Tag: 200-300

Zhang, Yan; Xia, Mingze; Li, Min; Ping, Qian; Yuan, Zhenbo; Liu, Xuanzhong; Yin, Huimin; Huang, Shuping; Rao, Yijian published an article in 2021. The article was titled 《Energy-transfer-mediated photocatalysis by a bioinspired organic perylene photosensitizer HiBRCP》, and you may find the article in Journal of Organic Chemistry.SDS of cas: 105942-08-3 The information in the text is summarized as follows:

Energy transfer plays a special role in photocatalysis by utilizing the potential energy of the excited state through indirect excitation, in which a photosensitizer determines the thermodn. feasibility of the reaction. Bioinspired by the energy-transfer ability of natural product Cercosporin, here we developed a green and highly efficient organic photosensitizer HiBRCP (hexaisobutyryl reduced Cercosporin) through structural modification of Cercosporin. After structural manipulation, its triplet energy was greatly improved, and then, it could markedly promote the efficient geometrical isomerization of alkenes from the E-isomer to the Z-isomer. Moreover, it was also effective for energy-transfer-mediated organometallic catalysis, which allowed realization of the cross-coupling of aryl bromides and carboxylic acids through efficient energy transfer from HiBRCP to nickel complexes. Thus, the study on the relationship between structural manipulation and their photophys. properties provided guidance for further modification of Cercosporin, which could be applied to more meaningful and challenging energy-transfer reactions. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3SDS of cas: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.SDS of cas: 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Journal of Medicinal Chemistry included an article by Sang, Yali; Han, Sheng; Pannecouque, Christophe; De Clercq, Erik; Zhuang, Chunlin; Chen, Fener. HPLC of Formula: 105942-08-3. The article was titled 《Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles》. The information in the text is summarized as follows:

A series of nondimethylphenyl-diarylpyrimidines with much lower cytotoxicities than their di-Me analogs were developed. Compound B13 with a difluorobiphenyl moiety showed the highest antiviral activity against WT, mutant strains, and RT. The hydrochloride form of B13 exhibited an improved water solubility of 5.6μg/mL compared with ETR (≪1μg/mL), better stability in human and rat liver microsomes, and a great oral bioavailability of 44%, making it promising as a drug candidate. In addition, no apparent toxicity was observed in the acute toxicity assay (2 g/kg) and HE staining.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3HPLC of Formula: 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.HPLC of Formula: 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2018,Yang, Xicheng; Yu, Haihua; Xu, Yulong; Shao, Liming published 《Regioselective Access to 3-Aryl-1-aminoisoquinolines via Nickel(I)-Catalyzed C-C and C-N Cascade Coupling Reactions from the Substituted 2-(Cyanomethyl)benzonitriles》.Journal of Organic Chemistry published the findings.Reference of 4-Bromo-2-fluorobenzonitrile The information in the text is summarized as follows:

A novel and regioselective Ni(I) catalyzed C-C and C-N cascade coupling reactions has been developed. The cascade furnishes atom-economic access to 40 3-aryl-1-aminoisoquinolines I (R1 = H, 7-Me, 6-MeO, 7-F, etc.; R2 = H, Me, Et, Ph, etc.; R3 = H, 4-F, 2-Me, 3-F, etc.). The regioselectivity of C(sp3)-cyano group over C(sp2)-cyano group was revealed and supported by mechanism studies as well as the preliminary d. functional theory (DFT) calculations In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Reference of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Reference of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 105942-08-3In 2017 ,《Experimental investigation of the influence of reaction atmosphere on the pyrolysis of printed circuit boards》 appeared in Applied Energy. The author of the article were Evangelopoulos, Panagiotis; Kantarelis, Efthymios; Yang, Weihong. The article conveys some information:

Printed circuit boards (PCB) are one of the most challenging fractions of waste elec. and electronic equipment (WEEE) in terms of recycling due to their complexity and diversity. Pyrolysis seems to be a promising alternative for production of energy carriers from its organic fraction with simultaneous recovery of metals. Reaction atm. is among the process parameters that affects the thermal decomposition as well as the products formation and distribution. In this study, the decomposition of two different PCB fractions in inert and steam atmospheres has been investigated by means of thermogravimetric anal. (TGA) and lab scale fixed bed reactor experiments It was found that the decomposition of the tested materials in steam atm. starts at lower temperatures and proceeds slower compared to the N2 atmosphere. Moreover, a two-step decomposition has been observed on the PCB sockets fraction due to the fact that high amount of antimony oxide was present, a common additive for improving the flame retardancy, which have been also observed on previous studies (Wu et al., 2014). The presence of steam influence the pyrolysis gas composition and promotes addnl. vaporisation of antimony as verified by powder X-ray diffraction (XRD) and SEM (SEM). Finally, the liquid fraction has been qual. analyzed using a GC/MS in order to determine the brominated compounds as well as other compounds that are produced from this process. In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Recommanded Product: 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Nickel-Catalyzed Tandem Reaction of Functionalized Arylacetonitriles with Arylboronic Acids in 2-MeTHF: Eco-Friendly Synthesis of Aminoisoquinolines and Isoquinolones》 was published in Chemistry – An Asian Journal in 2020. These research results belong to Zhen, Qianqian; Chen, Lepeng; Qi, Linjun; Hu, Kun; Shao, Yinlin; Li, Renhao; Chen, Jiuxi. Reference of 4-Bromo-2-fluorobenzonitrile The article mentions the following:

The first example of the nickel-catalyzed tandem addition/cyclization of 2-(cyanomethyl)benzonitriles R1-2-(NCCH(R2))C6H3CN (R1 = H, 4-Me, 6-Ph, 5-Br, etc.; R2 = H, Ph, thiophen-3-yl, i-Pr, etc.) with arylboronic acids ArB(OH)2 (Ar = Ph, thiophen-3-yl, benzo[d][1,3]dioxol-5-yl, etc.) in 2-MeTHF has been developed, which provides the facile synthesis of aminoisoquinolines I (R1 = H, 6-Me, 8-Ph, 7-Br, etc.) with good functional group tolerance under mild conditions. This chem. has also been successfully applied to the synthesis of isoquinolones II by the tandem reaction of Me 2-(cyanomethyl)benzoates with arylboronic acids. The use of the bio-based and green solvent 2-MeTHF as the reaction medium makes the synthesis process environmentally benign. The synthetic utility of this chem. is also indicated by the synthesis of biol. active mols. The experimental process involved the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Reference of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Reference of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Pyrrolopyrimidine vs. Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase》 were Revuelto, Alejandro; Ruiz-Santaquiteria, Marta; de Lucio, Hector; Gamo, Ana; Carriles, Alejandra A.; Gutierrez, Kilian Jesus; Sanchez-Murcia, Pedro A.; Hermoso, Juan A.; Gago, Federico; Camarasa, Maria-Jose; Jimenez-Ruiz, Antonio; Velazquez, Sonsoles. And the article was published in ACS Infectious Diseases in 2019. Application In Synthesis of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:

Disruption of protein-protein interactions of essential oligomeric enzymes by small mols. represents a significant challenge. We recently reported some linear and cyclic peptides derived from an α-helical region present in the homodimeric interface of Leishmania infantum trypanothione reductase (Li-TryR) that showed potent effects on both dimerization and redox activity of this essential enzyme. Here, we describe our first steps toward the design of nonpeptidic small-mol. Li-TryR dimerization disruptors using a proteomimetic approach. The pyrrolopyrimidine and the 5-6-5 imidazole-phenyl-thiazole α-helix-mimetic scaffolds were suitably decorated with substituents that could mimic three key residues (K, Q, and I) of the linear peptide prototype (PKIIQSVGIS-Nle-K-Nle). Extensive optimization of previously described synthetic methodologies was required. A library of 15 compounds bearing different hydrophobic alkyl and aromatic substituents was synthesized. The imidazole-phenyl-thiazole-based analogs outperformed the pyrrolopyrimidine-based derivatives in both inhibiting the enzyme and killing extracellular and intracellular parasites in cell culture. The most active imidazole-phenyl-thiazole compounds 3e and 3f inhibit Li-TryR and prevent growth of the parasites at low micromolar concentrations similar to those required by the peptide prototype. The intrinsic fluorescence of these compounds inside the parasites visually demonstrates their good permeability in comparison with previous peptide-based Li-TryR dimerization disruptors. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application In Synthesis of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kim, Young Ha; Lee, Hyuk; Kim, Yeong Joon; Kim, Bum Tae; Heo, Jung-Nyoung published an article on January 18 ,2008. The article was titled 《Direct One-Pot Synthesis of Phenanthrenes via Suzuki-Miyaura Coupling/Aldol Condensation Cascade Reaction》, and you may find the article in Journal of Organic Chemistry.Related Products of 325141-71-7 The information in the text is summarized as follows:

An efficient cascade reaction was developed where a Suzuki-Miyaura coupling is followed by an aldol condensation, for the construction of phenanthrene derivatives using microwave irradiation For example, the reaction of Me 2-bromophenylacetamide with 2-formylphenylboronic acid in the presence of a palladium catalyst and a base provided a biaryl intermediate, which underwent in situ cyclization to afford the corresponding phenanthrene I in high yield. This methodol. was used to synthesis a fluorescent phenanthrene excimer by bromination of 10-methylphenanthrene Et ester, a product from the previous cascade reaction, followed by lactamization with methylamine. The results came from multiple reactions, including the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7Related Products of 325141-71-7)

2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons.Related Products of 325141-71-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Safety of 4-Cyano-3-fluorophenyl 4-butylbenzoateOn June 3, 2015, Rozwadowski, Tomasz; Massalska-Arodz, Maria; Kolek, Lukasz; Grzybowska, Katarzyna; Bak, Andrzej; Chledowska, Krystyna published an article in Crystal Growth & Design. The article was 《Kinetics of Cold Crystallization of 4-Cyano-3-fluorophenyl 4-Butylbenzoate (4CFPB) Glass Forming Liquid Crystal. I. Nonisothermal Process As Studied by Microscopic, Calorimetric, and Dielectric Methods》. The article mentions the following:

For 4-cyano-3-fluorophenyl 4-butylbenzoate (4CFPB), the process of the crystallization of the CrII phase was studied in microscopic (POM), calorimetric (DSC), and dielec. (BDS) nonisothermal experiments with various (0.5-50 K/min) heating of the metastable nematic phase obtained from its glass. Growth of areas of crystal CrII in the microscopic texture of nematic phase during heating allows estimation of degree of crystallinity D(T) vs temperature curves similar to these obtained basing on DSC heat flow curves and for slow heating with help of dielec. relaxation (BDS) method. Two types of CrII crystallization mechanisms seem to be identified: (1) strong ϕ dependence on temperature of full crystallization Tc(ϕ) and half time of crystallization t1/2(ϕ) on slow heating up to 5 K/min points to diffusion-controlled mechanism with the energy barrier 57 kJ/mol, and (2) small effect of faster heating on Tc(ϕ) and t1/2(ϕ) seems to illustrate thermodn. mechanism with energy barrier 180 kJ/mol. The scenario of two mechanisms of CrII crystallization is in agreement with the results of new method proposed by Mo et al., using combination of Avrami and Ozawa equations for description of nonisothermal crystallization In addition to crystallization of CrII of 4CFPB, at higher temperature range CrII-CrI transformation to a stable CrI crystal was digitalized based on microscopic and DCS results for heating at 1 K/min. In the part of experimental materials, we found many familiar compounds, such as 4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5Safety of 4-Cyano-3-fluorophenyl 4-butylbenzoate)

4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Safety of 4-Cyano-3-fluorophenyl 4-butylbenzoate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 105942-08-3In 2018 ,《Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Liu, Jian; Qian, Chengbo; Zhu, Yehua; Cai, Jianguo; He, Yufang; Li, Jie; Wang, Tianlin; Zhu, Haohao; Li, Zhi; Li, Wei; Hu, Lihong. The article conveys some information:

Both histone deacetylase (HDAC) and fibroblast growth factor receptor (FGFR) are important targets for cancer therapy. Although combining dual HDAC pharmacophore with tyrosine kinase inhibitors (TKIs) had achieved a successful progress, dual HDAC/FGFR1 inhibitors haven’t been reported yet. Herein, we designed a series of hybrids bearing 1H-indazol-3-amine and benzohydroxamic acids scaffold with scaffold hopping and mol. hybridization strategies. Among them, compound 7j showed the most potent inhibitory activity against HDAC6 with IC50 of 34 nM and exhibited the great inhibitory activities against a human breast cancer cell line MCF-7 with IC50 of 9 μM in vitro. Meanwhile, the compound also exhibited moderate FGFR1 inhibitory activities. This study provides new tool compounds for further exploration of dual HDAC/FGFR1 inhibition. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application of 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Application of 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets》 was written by Lutter, Ferdinand H.; Grokenberger, Lucie; Perego, Luca Alessandro; Broggini, Diego; Lemaire, Sebastien; Wagschal, Simon; Knochel, Paul. COA of Formula: C7H3BrFN And the article was included in Nature Communications in 2020. The article conveys some information:

The metalation of 1-aryl-1H-1,2,3-triazoles and other related heterocycles with sterically hindered metal-amide bases were investigated. A room temperature and highly regioselective ortho-magnesiation of several aryl azoles using a tailored magnesium amide, TMPMgBu (TMP = 2,2,6,6-tetramethylpiperidyl) in hydrocarbon solvents followed by an efficient Pd-catalyzed arylation was reported. This scalable and selective reaction allows variation of the initial substitution pattern of the aryl ring, the nature of the azole moiety, as well as the nature of the electrophile. This versatile method can be applied to the synthesis of bioactive azole derivatives and complements existing metal-mediated ortho-functionalizations. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3COA of Formula: C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.COA of Formula: C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts