Tag: M.W=100-150

Rani, Anu published the artcile1H-1,2,3-triazole grafted tacrine-chalcone conjugates as potential cholinesterase inhibitors with the evaluation of their behavioral tests and oxidative stress in mice brain cells, SDS of cas: 1885-29-6, the main research area is triazole grafted tacrine chalcone conjugate cholinesterase inhibitor oxidative stress; 1H-1,2,3-triazole-tacrine-chalcone; Alzheimer’s disease; An Acetylcholinesterase inhibitor; Behavioral models; Butyrylcholinesterase inhibition; Molecular docking; Oxidative stress parameters.

The present paper explicates the synthesis of 1H-1,2,3-triazole tethered tacrine-chalcone conjugates and evaluation of their AChE and BuChE inhibitory activity. In-vitro AChE inhibition assay revealed three compounds, 9h, 9i, and 11f, being more potent than the standard drug tacrine and further evaluated against butyrylcholinesterase. The present study was extended to investigate the anti-amnestic effect of promising compounds on scopolamine-induced behavioral and neurochem. changes in mice. Inclined plane model and Elevated plus-maze model were performed to assess general limb motor activity and anxiety-like behavior, resp., in mice pre-treated with scopolamine. Oxidative stress parameters reduced glutathione contents (GSH) and lipid peroxidation products (TBARS) in the brain homogenates as estimated using ex-vivo studies. Furthermore, mol. docking studies were performed for the potent compounds to decipher the mechanism of observed activities.

Bioorganic Chemistry published new progress about Anxiety. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Strauss, Marie E. published the artcileValence-, Dipole- and Quadropole-Bound Electronically Excited States of Closed-Shell Anions Formed by Deprotonation of Cyano- and Ethynyl-Disubstituted Polycyclic Aromatic Hydrocarbons, Formula: C8H4N2, the main research area is dicyanobenzene naphthalene electronic state astrochem.

Dicyano-functionalized benzene and naphthalene anion derivatives exhibit a relatively rich population of electronically excited states in stark contrast to many assumptions regarding the photophysics of anions in general. The present work has quantum chem. analyzed the potential electronically excited states of closed-shell anions created by replacing hydrogen atoms with valence-bound lone pairs in benzene and naphthalene difunctionalized with combinations of -CN and -C2H. Dicyanobenzene anion derivatives can exhibit dipole-bound excited states as long as the cyano groups are not in para position to one another. This also extends to cyanoethynylbenzene anions as well as deprotonated dicyano- and cyanoethynylnaphthalene anion derivatives Diethynyl functionalization is less consistent. While large dipole moments are created in some cases for deprotonation on the -C2H group itself, the presence of electronically excited states beyond those that are dipole-bound is less consistent. Beyond these general trends, 2-dicyanonaphthalene-34 gives strong indication for exhibiting a quadrupole-bound excited state, and the 1-cyanoethynylnaphthalene-29 and -36 anion derivatives are shown to possess as many as two valence-bound excited states and one dipole-bound excited state. These photophys. properties may have an influence on regions where polycyclic aromatic hydrocarbons are known to exist such as in various astrochem. environments or even in combustion flames.

Chemistry (Basel, Switzerland) published new progress about Anions. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Otlyotov, Arseniy A. published the artcileGas-phase structures of hemiporphyrazine and dicarbahemiporphyrazine: Key role of interactions inside coordination cavity, Quality Control of 91-15-6, the main research area is hemiporphyrazine dicarbahemiporphyrazine moleclular structure electron diffraction hydrogen bond.

The structures of free hemiporphyrazine and dicarbahemiporphyrazine mols. were determined by gas-phase electron diffraction and DFT calculations Distance corrections (re – ra) were calculated using two different approaches: commonly applied Sipachev’s algorithm and a recently developed technique based on mol. dynamics simulations. Both approaches examined against each other for the first time in the refinement of a relatively large (52 atoms) structure were found to result in almost the same final structural parameters. Gas-phase structures of hemiporphyrazine and dicarbahemiporphyrazine are saddle distorted, in contrast to the planar structure previously found for the solid-state hemiporphyrazine. Doubly charged anionic form of hemiporphyrazine was calculated to be significantly saddle distorted, while the anion of dicarbahemiporphyrazine was determined to possess a planar equilibrium structure. Structural features of the mols. and their doubly charged anionic forms are discussed in terms of AIM and NBO analyses.

Journal of Molecular Structure published new progress about Anions. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bouaik, Hassan published the artcileOptimal parameters and structural composition of bio-oil and biochar from intermediate pyrolysis of red algal biomass, Safety of Picolinonitrile, the main research area is bio oil biochar nitrogen carbon biomass pyrolysis.

Intermediate pyrolysis of red algal biomass was performed in a fixed-bed tubular reactor. To study the parametric effect on product distribution, the experiments were carried out at different temperatures ranging from 400 to 600 °C and different heating rates of 15, 30 and 50 °C/min. The objective of this study is to understand the effect of pyrolysis temperature and heating rate on the yields and compositions of the pyrolysis products of red algal biomass. The bio-oil, biochar and biogas yields ranged between 33 and 45 wt%, 29 and 42 wt%, and 18 and 35 wt%, resp., at different pyrolysis conditions. The highest bio-oil yield (45.02%) was obtained at 450 °C temperature at a heating rate of 50 °C/min. The bio-oil was characterized by proximate and ultimate anal., FTIR, 1H-NMR and GC-MS anal. whereas the biochar was characterized by proximate, ultimate, FTIR, SEM and BET. Higher heating value and d. of the bio-oil were 20.11 MJ/kg, 1289 kg/m3, resp. The bio-oil with relatively high fuel potential can be obtained from the pyrolysis of the red algal biomass. The characterization of bio-oil showed a high percentage of aliphatic functional groups and presence of phenolic, ketone- and nitrogen-containing groups. The characterization results showed that the bio-oil obtained from red algal biomass can be potentially valuable as a source of value-added chems. The biochar obtained with a high heating value of 22.89 MJ/kg can be used as an adsorbent as well as a solid fuel.

Comptes Rendus Chimie published new progress about Biogas. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Azim Araghi, Mohammad Esmaeil published the artcileOptical, electrical, and gas sensing properties of chloroaluminium phthalocyanine thin film, Name: Phthalonitrile, the main research area is chloroaluminum phthalocyanine thin film optical elec gas sensing property.

In this research work, the optical, elec., and gas sensing properties of Chloroaluminum Phthalocyanine (ClAlPc) thin film have studied. We fabricated sandwich devices of ClAlPc with aluminum electrodes as Al/ClAlPc/Al, using evaporation deposition method in our Laboratory SEM anal. was carried out to determine the morphol., grains size and thickness of ClAlPc thin film. UV-vis anal. of thin film indicated B and Q absorption bands of ClAlPc, and its optical band gap was then calculated 3.24 eV. The current-voltage characteristic (I-V) of sandwich devices at different temperatures proved the ohmic and SCLC processes in the ClAlPc thin film. By plotting the LnI vs. 1000/T graph, the elec. band gap of ClAlPc was obtained 2.88 eV. In the finally section, the gas sensing behavior of sandwich devices in the presence of CO2 was investigated. To determine the temperature of maximum sensitivity (Tmax), the devices were exposed to CO2 gas over the temperature range 300-450 K at a fixed voltage. We found that Tmax = 360 K.

Optik (Munich, Germany) published new progress about Diodes. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shimoda, Yoko published the artcileSynthesis and Evaluation of Novel Radioligands Based on 3-[5-(Pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 5, Recommanded Product: 3-Amino-5-methoxybenzonitrile, the main research area is pyridinyltetrazolylbenzonitrile radioligand preparation positron emission tomog; benzonitrile metabotropic glutamate receptor subtype 5 binding affinity lipophility.

We found out 3-[5-(pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile analogs as the candidate for positron emission tomog. (PET) imaging agents of metabotropic glutamate receptor subtype 5 (mGluR5). Among these compounds, 3-methyl-5-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile (I, X = CH3) exhibited high binding affinity (Ki = 9.4 nM) and moderate lipophilicity (cLogD, 2.4). Subsequently, I (X = 11CH3) was radiosynthesized at 25 ± 14% radiochem. yield (n = 11) via C-[11C]methylation of the arylstannyl precursor 15 with [11C]methyl iodide. In vitro autoradiog. and PET assessments using I (X = 11CH3) showed high specific binding in the striatum and hippocampus, two brain regions enriched with mGluR5. Moreover, test-retest PET studies with I (X = 11CH3) indicated high reliability to quantify mGluR5 d., such as the intraclass correlation coefficient (0.90) and Pearson r (0.91) in the striatum of rat brain. We demonstrated that I (X = 11CH3) is a useful PET ligand for imaging and quant. anal. of mGluR5. Furthermore, I (X = 11CH3) might be modified using its skeleton as a lead compound

Journal of Medicinal Chemistry published new progress about Brain. 269411-71-4 belongs to class nitriles-buliding-blocks, name is 3-Amino-5-methoxybenzonitrile, and the molecular formula is C8H8N2O, Recommanded Product: 3-Amino-5-methoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Yuting published the artcileSynthesis and Properties of Benzoxazine Monomers Bearing Both 3-Methyltetrahydrophtalimide and Nitrile Groups: Para-Para vs. Ortho-Ortho, Synthetic Route of 1885-29-6, the main research area is methytetrahydrophtalimide nitrile functionalized benzoxazine polymerization thermomech flame retardant property.

Two 3-methytetrahydrophtalimide-functional benzoxazine monomers containing nitrile group have been prepared in order to achieve the basic design rules for developing high-performance thermosets via multifunctional benzoxazines. The chem. structures of the two new synthesized benzoxazine monomers have been confirmed by 1H NMR, 13C NMR and FT-IR. Besides, the polymerization behavior has been studied by using DSC and in situ FT-IR. In addition, the thermal stability and flame retardant properties of the resulting polybenzoxazines have also been investigated using TGA and MCC. The polybenzoxazine based on ortho-3-methytetrahydrophtalimide functional benzoxazine containing ortho-nitrile group exhibits excellent thermal stability and low flammability, with a Td10 of 378°C and a HRC value of 180 J/(g K).

Macromolecular Research published new progress about Chars. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Xiao-Fei published the artcileβ-Cyclodextrin-conjugated phthalocyanines as water-soluble and recyclable sensitizers for photocatalytic applications, Category: nitriles-buliding-blocks, the main research area is cyclodextrin conjugated phthalocyanines water soluble recyclable sensitizer photocatalyst.

Two zinc(II) phthalocyanines substituted with two and four permethylated β-cyclodextrin moieties at the α positions have been synthesized and immobilized on the surface of adamantane-modified silica nanoparticles through host-guest interactions. These mol. and supramol. systems can catalyze the photooxygenation of 1-naphthol and 2-furoic acid in organic and aqueous media with high conversion efficiency and reaction yield, and photodegradation of 2-chlorophenol in water. Having a higher photostability and recyclability, the supramol. nanosystems are particularly promising for these photocatalytic applications.

Chemical Communications (Cambridge, United Kingdom) published new progress about Air. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Teyateeti, Ajalaya published the artcileSurvival outcomes for yttrium-90 transarterial radioembolization with and without sorafenib for unresectable hepatocellular carcinoma patients, Application of Phthalonitrile, the main research area is 90Y; TheraSphere; adverse events; prognostic factors; selective internal radiation therapy.

Purpose: To assess the overall survival (OS) and progression-free survival (PFS) of unresectable hepatocellular carcinoma (HCC) patients undergoing yttrium-90 glass-microsphere transarterial radioembolization (TARE) with and without concurrent sorafenib. Methods: OS and PFS were analyzed in 55 patients with an intrahepatic tumor (IHT) �0% without advanced or aggressive disease features (ADFs), which was referred to presence of infitrative/ill-defied HCC, macrovascular invasion, or extrahepatic disease treated with only TARE (TARE_alone) and in 74 patients with IHT �0% with ADFs or IHT >50% treated with TARE and sorafenib (TARE_sorafenib). Prognostic factors for OS and PFS were identified using univariate and multivariate analyses. Results: Median OS and PFS of TARE_alone patients were 21.6 (95% CI 6.1-37.1) and 9.1 (95% CI 5.2-13.0) months, resp., and for TARE_sorafenib patients 12.4 (95% CI 9.1-15.6) and 5.1 (95% CI 2.6-7.5) months, resp. Better OS was associated with serum AFP <400 (HR 0.27, p=0.02) in TARE_alone, and IHT �0% (HR 0.39, p=0.004) and AFP <400 (HR 0.5, p=0.027) in TARE_sorafenib. Unilobar involvement (HR 0.43, p=0.029) and AFP <400 ng/mL (HR 0.52, p=0.015) correlated with better PFS in TARE_alone and TARE_sorafenib, resp. Adverse events (AEs) were more frequent in TARE_sorafenib than TARE_alone (92.4 vs 80.3%), but only 9.3% were grade 3 or higher AEs. Conclusion: TARE_alone provided the most prominent survival benefit in IHT �0%- without ADF patients who had unilobar HCC and serum AFP <400 ng/mL. TARE and sorafenib yielded the best outcomes in patients with IHT �0% and serum AFP <400 ng/mL, with some addnl. grade 1-2 AEs compared to TARE only. Journal of Hepatocellular Carcinoma published new progress about 90Y; TheraSphere; adverse events; prognostic factors; selective internal radiation therapy. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Okunrintemi, Victor published the artcileSex Differences in the Age of Diagnosis for Cardiovascular Disease and Its Risk Factors Among US Adults: Trends From 2008 to 2017, the Medical Expenditure Panel Survey., Recommanded Product: Picolinonitrile, the main research area is age of diagnosis; cardiovascular disease; risk factors; sex differences.

Background Sex differences in the trends for control of cardiovascular disease (CVD) risk factors have been described, but temporal trends in the age at which CVD and its risk factors are diagnosed and sex-specific differences in these trends are unknown. Methods and Results We used the Medical Expenditure Panel Survey 2008 to 2017, a nationally representative sample of the US population. Individuals â‰?8 years, with a diagnosis of hypercholesterolemia, hypertension, coronary heart disease, or stroke, and who reported the age when these conditions were diagnosed, were included. We included 100 709 participants (50.2% women), representing 91.9 million US adults with above conditions. For coronary heart disease and hypercholesterolemia, mean age at diagnosis was 1.06 and 0.92 years older for women, compared with men, respectively (both P<0.001). For stroke, mean age at diagnosis for women was 1.20 years younger than men (P<0.001). The mean age at diagnosis of CVD risk factors became younger over time, with steeper declines among women (annual decrease, hypercholesterolemia [women, 0.31 years; men 0.24 years] and hypertension [women, 0.23 years; men, 0.20 years]; P<0.001). Coronary heart disease was not statistically significant. For stroke, while age at diagnosis decreased by 0.19 years annually for women (P=0.03), it increased by 0.22 years for men (P=0.02). Conclusions The trend in decreasing age at diagnosis for CVD and its risk factors in the United States appears to be more pronounced among women. While earlier identification of CVD risk factors may provide opportunity to initiate preventive treatment, younger age at diagnosis of CVD highlights the need for the prevention of CVD earlier in life, and sex-specific interventions may be needed. Journal of the American Heart Association published new progress about age of diagnosis; cardiovascular disease; risk factors; sex differences. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts