Tag: 200-300

In 2017,Hofmayer, Maximilian S.; Hammann, Jeffrey M.; Lutter, Ferdinand H.; Knochel, Paul published 《Large-Scale Cobalt-Catalyzed Cross-Couplings of Functionalized Bench-Stable Arylzinc Pivalates with (Hetero)Aryl and Alkenyl Halides》.Synthesis published the findings.Recommanded Product: 105942-08-3 The information in the text is summarized as follows:

A robust and scalable CoCl2-catalyzed cross-coupling between functionalized arylzinc pivalates and various electron-poor (hetero)aryl and alkenyl halides is reported. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Recommanded Product: 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Langer, Peter; Appel, Bettina published an article in Tetrahedron Letters. The title of the article was 《Efficient synthesis of benzopyrano[2,3-b]pyridines by sequential reactions of 1,3-bis-silyl enol ethers with 3-cyanobenzopyrylium triflates》.Recommanded Product: 50743-32-3 The author mentioned the following in the article:

Benzopyrano[2,3-b]pyridines were efficiently prepared by condensation of 1,3-bis-silyl enol ethers with 3-cyanobenzopyrylium triflates and subsequent domino retro-Michael-lactonization-aldol reactions. For example, 2-ethoxycarbonylmethyl-5-oxo-5H-benzopyrano[2,3-b]pyridine was prepared in 46% yield from 3-cyano-4-benzopyranone and 1,3-bis(trimethylsilyloxy)-1,3-butadiene.6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Recommanded Product: 50743-32-3) was used in this study.

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Recommanded Product: 50743-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 4-Bromo-2-fluorobenzonitrileIn 2019 ,《Identification and Structure-Activity Relationship (SAR) of potent and selective oxadiazole-based agonists of sphingosine-1-phosphate receptor (S1P1)》 was published in Bioorganic Chemistry. The article was written by Liu, Tianqi; Jin, Jing; Chen, Yonghui; Xi, Qiumu; Hu, Jinping; Jia, Wenqiang; Chen, Xiaoguang; Li, Yan; Wang, Xiaojian; Yin, Dali. The article contains the following contents:

Agonism of S1P1 receptor has been proven to be responsible for peripheral blood lymphopenia and elicits the identification of various S1P1 modulators. In this paper the authors described a series of oxadiazole-based S1P1 direct-acting agonists disubstituted on terminal benzene ring, with high potency for S1P1 receptor and favorable selectivity against S1P3 receptor. In addition, two representative agents named I and II demonstrated impressive efficacy in lymphocyte reduction along with reduced effect on heart rate when orally administered. Furthermore, these compounds have been shown to possess desired pharmacokinetic (PK) and physicochem. profiles. The binding mode between I and the activated S1P1 model was also studied. The results came from multiple reactions, including the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Reference of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Reference of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Iwao, Masatomo; Motoi, Osamu published their research in Tetrahedron Letters on August 14 ,1995. The article was titled 《Methodology for the efficient synthesis of 3,4-differentially substituted indoles. Fluoride ion-induced elimination-addition reaction of 1-triisipropylsilylgramine methiodides》.Recommanded Product: 89245-35-2 The article contains the following contents:

1-Triisopropylsilylgramine methiodide reacted smoothly with a variety of nucleophiles in the presence of tetrabutylammonium fluoride to give 3-substituted indoles. The 3,4-disubstituted indoles were efficiently synthesized by sequential use of 4-selective lithiation of 1-triisopropylsilylgramine and this new substitution reaction. The experimental process involved the reaction of 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2Recommanded Product: 89245-35-2)

2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Recommanded Product: 89245-35-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C10H7BrN2On September 18, 2003 ,《Seco-C/D Ring Analogues of Ergot Alkaloids. Synthesis via Intramolecular Heck and Ring-Closing Metathesis Reactions》 was published in Organic Letters. The article was written by Kalinin, Alexey V.; Chauder, Brian A.; Rakhit, Suman; Snieckus, Victor. The article contains the following contents:

Intramol. Heck and ring-closing metathesis reactions on key intermediates I and II, resp., provide efficient entries into seco-C/D ring analogs of Ergot alkaloids III and IV, compounds of potential synthetic and biol. interest. In the experiment, the researchers used many compounds, for example, 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2Computed Properties of C10H7BrN2)

2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Computed Properties of C10H7BrN2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C18H16FNO2On May 15, 2016 ,《An integrated nematic liquid crystal in-fiber modulator derivates from capillary optical fiber》 appeared in Optics Communications. The author of the article were Guo, Xiaohui; Yang, Xinghua; Li, Song; Liu, Zhihai; Hu, Minggang; Qu, Bin; Yuan, Libo. The article conveys some information:

A novel liquid crystal integrated modulation-depth-adjustable in-fiber modulator is proposed. The liquid crystal is encapsulated in a specially designed capillary optical fiber with tubular structure. The exptl. results show that the liquid crystal under the elec. field can influence the light intensity in the tubular core of the fiber. The light at 632.8 nm in the circular waveguide can be modulated by only 2.71×10-2 nL of the liquid crystals under elec. field. The wide range of modulation-depth from 23% to 50% can be obtained by adjusting the strength of the external elec. field. In addition, the modulator shows good stability and repeatability. This work has great potentials in integrated in-fiber optical devices such as tunable modulators, optical switches and elec. field sensors. In the experimental materials used by the author, we found 4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5Computed Properties of C18H16FNO2)

4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Computed Properties of C18H16FNO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Stevens, Jason M.; Li, Jun; Simmons, Eric M.; Wisniewski, Steven R.; DiSomma, Stacey; Fraunhoffer, Kenneth J.; Geng, Peng; Hao, Bo; Jackson, Erika W. published an article in Organometallics. The title of the article was 《Advancing Base Metal Catalysis through Data Science: Insight and Predictive Models for Ni-Catalyzed Borylation through Supervised Machine Learning》.Application of 105942-08-3 The author mentioned the following in the article:

An expansive data set containing 33 substrates, 36 unique monophosphine ligands, and two solvents was produced for the NiCl2·6H2O catalyzed aryl (pseudo)halide borylation with tetrahydroxydiboron for a total of 1632 reactions. Exploratory data anal. revealed excellent reaction performance with simple triarylphosphines (P(p-F-Ph)3 and P(p-Anis)3) and mixed aryl-alkyl phosphines (PPh2Cy), in addition to the previously established high performance with Cy-JohnPhos. The data were used to train machine learning models that predicted out of sample reaction performance with a root-mean-square error of 18.4. The important features extracted from the models identified three phosphine parameters that offered reliable reactivity thresholds for identifying optimal ligand performance. The predictive models showed reasonable performance for predicting reaction yields employing ligands not included in model training, while the important feature boundaries accurately classified the performance of 10 of the 12 external ligands examined4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application of 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Application of 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aretz, Christopher D.; Kharade, Sujay V.; Chronister, Keagan; Rusconi Trigueros, Renata; Martinez Rodriguez, Erick J.; Piermarini, Peter M.; Denton, Jerod S.; Hopkins, Corey R. published an article in 2021. The article was titled 《Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides》, and you may find the article in ChemMedChem.Synthetic Route of C7H3BrFN The information in the text is summarized as follows:

Zika virus (ZIKV), dengue fever (DENV) and chikungunya (CHIKV) are arboviruses that are spread to humans from the bite of an infected adult female Aedes aegypti mosquito. As there are no effective vaccines or therapeutics for these diseases, the primary strategy for controlling the spread of these viruses is to prevent the mosquito from biting humans through the use of insecticides. Unfortunately, the commonly used classes of insecticides have seen a significant increase in resistance, thus complicating control efforts. Inhibiting the renal inward rectifier potassium (Kir) channel of the mosquito vector Aedes aegypti has been shown to be a promising target for the development of novel mosquitocides. We have shown that Kir1 channels play key roles in mosquito diuresis, hemolymph potassium homeostasis, flight, and reproduction Previous work from our laboratories identified a novel (phenylsulfonyl)piperazine scaffold as potent AeKir channel inhibitors with activity against both adult and larval mosquitoes. Herein, we report further the synthesis and SAR work around this scaffold and have identified addnl. compounds, e.g., I and II, with improved in vitro potency and mosquito larvae toxicity. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Synthetic Route of C7H3BrFN) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Synthetic Route of C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Yitao; Yao, Wenqiang; Lin, Jian; Gao, Guoliang; Huang, Chang; Wu, Yang published an article in 2021. The article was titled 《Design, synthesis, and biological evaluation of phenyloxadiazole derivatives as potential antifungal agents against phytopathogenic fungi》, and you may find the article in Monatshefte fuer Chemie.Recommanded Product: 4-Bromo-2-fluorobenzonitrile The information in the text is summarized as follows:

A novel series of picarbutrazox-inspired oxadiazole hybrids I (R = 4-cyanophenyl, 3,5-dibromophenyl, 3,5-dichloro-4-(3-methoxyphenoxy)phenyl, etc.) was synthesized and the derivatives’ biol. activity against phytopathogenic fungi was investigated. The mols. were designed by retaining the active fragment of tetrazolyl phenyloxime ether of lead compound picarbutrazox, while introducing the potentially active oxadiazole-derived fragment I. Bioassay results revealed that some of the title compounds showed potent in vivo antifungal activities to control cucumber downy mildew. Therefore, this novel oxadiazole phenyloxadiazole derivative I can be used as a potential antifungal agent to control cucumber downy mildew and other phytopathogenic fungi for crop protection. The experimental process involved the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Recommanded Product: 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Hammann, Jeffrey M.; Thomas, Lucie; Chen, Yi-Hung; Haas, Diana; Knochel, Paul published 《Cobalt-Catalyzed Cross-Couplings of Bench-Stable Alkynylzinc Pivalates with (Hetero)Aryl and Alkenyl Halides》.Organic Letters published the findings.Product Details of 105942-08-3 The information in the text is summarized as follows:

In the presence of CoCl2·2LiCl and TMEDA, selected terminal alkynylzinc pivalates underwent coupling with electron-deficient aryl and heteroaryl chlorides, bromides, and iodides and two alkenyl bromides to yield aryl alkynes and enynes chemoselectively; coupling of a silylethynylzinc pivalate with an (E)-alkenyl bromide and a (Z)-bromoacrylate yielded the corresponding (E)-enyne and (Z)-enynoate in 99:1 dr. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Product Details of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts