Tag: M.W=100-150

Park, Yunjeong; Bae, Song Yi; Hah, Jung-Mi; Lee, Sang Kook; Ryu, Jae-Sang published the artcile< Synthesis of stereochemically diverse cyclic analogs of tubulysins>, Recommanded Product: 2,2-Diethoxyacetonitrile, the main research area is tubulysin cyclic analog peptide peptidomimetic enantioselective synthesis thiazole; Diels Alder reaction stereoselective Danishefsky diene type peptide coupling; antitumor agent tubulin polymerization inhibiting structure activity; Antitumor agents; Asymmetric catalysis; Hetero Diels–Alder reaction; Peptides; Tubulysin.

The synthesis of tubulysin analogs containing stereochem. diverse cyclic Tuv moieties is described. A tetrahydropyranyl moiety was incorporated into the Tuv unit by enantioselective hetero Diels-Alder reactions of Danishefsky’s diene and thiazole aldehyde. Four different stereoisomers of cyclic Tuv units were used as surrogates for the Tuv moiety. The synthesized stereochem. diverse simplified cyclic analogs were evaluated for the inhibition of tubulin polymerization

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Recommanded Product: 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sato, Nagaaki; Ando, Makoto; Ishikawa, Shiho; Jitsuoka, Makoto; Nagai, Keita; Takahashi, Hirobumi; Sakuraba, Aya; Tsuge, Hiroyasu; Kitazawa, Hidefumi; Iwaasa, Hisashi; Mashiko, Satoshi; Gomori, Akira; Moriya, Ryuichi; Fujino, Naoko; Ohe, Tomoyuki; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro published the artcile< Discovery of Tetrasubstituted Imidazolines as Potent and Selective Neuropeptide Y Y5 Receptor Antagonists: Reduced Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity and Potent Antiobesity Effect>, COA of Formula: C6H11NO2, the main research area is aminoester fluorophenylmagnesium bromide bromofluoropyridine coupling ring opening closure reduction; imidazoline asym preparation; neuropeptide Y5 receptor antagonist antiobesity structure activity human.

A series of novel imidazoline derivatives was synthesized and evaluated as neuropeptide Y (NPY) Y5 receptor antagonists. Optimization of previously reported imidazoline leads, I and II, was attempted by introduction of substituents at the 5-position on the imidazoline ring and modification of the bis(4-fluorophenyl) moiety. A number of potent derivatives without human ether-a-go-go related gene potassium channel (hERG) activity were identified. Selected compounds, including III, were shown to have excellent brain and CSF permeability. Compound III displayed a suitable pharmacokinetic profile for chronic in vivo studies and potently inhibited D-Trp34NPY-induced acute food intake in rats. Oral administration of III resulted in a potent reduction of body weight in a diet-induced obese mouse model.

Journal of Medicinal Chemistry published new progress about Amino acid esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, COA of Formula: C6H11NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bagley, Mark C.; Glover, Christian published the artcile< Synthesis of methyl sulfomycinate, sulfomycinic amide and sulfomycinine, degradation products of the sulfomycin thiopeptide antibiotics>, Recommanded Product: 2,2-Diethoxyacetonitrile, the main research area is sulfomycin thiopeptide antibiotic methanolysis product synthesis methyl sulfomycinate; sulfomycinic amide sulfomycinine synthesis sulfomycin thiopeptide antibiotic degradation product; methyl sulfomycinate ammonolysis hydrolysis sulfomycinine; thiazole oxazole building block peptide coupling.

The convergent synthesis of Me sulfomycinate and sulfomycinic amide, two acidic methanolysis products of the sulfomycin thiopeptide antibiotics, is achieved starting from diethoxyacetonitrile. Further confirmation of structure is obtained by heating Me sulfomycinate at 110 °C in hydrochloric acid to give (±)-sulfomycinine hydrochloride, the acid hydrolyzate of sulfomycin I.

Tetrahedron published new progress about Ammonolysis. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Recommanded Product: 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kawamoto, Isao; Muramatsu, Shigeki; Yura, Yasuo published the artcile< New synthetic route to functionally substituted cyclopentenones>, Name: 2,2-Diethoxyacetonitrile, the main research area is cyclopentenone; jasmone; Wittig reaction oxoalkanoyldithiane.

2,2-Dialkoxynitriles with 2-lithio-1,3-dithiane (I), followed by hydrolysis, gave α-oxoalkanoyl-1,3-dithianes which with LiN(CHMe2)2 and vinyltriphenylphosphonium salts gave, after removal of triphenylphosphonium oxide, cyclopentenone derivatives E.g., MeC(OEt)2CN with I gave 68% II which with LiN(CHMe2)2 and CH2:CMeP+Ph3Br- in Me2SO gave 52% III. Desulfurization of IV, prepared similarly, gave dihydrojasmone (V).

Tetrahedron Letters published new progress about Cycloalkenones Role: RCT (Reactant), RACT (Reactant or Reagent). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Name: 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Barraclough, Paul; Collard, David; Smith, Steven; Vine, Susan J.; Wharton, Clifford J. published the artcile< Synthesis of a 2-arylimidazo[1,2-d][1,2,4]triazine derivative>, Application of C6H11NO2, the main research area is methoxyphenylimidazotriazinone preparation crystal mol structure; imidazotriazinone dimethoxyphenyl preparation structure.

Cyclocondensation of (EtO)2CHCN with 2,4-(MeO)2C6H3COCH2NH2.HCl in MeOH in the presence of MeONa gave 34% arylimidazolecarboxaldehyde acetal I which condensed with H2NNHCO2Et in AcOH to give 34% (dimethoxyphenyl)imidazolylmethylenecarbazate II. Heating II at 185° in Ph2O gave 43% arylimidazotriazinone III. The structure of III was confirmed by x-ray crystal anal.

Journal of Chemical Research, Synopses published new progress about Crystal structure. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Application of C6H11NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lang, Andreas; Pei, Yu; Ouahab, Lahcene; Kahn, Olivier published the artcile< Synthesis, crystal structure, and magnetic properties of 5-methyl-1,2,4-triazole-nitronyl nitroxide. A one-dimensional compound with unusually large ferromagnetic intermolecular interactions>, Electric Literature of 6136-93-2, the main research area is methyltriazolenitronyl nitroxide preparation magnetic property; crystal structure methyltriazolenitronyl nitroxide; mol structure methyltriazolenitronyl nitroxide; ferromagnetic intermol interaction methyltriazolenitronyl nitroxide.

The title compound I exhibits exceptionally strong ferromagnetic interactions. Its preparation, crystallog. data, and magnetic properties are described. Possible mechanisms for the origin of these properties are suggested.

Advanced Materials (Weinheim, Germany) published new progress about Crystal structure. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Electric Literature of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lambert, Kyle M.; Bobbitt, James M.; Eldirany, Sherif A.; Kissane, Liam E.; Sheridan, Rose K.; Stempel, Zachary D.; Sternberg, Francis H.; Bailey, William F. published the artcile< Metal-Free Oxidation of Primary Amines to Nitriles through Coupled Catalytic Cycles>, Recommanded Product: 2,2-Diethoxyacetonitrile, the main research area is primary amine acetamido TEMPO catalyst oxone oxidation; nitrile preparation green chem; amines; catalysis; nitriles; organic chemistry; synthetic methods.

Synergism among several intertwined catalytic cycles allowed for selective, room temperature oxidation of primary amines to the corresponding nitriles in 85-98 % isolated yield. This metal-free, scalable, operationally simple method employed a catalytic quantity of 4-acetamido-TEMPO (ACT; TEMPO = 2,2,6,6-tetramethylpiperidine N-oxide) radical and the inexpensive, environmentally benign triple salt oxone as the terminal oxidant under mild conditions. Simple filtration of the reaction mixture through silica gel afforded pure nitrile products.

Chemistry – A European Journal published new progress about Green chemistry. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Recommanded Product: 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Murakami, Teiichi; Otsuka, Masami; Kobayashi, Susumu; Ohno, Masaji published the artcile< Synthesis of 2-formyladenosine using diethoxyacetonitrile as a synthon>, Name: 2,2-Diethoxyacetonitrile, the main research area is formyladenosine; adenosine formyl; formyladenine; adenine formyl; aminoribofuranosylimidazolecarbonitrile cyclization diethoxyacetonitrile; nucleoside formyladenosine.

Imidazole I was heated with (EtO)2CHCN in BuOH-pyridine at 120° for 10 min in the presence of BuONa to give 90% nucleoside II [R = CH(COEt)2] which on hydrolysis with H2O-AcOH gave 96% II (R = CHO). II (R = CHO) was further converted into II (R = CH:NOH) and II (R = cyano). 2-Formyladenine was analogously prepared

Heterocycles published new progress about Cyclization. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Name: 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Reference of 3032-92-6.

Huang, Qiang;Su, Yu-Xuan;Sun, Wei;Hu, Meng-Yang;Wang, Wei-Na;Zhu, Shou-Fei research published 《 Iron-Catalyzed Vinylzincation of Terminal Alkynes》, the research content is summarized as follows. Organozinc reagents are among the most commonly used organometallic reagents in modern synthetic chem., and multifunctionalized organozinc reagents can be synthesized from structurally simple, readily available ones by alkyne carbozincation. However, this method suffers from poor tolerance for terminal alkynes, and transformation of the newly introduced organic groups is difficult, which limits its applications. Herein, the authors report a method for vinylzincation of terminal alkynes catalyzed by newly developed Fe catalysts bearing 1,10-phenanthroline-imine ligands. This method provides efficient access to novel organozinc reagents with a diverse array of structures and functional groups from readily available vinylzinc reagents and terminal alkynes. The method features excellent functional group tolerance (tolerated functional groups include amino, amide, cyano, ester, hydroxyl, sulfonyl, acetal, phosphono, pyridyl), a good substrate scope (suitable terminal alkynes include aryl, alkenyl, and alkyl acetylenes bearing various functional groups), and high chemoselectivity, regioselectivity, and stereoselectivity. The method could significantly improve the synthetic efficiency of various important bioactive mols., including vitamin A. Mechanistic studies indicate that the new Fe-1,10-phenanthroline-imine catalysts developed in this study has an extremely crowded reaction pocket, which promotes efficient transfer of the vinyl group to the alkynes, disfavors substitution reactions between the Zn reagent and the terminal C-H bond of the alkynes, and prevents the further reactions of the products. The authors’ findings show that Fe catalysts can be superior to other metal catalysts in terms of activity, chemoselectivity, regioselectivity, and stereoselectivity when suitable ligands were used.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Reference of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Name: 4-Ethynylbenzonitrile.

Hulce, Kaitlin R.;Jaishankar, Priyadarshini;Lee, Gregory M.;Bohn, Markus-Frederik;Connelly, Emily J.;Wucherer, Kristin;Ongpipattanakul, Chayanid;Volk, Regan F.;Chuo, Shih-Wei;Arkin, Michelle R.;Renslo, Adam R.;Craik, Charles S. research published 《 Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine》, the research content is summarized as follows. Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antivirals address only a fraction of the potential viral human pathogens. Here, we provide a methodol. for managing human herpesvirus (HHV) infection by covalently inactivating the HHV maturational protease via a conserved, non-catalytic cysteine (C161). Using human cytomegalovirus protease (HCMV Pr) as a model, we screened a library of disulfides to identify mols. that tether to C161 and inhibit proteolysis, then elaborated hits into irreversible HCMV Pr inhibitors that exhibit broad-spectrum inhibition of other HHV Pr homologs. We further developed an optimized tool compound targeted toward HCMV Pr and used an integrative structural biol. and biochem. approach to demonstrate inhibitor stabilization of HCMV Pr homodimerization, exploiting a conformational equilibrium to block proteolysis. Irreversible HCMV Pr inhibition disrupts HCMV infectivity in cells, providing proof of principle for targeting proteolysis via a non-catalytic cysteine to manage viral infection.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Name: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts