Tag: M.W=100-150

Aghapoor, Kioumars published the artcileCrystalline salicylic acid as an efficient catalyst for ultrafast Paal-Knorr pyrrole synthesis under microwave induction, Computed Properties of 1885-29-6, the main research area is pyrrole preparation green; primary amine hexanedione Paal Knorr cyclocondensation crystalline salicylic acid.

In this study, the viability of a wide range of crystalline aromatic and aliphatic carboxylic acids as organocatalysts has been investigated for solvent-free Paal-Knorr pyrrole synthesis under microwave activation. Among these potential catalysts, crystalline salicylic acid proved to be a remarkable catalyst because its efficiency remained high even under low microwave power irradiation or a shorter reaction time for the model reaction. The outstanding catalytic activity of salicylic acid allowed the Paal-Knorr cyclocondensation with a turnover frequency up to 1472 h-1 which is unique in the context of a metal-free homogeneous catalysis. The attractive feature of this organocatalyst is its assistance in ultrafast pyrrole synthesis with no risk of metal contamination.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Green chemistry. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moeini, Nazanin published the artcileSelective oxidation of sulfides and synthesis of 5-substituted 1H-tetrazoles on Ce (III) immobilized CoFe2O4 as a magnetically separable, highly active, and reusable nanocatalyst, COA of Formula: C8H4N2, the main research area is cobalt iron oxide nanocatalyst cerium immobilized amino glycol preparation; tetrazole green preparation; nitrile sodium azide cobalt iron oxide nanocatalyst cerium immobilized; sulfoxide green preparation; sulfide oxidation cobalt iron oxide nanocatalyst cerium immobilized.

Reactions of CoFe2O4 magnetic nanoparticles supported ligands, 2-amino-2-methyl-1,3-propanediol (Amino glycol), with cerium salts provided the resp. anchored complex CoFe2O4 @Amino glycol/Ce. The nanocatalyst was characterized perfectly using thermogravimetric analyzes, FT-IR spectroscopy, SEM, energy-dispersive X-ray inductively coupled plasma optical emission spectroscopy vibrational sample magnetometry and powder X-ray diffraction. CoFe2O4 magnetic nanoparticles supported ligands with cerium salts afforded active catalysts for the synthesis of 5-substituted 1H-tetrazoles I [R = Ph, 2-ClC6H4, Bn, etc.] via reaction of nitriles and sodium azide/oxidation of sulfides RSR1 [R = Ph, n-Pr, Et, etc.; R1 = Me, Bn, Ph, etc.] using Me Ph sulfide with H2O2 as oxidant at mild reaction conditions in the green medium under optimized conditions. The ligand and metal atom identity influenced the catalytic activity of the nanocatalyst. The immobilized complexes were easily collected via an external magnetic field and further reused at least 6 times without significant loss of catalytic activity and selectivity.

Research on Chemical Intermediates published new progress about Green chemistry. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, COA of Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Borjian Boroujeni, Mahmoud published the artcileA Novel and Green In Situ Strategy for the Synthesis of Metallophthalocyanines on Chitosan and Investigation Their Catalytic Activity in the CO2 Fixation, Computed Properties of 91-15-6, the main research area is green metallophthalocyanine chitosan catalyst cyclic carbonate.

Abstract: In this work, a novel and green strategy for the in situ synthesis of metallophthalocyanines on chitosan (MPcs@CS; M=Cu, Ni, Co) in deep eutectic solvents (DESs) at 120 °C has been reported. The chem. and structural properties of the MPcs@CS were determined by SEM (SEM), energy-dispersive X-ray(EDS), X-ray powder diffraction (XRD), Fourier transformation IR spectroscopy(FT-IR), thermogravimetric anal.(TGA) and flame at. absorption spectroscopies(FAAS). This new MPcs@CS is a highly efficient, active and reusable catalyst for the synthesis of cyclic carbonates from promoting the reaction of CO2 with epoxides under mild reaction conditions (at 80 °C and 1 atm CO2 pressure) with good to excellent yield of products. The order of catalytic activity is CuPc@CS, CoPc@CS and NiPc@CS from the conversion, temperature and time point of view, resp.

Catalysis Letters published new progress about Green chemistry. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Darwish, Wael M. published the artcileTargeted photoimmunotherapy based on photosensitizer-antibody conjugates for multiple myeloma treatment, HPLC of Formula: 91-15-6, the main research area is multiple myeloma treatment photosensitizer antibody photoimmunotherapy; Antibody; Myeloma; Photoimmunotherapy; Phthalocyanine polymers; Radioimmunotherapy.

Despite the high in vitro efficacy of photodynamic therapeutics, lack of tumor targeting significantly reduces their in vivo efficacy and thus limits their clin. use. Photoimmunotherapy (PIT) is a new synthetic strategy to target and treat cancer by photodynamic therapy (PDT). In this study, we describe design and synthesis of a third-generation photosensitizer comprising a PEGylated-phthalocyanine star-polymer photosensitizer that covalently bound to a myeloma tumor-selective antibody (MAb) via the carbodiimide chem. The free photosensitizer demonstrated a min. dark toxicity when tested in mammalian myeloma cell line (SP2/OR); and a moderate phototoxicity after irradiation with non thermal laser red light as a result of light-induced production of cytotoxic singlet oxygen species. Covalent attachment of the photosensitizer (Pc) to the MAb resulted in a significantly enhanced phototoxicity. This is mainly ascribed to the fact that internalization enhances phototoxicity of Pc-MAb bioconjugates. The radioactivated photoimmuno-conjugates 131I(PcMAb) demonstrated the highest phototoxicity to myeloma cells. The suggested bioconjugates are promising candidates as multiple therapeutic models for in vivo treatment of myeloma.

Journal of Photochemistry and Photobiology, B: Biology published new progress about Laser radiation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Malik, Nadeem A. published the artcileTurbulent particle pair diffusion: Numerical simulations, Quality Control of 100-70-9, the main research area is turbulent particle pair diffusion coefficient Kolmogorov turbulence numerical simulation.

A theory for turbulent particle pair diffusion in the inertial subrange [Malik NA, PLoS ONE 13(10):e0202940 (2018)] is investigated numerically using a Lagrangian diffusion model, Kinematic Simulations [Kraichnan RH, Phys. Fluids 13:22 (1970); Malik NA, PLoS ONE 12(12):e0189917 (2017)]. All predictions of the theory are observed in flow fields with generalised energy spectra of the type, E(k) ∼ k-p. Most importantly, two non-Richardson regimes are observed: for short inertial subrange of size 102 the simulations yield quasi-local regimes for the pair diffusion coefficient, K(l)∼σl(1+p)/2; and for asymptotically infinite inertial subrange the simulations yield non-local regimes K(l)∼σlγ, with γ intermediate between the purely local scaling γnl = (1 + p)/2 and the purely non-local scaling γnl = 2. For intermittent turbulence spectra, E(k) ∼ k-1.72, the simulations yield K∼σl1.556, in agreement with the revised 1926 dataset K∼σl1.564 [Richardson LF, Proc.Roy.Soc.Lond.A 100:709 (1926); Malik NA, PLoS ONE 13(10):e0202940 (2018)]. These results lend support to the phys. picture proposed in the new theory that turbulent diffusion in the inertial subrange is governed by both local and non-local diffusion transport processes.

PLoS One published new progress about Reynolds number. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mao, Qing published the artcileDesign, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors, Safety of 4-Hydroxyisophthalonitrile, the main research area is alkoxycyanophenyl oxodihydropyrimidine carboxylic acid preparation xanthine oxidase inhibitor SAR; acute toxicity docking hypouricemic alkoxycyanophenyl oxodihydropyrimidine carboxylic acid preparation; 1,6-Dihydropyrimidine-5-carboxylic acid; Biological evaluation; Synthesis; Xanthine oxidase inhibitor.

A series of 2-(4-alkoxy-3-cyano)phenyl-1,6-dihydropyrimidine-5-carboxylic acid derivatives I [R = O, NH; R1 = i-Pr, allyl, Bn, etc.; R2 = H, Me] was synthesized as novel xanthine oxidase (XO) inhibitors. These compounds exhibited remarkable in vitro XO inhibitory potency with IC50 values ranging from 0.0181 μM to 0.5677 μM. Specifically, compounds I [R = NH; R1 = (CH2)2CH(CH3)2, 2-methylallyl], with IC50 values of 0.0240 μM and 0.0181 μM, resp., emerged as the most potent XO inhibitors and their potencies were comparable to that of febuxostat. Structure-activity relationship anal. revealed that the Me group at 4-position of pyrimidine ring could damage the potency and the XO inhibitory potency was maintained when carbonyl group was changed to an imino group. Lineweaver-Burk plot anal. revealed that the representative compound I [R = NH; R1 = (CH2)2CH(CH3)2] acted as a mixed-type inhibitor. A potassium oxonate induced hyperuricemia model in rats was chosen to further confirm the hypouricemic effect of compound I [R = NH; R1 = (CH2)2CH(CH3)2] and the results showed that compound I [R = NH; R1 = (CH2)2CH(CH3)2] (5 mg/kg) was able to significantly lower the serum uric acid level. Furthermore, in acute oral toxicity study, no sign of toxicity was observed when the mice were administered with a single 2000 mg/kg oral dose of compound I [R = NH; R1 = (CH2)2CH(CH3)2]. These results suggested that compound I [R = NH; R1 = (CH2)2CH(CH3)2] was a potent and promising uric acid-lowing agent for the treatment of hyperuricemia.

European Journal of Medicinal Chemistry published new progress about Acute toxicity. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Safety of 4-Hydroxyisophthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Matlou, Gauta Gold published the artcileEvaluation of the photosensitizing properties of zinc and indium tetra cinnamic acid phthalocyanines linked to magnetic nanoparticles on human breast adenocarcinoma cells, Recommanded Product: Phthalonitrile, the main research area is zinc indium cinnamic acid phthalocyanine magnetic nanoparticle; nanoparticle human breast adenocarcinoma cell photosensitizing property.

This work reports on the synthesis, photophysico-chem. properties and photodynamic therapy activity of novel zinc (1) and indium (2) tetra substituted cinnamic acid phthalocyanine (Pc) complexes linked to amino functionalized magnetic nanoparticles (AMNPs) through an amide bond. Asym. ZnPc complex (3) showed better triplet and singlet oxygen quantum yields as compared to its sym. analogs (1 and 2). The AMNPs (1-AMNPs and 2-AMNPs) linked conjugates depicted increased triplet quantum yields in comparison to their unlinked Pcs, while 3-AMNPs showed a decrease compared to 3. The complexes showed increased in-vitro photo-cytotoxic effect against MCF-7 cells with an increase in drug concentration At 80 μg/mL, 2 and 3, 2-AMNPs and 3-AMNPs with higher singlet oxygen quantum yields caused more cytotoxic effect on the cancer cells in the presence of light as compared to 1 and 1-AMNPs resp.

Journal of Luminescence published new progress about Adenocarcinoma. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Elsom, L. F. published the artcilePyrrole studies. XIV. Spectroscopic characteristics of cyanopyrroles, COA of Formula: C7H8N2, the publication is Journal of the Chemical Society [Section] B: Physical Organic (1970), 79-81, database is CAplus.

Data for pyrroles containing Me and CN groups show that the NH stretching frequency may be represented by the equation: νNH(cm-1) = 3496 – 9nαMe + 2nβMe – 22nαCN – 12nβCN, where nα and nβ are the number of substituents in the α- and β-positions resp. The electronic spectra indicate that in the excited state the resonance stabilization by the α-CN group is greater than that of the β-CN group to the extent of about 10.5 kcal/mole.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about 26187-28-0. 26187-28-0 belongs to nitriles-buliding-blocks, auxiliary class Pyrrole,Nitrile, name is 2,4-Dimethyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C7H8N2, COA of Formula: C7H8N2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Melent’eva, T. A. published the artcilePolarographic reduction of hydrobromides of dipyrrylmethenes, Related Products of nitriles-buliding-blocks, the publication is Zhurnal Obshchei Khimii (1972), 42(10), 2274-9, database is CAplus.

In I (R = Me, Et, CO2Et, NO2, CN, Ac, CH2CO2H), prepared by heating 2-formyl-3-acetyl-4-methyl-5-carbethoxypyrrole and pyrroles unsubstituted in the 2-position in the presence of HBr, the polarog. curves show a linear relation between halfwave potentials and the substituent constants The transmission of the substituent effect in the β-position with respect to dipyrrolylmethene chromophore occurs mainly through resonance. MeCOCH2CO2Et in AcOH, treated with aqueous NaNO2 and AcOH, followed by Zn dust and Et levulinate, gave 10% 2,4-dimethyl-3-carbethoxymethyl-5-carbethoxypyrrole, which with aqueous alc. NaOH gave the free dicarboxylic acid. The latter was heated with ethanolamine at 150° to give 2,4-dimethyl-3-carboxymethylpyrrole in 50% yield.

Zhurnal Obshchei Khimii published new progress about 26187-28-0. 26187-28-0 belongs to nitriles-buliding-blocks, auxiliary class Pyrrole,Nitrile, name is 2,4-Dimethyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C7H8N2, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ieda, Naoya published the artcilePhotomanipulation of Vasodilation with a Blue-Light-Controllable Nitric Oxide Releaser, Computed Properties of 26187-28-0, the publication is Journal of the American Chemical Society (2014), 136(19), 7085-7091, database is CAplus and MEDLINE.

Spatiotemporally controllable nitric oxide (NO)-releasers allow us to analyze the physiol. effects of NO, a gaseous mediator that modulates many biol. signaling networks, and are also candidate chemotherapeutic agents. We designed and synthesized a blue-light-controllable NO releaser, named NOBL-1, which bears an N-nitrosoaminophenol moiety for NO release tethered to a BODIPY dye moiety for harvesting blue light. Photoinduced electron transfer from N-nitrosoaniline to the antenna moiety upon irradiation with relatively noncytotoxic blue light (470-500 nm) should result in NO release with formation of a stable quinone moiety. NO release from NOBL-1 was confirmed by ESR spin trapping and fluorescence detection. Spatially controlled NO release in cells was observed with DAR-4M AM, a fluorogenic NO probe. We also demonstrated temporally controlled vasodilation of rat aorta ex vivo by blue-light-induced NO release from NOBL-1. This compound should be useful for precise examination of the functions of NO with excellent spatiotemporal control.

Journal of the American Chemical Society published new progress about 26187-28-0. 26187-28-0 belongs to nitriles-buliding-blocks, auxiliary class Pyrrole,Nitrile, name is 2,4-Dimethyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C7H8N2, Computed Properties of 26187-28-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts