Tag: 200-300

PS-SNAP, a practical polymer-supported nitrosation reagent in organic synthesis was written by Roche, Didier;Lardy, Claude;Tournier, Lucie;Prunier, Marc;Valeur, Eric. And the article was included in Tetrahedron Letters in 2010.HPLC of Formula: 319016-04-1 The following contents are mentioned in the article:

PS-SNAP was designed and evaluated as a practical nitrosating polymer-supported reagent for the nitrosation of sec-amines. Nitrosated dialkyl amines, alkyl anilines, and bis-anilines were obtained in good yields and high purities after shaking the corresponding amines in the presence of an excess of the newly described reagent followed by simple filtration and removal of solvents. This study involved multiple reactions and reactants, such as 4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1HPLC of Formula: 319016-04-1).

4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.HPLC of Formula: 319016-04-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Oxidation of hexamethylbenzene and 2,3,4,5,6-pentamethylbenzyl cation in fluorosulfonic acid was written by Rudenko, A. P.;Zarubin, M. Ya.;Fedorova, E. M.. And the article was included in Zhurnal Organicheskoi Khimii in 1985.Synthetic Route of C15H15N3 The following contents are mentioned in the article:

Oxidation of hexamethylbenzene (I) in HSO₃F-PbO₂ involved the conversion of protonated I to 2,3,4,5,6-pentamethylbenzyl cation, which underwent further oxidation to give products such as II and III. This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3Synthetic Route of C15H15N3).

2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Synthetic Route of C15H15N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Selective recognition of NH₄⁺ over K⁺ with tripodal oxazoline receptors was written by Ahn, Kyo Han;Kim, Sung-Gon;Jung, Junyang;Kim, Kyung-Hyun;Kim, Jaheon;Chin, Jik;Kim, Kimoon. And the article was included in Chemistry Letters in 2000.Application In Synthesis of 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile The following contents are mentioned in the article:

Benzene-based tripodal tris(oxazolines) are found to be promising receptors for the selective recognition of NH₄⁺ over K⁺ with high binding affinities. This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3Application In Synthesis of 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile).

2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Application In Synthesis of 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

P(III)/P(V)-Catalyzed Methylamination of Arylboronic Acids and Esters: Reductive C-N Coupling with Nitromethane as a Methylamine Surrogate was written by Li, Gen;Qin, Ziyang;Radosevich, Alexander T.. And the article was included in Journal of the American Chemical Society in 2020.Safety of 4-((4-Methoxyphenyl)amino)benzonitrile The following contents are mentioned in the article:

The direct reductive N-arylation of nitromethane by organophosphorus-catalyzed reductive C-N coupling with arylboronic acid derivatives is reported. This method operates by the action of a small ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) together with a mild terminal reductant hydrosilane to drive the selective installation of the methylamino group to (hetero)aromatic boronic acids and esters. This method also provides for a unified synthetic approach to isotopically labeled N-methylanilines from various stable isotopologues of nitromethane (i.e., CD₃NO₂, CH₃¹⁵NO₂, and ¹³CH₃NO₂), revealing this easy-to-handle compound as a versatile precursor for the direct installation of the methylamino group. This study involved multiple reactions and reactants, such as 4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1Safety of 4-((4-Methoxyphenyl)amino)benzonitrile).

4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Safety of 4-((4-Methoxyphenyl)amino)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Palladium-Catalyzed Amination of Aryl Nonaflates was written by Anderson, Kevin W.;Mendez-Perez, Maria;Priego, Julian;Buchwald, Stephen L.. And the article was included in Journal of Organic Chemistry in 2003.Computed Properties of C14H12N2O The following contents are mentioned in the article:

The first detailed study of the palladium-catalyzed amination of aryl nonaflates is reported. Use of ligands such as BINAP allows for the catalytic amination of electron-rich and -neutral aryl nonaflates with both primary and secondary amines. With use of Xantphos, the catalytic amination of a variety of functionalized aryl nonaflates resulted in excellent yields of anilines; even 2-carboxymethyl aryl nonaflate is effectively coupled with a primary alkylamine. Moderate yields were obtained when coupling halo-aryl nonaflates with a variety of amines, where in most cases the aryl nonaflate reacted in preference to the aryl halide. Overall, aryl nonaflates are an effective alternative to triflates in palladium-catalyzed C-N bond-forming processes due to their increased stability under the reaction conditions. This study involved multiple reactions and reactants, such as 4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1Computed Properties of C14H12N2O).

4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Computed Properties of C14H12N2O

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Intermolecular Reductive C-N Cross Coupling of Nitroarenes and Boronic Acids by P^III/P^V=O Catalysis was written by Nykaza, Trevor V.;Cooper, Julian C.;Li, Gen;Mahieu, Nolwenn;Ramirez, Antonio;Luzung, Michael R.;Radosevich, Alexander T.. And the article was included in Journal of the American Chemical Society in 2018.SDS of cas: 319016-04-1 The following contents are mentioned in the article:

A main group-catalyzed method for the synthesis of aryl- and heteroarylamines by intermol. C-N coupling is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane) and a terminal hydrosilane reductant (phenylsilane) to drive reductive intermol. coupling of nitro(hetero)arenes with boronic acids. Applications to the construction of both C_sp2-N (from arylboronic acids) and C_sp3-N bonds (from alkylboronic acids) are demonstrated; the reaction is stereospecific with respect to C_sp3-N bond formation. The method constitutes a new route from readily available building blocks to valuable nitrogen-containing products with complementarity in both scope and chemoselectivity to existing catalytic C-N coupling methods. This study involved multiple reactions and reactants, such as 4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1SDS of cas: 319016-04-1).

4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.SDS of cas: 319016-04-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electrochemical oxidation of organic compounds in fluorosulfuric acid. IV. Voltammetric study of the formation and of the anodic behavior of some benzyl cations and arenium ions was written by Rudenko, A. P.;Zarubin, M. Ya.;Pragst, F.. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1983.Related Products of 16144-65-3 The following contents are mentioned in the article:

A cyclic voltammetric study of the oxidation of benzylic alcs., ethers, acetates, and cyanides and of aromatic hydrocarbons in FSO₃H at -76° was reported. Benzyl cations were oxidized at potentials 0.7-0.8 V more pos. than those of the neutral compounds to [ArCH₂OSO₂F]⁺• cation radicals. In a subsequent step another Me group was functionalized to CH₂OSO₂F. The anodic peak potentials of the arenium ions was ∼1.1 V more pos. than those of the nonprotonated hydrocarbons. The dissociation equilibrium of ArCH₂OSO₂F and the protonation equilibrium of the hydrocarbons were discussed in terms of the donor ability of the aromatic compounds in borderline cases. This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3Related Products of 16144-65-3).

2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Related Products of 16144-65-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

“On Water” Promoted Ullmann-Type C-N Bond-Forming Reactions: Application to Carbazole Alkaloids by Selective N-Arylation of Aminophenols was written by Chakraborti, Gargi;Paladhi, Sushovan;Mandal, Tirtha;Dash, Jyotirmayee. And the article was included in Journal of Organic Chemistry in 2018.Application of 319016-04-1 The following contents are mentioned in the article:

The Ullmann-type cross coupling of a variety of aromatic, aliphatic amines with aryl halides is reported using a CuI-based catalytic system in combination with an easily accessible prolinamide ligand in aqueous media. The method is mild and tolerant to air, moisture, and a wide range of functional groups, providing a novel way to access a variety of aminated products. Secondary amines like heteroaromatic amines and nucleobases have also been used, affording the corresponding coupling products in good to excellent yields. Moreover, this method has been employed for chemoselective C-N arylation of aminophenols and further utilized for the synthesis of carbazole natural products, avoiding the protection and deprotection steps. This study involved multiple reactions and reactants, such as 4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1Application of 319016-04-1).

4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Application of 319016-04-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Breaking the C₃-Symmetry of Chiral Tripodal Oxazolines: Enantio-Discrimination of Chiral Organoammonium Ions was written by Kim, Jeongryul;Kim, Sung-Gon;Seong, Hye Ran;Ahn, Kyo Han. And the article was included in Journal of Organic Chemistry in 2005.Safety of 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile The following contents are mentioned in the article:

A phenylglycinol-derived tripodal oxazoline with C₁-symmetry (C₁-PhBTO) was synthesized, and its enantioselective recognition behavior toward α-chiral primary organoammonium ions was studied. The C₁-PhBTO receptor showed higher selectivity with an opposite sense of enantio-discrimination compared to other C₁-sym. analogs examined but lower selectivity with the same sense of enantioselection compared to its C₃-sym. analog. Binding studies indicated that the C₁-sym. receptors, particularly C₁-PhBTO, interact with the guests in a 2:1 host-guest complex mode in stark contrast to its C₃-sym. analogs. This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3Safety of 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile).

2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Safety of 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Light-Promoted C-N Coupling of Aryl Halides with Nitroarenes was written by Li, Gang;Yang, Liu;Liu, Jian-Jun;Zhang, Wei;Cao, Rui;Wang, Chao;Zhang, Zunting;Xiao, Jianliang;Xue, Dong. And the article was included in Angewandte Chemie, International Edition in 2021.Reference of 319016-04-1 The following contents are mentioned in the article:

A photochem. C-N coupling of aryl halides with nitroarenes is demonstrated for the first time. Catalyzed by a Ni^II complex in the absence of any external photosensitizer, readily available nitroarenes undergo coupling with a variety of aryl halides, providing a step-economic extension to the widely used Buchwald-Hartwig C-N coupling reaction. The method tolerates coupling partners with steric-congestion and functional groups sensitive to bases and nucleophiles. Mechanistic studies suggest that the reaction proceeds via the addition of an aryl radical, generated from a Ni^I/Ni^III cycle, to a nitrosoarene intermediate. This study involved multiple reactions and reactants, such as 4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1Reference of 319016-04-1).

4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Reference of 319016-04-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts