Tag: 200-300

New Green, Recyclable Magnetic Nanoparticles Supported Amino Acids as Simple Heterogeneous Catalysts for Knoevenagel Condensation was written by Girija, D.;Bhojya Naik, H. S.;Kumar, B. Vinay;Sudhamani, C. N.;Harish, K. N.. And the article was included in Letters in Organic Chemistry in 2013.SDS of cas: 51473-74-6 This article mentions the following:

Coumarin derivatives were synthesized using magnetically recoverable iron oxide nanoparticles supported amino acids as heterogeneous catalysts via one-pot multi component reaction using MW irradiation Easy recovery of the catalyst using an external magnet, efficient recycling, and reusable without significant loss of their catalytic efficiency makes the protocol greener and sustainable. In the experiment, the researchers used many compounds, for example, 7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6SDS of cas: 51473-74-6).

7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.SDS of cas: 51473-74-6

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Heterometallic coordination polymers: syntheses, structures and heterogeneous catalytic applications was written by Bansal, Deepak;Pandey, Saurabh;Hundal, Geeta;Gupta, Rajeev. And the article was included in New Journal of Chemistry in 2015.Recommanded Product: 2-(Anthracen-9-ylmethylene)malononitrile This article mentions the following:

A metalloligand Na[Co(L)₂] (1) of the ligand H₂L (N²,N⁶-bis(4,5-dihydrothiazol-2-yl)pyridine-2,6-dicarboxamide) offering appended thiazoline rings has been used for the synthesis of one-dimensional {Co³⁺L₂Zn²⁺(H₂O)₂}·ClO₄ (2), {Co³⁺L₂Cd²⁺}·ClO₄ (3) and {Co³⁺L₂Hg²⁺Cl} (4) coordination polymers. 1 Offers appended thiazoline rings having both soft sulfur and hard nitrogen donors. The crystal structures of 2 and 3 display the coordination of hard thiazoline-N donors to Zn²⁺ and Cd²⁺ ions. 4 Illustrates the bonding through both hard thiazoline-N and soft thiazoline-S donors. The three heterometallic coordination polymers have been used as reusable heterogeneous catalysts for the ring-opening reactions of oxiranes and thiairanes; Knoevenagel condensation of benzaldehydes and benzothialdehydes; and cyanation reactions of aldehydes and carbothialdehydes. The authors’ results demonstrate that the relative size and Lewis acidity of secondary metals potentially control the catalytic outcome via preferential interaction with the substrates. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4Recommanded Product: 2-(Anthracen-9-ylmethylene)malononitrile).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Recommanded Product: 2-(Anthracen-9-ylmethylene)malononitrile

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Study of the microwave-assisted hydrolysis of nitriles and esters and the implementation of this system in rapid microwave-assisted Pd-catalyzed amination was written by Van Baelen, Gitte;Maes, Bert U. W.. And the article was included in Tetrahedron in 2008.Name: 4-(Benzylamino)benzonitrile This article mentions the following:

Microwave-assisted hydrolysis of benzonitriles and Me benzoates has been studied using a toluene/concentrated aqueous KOH two phase system in the presence and absence of phase transfer catalyst. Conditions to allow and avoid smooth hydrolysis could be identified. Based on the latter, the first microwave protocol which allows the rapid Pd-catalyzed amination of aliphatic amines with chlorobenzenes containing sensitive functional groups has been developed. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Name: 4-(Benzylamino)benzonitrile).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Name: 4-(Benzylamino)benzonitrile

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Nitrile – Wikipedia,
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One-pot Reductive Amination of carbonyl Compounds with Nitro Compounds by Transfer Hydrogenation over Co-N_x as catalyst was written by Zhou, Peng;Zhang, Zehui. And the article was included in ChemSusChem in 2017.Formula: C14H12N2 This article mentions the following:

A new method was developed for the synthesis of secondary amines through the one-pot reductive amination of carbonyl compounds with nitro compounds using formic acid as the hydrogen donor over a heterogeneous non-noble-metal catalyst (Co-N_x/C-800-AT, generated by the pyrolysis of the cobalt phthalocyanine/silica composite at 800° under a N₂ atmosphere and subsequent etching by HF). Both nitrogen and cobalt were of considerable importance in the transfer hydrogenation reactions with formic acid. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Formula: C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Formula: C14H12N2

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Nitrile – Wikipedia,
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A novel adenine-based zinc(II) metal-organic framework featuring the Lewis basic sites for heterogeneous catalysis was written by Zhang, Shixing;He, Hongming;Sun, Fuxing;Zhao, Nian;Du, Jianshi;Pan, Qinhe;Zhu, Guangshan. And the article was included in Inorganic Chemistry Communications in 2017.HPLC of Formula: 55490-87-4 This article mentions the following:

Metal-organic frameworks (MOFs), as a new sort of crystalline materials, have attracted lots of interest in many applications during the past decades. Recently, many efforts were focused on the development of MOFs as heterogeneous catalysis. The authors selected adenine (ad) and tetracarboxylic acid, 5,5′-(1,3,6,8-tetraoxobenzo[Imn] Li et al. (1999), He et al. (2016) phenanthroline-2,7-diyl)bis-1,3-benzenedicarboxylic acid (H₄L), as organic linkers to assemble with Zn(II) ions to construct a novel adenine-based porous MOF. There are three different inorganic clusters in the framework, including ZnO₂N₂, Zn₂O₂N₆, and ZnO₅N clusters. Interesting, the resultant porous MOF, [H₂NMe₂]·[Zn₄(L)_1.5(ad)₃(H₂O)₂]·4DMF, retains free amino groups in the framework, which can be served as Lewis basic sites to catalyze Knoevenagel condensation reaction. The catalytic study exhibits that the as-synthesized MOF with free amino groups can be used as heterogeneous catalysis with remarkable catalytic efforts and good recycle. CCDC 1501692. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4HPLC of Formula: 55490-87-4).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.HPLC of Formula: 55490-87-4

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Spectroscopic and theoretical studies of arylmethylenemalonodinitriles. I. Electronic spectra was written by Kaneti, J.;Vitanov, D.;Yuchnovski, I.;Yuritsin, V.. And the article was included in Izvestiya po Khimiya in 1978.Quality Control of 2-(Anthracen-9-ylmethylene)malononitrile This article mentions the following:

The UV invisible absorption spectra of arylmethylene (aryl = substituted Ph, 1-naphthyl, 4-biphenylyl, 9-anthryl, etc.) of malonodinitrile are studied using PPP MO calculations The electronic spectra are similar to those of polyenes with the same mol. topol. The introduction of cyano groups in the conjugated system does not give rise to charge-transfer states. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4Quality Control of 2-(Anthracen-9-ylmethylene)malononitrile).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Quality Control of 2-(Anthracen-9-ylmethylene)malononitrile

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Copper-promoted cross-coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines using a peroxide-driven radical reductive strategy was written by Jiang, Hui-Min;Qin, Jing-Hao;Sun, Qing;Zhang, Dong;Jiang, Jin-Peng;Ouyang, Xuan-Hui;Song, Ren-Jie;Li, Jin-Heng. And the article was included in Organic Chemistry Frontiers in 2022.Related Products of 10282-32-3 This article mentions the following:

A copper-promoted reductive cross-coupling of nitroarenes RNO₂ (R = Ph, 4-iodiphenyl, pyridin-3-yl, etc.) with 4-alkyl-1,4-dihydropyridines I (R¹ = Pr, cyclohexyl, Bn, etc.) for producing N-alkylbenzenamines RNHR¹ is described. Using 4-alkyl-1,4-dihydropyridines I as alkyl radical sources and internal reducing agents enables the construction of C(sp³)-N bonds under oxidative conditions, which provide an elegant complementary platform to assemble N-alkylbenzenamines with good tolerance for sensitive functional groups. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Related Products of 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Related Products of 10282-32-3

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis of strontium ranelate was written by Xu, Yan;Su, Man;Qu, Chun-sheng. And the article was included in Qilu Yaoshi in 2012.Product Details of 58168-20-0 This article mentions the following:

The synthesis of strontium ranelate was studied. The strontium ranelate was synthesized from citric acid by decarboxylation, esterification, cyclization, alkylation, hydrolyzation and then salt formation. The structure of strontium ranelate was confirmed by IR, ¹H-NMR, ¹³C-NMR and the total yield was approx. 41.4%. This synthesis route was simple with low cost and high purity, and it was suitable for industrial production In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Product Details of 58168-20-0).

Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitrile carbon shifts are in the range of 115�25 ppm whereas in isonitriles the shifts are around 155�65 ppm. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Product Details of 58168-20-0

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Nitrile – Wikipedia,
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Fast and efficient bromination of aromatic compounds with ammonium bromide and oxone was written by Naresh, Mameda;Kumar, Macharla Arun;Reddy, Marri Mahender;Swamy, Peraka;Nanubolu, Jagadeesh Babu;Narender, Nama. And the article was included in Synthesis in 2013.COA of Formula: C7H4Br2N2 This article mentions the following:

A highly efficient, rapid and regioselective protocol was developed for the ring bromination of aromatic compounds under mild conditions with ammonium bromide as a source of bromine source and Oxone (potassium peroxysulfate) as an oxidant. No metal catalyst or acidic additive is required. A variety of aromatic compounds, including methoxy, hydroxy, amino, and alkyl arenes, reacted smoothly to give the corresponding monobrominated products in good to excellent yields in very short reaction times. Moreover, dibromination of deactivated anilines to give the corresponding dibromides proceeded in high yields. Interestingly, 1-(2-naphthyl)ethanone provided a ring-brominated product. In the experiment, the researchers used many compounds, for example, 2-Amino-3,5-dibromobenzonitrile (cas: 68385-95-5COA of Formula: C7H4Br2N2).

2-Amino-3,5-dibromobenzonitrile (cas: 68385-95-5) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).COA of Formula: C7H4Br2N2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

N-Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes was written by Moutaoukil, Zakaria;Serrano-Diez, Emmanuel;Collado, Isidro G.;Jimenez-Tenorio, Manuel;Botubol-Ares, Jose Manuel. And the article was included in Organic & Biomolecular Chemistry in 2022.Product Details of 10282-32-3 This article mentions the following:

An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides was developed employing novel pentamethylcyclopentadienylruthenium(II) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The acetonitrile complex I was proved to be particularly effective with a broad range of substrates with low catalyst loading (0.1-2.5 mol%) and high functional group tolerance under mild conditions. A total of 52 N-alkylated organonitrogen compounds including biol. relevant scaffolds were synthesized from (hetero)aromatic and aliphatic amines, amides and sulfonamides using alcs. or diols as alkylating agents in up to 99% isolated yield, even on gram-scale reactions. In the case of sulfonamides, it was the first example of N-alkylation employing a transition-metal complex bearing NHC ligands. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Product Details of 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Product Details of 10282-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts