Tag: 200-300

On December 31, 1980, Kadir, Kamaliah; Shaw, Gordon; Wright, David published an article.Application of 5098-14-6 The title of the article was Purines, pyrimidines, and imidazoles. Part 56. Some aminoimidazolecarboxamidines and derived adenines. And the article contained the following:

Cyclohexylimidazole I, prepared (37%) from H2NCH(CN)2, CH(OEt)3, and cyclohexylamine, gave 66% carboximidate II (R = OMe) on treatment with MeOH/HCl, which with NH3 gave 64% carboxamidine II (R = NH2) (III). Formylation of III gave N6-formyladenine IV (R = cyclohexyl), which was also prepared by formylation of 9-cyclohexyladenine. IV [R = CH2CH(OH)CH2OH] was similarly prepared The reaction of II (R = H) with HCO2H/Ac2O gave N6-formyladenine (IV; R = H), which was also prepared by formylation of adenine, whereas adenosine was not N-formylated under the same conditions. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Application of 5098-14-6

The Article related to aminomalononitrile cyclocondensation, aminoimidazole, imidazole amino, carboxamidine formylation, cyclohexylimidazole, nucleoside analog adenine, Heterocyclic Compounds (More Than One Hetero Atom): Purines and Pteridines and other aspects.Application of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 31, 1985, Makosza, Mieczyslaw; Wenall, Maria; Golinski, Miroslaw; Kinowski, Andrzej published an article.Application of 13544-06-4 The title of the article was Reactions of organic anions. Part 130. Specific ortho-cyanomethylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen. And the article contained the following:

The reactions of 3-RC6H4NO2 (I, R = MeO, CF3, NO2, MeSO2 halo, cyano) with ClCH2CN (II), PhOCH2CN, and Me2NCS2CH2CN yielded products substituted ortho to the NO2 group. Ortho substitution also resulted in the reactions of II with o- and p-substituted nitrobenzenes. Thus, II and I (R = 2-Cl) in THF containing Me3COK at -10° to -20° gave 10% 2,3-O2N(Cl)C6H3CH2CN. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Application of 13544-06-4

The Article related to cyanomethylation nitroarene regiochem, nucleophile substitution nitroarene regiochem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitro and Nitroso Compounds and other aspects.Application of 13544-06-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 31, 2020, Vitkovska, Viktorija; Zogota, Rimants; Kalnins, Toms; Zelencova, Diana; Suna, Edgars published an article.Computed Properties of 5098-14-6 The title of the article was Aliphatic chain-containing macrocycles as diazonamide A analogs. And the article contained the following:

Aliphatic alkyl chain-containing 12-14-membered macrocycles were designed as structural analogs of antimitotic natural product diazonamide A. Macrocycles were synthesized from 5-bromooxazole in 7 to 9 linear steps using Ru-catalyzed ring-closing metathesis as the key transformation. Heat effect of binding to α,β-tubulin tetramer (T4-RB3 complex) has been measured for the synthesized macrocycles by isothermal titration calorimetry method. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Computed Properties of 5098-14-6

The Article related to diazonamide a analog aliphatic chain macrocycle preparation dissociation constant, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Computed Properties of 5098-14-6

Referemce:
Nitrile – Wikipedia,
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On August 5, 2021, Lamotte, Yann; Dodic, Nerina; Tap, Aurelien; Denis, Alexis; Brusq, Jean-Marie; Daoubi Khamlichi, Mourad; Benderitter, Pascal Andre Rene published a patent.Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile The title of the patent was Preparation of macrocyclic RIP2-kinase inhibitors. And the patent contained the following:

The invention relates to macrocyclic compounds of formula I and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of RIP2-kinase, and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of RIP2-kinase associated diseases. Moreover, the invention provides methods of using said compounds, for instance as a medicine or diagnostic agent. Compounds of formula I, wherein R1 is halo, alkynyl, CN, etc.; R2 and R10 are independently H and halo; R3, R3′, R4, R4′, R7 and R8 are independently H and C1-6 alkyl; R5 is OH, halo, CN, etc.; R6 is H, halo, C1-6 alkyl, etc.; R9 is H, C1-6 alkyl, COC1-6alkyl, etc.; and stereoisomers, tautomers, racemates, salts, hydrates, N-oxide forms, and solvates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their RIP-2 kinase inhibitory activities (some data given). The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

The Article related to macrocycle rip2 kinase inhibitor preparation diagnostic treatment, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 25, 2018, Tuo, Wei; Bollier, Melanie; Leleu-Chavain, Natascha; Lemaire, Lucas; Barczyk, Amelie; Dezitter, Xavier; Klupsch, Frederique; Szczepanski, Fabien; Spencer, John; Chavatte, Philippe; Millet, Regis published an article.Electric Literature of 5098-14-6 The title of the article was Development of novel oxazolo[5,4-d]pyrimidines as competitive CB2 neutral antagonists based on scaffold hopping. And the article contained the following:

A series of novel oxazolo[5,4-d]pyrimidines I [R1 = H, Cl, F, CF3; R2 = H, Me; R3 = n-Bu, cyclohexylmethyl, 1-methylpiperazinyl, etc.] was designed via a scaffold hopping strategy and synthesized through a newly developed approach. All these compounds I were evaluated for their biol. activity toward CB1/CB2 cannabinoid receptors, their metabolic stability in mice liver microsomes and their cytotoxicity against several cell lines. Eight compounds I [R1 = Cl, CF3; R2 = H, Me; R3 = 1-methylpiperazinyl, 1-ethylpiperazinyl, 1-acetylpiperazinyl] were identified as CB2 ligands with Ki values less than 1 ΜM. It was noteworthy that compounds I [R1 = Cl; R2 = Me; R3 = 1-methylpiperazinyl, 1-ethylpiperazinyl] showed CB2 binding affinity in the nanomolar range and significant selectivity over CB1 receptors. Interestingly, functionality studies imply that they behaved as competitive neutral antagonists. Moreover, all tested compounds I were devoid of cytotoxicity toward several cell lines, including Chinese hamster ovary cells (CHO) and human colorectal adenocarcinoma cells HT29. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Electric Literature of 5098-14-6

The Article related to oxazolopyrimidine preparation cytotoxicity sar cannabinoid receptor antagonist, cb(2) receptor, cannabinoid, neutral antagonist, oxazolo[5,4-d]pyrimidine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Lu; Li, Lei; Mao, Shukuan; Wang, Xin; Zhou, Ming-Dong; Zhao, Yu-long; Wang, He published an article in 2020, the title of the article was Synthesis of pyrazolo[1,5-c]quinazoline derivatives through the copper-catalyzed domino reaction of o-alkenyl aromatic isocyanides with diazo compounds.Electric Literature of 13544-06-4 And the article contains the following content:

A novel copper-catalyzed domino reaction between o-alkenyl aromatic isocyanides and diazo compounds was developed under mild reaction conditions. Various o-alkenyl aromatic isocyanides were prepared from readily available reactants. The reaction provided a general and efficient method for synthesis of pyrazolo[1,5-c]quinazolines I [R1 = cyclohexyl, 2-thienyl, 2-naphthyl, etc.; R2 = H, 8-MeO, 7-Cl, etc.; R3 = OEt, OBn, 4-ClC6H4, etc.] by the formation of two rings and three new bonds in a single step from readily available acyclic starting materials. A mechanism involving a tandem (3+2) cyclization/elimination/intramol. aza-addition sequence was proposed. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Electric Literature of 13544-06-4

The Article related to pyrazoloquinazoline preparation, ortho alkenyl aryl isocyanide diazo compound tandem copper catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 13544-06-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Xuqing; Ng, Raymond; Lanter, James; Sui, Zhihua published an article in 2007, the title of the article was Synthesis of novel pyrazolines via 1,3-dipolar cycloadditions of heterocyclic isopropenes.Name: 4,5-Diamino-2-(trifluoromethyl)benzonitrile And the article contains the following content:

An efficient and practical synthesis of novel pyrazoline structures was achieved through 1,3-dipolar cycloaddition of the corresponding heterocyclic isopropenes and diazo precursors. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Name: 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to heterocyclic isopropene preparation dipolar cycloaddition diazo compound, pyrazoline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 4,5-Diamino-2-(trifluoromethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Belley, Michel; Sauer, Effiette; Beaudoin, Daniel; Duspara, Petar; Trimble, Laird A.; Dube, Pascal published an article in 2006, the title of the article was Synthesis and reactivity of N-hydroxy-2-aminoindoles.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile And the article contains the following content:

Catalytic hydrogenation of (2-nitrophenyl)acetonitriles I (R1 = H, Cl, F, F3C, MeO, MeSO2, MeCONH; R2 = EtO2C, CN, MeSO2, PhSO2) bearing an electron-withdrawing substituent α to the nitrile, using Pd/C and (Ph3P)4Pd, affords N-hydroxy-2-aminoindoles II in good to excellent yields. (Ph3P)4Pd decreases the reduction rate of the intermediate hydroxylamine and acts as a catalyst during the cyclization onto the nitrile. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

The Article related to acetonitrile nitrophenyl hydrogenation palladium catalyst, indole hydroxy amino preparation alkylation reduction acylation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 6, 2021, Liu, Lu; Li, Lei; Wang, Xin; Sun, Ran; Zhou, Ming-Dong; Wang, He published an article.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile The title of the article was Mn(III)-Mediated Radical Cyclization of o-Alkenyl Aromatic Isocyanides with Boronic Acids: Access to N-Unprotected 2-Aryl-3-cyanoindoles. And the article contained the following:

The synthesis of N-unprotected 2-aryl-3-cyanoindoles was realized via the Mn(III)-mediated radical cascade cyclization of o-alkenyl aromatic isocyanides with boronic acids. A possible mechanism involving a sequential intermol. radical addition, intramol. cyclization, and cleavage of the C-C bond under mild reaction conditions is proposed. Mechanism studies show that H2O or O2 might provide the oxygen source for the elimination of benzaldehyde. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

The Article related to aryl cyanoindole preparation regioselective, alkenyl aromatic isocyanide boronic acid radical addition cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On November 4, 2016, Choi, Isaac; Chung, Hyunho; Park, Jang Won; Chung, Young Keun published an article.SDS of cas: 13544-06-4 The title of the article was Active and Recyclable Catalytic Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Co-Rh Heterobimetallic Nanoparticles with Atmospheric Hydrogen under Mild Conditions. And the article contained the following:

A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 °C). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).SDS of cas: 13544-06-4

The Article related to indole synthesis reductive cyclization nitroarylacetonitrile cobalt rhodium nanoparticle catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 13544-06-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts