Tag: M.W=100-150

Wang, Wenzhi published the artcileMethoxypolyethylene Glycol-Substituted Zinc Phthalocyanines for Multiple Tumor-Selective Fluorescence Imaging and Photodynamic Therapy, Computed Properties of 91-15-6, the main research area is photodynamic therapy fluorescence imaging pharmacokinetics.

Highly tumor-tissue-selective drugs are a prerequisite for accurate diagnosis and efficient photodynamic therapy (PDT) of tumors, but the currently used fluorescent dyes and photosensitizers generally lack the ability for high accumulation and precise localization in tumor tissues. Here we report that monomethoxy polyethylene glycol (MPEG)-modified zinc phthalocyanine (ZnPc) can be selectively accumulated in multiple tumor tissues, and that the selectivity is controlled by the chain length of MPEG. MPEG-monosubstituted ZnPcs with different chain lengths were synthesized, among which the shorter chain (mw < 2k)-modified ZnPc did not show tumor tissue selectivity, while MPEG2k-5k-substituted ZnPc could be rapidly and selectively accumulated in H22 tumor tissues in mice after i.v. injection. Especially, MPEG4k-Pc showed the best tumor tissue selectivity with a tumor/liver (T/L) ratio of 1.7-2.2 in HepG2, MDA-MB231, AGS, and HT-29 tumor-bearing mice. It also exhibited potent photodynamic therapy effects after one PDT treatment, and tumor growth was significantly inhibited in H22-bearing mice with an inhibition rate over 98% and no obvious toxicity. Consequently, MPEG-modified ZnPc could serve as a potential platform for selective fluorescence imaging and photodynamic therapy of multiple tumors. Biomacromolecules published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ishikawa, Yuta published the artcileRed-light-activatable ruthenium phthalocyanine catalysts, Name: Phthalonitrile, the main research area is ruthenium phthalocyanine red light activatable catalyst.

Phthalocyanine ruthenium complexes were identified as red-light activatable catalysts for trifluoromethylation reactions. The red-light mediated chlorotrifluoromethylation of alkenes could proceed without any sacrificial reducing reagents. This reaction exhibited good compatibility with a blue-light-absorbing substrate, while under irradation with blue light, i.e., under traditional photoreaction conditions, this substrate decomposed completely.

Chemical Communications (Cambridge, United Kingdom) published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rocker, Johannes published the artcileAlternatives to Iridium: A Polyaza[7]helicene as a Strongly Reductive Visible Light Photoredox Catalyst, Name: Picolinonitrile, the main research area is poly azahelicene photo redox catalyst.

The use of a readily accessible polyazahelicene as a strongly reducing metal-free alternative to the commonly used precious metal based photo redox catalysts is demonstrated. An improved two-step synthesis of the catalyst is described, and its photophys. properties with respect to its use as a photo redox catalyst are evaluated. Its activity under visible light irradiation is proven by application in two double radical light-driven multi-component reactions. The azahelicene gave comparable results to an iridium-based catalyst originally used for the same transformations.

ACS Organic & Inorganic Au published new progress about Absorption. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bayrak, Nilufer published the artcileStructure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinolinequinone LY analog antichronic myelogenous leukemia activity; Aminoquinone; Apoptosis; Chronic myelogenous leukemia (CML); DNA-Cleavage; LY83583; Quinolinequinones; Structure-activity relationship (SAR).

Quinone-based small mols. are the promising structures for antiproliferative drug design and can induce apoptosis in cancer cells. Among them, one of the quinolinequinones, named as 6-anilino-5,8-quinolinequinone, LY83583 has the ability to inhibit the growth of cancer cells as an inhibitor of cyclase. The biol. potential of all synthesized compounds as the analogs of the identified lead mol. LY83583 that possessed the antiproliferative efficiency was determined The two series of the LY83583 analogs containing electron-withdrawing or electron-donating group(s) were synthesized and subsequently in vitro evaluated for their cytotoxic activity against K562, Jurkat, MT-2, and HeLa cell lines using MTT assay. All the LY83583 analogs showed antiproliferative activity with good IC50 values (less than pos. control imatinib). Four analogs from each series were also selected for the determination of selectivity against human peripheral blood mononuclear cells (PBMCs). The analog AQQ15 showed high potency towards all cancer cell lines with almost similar selectivity of imatinib. In order to get a better insight into cytotoxic effects of the analog AQQ15 in K562 cells, further apoptotic effects due to annexin V/ethidium homodimer III staining, ABL1 kinase inhibition, and DNA cleaving ability were examined The analog AQQ15 induced apoptotic cell death in K562 cells with 34.6% compared to imatinib (6.5%). This analog showed no considerable ABL1 kinase inhibitory activity but significant DNA cleavage activity indicating DNA fragmentation-induced apoptosis. Besides, mol. docking studies revealed that the analog AQQ15 established proper interactions with the deoxyribose sugar attached with the nucleobases adenine and guanidine resp., in the minor groove of the double helix of DNA. In silico predicted pharmacokinetic parameters of this analog were found to comply with the standard range making it an efficient anticancer drug candidate for further research.

Chemico-Biological Interactions published new progress about Absorption. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Abdelhameed, Reda M. published the artcileBoosting the photocatalytic activity of Ti-MOF via emerging with metal phthalocyanine to degrade hazard textile pigments, Safety of Phthalonitrile, the main research area is metal phthalocyanine titanium photocatalytic activity textile pigment.

Metal-organic frameworks (MOFs) have shown a great potential for producing efficient and eco-friendly photocatalysts. Furthermore, phthalocyanines (PCs) are promising materials in photocatalytic reactions because of their unique adsorption and photosensitizing properties. Here, three phthalocyanines (Pcs) derivatives with Al3+ and Co2+ ions as the central metal were prepared to attach them to the MOFs matrix. The photocatalytic decay performance of methylene blue (MB) and methyl orange (MO) and their mixtures were investigated under visible light illumination. The photocatalyst NH2-MIL-125, Al-PcCl@NH2-MIL-125, CoPc@NH2-MIL-125, and CoPcPA@NH2-MIL-125 show 0.01, 0.012, 0.035, and 0.046 min-1 MB degradation rate, resp., while, the degradation rates of MO were 0.021, 0.027, 0.052 and 0.082, resp. Amazingly, the degradation rates of MB in presence of MO showed boosted photocatalytic decomposition with the degradation rate of 0.066, 0.069, 0.085, and 0.120 min-1, resp. This study illustrates a high performance for utilizing porous MOF-based materials not only as supports but as electron acceptors that enhance both photostability and photocatalytic activity.

Journal of Alloys and Compounds published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gounden, Denisha published the artcileMetallophthalocyanines in a ternary photoactive layer (P3HT:MPc:PC70BM) for bulk heterojunction solar cells, Synthetic Route of 91-15-6, the main research area is metallophthalocyanine PHT PCBM bulk heterojunction solar cell.

Novel bulk heterojunction (BHJ) organic photovoltaic (OPV) solar cells have been fabricated by introducing a series of metallophthalocyanines (MPcs) into a blend of a poly(3-hexylthiophene-2,5-diyl) (P3HT) and [6,6]-Ph C70 butyric acid Me ester (PC70BM) photoactive layer. Sixteen MPcs have been synthesized with due consideration of the metal type and valency, functionalised ligand moieties and their resp. mol. energy levels. The MPcs were expected to act as an electron cascade material that improves the photovoltaic performance in a two-fold manner: first, to provide an efficient energy level offset between the polymeric donor (P3HT) and the fullerene-based derivative acceptor (PC70BM) to enhance charge transfer and reduce recombination within the OPV solar cells, and second, to harvest a greater portion of the solar spectrum as MPcs are associated with absorption near the near-IR region. BHJ OSCs were fabricated in the following inverted configuration: ITO/TiO2/P3HT:MPc:PC70BM/WO3/Ag and were investigated for their optimum photovoltaic performance. The BHJ OSCs comprising P3HT, PC70BM and the manganese MPc (MnPc) series photoactive layer displayed the best PCEs in the range of 2.36-2.62% which were approx. 47.5-63.7% higher than those of the binary reference BHJ OSCs.

Materials Advances published new progress about Absorption. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

O’Neill, Matthew F. published the artcileSustainable Synthesis of Dimethyl- and Diethyl Carbonate from CO2 in Batch and Continuous Flow-Lessons from Thermodynamics and the Importance of Catalyst Stability, SDS of cas: 100-70-9, the main research area is sustainable dimethyl diethyl carbonate CO2 batch lesson thermodn catalyst.

Equilibrium conversions for the direct condensation of MeOH and EtOH with CO2 to give dimethyl- and di-Et carbonate, resp., have been calculated over a range of exptl. relevant conditions. The validity of these calculations has been verified in both batch and continuous flow experiments over a heterogeneous CeO2 catalyst. Operating under optimized conditions of 140°C and 200 bar CO2, record productivities of 235 mmol/L·h DMC and 241 mmol/L·h DEC have been achieved using neat alc. dissolved in a continuous flow of supercritical CO2. Using our thermodn. model, we show that to achieve maximum product yield, both dialkyl carbonates and water should be continuously removed from the reactor instead of the conventionally used strategy of removing water alone, which is much less efficient. Catalyst stability rather than activity emerges as the prime limiting factor and should thus become the focus of future catalyst development.

ACS Sustainable Chemistry & Engineering published new progress about Drying agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saiful, Islam published the artcileLigand Rotation Induced Oxidation State Change and Spin Appearance of the Bis(phthalocyaninato)cerium (CePc2) Molecule on the Au(111) Surface, Quality Control of 91-15-6, the main research area is phthalocyaninatocerium gold surface structure mol rotation.

We demonstrate that a nonmagnetic mol. is changed into magnetic when its internal structure is rotated by forming an ordered film on a metal surface. We used a double-decker complex, bis(phthalocyaninato)cerium (CePc2), where the valence of the Ce atom changes between +3 and +4 with a small energy barrier. CePc2 is nonmagnetic in bulk and becomes magnetic in the monolayer film on Au(111). The intra-mol. structure and the magnetic property are revealed using scanning tunneling microscopy/spectroscopy. We attribute the mechanism to a change of the rotational angle (θ) between the upper and lower Pc ligands, driven by the steric repulsive force originating from forming an almost square lattice on Au(111). The θ changes from θ = 45° of the bulk value into θ = 0° for the film. GGA + U calculation indicates that the change from θ = 45° to θ = 0° causes the Ce valence change from the nonmagnetic +4 state into the magnetic +3 state.

Journal of Physical Chemistry C published new progress about Force, steric. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Xinye published the artcileStudies on the isomeric effect of nitrile functionality on the polymerization and thermal properties of ortho-norbornene-based benzoxazine resins, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is nitrile norbornene benzoxazine resin polymerization isomeric effect thermal property.

Three norbornene-functional mono-benzoxazines with attached nitrile group at the para-, meta-, and ortho-position with respect to the nitrogen atom in the oxazine ring, resp., have been synthesized to investigate the isomeric effect of nitrile group on the polymerization and thermal properties of resulting polybenzoxazines. The chem. structures of newly obtained benzoxazine monomers are investigated by 1H and 13C NMR spectroscopy and FT-IR spectroscopy. Besides, the polymerization behaviors including oxazine ring, nitrile group as well as norbornene functionality in each benzoxazine are studied by differential scanning calorimetry (DSC) and in situ FT-IR. In addition, the thermal properties of corresponding polybenzoxazines are investigated by TGA. The nitrile group at ortho-position in benzoxazine has been found to be easier activated to polymerize compared with other two isomers. Moreover, the resulting polybenzoxazine derived from ortho-nitrile containing benzoxazine also shows the best thermal stability with a Td5 of 371°C, and a char yield of 56%.

Journal of Polymer Research published new progress about Melting point. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, He-Ye published the artcileA Calix[3]acridan-Based Host-Guest Cocrystal Exhibiting Efficient Thermally Activated Delayed Fluorescence, Application of Phthalonitrile, the main research area is thermally activated delayed fluorescence; Charge Transfer; Cocrystal; Host-Guest Interactions; Macrocycles; Thermally Activated Delayed Fluorescence.

A supramol. strategy to construct thermally activated delayed fluorescence (TADF) materials through host-guest charge transfer interactions was proposed. Consequently, a new class of macrocycle namely calix[3]acridan was conveniently synthesized in 90% yield. The host-guest cocrystal formed by calix[3]acridan and 1,2-dicyanobenzene exhibited efficient TADF properties due to intense intermol. charge transfer interactions. Moreover, the spatially separated HOMO and LUMO resulted in a very small singlet-triplet energy gap of 0.014 eV and hence guaranteed an efficient reverse intersystem crossing for TADF. Especially, a high photoluminescence quantum yield of 70% was achieved, and it represents the highest value among the reported intermol. donor-acceptor TADF materials.

Angewandte Chemie, International Edition published new progress about Absorptivity. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts