Tag: 200-300

On March 16, 2021, Levkov, Igor V.; Kysil, Andrii I.; Biitseva, Angelina V.; Shilin, Sergey V.; Saffon-Merceron, Nathalie; Yegorova, Tatyana V.; Voitenko, Zoia V. published an article.COA of Formula: C8H5BrFN The title of the article was Synthesis of 2-(methoxymethyl)isoindolin-1-imine derivatives via an unusual Delepine reaction. And the article contained the following:

The synthesis of 2-(methoxymethyl)isoindolin-1-imine derivatives via an unusual Delepine reaction was reported. The substrate substituents’ influence on the reaction course was studied, and a possible reaction mechanism proposed. The structure of 2-(methoxymethyl)isoindolin-1-imine was confirmed by X-ray diffraction anal. The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).COA of Formula: C8H5BrFN

The Article related to methoxymethylisoindolinimine preparation, bromomethylbenzonitrile methanol delepine reaction, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C8H5BrFN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 28, 2001, Belley, Michel; Scheigetz, John; Dube, Pascal; Dolman, Sarah published an article.Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile The title of the article was Synthesis of N-aminoindole ureas from ethyl 1-amino-6-(trifluoromethyl)-1H-indole-3-carboxylate. And the article contained the following:

Two routes to the synthesis of Et 6-(trifluoromethyl)-1H-indole-3-carboxylate are described. N-Amination of this key intermediate with O-(diphenylphosphinyl)hydroxylamine and subsequent reactions with aryl isocyanates, using pyridine as solvent, gave 1-indolylureas in good yields. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

The Article related to indolylurea preparation, indolecarboxylate preparation isocyanate addition, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 4, 1997, Mitchell, Glynn; Smith, Stephen Christopher published a patent.Application of 13544-06-4 The title of the patent was Preparation of 1-aminoacetylindolines and analogs as herbicides. And the patent contained the following:

RC(:W1)CR1R2YC(:W2)ZR3 [I; R = (un)substituted indolino; R1,R2 = H or alkyl; R3 = H or (halo)aliphatyl, etc.; W1,W2 = O or S; Y = O or NR4; R4 = H, alkoxy, aliphatyl; Z = NR5 or CR6R7; R5-R7 = H or aliphatyl; R4R5 = CH2CH2, CH:CH, COCO, CH2CO; R6R7 = atoms to complete a carbocyclic ring] were prepared Thus, (EtO2CCH2)2NH was N-acylated by Me3CNCO and the product cyclized to give, after saponification, 2,4-dioxo-3-tert-butylimidazolidine-1-acetic acid which was chloridnated and the product amidated by 6-chloroindoline to give title compound II. Data for biol. activity of I were given. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Application of 13544-06-4

The Article related to aminoacetylindoline preparation herbicide, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 13544-06-4

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Nitrile – Wikipedia,
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On December 27, 2018, Du-Cuny, Lei; Xiao, Qitao; Xun, Guoliang; Zheng, Qiangang published a patent.Product Details of 1036991-35-1 The title of the patent was Preparation of substituted 5-cyanoindole compounds for the treatment of lysine (K)-specific demethylase 1A mediated diseases. And the patent contained the following:

A compound of formula I, or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) – mediated diseases or disorders. Compounds of formula I wherein R1 is substituted C1-6 alkyl, substituted C3-6 cycloalkyl, substituted 7- to 11-membered spirocyclyl, etc.; R2 is H, halo, C1-4 alkyl, C1-4 haloalkyl, etc.; R3 is (un)substituted aminophenyl, (un)substituted aminopyridinyl, (un)substituted indolinyl, etc.; R4 is H, halo and C1-4 alkyl; R5 is H, halo, C1-4 alkyl, C1-4 haloalkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their LSD1 modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 0.010 μM. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Product Details of 1036991-35-1

The Article related to cyanoindole preparation lsd1 modulator, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 1036991-35-1

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Nitrile – Wikipedia,
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On August 11, 2022, Zhai, Wenqiang; Zhang, Zhimin; Pan, Hao; Wang, Zhe; Guo, Liubin; Zhang, Yuren; Liu, Dongzhou published a patent.Category: nitriles-buliding-blocks The title of the patent was Pyrrolopyridazine compound, and preparation method therefor and use thereof. And the patent contained the following:

The present invention relates to a pyrrolopyridazine compound as represented by a formula I [wherein X = C or N; R1 = H, halo, alkyl, alkenyl, etc.; Y = H, halo, OH, NH2, etc.; R3 = H, halo, alkyl, alkenyl, etc.; L2 = a single bond, CO, alkylene, etc.; Cy2 = cycloalkylene, heterocyclylene, O, etc.; R6 = independently halo, OH, NH2, CN, etc.; L3 = a single bond, O, or alkylene; Cy3 = cycloalkyl, heterocyclyl, aryl, or heteroaryl; R8 = independently H, halo, alkyl, etc.; m = 0-4; p = 0-3; with provisos] or a pharmaceutically acceptable salt thereof, and also relates to a pharmaceutical preparation, a pharmaceutical composition and the use thereof, wherein the compound can be used for the preparation of drugs for treating or preventing related diseases mediated by HPK1. For example, II was prepared in a multi-step synthesis. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Category: nitriles-buliding-blocks

The Article related to pyrrolopyridazine hpk1 treatment cancer human, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 1, 2007, Brooks, Carl; Cleary, Pamela A.; Goodman, Krista B.; Peace, Simon; Philp, Joanne; Sehon, Clark A.; Smethurst, Christian; Watson, Stephen Paul published a patent.Electric Literature of 13544-06-4 The title of the patent was Preparation of azolylmethylbenzenesulfonamides as CCR2 chemokine receptor antagonists.. And the patent contained the following:

Title compounds [I; R1 = (substituted) aryl, thienyl, benzothienyl, imidazolyl, pyridyl, isoquinolinyl, piperonyl, benxoxathiadiazolyl, benzodiazolyl; m = 1-3; R2 = halo, cyano, OCF3, CF3; R3 = (substituted) heteroaryl, heterocycloalkyl], were prepared as CCR2 chemokine receptor antagonists (no data). Thus, [5-chloro-2-(1H-1,2,3-triazol-1-ylmethyl)phenyl]amine (preparation given) in pyridine was treated with 4-dimethylaminopyridine and 3,4-dichlorobenzoyl chloride followed by heating of the mixture at 90掳 for 4 h to give 3,4-dichloro-N-[5-chloro-2-(1H-1,2,3-triazol-1-ylmethyl)phenyl]benzenesulfonamide. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Electric Literature of 13544-06-4

The Article related to azolylmethylbenzenesulfonamide preparation ccr2 chemokine receptor antagonist, benzenesulfonamide azolylmethyl preparation ccr2 chemokine receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 13544-06-4

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 2009, Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua published an article.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile The title of the article was An efficient synthetic process for scale-up production of 4,5-diamino-2-(trifluoromethyl)benzonitrile and 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine. And the article contained the following:

Starting from 4-amino-2-(trifluoromethyl)benzonitrile, an efficient and nonchromatog. process was developed for multihundred gram production of 4,5-diamino-2-(trifluoromethyl)benzonitrile in 73% yield and 98 HPLC area% purity over four synthetic steps. The same synthetic strategy was applied to 4-bromo-2-(trifluoromethyl)aniline that afforded 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine in 81% overall yield and 99% HPLC area% purity. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to fluoromethyldiaminobenzonitrile production, bromotrifluoromethylbenzenediamine production, amination aniline fluoromethyl derivative, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 1984, Pastor, Stephen D.; Nelson, Aaron L. published an article.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Substituted 5-(D,L-erythro-1′,2′-dihydroxypropyl)pyrazines. Potential precursors for the synthesis of biopterin derivatives. And the article contained the following:

Substituted 5-(D,L-erythro-1′,2′-dihydroxypropyl)pyrazines I (R = cyano, CO2CH2Ph) were prepared from crotonic acid. Functionalized 2-oximino-3-oxoesters II (R1 = Me, CMe3) showed anomalous behavior during decarboxylation. The structures of prepared compounds were determined by spectroscopic methods. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to dihydroxypropylpyrazinecarboxylate lactone, pyrazinecarboxylate dihydroxypropyl lactone, dihydroxydioxohexanoate monoxime decarboxylation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 31, 1988, Sato, Nobuhiro; Saito, Noriko published an article.Category: nitriles-buliding-blocks The title of the article was Studies on pyrazines. 17. An efficient synthesis of pteridine-6-carboxylic acids. And the article contained the following:

2,4-Diaminopteridine-6-carboxylic acid (I) and pterin-6-carboxylic acid (II) were prepared by permanganate oxidation of the corresponding 6-(2-furyl)-substituted pteridines under mild conditions. Several attempts to cleave the furan ring with other oxidizing agents are also described. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to aminopterincarboxylic acid, pteridinecarboxylic acid diamino, furan synthon carboxylic acid group, oxidation furan permanganate, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 3, 2020, Grosse, Sandrine Celine; Deratt, Lindsey Graham; Vandyck, Koen; Raboisson, Pierre Jean-Marie Bernard; Pieters, Serge Maria Aloyssius; Kesteleyn, Bart Rudolf Romanie; Verschueren, Wim Gaston; Berke, Jan Martin; LeComte, Morgan Charles R.; Martinez Lamenca, Carolina; Jonckers, Tim Hugo Maria; Deng, Gang; Jiang, Yimin; Xu, Yanping; Cheng, Zhangling; Hu, Lili; Kuduk, Scott D. published a patent.COA of Formula: C8H5BrFN The title of the patent was Fused heterocyclic derivatives as antiviral agents and their preparation. And the patent contained the following:

The application describes fused heterocycle derivatives of formula I, pharmaceutical compositions comprising these compounds, chem. processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection. Compounds of formula I wherein A is absent and CH2; X is CH2 and O; Y is NH and derivatives; W is CHR3 and CH:CH2; Z is CO and CS; R1 is (un)substituted 5- to 10-membered (mono/bi)cyclic ring optionally containing heteroatoms; R2 is H and (un)substituted C1-4 alkyl; R3 is H, F, OH, (un)substituted C1-4 alkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cyclization of Et 2-(2-aminoethyl)-5-(3,4-dichlorobenzoyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carboxylate bistrifluoroacetate. The invention compounds were evaluated for their antiviral activity. From the assay, it was determined that compound II exhibited an EC50 value 9.628渭M and a CC50 value of > 50渭M. The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).COA of Formula: C8H5BrFN

The Article related to heterocycle preparation antiviral, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C8H5BrFN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts