzymic family of heme oxygenase (HO) is accountable for heme breakdown. Among the two isoforms characterized to date, HO-2 is poorly investigated due to the lack of potent HO-2 chem. modulators and the greater attentiveness towards HO-1 isoform. In the present paper, we report the rational design and synthesis of HO-2 inhibitors achieved by modulating the volume of known HO-1 inhibitors. The inhibition preference has been moved from HO-1 to HO-2 by merely increasing the volume of the substituent in the western region of the inhibitors. Docking studies demonstrated that new derivatives soak differently in the two binding pockets, probably due to the presence of a Tyr187 residue in HO-2. These findings could be useful for the design of new selective HO-2 compounds The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3HPLC of Formula: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.HPLC of Formula: 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts