Tag: 200-300

Name: 4-Bromo-2-fluorobenzonitrileIn 2020 ,《Substrate profiling of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870》 was published in Molecules. The article was written by Mashweu, Adelaide R.; Chhiba-Govindjee, Varsha P.; Bode, Moira L.; Brady, Dean. The article contains the following contents:

The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in size from small (90 Da) to large (325 Da) were evaluated. Larger compounds included those with a bi-aryl axis, prepared by the Suzuki coupling reaction, Morita-Baylis-Hillman adducts, heteroatom-linked diarylpyridines prepared by Buchwald-Hartwig cross-coupling reactions and imidazo[1,2-a]pyridines prepared by the Groebke-Blackburn-Bienayme multicomponent reaction. The enzyme active site was moderately accommodating, accepting almost all of the small aromatic nitriles, the diarylpyridines and most of the bi-aryl compounds and Morita-Baylis-Hillman products but not the Groebke-Blackburn-Bienayme products. Nitrile conversion was influenced by steric hindrance around the cyano group, the presence of electron donating groups (e.g., methoxy) on the aromatic ring, and the overall size of the compound4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Name: 4-Bromo-2-fluorobenzonitrile) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Name: 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Zhao, Rongrong; Wen, Simiaomiao; Fu, Hao; Liu, Mengna; Liu, Qixing; Zhou, Haifeng published an article in Green Chemistry. The title of the article was 《Bis(2-methoxyethyl)ether promoted intramolecular acceptorless dehydrogenative coupling to construct structurally diverse quinazolinones by molecular oxygen》.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:

A simple, efficient and clean approach for the synthesis of diverse dihydroisoquinolino[2,1-a]quinazolinones, 2-aryl quinazolinones and analogs through intramol. acceptorless dehydrogenative coupling has been achieved. The combination of bis(2-methoxyethyl)ether and mol. oxygen was identified as a highly efficient system for this oxidative dehydrogenative coupling sequential transformation without an external initiator, catalyst and additive. The applicability and practicability were demonstrated by a scope of twenty-nine examples and a gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application In Synthesis of 4-Bromo-2-fluorobenzonitrile) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Wang, Jianhua; Li, Xiaoxun published an article in Chemical Science. The title of the article was 《Asymmetric β-arylation of cyclopropanols enabled by photoredox and nickel dual catalysis》.Synthetic Route of C7H3BrFN The author mentioned the following in the article:

The enantioselective functionalization and transformation of readily available cyclopropyl compounds are synthetically appealing yet challenging topics in organic synthesis. Here authors report an asym. β-arylation of cyclopropanols with aryl bromides enabled by photoredox and nickel dual catalysis. This dual catalytic transformation features a broad substrate scope and good functional group tolerance at room temperature, providing facile access to a wide array of enantioenriched β-aryl ketones bearing a primary alc. moiety in good yields with satisfactory enantioselectivities (39 examples, up to 83% yield and 90% ee). The synthetic value of this protocol was illustrated by the concise asym. construction of natural product calyxolane B analogs. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Synthetic Route of C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Synthetic Route of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Dziaduszek, J.; Dabrowski, R.; Urban, S.; Garbat, K.; Glushchenko, A.; Czuprynski, K. published 《Selected fluorosubstituted phenyltolanes with a terminal group: NCS, CN, F, OCF3 and their mesogenic and dielectric properties and use for the formulation of high birefringence nematic mixtures to GHz and THz applications》.Liquid Crystals published the findings.Computed Properties of C7H3BrFN The information in the text is summarized as follows:

Thirty laterally fluorosubstituted new 4-isothiocyanato-, 4-cyano-, 4-fluoro- and 4-(1,1,1-trifluorometoxy)-4′-(4-alkylphenyl)tolanes have been synthesized and their phase transition temperatures and enthalpies and elec. permittivity have been measured. These data have been analyzed together with data for earlier prepared similar compounds and with recently prepared analogously substituted 4″”-alkyl-terphenyls. It was shown that some di-, tri- and tetra-fluorosubstituted 4-isothiocyanato- and 4-cyano-4′-(4-alkylphenyltolanes) are very useful components for the formulation of high birefringence (Δn up to 0.5 measured at 589 nm) and large temperature range nematic mixtures for photonic applications, especially in the infra-red, GHz and THz range of electromagnetic radiation. Three ways of formulation of high birefringence mixtures were proposed. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Computed Properties of C7H3BrFN) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Computed Properties of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Garcia-Lopez, Victor; Alemany, Lawrence B.; Chiang, Pinn-Tsong; Sun, Jiuzhi; Chu, Pin-Lei; Marti, Angel A.; Tour, James M. published 《Synthesis of light-driven motorized nanocars for linear trajectories and their detailed NMR structural determination》.Tetrahedron published the findings.Formula: C7H3BrFN The information in the text is summarized as follows:

The design and synthesis of a fluorescent light-driven motorized nanocar with a linear geometry is described. Due to its structural design, the nanocar is present as a mixture of two photo-interconvertible diastereomers. An extensive and detailed NMR study allowed the full assignment of the chem. shifts of the two diastereomers in the mixture The nanocar is expected to translate in a linear motion due to the light-driven motor providing a paddle-wheel like propulsion. The quantum yield of 0.56 and the photostability of the dye make this nanocar suitable for future single-mol. fluorescence microscopy studies. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Formula: C7H3BrFN) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Formula: C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Egami, Hiromichi; Hotta, Ryo; Otsubo, Minami; Rouno, Taiki; Niwa, Tomoki; Yamashita, Kenji; Hamashima, Yoshitaka published an article in Organic Letters. The title of the article was 《Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst》.COA of Formula: C10H7BrN2 The author mentioned the following in the article:

Asym. dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeded under mild reaction conditions to provide fluoropyrroloindoline derivatives I [R1 = H, 4-Me, 5-Cl, etc.; R2 = H, Me, Bn, etc.; R3 = SO2Me, 4-MeC6H4SO2, C6H5SO2] in a highly enantioselective manner. Various substitution patterns on the indole ring were well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water was essential and its possible role was discussed. In the part of experimental materials, we found many familiar compounds, such as 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2COA of Formula: C10H7BrN2)

2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.COA of Formula: C10H7BrN2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 50743-32-3On May 1, 1981 ,《Synthesis of 3-substituted-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine derivatives》 appeared in Heterocycles. The author of the article were Ishiguro, Toshihiro; Ukawa, Kiyoshi; Sugihara, Hirosada; Nohara, Akira. The article conveys some information:

Oxobenzopyranopyridines I (R = H, 7-Me, 7-Et, 7-Me2CH, 7-Me3C, 7-Cl, 7-Me2CHO, 9-MeO, R1 = H; R = 7-Me, R1 = 9-Me; R2 = CN, CHO, alkoxycarbonyl) were prepared by cyclization reactions of the corresponding benzopyrancarboxaldehydes II with acetylenes or active methylene compounds Thus, cyclization of II (R = R1 = H) (III) with HCCCN or HCCCO2Et in DMF gave 32% I (R = R1 = H, R2 = CN) and 49% I (R = R1 = H, R2 = CO2Et), resp. Cyclocondensation of III with CH2[CH(OMe)2]2 in HCO2H containing F3B.OEt2 gave 10% I (R = R1 = H, R2 = CHO). I (R = H; R1 = 7-Et, 7-Me2CH; R2 = CN) were also prepared by hydrogenolysis of the corresponding 2-chloro derivatives of I (R2 = CN). In the part of experimental materials, we found many familiar compounds, such as 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Application of 50743-32-3)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Application of 50743-32-3 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《One-pot synthesis of new aza- and diaza-aminophenanthrenes》 was published in Tetrahedron in 2011. These research results belong to Rochais, Christophe; Yougnia, Rodrigue; Cailly, Thomas; Sopkova-de Oliveira Santos, Jana; Rault, Sylvain; Dallemagne, Patrick. Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile The article mentions the following:

The synthesis of a series of benzo(iso)quinoline and phenanthroline derivatives has been achieved using an efficient one-pot procedure. It proceeds through a Suzuki-Miyaura cross-coupling followed by a Dieckmann-Thorpe ring closure under microwave irradiation and provides easy access to building blocks not readily available through other methods. In the part of experimental materials, we found many familiar compounds, such as 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile)

2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of C7H3BrFNIn 2019 ,《Highly efficient yellow nondoped thermally activated delayed fluorescence OLEDs by utilizing energy transfer between dual conformations based on phenothiazine derivatives》 was published in Dyes and Pigments. The article was written by Xiang, Songpo; Guo, Runda; Huang, Zhi; Lv, Xialei; Sun, Shuaiqiang; Chen, Hongting; Zhang, Qing; Wang, Lei. The article contains the following contents:

The nondoped thermally activated delayed fluorescence (TADF) devices are increasingly attracting attention due to the superior performances and simple fabrication process. By incorporating two acceptors with phenothiazine, two materials 2-(10H-phenothiazine-10-yl)-10-phenyl-10H-phenothiazine-5,5-dioxide (PTZ-2PTO) and 3-(10H-phenothiazin-10-yl)-10-phenylacridin-9(10H)-one (PTZ-AD) are designed and investigated. Both the two materials possess dual conformations, whereas the quasi-axial conformer is the main configuration of PTZ-2PTO and quasi-equatorial conformer of PTZ-AD is more stable. The quasi-axial conformers show classical fluorescence emission, and the quasi-equatorial conformers exhibit TADF characteristic. Fascinatingly more, efficient energy transfer can be achieved between quasi-axial conformers and quasi-equatorial conformers, exhibiting similar mechanism to the traditional host-guest system. Based on this characteristic, yellow nondoped TADF-OLED device of PTZ-AD has realized the efficiency of up to 17.08%, 50.48 cd A-1 and 60.04 lm W-1. Meanwhile, the PTZ-AD based nondoped device exhibits low turn-on voltage and low efficiency roll-off, which is among the best performance for yellow nondoped TADF devices. In addition, PTZ-AD based doped device realizes high efficiency of 20.23%, 61.04 cd A-1 and 68.45 lm W-1. This dual conformations forming host-guest system provides a new strategy for obtaining highly efficient nondoped OLEDs devices. After reading the article, we found that the author used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Electric Literature of C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Electric Literature of C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ansari, Tharique N.; Sharma, Sudripet; Bora, Pranjal P.; Ogulu, Deborah; Parmar, Saurav; Gallou, Fabrice; Kozlowski, Pawel M.; Handa, Sachin published their research in ChemSusChem in 2021. The article was titled 《Photoassisted Charge Transfer Between DMF and Substrate: Facile and Selective N,N-Dimethylamination of Fluoroarenes》.Name: 4-Bromo-2-fluorobenzonitrile The article contains the following contents:

A reversible Van der Waals complex formation between the electron-deficient fluorinated aromatic ring and N,N-dimethylformamide (DMF) mols. followed by light irradiation resulted in charge transfer (CT) process. The complex was stabilized by ammonium formate and further decomposed to form the C-N bond. Control experiments revealed that the simultaneous SNAr pathway also contributes to product formation. This methodol. is mild, metal-free, and effective for the amination of a variety of substrates. The reproducibility of this methodol. was also verified on gram-scale reactions. The CT states were supported by control UV/Vis spectroscopy and computational studies. Thus, e.g., perfluoronaphthalene + DMF → 2-(dimethylamino)-1,3,4,5,6,7,8-heptafluoronaphthalene (90%, 80% isolated) in presence of ammonium formate additive under white light, together with 2-amino-1,3,4,5,6,7,8-heptafluoronaphthalene as byproduct (10%). The experimental part of the paper was very detailed, including the reaction process of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Name: 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Name: 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts