Tag: 200-300

Second-order nonlinear optical properties of new organic conjugated molecules was written by Kawabe, Y.;Ikeda, H.;Sakai, T.;Kawasaki, K.. And the article was included in Journal of Materials Chemistry in 1992.Computed Properties of C18H10N2 This article mentions the following:

Both real and imaginary parts of the second-order nonlinear optical coefficients for a wide range of new organic conjugated materials were measured. The technique of elec.-field-induced second-harmonic generation to determine the optical nonlinearity is described for materials highly absorptive at the harmonic wavelength. The authors evaluated the mol. nonlinear optical coefficients of nitro compounds and aldehydes, barbituric acid derivatives, fulvene derivatives, chalcone derivatives, retinal derivatives, Schiff base compounds, and fused-ring mols., at 1.064 μm. Among these materials, nitro mols. and Schiff base compounds had large optical nonlinearities and good transparency at visible wavelengths. Barbituric acid derivatives and retinal derivatives also had large nonlinearities, but displayed strong absorption of the harmonics. A large enhancement of nonlinearities was achieved in fulvene derivatives by extending the conjugated chains. S atoms, non-benzoic conjugated systems, and fused rings contributed to nonlinear optical effects. Several mols. had very large second-order optical nonlinearities; the products of the mol. nonlinearities and permanent dipole moments μ₀β of these were of the order of 10^-45-10^-44 esu. The relations between mol. nonlinearity and absorption peak energy are discussed. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4Computed Properties of C18H10N2).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Computed Properties of C18H10N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A Highly Active Palladium Catalyst for Intermolecular Hydroamination. Factors that Control Reactivity and Additions of Functionalized Anilines to Dienes and Vinylarenes was written by Johns, Adam M.;Utsunomiya, Masaru;Incarvito, Christopher D.;Hartwig, John F.. And the article was included in Journal of the American Chemical Society in 2006.COA of Formula: C14H12N2 This article mentions the following:

We report a catalyst for intermol. hydroamination of vinylarenes that is substantially more active for this process than catalysts published previously. With this more reactive catalyst, we demonstrate that additions of amines to vinylarenes and dienes occur in the presence of potentially reactive functional groups, such as ketones with enolizable hydrogens, free alcs., free carboxylic acids, free amides, nitriles, and esters. The catalyst for these reactions is generated from [Pd(η³-allyl)Cl]₂ (with or without added AgOTf) or [Pd(CH₃CN)₄](BF₄)₂ and Xantphos (9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene), which generates complexes with large P-Pd-P bite angles. Studies on the rate of the C-N bond-forming step that occurs by attack of amine on an η³-phenethyl and an η³-allyl complex were conducted to determine the effect of the bite angle on the rate of this nucleophilic attack. Studies on model η³-benzyl complexes containing various bisphosphines showed that the nucleophilic attack was faster for complexes containing larger P-Pd-P bite angles. Studies of substituted unsym. and unsubstituted sym. model η³-allyl complexes showed that nucleophilic attack on complexes ligated by Xantphos was faster than on complexes bearing ligands with smaller bite angles and that nucleophilic attack on unsym. allyl complexes with larger bite angle ligands was faster than on unsym. allyl complexes with smaller bite angle ligands. However, monitoring of catalytic reactions of dienes by ³¹P NMR spectroscopy showed that the concentration of active catalyst was the major factor that controlled rates for reactions of sym. dienes catalyzed by complexes of phosphines with smaller bite angles. The identity of the counterion also affected the rate of attack:reactions of allylpalladium complexes with chloride counterion occurred faster than reactions of allylpalladium complexes with triflate or tetrafluoroborate counterion. As is often observed, the dynamics of the allyl and benzyl complexes also depended on the identity of the counterion. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3COA of Formula: C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. COA of Formula: C14H12N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Covalent-assembly based fluorescent probes for detection of hNQO1 and imaging in living cells was written by Han, Jialing;Cheng, Longhao;Zhu, Ya;Xu, Xiaowei;Ge, Chaoliang. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2020.Computed Properties of C14H14N2O2 This article mentions the following:

Human NAD(P)H: quinone oxidoreductase (hNQO1) is an important biomarker for human malignant tumors. Detection of NQO1 accurately is of great significance to improve the early diagnosis of cancer and prognosis of cancer patients. In this study, based on the covalent assembly strategy, hNQO1-activated fluorescent probes 1 and 2 are constructed by introducing coumarin precursor 2-cyano-3-(4-(diethylamino)-2-hydroxyphenyl) acrylic acid and self-immolative linkers. Under reaction with hNQO1 and NADH, turn-on fluorescence appears due to in-situ formation of the organic fluorescent compound 7-diethylamino-3-cyanocoumarin, and fluorescent intensity changes significantly. Probe 1 and 2 for detection of hNQO1 are not interfered by other substances and have low toxicity in cells. In addition to quant. detection of hNQO1 in vitro, they have also been successfully applied to fluorescent imaging in living cells. In the experiment, the researchers used many compounds, for example, 7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6Computed Properties of C14H14N2O2).

7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Computed Properties of C14H14N2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cobalt encapsulated in N-doped graphene sheet for one-pot reductive amination to synthesize secondary amines was written by Liu, Lin;Li, Wenxiu;Qi, Ran;Zhu, Qingqing;Li, Jing;Fang, Yuzhen;Kong, Xiangjin. And the article was included in Molecular Catalysis in 2021.Product Details of 10282-32-3 This article mentions the following:

In this study, an efficient N-doped graphene sheet-coated cobalt catalyst (Co@CN-800) was developed through a simple pyrolysis process, which could gave 99.5% yield of N-benzylaniline by one-pot reductive amination of nitrobenzene with benzaldehyde during at least 5 cycles. Catalyst characterization and control experiments confirmed that the robust catalytic performance of the catalyst is probably due to the synergy effect of in situ generated Co-Nx encapsulated in N-doped graphene layer and appropriate meso-pore structure. Addnl., the substrate adaptability of the catalyst was proved since a variety of corresponding secondary amines RCH₂NHR¹ (R = C₆H₅, 4-pyridyl, cyclohexyl, etc.; R¹ = C₆H₅, 4-FC₆H₄, cyclohexyl, etc.) were smoothly obtained under relatively mild conditions, which makes the secondary amine synthesis strategy based on Co@CN-800 shows excellent application prospect. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Product Details of 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Product Details of 10282-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A facile synthesis of trifluoromethylamines by oxidative desulfurization-fluorination of dithiocarbamates was written by Kanie, Kiyoshi;Mizuno, Katsuya;Kuroboshi, Manabu;Hiyama, Tamejiro. And the article was included in Bulletin of the Chemical Society of Japan in 1998.Quality Control of 4-(Benzylamino)benzonitrile This article mentions the following:

Trifluoromethylamines are easily synthesized from dithiocarbamates by a reagent system consisting of tetrabutylammonium dihydrogen trifluoride and an N-halo imide under mild conditions. When this reaction was applied to dithiocarbamates ArN(R)CS₂Me at higher temperatures, the trifluoromethylation was accompanied by halogen substitution at the p-position of the Ar group. The synthesis of trifluoromethyl-substituted adenosine is also described. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Quality Control of 4-(Benzylamino)benzonitrile).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Quality Control of 4-(Benzylamino)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Disarming the alkoxide trap to access a practical FeCl₃ system for borrowing-hydrogen N-alkylation was written by Ye, Zongren;Yang, Zhenjie;Yang, Chenhui;Huang, Ming;Xu, Xianfang;Ke, Zhuofeng. And the article was included in Organic Chemistry Frontiers in 2022.Related Products of 10282-32-3 This article mentions the following:

Borrowing hydrogen N-alkylation is one of the most valuable transformations in organic synthesis, with high selectivity and at. economy. The general non-noble metal catalysts for borrowing hydrogen usually have limitations on operational convenience or catalytic efficiency. In particular, the development of practical and mild Fe(III) catalysis is a big challenge due to the alkoxide trap in terms of d-wall issues. Inspired by the theor. design, utilizing an in situ reaction strategy to overcome the alkoxide trap of Fe(III), authors present here a practical in situ ferric chloride and bis-(N-heterocyclic carbene) (bis-NHC) system for the borrowing-hydrogen N-alkylation of amines by alcs. under mild reaction conditions, attributed to the merits of bis-NHC in strong-field ligands, strong σ-donation and π-back-donation, and the trans effect. This system was applied to a wide range of alcs. and amines. Through comprehensive experiments and DFT calculations, the mechanism of the reaction was studied, which highlighted the roles of strong-field ligands, strong σ-donation and π-back-donation, and the trans effect by bis-NHC in ensuring the in situ reduction of Fe(III) to Fe(II) and triggering the borrowing of hydrogen under mild conditions. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Related Products of 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Related Products of 10282-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines was written by Fuwa, Haruhiko;Kobayashi, Toshitake;Tokitoh, Takashi;Torii, Yukiko;Natsugari, Hideaki. And the article was included in Synlett in 2004.Reference of 10282-32-3 This article mentions the following:

A novel intramol. nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-one derivatives induced by base treatment and its application to the expeditious synthesis of secondary aryl amines, including diaryl amines, are described. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Reference of 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Reference of 10282-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Single-Crystalline, Size, and Orientation Controllable Nanowires and Ultralong Microwires of Organic Semiconductor with Strong Photoswitching Property was written by Jiang, Lang;Fu, Yanyan;Li, Hongxiang;Hu, Wenping. And the article was included in Journal of the American Chemical Society in 2008.COA of Formula: C18H10N2 This article mentions the following:

Single-crystalline, precise size-controlled nanowires and ultralong microwires with lengths reaching several millimeters of 2-anthracen-9-ylmethylenemalonitrile were prepared in large scale by cast assembly. The size and d. of the nanowires and microwires could be controlled by simply adjusting the concentration of the compound in casting solutions More importantly, the formation of these nanowires and microwires showed no substrate and solvent dependence and was orientation controllable. Highly reproducible and sensitive photoresponse characteristics were observed in these nanowires and microwires. Fast and reversible photoswitchers based on multiple or individual single-crystal microwires were fabricated via “multi times gold wire mask moving” technique with switch ratio over 100. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4COA of Formula: C18H10N2).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).COA of Formula: C18H10N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

ZIF-8 nanoparticles as an efficient and reusable catalyst for the Knoevenagel synthesis of cyanoacrylates and 3-cyanocoumarins was written by Kolmykov, Oleksii;Chebbat, Nassima;Commenge, Jean-Marc;Medjahdi, Ghouti;Schneider, Raphael. And the article was included in Tetrahedron Letters in 2016.Related Products of 51473-74-6 This article mentions the following:

Zeolitic imidazolate framework (ZIF-8) particles with an average size of ca. 355 nm and a sp. surface area of 1786 m².g^-1 were used as an heterogenous catalyst for the Knoevenagel synthesis of α,β-unsaturated cyanoesters and 3-cyanocoumarins. The preparation of 3-cyanocoumarins was efficiently achieved using DMF as the solvent and conducting the condensation at 80°. When the reaction was performed in ethanol, only the intermediates α,β-unsaturated cyanoesters were obtained. The ZIF-8 catalyst could be reused up to five times without any degradation in activity. SEM and XRD analyses demonstrated the high stability of ZIF-8 crystals during the recycling test. In the experiment, the researchers used many compounds, for example, 7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6Related Products of 51473-74-6).

7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Related Products of 51473-74-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Two Hg(II)-Based Macrocycles Offering Hydrogen Bonding Cavities: Influence of Cavity Structure on Heterogeneous Catalysis was written by Pachisia, Sanya;Gupta, Rajeev. And the article was included in Crystal Growth & Design in 2019.HPLC of Formula: 55490-87-4 This article mentions the following:

We present the synthesis and characterization of two Hg-macrocycles offering H-bonding based cavities of varying dimensions. Both Hg-macrocycles illustrate a noteworthy difference in their catalytic performance that has been related to their cavity structures. This work presents the synthesis and characterization of two Hg-macrocycles offering H-bonding based cavities of varying dimensions. Both Hg-macrocycles illustrated a noteworthy difference in their catalytic performance that has been related to their cavity structures. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4HPLC of Formula: 55490-87-4).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.HPLC of Formula: 55490-87-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts