Tag: 200-300

The author of 《Signatures of glass transition in partially ordered phases》 were Jasiurkowska-Delaporte, Malgorzata; Juszynska, Ewa; Kolek, Lukasz; Krawczyk, Jan; Massalska-Arodz, Maria; Osiecka, Natalia; Rozwadowski, Tomasz. And the article was published in Liquid Crystals in 2013. Category: nitriles-buliding-blocks The author mentioned the following in the article:

Features of glass transition in liquid crystalline nematic and smectic E, B and IA phases of selected materials observed by means of the polarising microscopy and Fourier transform IR spectroscopy (FTIR) are reported. Evolution of cracking in the glass and a coincidence of its disappearance temperature with the glass transition temperature (Tg) on heating is shown and discussed in the context of processes that occur in the glass. The shape of temperature dependencies of absorption bands is shown as the signature of the glass transition. In the part of experimental materials, we found many familiar compounds, such as 4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5Category: nitriles-buliding-blocks)

4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2018,Angewandte Chemie, International Edition included an article by Xue, Fei; Hayashi, Tamio. Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile. The article was titled 《Asymmetric Synthesis of Axially Chiral 2-Aminobiaryls by Rhodium-Catalyzed Benzannulation of 1-Arylalkynes with 2-(Cyanomethyl)phenylboronates》. The information in the text is summarized as follows:

In the presence of [RhCl(coe)]2 and nonracemic bicyclooctadienecarboxamide I, internal aryl alkynes such as 1-(1-propynyl)naphthalene with ortho-substituted aryl moieties underwent regioselective and enantioselective cyclization reactions with o-(pinacolboronato)phenylacetonitriles mediated by K3PO4 in aqueous 1,4-dioxane to yield nonracemic biarylamines such as binaphthylamine II with stereogenic axes in 72-97% ee (all but one compound formed in >90% ee). In the experiment, the researchers used many compounds, for example, 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile)

2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile(cas: 325141-71-7) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C10H7BrN2On September 25, 1985 ,《The chemistry of indoles. XXIV. Syntheses of 3-indoleacetic acid and 3-indoleacetonitrile having a halo group and a carbon functional group at the 4-position》 was published in Chemical & Pharmaceutical Bulletin. The article was written by Somei, Masanori; Kizu, Kiyomi; Kunimoto, Masako; Yamada, Fumio. The article contains the following contents:

Various 4-halo-3-indoleacetic acids and -3-indoleacetonitriles were synthesized for the first time by means of the Sandmeyer or Schiemann reaction, demonstrating the versatility of 4-indolediazonium salts in 4-substituted indole chem. A practical synthetic method for 4-haloindoles consists of regioselective thallation-halogenation, and the products were also converted to 4-halo-3-indoleacetic acids. The first synthesis of 4-formyl-3-indoleacetonitrile is also reported. The results came from multiple reactions, including the reaction of 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2Computed Properties of C10H7BrN2)

2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Computed Properties of C10H7BrN2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Liu, Jian; Zhou, Jingxian; He, Fengjun; Gao, Liang; Wen, Yu; Gao, Lina; Wang, Ping; Kang, Di; Hu, Lihong. Related Products of 105942-08-3 The article mentions the following:

Based on fragment-based virtual screening and bioisosterism strategies, novel indazoles I [R = C6H5, 4-C5H4N, 3-C4H3S etc.; X = C; Y = (CH2)3, (CH2)4, (CH2)6, etc.] and pyrazolo[3,4-b] pyridine derivatives I [R = 3-MeO-C6H4, 4-MeO-C6H4; X = N; Y = (CH2)6] as HDACs inhibitors were synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDACs, especially compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] were identified as potent inhibitors of HDAC1 (IC50 = 2.7 nM and IC50 = 3.1 nM), HDAC2 (IC50 = 4.2 nM and IC50 = 3.6 nM) and HDAC8 (IC50 = 3.6 nM and IC50 = 3.3 nM). Further anti-proliferation assays revealed that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] showed better anti-proliferative activities against HCT-116 and HeLa cells than pos. control SAHA. The western blot anal. results indicated that compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] noticeably up-regulated the level of acetylated α-tubulin and histone H3. In addition, the two compounds I [R = 4-MeO-C6H4, 4-Cl-C6H4; X = C; Y = (CH2)6] could arrest cell cycle in G2/M phase and promote cell apoptosis, which was similar as the reference compound SAHA. Through the mol. docking and dynamic studies, the potent HDAC inhibitory activities mainly caused by van der Waals and electrostatic interactions with the HDACs. The experimental process involved the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Related Products of 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Related Products of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2018,Cao, Qun; Howard, Joseph L.; Wheatley, Emilie; Browne, Duncan L. published 《Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling》.Angewandte Chemie, International Edition published the findings.SDS of cas: 105942-08-3 The information in the text is summarized as follows:

A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochem. methods is reported. The reported method exhibits a broad substrate scope for both C(sp3)-C(sp2) and C(sp2)-C(sp2) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochem. methods. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3SDS of cas: 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.SDS of cas: 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

SDS of cas: 86776-52-5On September 30, 1984 ,《Synthesis and some properties of 3-fluoro-4-cyanophenyl 4′-n-alkylbenzoates》 was published in Molecular Crystals and Liquid Crystals. The article was written by Sasaki, M.; Takeuchi, K.; Sato, H.; Takatsu, H.. The article contains the following contents:

A series of 3-fluoro-4-cyanophenyl 4′-n-alkylbenzoates, which show monotropic nematic phases, was prepared and their transition temperatures and melting enthalpies were measured. The 3-fluoro-4-cyanophenyl 4′-n-propylbenzoate, 3-chloro-4-cyanophenyl 4′-n-propylbenzoate, and 4-cyanophenyl 4′-n-propylbenzoate were mixed with a nematic mixture (A) of 4-n-alkoxyphenyl 4′-n-alkylcyclohexane-1′-carboxylates. 3-Fluoro-4-cyanophenyl 4′-n-propylbenzoate decreases the N-I transition temperature less, increases the birefringence more, and increases the bulk viscosity less than 3-chloro-4-cyanophenyl 4′-n-propylbenzoate, and reduces the threshold voltage to the greatest extent. The dielec. anisotropies of 3-fluoro-4-cyanophenyl 4′-n-propylbenzoate and 4-cyanophenyl 4′-n-propylbenzoate determined from a series of solutions of the compounds in nematic mixture (A) are 35.9 and 29.6, resp. In the part of experimental materials, we found many familiar compounds, such as 4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5SDS of cas: 86776-52-5)

4-Cyano-3-fluorophenyl 4-butylbenzoate(cas: 86776-52-5) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 86776-52-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrileOn October 25, 1985 ,《Synthesis of the metabolites and degradation products of 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid (amoxanox)》 was published in Chemical & Pharmaceutical Bulletin. The article was written by Ukawa, Kiyoshi; Ishiguro, Toshihiro; Kuriki, Hisashi; Nohara, Akira. The article contains the following contents:

Benzopyranopyridinecarboxylic acid I (R = CHMe2), a promising drug for bronchial asthma, was converted to various degradation products, I (R = CMe2OH, CHMeCH2OH, COMe), which were also synthesized from benzopyranonitrile. On testing for passive cutaneous anaphylaxis in rats, I (R = CHMe2, CMe2OH, COMe) were 260 times as potent as disodium cromoglycate (DSCG) while I (R = CMeCH2OH) was 1500 times as potent as DSCG. In the experimental materials used by the author, we found 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)

6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Recommanded Product: 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Prasad, A. S. G.; Rao, T. Bhaskara; Rambabu, D.; Basaveswara Rao, Mandava V.; Pal, Manojit published 《Ultrasound Assisted Faster and Milder Approach to 6H-pyrido[1,2-a] quinazolin-6-imine Derivatives as Potential Inhibitors of PDE4》.Letters in Drug Design & Discovery published the findings.Category: nitriles-buliding-blocks The information in the text is summarized as follows:

Background: The ultrasound assisted methodol. has been explored first time for the quicker synthesis of 6H-pyrido[1,2-a]quinazolin-6-imine derivatives via the reaction of 2-aminopyridines and 2-fluorobenzontriles under mild conditions. Methods: The methodol. is free from the use of any transition metal catalyst and afforded the desired products in good yields. Some of the synthesized compounds were evaluated for their potential PDE4 inhibition in silico and subsequently in vitro. Conclusion: One compound showed dose dependent inhibition of PDE4B and favorable pharmacol. properties indicating potential of this scaffold for the discovery of new inhibitors of PDE4. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Category: nitriles-buliding-blocks)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Category: nitriles-buliding-blocks 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Microfluidic electrochemistry for single-electron transfer redox-neutral reactions》 was written by Mo, Yiming; Lu, Zhaohong; Rughoobur, Girish; Patil, Prashant; Gershenfeld, Neil; Akinwande, Akintunde I.; Buchwald, Stephen L.; Jensen, Klavs F.. Category: nitriles-buliding-blocks And the article was included in Science (Washington, DC, United States) in 2020. The article conveys some information:

Electrochem. offers opportunities to promote single-electron transfer (SET) redox-neutral chemistries similar to those recently discovered using visible-light photocatalysis but without the use of an expensive photocatalyst. Herein, the authors introduce a microfluidic redox-neutral electrochem. (μRN-eChem) platform that has broad applicability to SET chem., including radical-radical cross-coupling, Minisci-type reactions, and Ni-catalyzed C(sp2)-O cross-coupling. The cathode and anode simultaneously generate the corresponding reactive intermediates, and selective transformation is facilitated by the rapid mol. diffusion across a microfluidic channel that outpaces the decomposition of the intermediates. μRN-eChem was shown to enable a two-step gram-scale electrosynthesis of a nematic liquid crystal compound, demonstrating its practicality.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Category: nitriles-buliding-blocks) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Category: nitriles-buliding-blocks It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Dual Catalytic Strategy for Forging sp2-sp3 and sp3-sp3 Architectures via β-Scission of Aliphatic Alcohol Derivatives》 was published in Journal of the American Chemical Society in 2020. These research results belong to Cong, Fei; Lv, Xin-Yang; Day, Craig S.; Martin, Ruben. Product Details of 105942-08-3 The article mentions the following:

A dual platform for forging sp2-sp3 and sp3-sp3 carbon bonds via catalytic β-scission of aliphatic alc. derivatives with both aryl and alkyl halides is disclosed [e.g., I + p-(F3C)C6H4Br → II (84%, 77% isolated) in presence of photocatalyst, Hantzsch ester under blue LED irradiation with Ni/(4,4′-di-tert-butyl-2,2′-bipyridyl)]. This protocol is distinguished by its wide substrate scope and broad applicability, even in the context of late-stage functionalization. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Product Details of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts