Tag: M.W=100-150

Acharyya, Shankha S. published the artcileUnprecedented Catalysis of Cs+ Single Sites Confined in Y Zeolite Pores for Selective Csp3-H Bond Ammoxidation: Transformation of Inactive Cs+ Ions with a Noble Gas Electronic Structure to Active Cs+ Single Sites, Quality Control of 91-15-6, the main research area is Catalysis Cs Single Sites Confined Y Zeolite Pores; ammoxidation toluene benzonitrile with O2 NH3 DFT.

We report the transformation of Cs+ ions with an inactive noble gas electronic structure to active Cs+ single sites chem. confined in Y zeolite pores (Cs+/Y), which provides an unprecedented catalysis for oxidative cyanation (ammoxidation) of Csp3-H bonds with O2 and NH3, although in general, alkali and alk. earth metal ions without a moderate redox property cannot activate Csp3-H bonds. The Cs+/Y catalyst was proved to be highly efficient in the synthesis of aromatic nitriles with yields >90% in the selective ammoxidation of toluene and its derivatives as test reactions. The mechanisms for the genesis of active Cs+ single sites and the ammoxidation pathway of Csp3-H bonds were rationalized by d. functional theory (DFT) simulations. The chem. confinement of large-sized Cs+ ions with the pore architecture of a Y zeolite supercage rendered the HOMO (HOMO)-LUMO (LUMO) gap reduction, HOMO component change, and preferable coordination arrangement for the selective reaction promotion, which provides a trimol. assembly platform to enable the coordination-promoted concerted ammoxidation pathway working closely on each Cs+ single site. The new reaction pathway without involvement of O2-dissociated O atom and lattice oxygen differs from the traditional redox catalysis mechanisms for the selective ammoxidation

ACS Catalysis published new progress about Ammoxidation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Kai-Jin published the artcileSynthesis, characterization and crystal structure of 2-pyridinecarboxamide, Recommanded Product: Picolinonitrile, the main research area is pyridinecarboxamide preparation crystal mol structure.

The 2-pyridinecarboxamide was synthesized from 2-picoline through two-steps reaction. Initially, 2-picoline was converted into 2-cyanopyridine by ammoxidation in a stainless-steel fixed-bed reactor at 370°C with V2O5 loaded on TiO2 as catalyst. The 2-cyanopyridine was transformed into 2-pyridinecarboxamide through oxidation hydrolysis in basic solution using MnO2 as oxidant at 70°C. The crystal structure of 2-pyridinecarboxamide was investigated using X-ray diffraction and SHELX 2018/3 (sh) software and the result indicated that 2-pyridinecarboxamide crystallized in the monoclinic system, space group P21/n with a = 5.207(2), b = 7.097(3), c = 16.243(6) Å, V = 595.7 (4) Å3; Z = 4.

Asian Journal of Chemistry published new progress about Ammoxidation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Khan, Jallat published the artcileInsight into the phytochemical composition, biological activities and docking studies of Moringa oleifera Lam. to authenticate its use in biopharmaceutical industries, SDS of cas: 100-70-9, the main research area is Moringa extract phytochem composition biochem activity biopharmaceutical industry.

Moringa oleifera Lam. is a fast-growing deciduous tree native to the subcontinent with a wide array of uses. It is used as food plant by human and animals. Since it contains beneficial higher calcium, vitamin A, vitamin C, protein, potassium and iron contents, it is also used to treat malnutrition in children. The present study is conducted for comprehensive phytochem. profiling via total bioactive contents and ultra-high performance liquid chromatog. (UHPLC-MS) analyses, and biol. profiling by determining the antioxidant potential via DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid), FRAP (ferric reducing antioxidant power), CUPRAC (cupric reducing antioxidant power), phosphomolybdenum and metal chelation assays. In addition, α-amylase, α-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase inhibition assays were also performed. Multivariate statistical anal. was used to investigate the relationship between biol. activities and total bioactive content of the extracts Chem. profiling showed that total phenolic contents are present in highest concentrations in Et acetate extracts of the aerial parts and seed. Further total bioactive contents were correlated with their optimum anti-oxidant capacities for ABTS, FRAP and CUPRAC. Altogether 67 phytochems. were identified from aerial parts of the plant and its seed with major classes as phenolics, flavonoids, sesquiterpenoids and alkaloids. The Et acetate extract of seed showed good inhibition of AChE (2.77 mg GALAE/g extract) and BChE (8.05 mg GALAE/g extract) followed by the inhibition potential of water extract as 8.34 mg GALAE/g extract The Et acetate extract also showed most significant (61.93 mg-KAE/g) tyrosinase inhibitory activity. The hexane extract of seed showed good inhibition of α-glucosidase (6.32 mmol ACAE/g extract) and α-amylase (0.47 mmol ACAE/g extract). In silico docking studies were performed, where two herbimycin and prekinamycin showed good binding affinity with all the enzymes. It can be concluded that the presence of complex phytochems. with multi-functional potential distinguishes Moringa oleifera Lam. as a promising source of health-promoting component and recommended its use in biopharmaceutical industries.

Industrial Crops and Products published new progress about Antioxidants. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiao, Hang published the artcileA High-Mechanical-Strength Carbon/Graphene Porous Composite with Improved EMI Shielding Derived from High Nitrogen-Containing Bio-based Adenine-Containing Phthalonitrile Resin, COA of Formula: C8H4N2, the main research area is carbon graphene porous composite EMI shielding mech property.

Abstract: Nitrogen-doped porous graphene/adenine-containing phthalonitrile (graphene/ADCN) carbon composites with excellent mech. properties and electromagnetic interference (EMI) shielding performance were prepared by the high-energy ball milling molding-sintering method. The structure, morphol., elec. conductivity, dielec. properties, EMI shielding performance, and mech. properties were characterized. The results show that the introduction of the dipole effect can confer improved elec. conductivity and EMI shielding properties to graphene/ADCN carbon composites. The porous structure increases the multiple reflections and improves the EMI performance. As a mech. reinforcement phase, graphene was introduced to maintain the porous structure and improve the mech. properties. The EMI performance of graphene/ADCN carbon composites reached 47dB (7.5wt.% graphene) with only 0.94 mm thickness. Meanwhile, the maximum bending stress reached 292 MPa, and the maximum compressive stress reached 143 MPa. Graphical Abstract: [graphic not available: see fulltext].

Journal of Electronic Materials published new progress about Ball milling. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, COA of Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tejerina, Lara published the artcileOne-Pot Synthesis of π-Extended Fluorenone-Fused Subphthalocyanines, Category: nitriles-buliding-blocks, the main research area is fluorenone fused Subphthalocyanine.

A family of inherently chiral nonplanar aromatic chromophores, comprising Subphthalocyanines bearing fluorenone-fused units (SubFcs), were prepared by an innovative one-pot synthesis, which relies on the standard cross-cyclotrimerization of phthalonitriles followed by intramol. Friedel-Crafts acylation. Their Q-band absorption experiences a ca. 20 nm red shift per fused fluorenone as a consequence of the enlarged conjugated π-system.

Organic Letters published new progress about Chromophores. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Limin published the artcileGroup IIA alkaline-earth metal phthalocyanines: Synthesis, photoluminescence and singlet oxygen formation, Computed Properties of 91-15-6, the main research area is metallophthalocyanine fluorescence lifetime singlet oxygen formation.

We have synthesized Group IIA alk.-earth metal phthalocyanine (PC) complexes (BePC, MgPC, CaPC, SrPC, BaPC) using four different methods to study their photoluminescence and singlet oxygen photosensitizing properties. Their UV-Vis electronic absorption, fluorescence emission and excitation spectra, fluorescence quantum yields and lifetimes, as well as singlet oxygen formation quantum yields have been measured. The results reveal that alkali-earth metal PCs (BePC, MgPC, CaPC, SrPC, and BaPC) have high fluorescence quantum yields (0.50 to 0.70) and long fluorescence lifetimes (7.1 to 7.9 ns). SrPC, and BaPC also show high quantum yield of singlet oxygen formation (0.40 to 0.50). Therefore, alk.-earth metal phthalocyanines are appealing fluorescent sensors and singlet oxygen photosensitizers for photodynamic therapy of tumors.

Journal of Molecular Structure published new progress about Fluorescence. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Makkad, Sarabjot Kaur published the artcileAmine decorated polystyrene nanobeads incorporating π-conjugated OPV chromophore for picric acid sensing in water, Application of Phthalonitrile, the main research area is amine polystyrene phenylenevinylene nanobead picric acid sensor.

A solution as well as solid state based sensor has been developed for selective detection of picric acid (PA) in water. Oligo (p-phenylenevinylene) (OPV) incorporated polystyrene nanobeads (PS-OPV-NH2) having an average size of 180 nm have been synthesized through miniemulsion polymerization Amine (-NH2) functionalization was performed on the nanobead surface to enhance the efficiency of the sensor among a library of other nitro-organics and library of cations and anions.

RSC Advances published new progress about Fluorescence. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Koptyaev, A. I. published the artcileLanthanide Double-Decker Complexes with Tetra-tert-butyltetrabenzoporphyrin and Phthalocyanine Ligands. Synthesis and Properties, Recommanded Product: Phthalonitrile, the main research area is lanthanide lutetium erbium dysprosium gadolinium europium tetrabenzoporphyrin phthalocyanine preparation; uv vis luminescence lanthanide double decker complex tetrabenzoporphyrin phthalocyanine.

Mixed-ligand double-decker lutetium, erbium, dysprosium, gadolinium, and europium complexes with tetra-tert-butyltetrabenzoporphyrin and phthalocyanine have been synthesized, and their structure was confirmed by IR, 1H NMR, and mass spectra. Relations have been found between the electronic absorption and luminescence spectra of the complexes and radius of the central metal ion.

Russian Journal of Organic Chemistry published new progress about Fluorescence. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bhardwaj, Vijay Kumar published the artcileComputer simulation to identify selective inhibitor for human phosphodiesterase10A, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is phosphodiesterase computer simulation mol docking.

Phosphodiesterases (PDEs) play an important function in transduction of cellular signals by modulating the activation of G-proteins by hydrolyzing cAMP and cGMP. PDE10A has emerged as an inhibitory target for development of effective therapeutics against various disorders such as schizophrenia, psychosis, Huntington disease, and other disorders related to the central nervous system. We utilized various computational methods such as mol. docking, mol. dynamic simulations, and MM-PBSA to find a more potent and selective PDE10A inhibitor compared to papaverine, which is a known standard inhibitor of PDE10A. Mol. docking of papaverine and twenty-eight in house synthesized 3-Methylenisoindolin-1-one based mols. provided two potential lead mols. (mol. #3 and mol. #28), which could be developed as potent PDE10A inhibitors. However, mol. #28 was excluded from further studies due to its cross reactivity with other PDE isoforms. Mol. dynamics and MM-PBSA techniques were used to further analyze the mol. docking results. Mol. #3 binds to the conserved substrate recognizing residue (Gln726) and also fits into the selectivity pocket by anchoring to the hydrophobic residue Tyr693. This study provides a promising candidate mol. that could be developed as a more potent and selective inhibitor of PDE10A.

Journal of Molecular Liquids published new progress about Homo sapiens. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Iwaki, Yuzo published the artcileTowards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249, Formula: C7H6N2, the main research area is TREK1 TREK2 potassium ion channel activator; Activator; K(2P) channel; Potassium ion channel; TREK-1; TREK-2.

This letter describes a focused, multi-dimensional optimization campaign around BL-1249, a fenamate class non-steroidal anti-inflammatory and a known activator of the K2P potassium channels TREK-1 (K2P2.1) and TREK-2 (K2P10.1). While BL-1249 has been widely profiled in vitro as a dual TREK-1/2 activator, poor physicochem. and DMPK properties have precluded a deeper understanding of the therapeutic potential of these key K2P channels across a broad spectrum of peripheral and central human disease. Here, we report multi-dimensional SAR that led to a novel TREK-1/2 dual activator chemotype, exemplified by ONO-2960632/VU6011992, with improved DMPK properties, representing a new lead for further optimization towards robust in vivo tool compounds

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts