Tag: 200-300

Taylor, Edward C.; Abdulla, Riaz F. published an article in 1973, the title of the article was Pteridines. XXXI. New and unequivocal synthesis of isoxanthopterin-6-carboxylic acid (Cyprino-Pourpre B).COA of Formula: C10H11N3O3S And the article contains the following content:

Condensation of HC(CN)2NH2 with HON:CHCOCH:NOH gave 2-amino-3-cyano-5-oximinomethylpyrazine 1-oxide which cyclized with guanidine to the pteridine oxide (I). Heating I in POCl3-DMF gave the chloronitrile (II) which under reflux in aqueous NaOH gave isoxanthopterin-6-carboxylic acid (III). The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).COA of Formula: C10H11N3O3S

The Article related to pteridine, isoxanthopterincarboxylic acid, cyprino pourpre b, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.COA of Formula: C10H11N3O3S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Taylor, Edward C.; Perlman, Katherine L.; Kim, Young-Ho; Sword, Ian P.; Jacobi, Peter A. published an article in 1973, the title of the article was Pteridines. XXIX. Unequivocal route to 2,4-diamino-6-substituted pteridines.Synthetic Route of 5098-14-6 And the article contains the following content:

2,4-Diamino-6-substituted pteridines (I) are prepared Reaction of an α-keto-aldoxime with aminomalononitrile gives 2-amino-3-cyano-5-substituted pyrazine 1-oxides which yield 2,4-diamino-6-substituted pteridine 8-oxides upon cyclization with guanidine. 2,4-Diaminopteridines are then obtained by deoxygenation of the corresponding 8-oxides, or alternately by prior deoxygenation of these pyrazine 1-oxides, followed by cyclization with guanidine. The conversion of 2-amino-3-cyano-5-methylpyrazine 1-oxide to the corresponding 1,4-dioxide, and a number of chem. transformations of this latter intermediate, are also described. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Synthetic Route of 5098-14-6

The Article related to pteridine diamino preparation, aminopteridine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.Synthetic Route of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Taylor, Edward C.; Jacobi, Peter A. published an article in 1973, the title of the article was Pteridines. XXX. Facile synthesis of xanthopterin.Reference of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Pterin 8-oxide (I) rearranges quant. to xanthopterin (II) upon dissolution in a mixture of CF3CO2H/(CF3CO)2O at 50°. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Reference of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to pterin oxide rearrangement xanthopterin, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.Reference of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 30, 1989, Freeman, Fillmore; Kim, Darrick S. H. L. published an article.Recommanded Product: 5098-14-6 The title of the article was Preparation of (E,E)-4-amino-1-aryl-3-cyano-4-methoxy-2-azabutadienes. And the article contained the following:

Treatment of (NC)2CHN+H3 4-MeC6H4SO3- with NaOAc and RCHO (R = Ph, 2-BrC6H4, 2-ClC6H4, 2-O2NC6H4, 4-O2NC6H4, 4-HOC6H4, 2-naphthyl) in MeOH gave 23-99% (E,E)-RCH:NC(CN):C(OMe)NH2. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 5098-14-6

The Article related to ammoniomalononitrile tosylate condensation aromatic aldehyde, aminoarylcyanomethoxyazabutadiene, azabutadiene aminoarylcyanomethoxy, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Naphthalenes and other aspects.Recommanded Product: 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 28, 2012, Spencer, John; Patel, Hiren; Amin, Jahangir; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.; Furman, Christophe; Mansouri, Roxane; Chavatte, Philippe; Millet, Regis published an article.Category: nitriles-buliding-blocks The title of the article was Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library. And the article contained the following:

A 2-substituted 5-aminooxazole-4-carbonitrile library has been synthesized and modified via microwave-mediated and flow chemistries. One synthesized compound, 5-(1H-pyrrol-1-yl)-4-(1H-tetrazol-5-yl)-2-(thien-2-yl)oxazole, contains three distinct heterocycles attached to the central oxazole core, highlighting the structural diversity of this approach. Three oxazoles had micromolar ki values against cannabinoid (CB1/CB2) receptors. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to aminooxazolecarbonitrile library preparation reaction, oxazolecarbonitrile amino library preparation reaction, cannabinoid receptor affinity aminooxazolecarbonitrile, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 31, 1997, Freeman, Fillmore; Chen, Tao; Van der Linden, Johannes B. published an article.Computed Properties of 5098-14-6 The title of the article was Synthesis of highly functionalized 1,3-oxazoles. And the article contained the following:

A convenient 1-pot method for the preparation of 2-substituted 5-amino-4-cyano-1,3-oxazoles from carboxylic acids and aminomalononitrile tosylate is reported. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Computed Properties of 5098-14-6

The Article related to cyanooxazolamine preparation, aminooxazolenitrile preparation, oxazole amino cyano preparation, carboxylic acid aminomalononitrile tosylate cyclocondensation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Computed Properties of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Freeman, Fillmore; Kim, Darrick S. H. L. published an article in 1989, the title of the article was Preparation of 2-alkyl- and 2-aryl-5-amino-4-cyano-1,3-oxazoles.Application In Synthesis of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Aminopropanedinitrile p-toluenesulfonate reacts with acid chlorides to give 5-amino-4-cyano-1,3-oxazoles I (R = Me, Et, CHMe2, Ph, 4-MeOC6H4, 4-O2NC6H4, 2-furyl) in 51-95% yields. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Application In Synthesis of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to acid chloride cyclocondensation aminomalonitrile tosylate, oxazole amino cyano aryl alkyl, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Application In Synthesis of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 1, 2018, Nikseresht, Ahmad; Ghasemi, Saba; Parak, Soraya published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was [Cu3(BTC)2]: A metal-organic framework as an environment-friendly and economically catalyst for the synthesis of tacrine analogues by Friedlaender reaction under conventional and ultrasound irradiation. And the article contained the following:

Using a green and simple route with ultrasound illumination, atm. pressure and room temperature, for synthesizing tacrine analogs in the presence of [Cu3(BTC)2] as an environment-friendly and economically catalyst was considered. [Cu3(BTC)2] is one of the heterogeneous catalysts on hand capable of being employed, in the Friedlaender reaction, whenever 5-amino-4-cyano-2-phenyl-1,3-oxazole and appropriately substituted carbonyl derivatives under conventional and ultrasonic irradiation The results of this study indicate that the active sites in the [Cu3(BTC)2] for synthesis of cyclohepta[b]oxazolo[4,5-e]pyridine are mainly copper atoms and the role of Bronsted acid organic ligand in the MOF is negligible. These procedures were properly arranged to provide the utmost yields in a short while. The crystal stability in the process of catalysis was studied by various techniques such as XRD, BET and ICP that demonstrate excellent stability in reaction conditions. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to tacrine analog green preparation friedlaender copper benzenetricarboxylate mof catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 17, 2022, Li, Chao; Wang, He; Liu, Lu; Sun, Ran; Wang, Xin; Zhou, Ming-Dong; Li, Lei published an article.COA of Formula: C9H5F3N2O2 The title of the article was Base-Catalyzed Intramolecular Self-Cyclization of o-Alkenylaryl Isocyanides: Access to 4-Cyano-3-arylquinolines. And the article contained the following:

A novel base-catalyzed intramol. self-cyclization reaction of o-alkenylaryl isocyanides [2-N+C–C6H3(R)-C(CN)(=CHR1)] (R = H, 3-Cl, 4-F, 5-Me, etc.; R1 = Ph, 4-chlorophenyl, 3,4-dimethylphenyl, 2-naphthyl, thiophen-2-yl, etc.) has been successfully developed. This reaction provides a general, efficient and atom-economic method to access 4-cyano-3-arylquinolines I (R2 = H, 8-Cl, 7-F, 6-Me, etc.) with broad scope of substrates and excellent functional group compatibilities. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).COA of Formula: C9H5F3N2O2

The Article related to aryl quinoline preparation, alkenylaryl isocyanide tandem heterocyclization cesium carbonate catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.COA of Formula: C9H5F3N2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 11, 2020, Fu, Bang; Li, Yinlong; Ren, Wei; Chen, Jie; Liu, Xiangyong; Wang, Jiabing; Ding, Lieming published a patent.Recommanded Product: 882978-62-3 The title of the patent was Preparation of substituted pyrazolopyrimidines as tyrosine kinase inhibitors, compositions and methods thereof. And the patent contained the following:

The invention relates to compounds of formula I and isomerides, stereoisomers, tautomers, pharmaceutically acceptable salts, prodrugs, chelates, non-covalent complexes, and solvates thereof, methods of using the compounds as Trk inhibitors, and pharmaceutical compositions comprising such compds; their preparation and use in treating cancer. Compounds of formula I, wherein ring A is C5-6 heterocyclyl; ring B is 5-membered aromatic heterocyclyl; X and Z are independently C, N, O, and S; Y is C and N;R1 is absent, H, and C1-8 alkyl; R2 is H, C1-4 alkyl-NH2, C0-4 alkyl-OH, etc.; R3 absent, C3-10 heterocyclyl; R2 and R3 can be taken together to form 5- to 6-membered carbocyclyl, heterocyclyl, aryl, etc.; R4 is (un)substituted 5- to 6-membered heteroaryl, and isomerides, stereoisomers, tautomers, pharmaceutically acceptable salts, prodrugs, chelates, non-covalent complexes, and solvates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their tyrosine kinase inhibitory activity (some data given). The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Recommanded Product: 882978-62-3

The Article related to substituted pyrazolopyrimidine tyrosine kinase inhibitor preparation treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 882978-62-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts