Tag: 200-300

On September 10, 1982, Colvin, Ernest W.; Kirby, Gordon W.; Wilson, Arthur C. published an article.Category: nitriles-buliding-blocks The title of the article was O-(Diphenylphosphinyl)hydroxylamine: a new reagent for electrophilic C-amination. And the article contained the following:

Ph2P(O)ONH2 (I) efficiently aminated (EtO)2P(O)CH-CO2CH2Ph, (EtO2C)2CH-, (NC)2CH-, PhMgBr, and Me(CH2)5MgBr in THF at -78掳 under Ar. E.g., treatment of (EtO)2P(O)CH2CO2CH2Ph with NaH at room temperature under Ar, then I at -78掳 gave 60% (EtO)2P(O)CH(NH2)CO2CH2Ph. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to phosphinylhydroxylamine amination phosphonoacetate malonate anion, grignard reagent amination phosphinylhydroxylamine, hydroxylamine phosphinyl amination phosphonoacetate anion and other aspects.Category: nitriles-buliding-blocks

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On November 20, 1996, Bernasconi, Claude F.; Wenzel, Philip J. published an article.Synthetic Route of 13544-06-4 The title of the article was Kinetics of Proton Transfer from 2-Nitro-4-X-phenylacetonitriles to Piperidine and Morpholine in Aqueous Me2SO. Solvent and Substituent Effects on Intrinsic Rate Constants. Transition State Imbalances. And the article contained the following:

Rate constants (k1B) for the deprotonation of 2-nitro-4-X-phenylacetonitrile, 2-X (X = NO2, SO2CH3, CN, CF3, Br, and Cl) by piperidine and morpholine and for the reverse reaction (k-1BH) have been determined in 90% Me2SO-10% water, 50% Me2SO-50% water, and water (X = NO2, SO2CH3, CN only). Broensted 尾B values (dlog k1B/dpKaBH), Broensted 伪CH values (dlog k1B/dlog KaCH), and intrinsic rate constants (log ko = log(k1/q) for pKaBH – pKaCH + log(p/q) = 0) were calculated from these data. 伪CH Is smaller than 尾B, implying an imbalance which is consistent with a transition state in which delocalization of the neg. charge into the 2-nitrophenyl moiety lags behind proton transfer. A consequence of this imbalance is that the intrinsic rate constant decreases with increasing electron withdrawing strength of X. For 蟺-acceptor substituents (NO2, SO2CH3, CN) there is a further decrease in ko due to a lag in the delocalization of the charge into X. The intrinsic rate constants depend very little on the Me2SO content of the solvent which is shown to be the result of compensation of mainly two competing factors. One is the stabilization of the polarizable transition state by the polarizable Me2SO which increases ko; the other is attributed to a lag in the solvation of the developing carbanion behind proton transfer at the transition state which leads to a decrease in ko. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Synthetic Route of 13544-06-4

The Article related to deprotonation nitrophenylacetonitrile piperidine kinetics mechanism, broensted lfer deprotonation nitrophenylacetonitrile, solvent effect deprotonation nitrophenylacetonitrile and other aspects.Synthetic Route of 13544-06-4

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On October 15, 2019, Jung, J.; Menzies, D. J.; Thissen, H.; Easton, C. D.; Evans, R. A.; Henry, R.; Deletic, A.; McCarthy, D. T. published an article.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was New prebiotic chemistry inspired filter media for stormwater/greywater disinfection. And the article contained the following:

Greywater and stormwater have received significant attention due to increasing water scarcity. Passive filtration such as biofiltration has been a popular treatment method with its low energy input and environmental friendliness. However, pathogen removal capacity needs improvement to achieve safe water quality. In this study, a prebiotic chem. inspired copolymer based on aminomalononitrile and 3,4,5-trihydroxybenzaldehyde (AMNT30) was introduced to develop antimicrobial media for passive filtration. The AMNT30 polymer provided an adhesive coating on zeolite substrates following a spontaneous polymerization process at room temperature AMNT30 coated media were investigated for metal loading capacity, surface morphol., E. coli removal and metal leaching after filtration of different water sources (i.e. stormwater, greywater, and deionized water) at low/high conductivity The coating enhanced metal ion loading on the surface and demonstrated that >8 log reduction of E. coli can be achieved for silver loaded materials compared to a 1 log reduction for copper loaded materials. The coating also increased the stability of the metals on the media irresp. of inflow characteristics. This study provided the first example using AMNT30 to create antimicrobial water purification media. It is expected that this technol. will find applications in the water treatment industry. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to prebiotic chem inspired media stormwater greywater disinfection, antimicrobial media, disinfection, filter media, greywater, prebiotic chemistry inspired polymer, stormwater and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

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On July 3, 2008, Berdini, Valerio; Besong, Gilbert Ebai; Callaghan, Owen; Carr, Maria Grazia; Congreve, Miles Stuart; Gill, Adrian Liam; Griffiths-Jones, Charlotte Mary; Madin, Andrew; Murray, Christopher William; Nijjar, Rajdeep Kaur; O’Brien, Michael Alistair; Pike, Andrew; Saxty, Gordon; Taylor, Richard David; Vickerstaffe, Emma published a patent.Product Details of 1036991-35-1 The title of the patent was Preparation of bicyclic heterocyclic compounds as FGFR inhibitors. And the patent contained the following:

The title compounds I [X1, X2, X3 = C or N, such that at least one of X1-X3 = N; X4 = CR3 or N; X5 = CR5, N or C(O); provided that no more than 3 of X1-X5 = N; R1 = NHCONR4R5, NHCO2R4, NHCSOR4, etc.; R3 = halo, H, alkyl, etc.; R3 = H, halo, alkyl, etc.; R4, R5 = H, alkyl, cycloalkyl, etc.; A = (un)substituted (non)aromatic carbocyclic or heterocyclic group; with the provisos], useful in the treatment of diseases, e.g. cancer, were prepared E.g., a 2-step synthesis of II, starting from 6-chloro-3-iodoimidazo[1,2-a]pyridine with 3-acetylaminophenylboronic acid, was given. Exemplified compounds I were tested in in vitro FGFR3 and PDGFR kinase assays. Many compounds I showed IC50 of <10 渭M or provided at least 50% inhibition of the FGFR3 activity at a concentrate of 10 渭M. Preferred I showed IC50 of <1 渭M or provided at least 50% inhibition of the FGFR3 activity at a concentrate of 1 渭M. Pharmaceutical composition comprising the compound I is disclosed. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Product Details of 1036991-35-1

The Article related to bicyclic heterocyclic imidazopyridine preparation fibroblast growth factor receptor inhibitor, fgfr3 inhibitor antitumor bicyclic heterocyclic imidazopyridine preparation and other aspects.Product Details of 1036991-35-1

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Wang, Hung-Kai; Chio, Yu-Lun; Pallikonda, Gangaram; Wu, Hsyueh-Liang; Su, Haw-Lih; Hsieh, Jen-Chieh published an article in 2020, the title of the article was Copper-catalyzed dual cyclization for the synthesis of quinindolines.Category: nitriles-buliding-blocks And the article contains the following content:

A synthetic approach to quinindoline derivatives I (R = H, F, CF3, OMe, ; R1 = H, F, Me, OMe, NMe2; R2 = H, F, CF3, OMe; R3 = H, F, Cl, Me, NMe2, N(n-C4H9)2, OMe; R4 = H; RR1 = R2R3 = -OCH2O-; R3R4 = -CH:CH-CH:CH-) by the Cu-catalyzed dual cyclization has been developed. This catalytic reaction is a practical method for the systematic synthesis of quinindoline core structure I, which contains a limited-step synthetic strategy and can tolerant a wide variety of substituents. In addition, the mechanistic study reveals that the reaction initiates from a Lewis acid accelerated addition of aniline to nitrile and provides the indole substructure, and then the subsequent Cu-catalyzed C-N coupling reaction furnishes the quinoline subunit and affords the quinindoline structure I. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Category: nitriles-buliding-blocks

The Article related to quinindoline preparation, anilino bromophenyl acrylonitrile dual cyclization copper catalyst, n-heterocycle, copper-catalyzed, cyclization, natural alkaloid, quinindoline and other aspects.Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
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On February 12, 2015, Motiyenko, Roman A.; Margules, Laurent; Alekseev, Eugen A.; Guillemin, Jean-Claude published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was High-Resolution Millimeter Wave Spectroscopy and Ab Initio Calculations of Aminomalononitrile. And the article contained the following:

The HCN trimer aminomalononitrile (H2NCH(CN)2, AMN) is considered as a key compound in prebiotic chem. and a potential candidate for detection in the interstellar medium. In this view, we studied the rotational spectrum of AMN in the 120-245 GHz frequency range. The spectroscopic work was augmented by high-level ab initio calculations The calculations showed that between two existing rotamers, sym. and asym., the most stable is the asym. conformation, and it is the only conformation observed in the recorded spectra. The sym. conformation is 6.7 kJ/mol higher in energy and thus has a very low Boltzmann factor. The anal. of the rotational spectra of the A conformation has shown that the observed lines exhibit a doublet or quartet structure owing to two large-amplitude motions, C-N torsion and amino group inversion. To study the large-amplitude motions in detail, we calculated a two-dimensional potential energy surface and determined the barrier heights for the torsion and inversion, Vt = 12.5 kJ/mol and Vi = 19.1 kJ/mol. About 2500 assigned rotational transitions in the ground vibrational state were fitted within exptl. accuracy using the reduced axes system Hamiltonian. The set of obtained spectroscopic parameters allows accurate calculation of transition frequencies and intensities for an astrophys. search of AMN. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to aminomalononitrile millimeter wave spectroscopy ab initio, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 31, 2020, Kuroda, Chiaki; Kobayashi, Reiri; Kurebayashi, Saeka; Tazawa, Kanako; Masuda, Arisa; Takeuchi, Ryo; Washio, Ayako; Onuki, Hiroyuki published an article.Formula: C10H11N3O3S The title of the article was Reaction of Aminomalononitrile and Benzylic Compounds as a Plausible Route to Phenylalanine. And the article contained the following:

As a possible route to phenylalanine, reaction of aminomalononitrile with benzylic compounds was studied. 2-Benzyl-2-aminomalononitrile was obtained in a good yield when aminomalononitrile p-toluenesulfonate was treated with benzyl bromide in THF using triethylamine as a base. The reaction proceeded in the presence of water. 2-Benzyl-2-aminomalononitrile was hydrolyzed to afford phenylalanine. The aminomalononitrile route can explain the presence of not only 1 methylene in aromatic amino acids, but also 伪-hydrogen in all 20 proteinogenic amino acids. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Formula: C10H11N3O3S

The Article related to aminomalononitrile benzylic compound benzylation, benzyl aminomalononitrile hydrolysis, phenylalanine preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Formula: C10H11N3O3S

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Nitrile – Wikipedia,
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On January 5, 2018, Bollier, Melanie; Klupsch, Frederique; Six, Perrine; Dubuquoy, Laurent; Azaroual, Nathalie; Millet, Regis; Leleu-Chavain, Natascha published an article.Electric Literature of 5098-14-6 The title of the article was One- or Two-Step Synthesis of C-8 and N-9 Substituted Purines. And the article contained the following:

A novel and original strategy to obtain rapidly a large diversity of C-8 and N-9 substituted purines was developed. The present procedure describes annulation reactions in one or two steps starting from 5-aminoimidazole-4-carbonitriles 1-8 in moderate to good yields. 8,9-Disubstituted-6,9-dihydro-1H-purin-6-ones 9-14, 6-amino-8,9-disubstituted-3,9-dihydro-2H-purin-2-ones 15-20, 8,9-disubstituted-3,9-dihydro-2H-purin-2,6-diamines 21-24 and 6-imino-1-phenyl-8,9-disubstituted-6,9-dihydro-1H-purin-2-(3H)-ones 25-26 were synthesized in one step using formic acid, urea, guanidine carbonate, and Ph isocyanate, resp., whereas 8,9-disubstituted-9H-purin-6-amines 27-31 and 6-imino-8,9-disubstituted-6,9-dihydro-1H-purin-1-amines 32-33 were obtained in two steps using formamide and hydrazine, resp. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Electric Literature of 5098-14-6

The Article related to disubstituted purine preparation, aminoimidazole carbonitrile preparation cyclization urea guanidine carbonate phenyl isocyanate, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 5098-14-6

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Nitrile – Wikipedia,
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On February 1, 2007, Brooks, Carl; Cleary, Pamela A.; Goodman, Krista B.; Peace, Simon; Philp, Joanne; Sehon, Clark A.; Smethurst, Christian; Watson, Stephen Paul published a patent.Electric Literature of 13544-06-4 The title of the patent was Preparation of azolylmethylbenzenesulfonamides as CCR2 chemokine receptor antagonists.. And the patent contained the following:

Title compounds [I; R1 = (substituted) aryl, thienyl, benzothienyl, imidazolyl, pyridyl, isoquinolinyl, piperonyl, benxoxathiadiazolyl, benzodiazolyl; m = 1-3; R2 = halo, cyano, OCF3, CF3; R3 = (substituted) heteroaryl, heterocycloalkyl], were prepared as CCR2 chemokine receptor antagonists (no data). Thus, [5-chloro-2-(1H-1,2,3-triazol-1-ylmethyl)phenyl]amine (preparation given) in pyridine was treated with 4-dimethylaminopyridine and 3,4-dichlorobenzoyl chloride followed by heating of the mixture at 90掳 for 4 h to give 3,4-dichloro-N-[5-chloro-2-(1H-1,2,3-triazol-1-ylmethyl)phenyl]benzenesulfonamide. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Electric Literature of 13544-06-4

The Article related to azolylmethylbenzenesulfonamide preparation ccr2 chemokine receptor antagonist, benzenesulfonamide azolylmethyl preparation ccr2 chemokine receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 13544-06-4

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Nitrile – Wikipedia,
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On June 30, 2009, Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua published an article.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile The title of the article was An efficient synthetic process for scale-up production of 4,5-diamino-2-(trifluoromethyl)benzonitrile and 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine. And the article contained the following:

Starting from 4-amino-2-(trifluoromethyl)benzonitrile, an efficient and nonchromatog. process was developed for multihundred gram production of 4,5-diamino-2-(trifluoromethyl)benzonitrile in 73% yield and 98 HPLC area% purity over four synthetic steps. The same synthetic strategy was applied to 4-bromo-2-(trifluoromethyl)aniline that afforded 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine in 81% overall yield and 99% HPLC area% purity. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to fluoromethyldiaminobenzonitrile production, bromotrifluoromethylbenzenediamine production, amination aniline fluoromethyl derivative, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts