Tag: M.W=100-150

Tak, Raj K. published the artcileLigand-enabled, copper-catalyzed electrophilic amination for the asymmetric synthesis of β-amino acids, Application In Synthesis of 100-70-9, the main research area is amino acid beta cyclic linear enantioselective synthesis solvent effect; electrophilic amination copper catalyst isoxazolidinone nitrene; asym desymmetrization kinetic resolution nitrene transfer.

Catalytic asym. nitrene transfer has emerged as a reliable method for the synthesis of nitrogen-containing chiral compounds Herein, we report the copper-catalyzed intramol. asym. electrophilic amination of aromatic rings. The reactive intermediate is a copper-alkyl nitrene generated from isoxazolidin-5-ones. Copper catalysis promotes three classes of asym. transformations, namely, asym. desymmetrization, parallel kinetic resolution, and kinetic resolution, expanding the repertoire of alkyl nitrene transfer and providing various cyclic and linear β-amino acids in their enantioenriched forms.

Organic Letters published new progress about Amination. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, Fabin published the artcileA terphenyl phosphine as a highly efficient ligand for palladium-catalysed amination of aryl halides with 1° anilines, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl halide aniline amination palladium complex catalyst.

A terphenyl phosphine ligand (2,6-bis(2,4,6-triisopropylphenyl)phenyl-dicyclohexylphosphine, TXPhos) and its supported palladium complex [(TXPhos)(allyl)PdCl] have been developed and the catalyst system is highly efficient in amination of aryl halides ArX (Ar = Ph, 2-methoxyphenyl, 4-cyanophenyl, etc.; X = Cl, Br, I) with 1° anilines RNH2 (R = Ph, 2-nitrophenyl, 2,5-dimethylphenyl, etc.), especially effective for densely functionalized substrates including both partners possessing ortho-ester, acetyl, nitrile and nitro groups. With the TXPhos-supported catalyst system, many partner combinations have been unprecedentedly realized and the base scope has been even extended to KOAc, which is even the best choice in the amination of 2-nitrochlorobenzene.

Journal of Catalysis published new progress about Amination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vijeta, Arjun published the artcileAn Integrated Carbon Nitride-Nickel Photocatalyst for the Amination of Aryl Halides Using Sodium Azide, Computed Properties of 1885-29-6, the main research area is primary aniline preparation; haloarene sodium azide amination integrated carbon nitride nickel photocatalyst; Carbon Nitride; Green Chemistry; Heterogeneous Catalysis; Organic Synthesis; Photocatalysis.

A photocatalytic protocol for the selective synthesis of primary anilines RNH2 [R = Ph, 4-BrC6H4, 3-pyridyl, etc.] via cross-coupling of a wide range of aryl/heteroaryl halides with sodium azide using a photocatalyst powder consisting of nickel(II) deposited on mesoporous carbon nitride (Ni-mpg-CNx) was reported. This heterogeneous photocatalyst contained a high surface area with a visible light-absorbing and adaptive “”built-in”” solid-state ligand for the integrated catalytic Ni site. The method displayed a high functional group tolerance, required mild reaction conditions, and benefited from easy recovery and reuse of the photocatalyst powder. Thereby, it overcame the need of complex ligand scaffolds required in homogeneous catalysis, precious metals and elevated temperatures/pressures in existing protocols of primary anilines synthesis. The reported heterogeneous Ni-mpg-CNx held potential for applications in the academic and industrial synthesis of anilines and exploration of other photocatalytic transformations.

Angewandte Chemie, International Edition published new progress about Amination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gillespie, James E. published the artcileRegioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines, COA of Formula: C7H6N2, the main research area is ortho phenylenediamine preparation regioselective radical arene amination; monoalkyl amine benzimidazole benzotriazole preparation; anionic substrate radical cation regioselective radical amination.

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactive N-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the arene ortho position. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly to ortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsym., selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuable ortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

Journal of the American Chemical Society published new progress about Amination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Jing published the artcilePalladium-Catalyzed Sequential C-H Activation/Amination with Diaziridinone: An Approach to Indoles, COA of Formula: C7H6N2, the main research area is iodostyrene diaziridinone palladium catalyst bond activation amination tandem; indole preparation.

Indoles are an important class of mols. This paper describes an efficient palladium-catalyzed synthesis of indoles from 2-iodostyrenes and di-t-butyldiaziridinone with a simultaneous installation of two C-N bonds. The reaction process likely proceeds through the oxidative insertion of Pd to aryl iodide and subsequent vinyl C-H activation to from a pallada(II)cycle intermediate, which is bisaminated by di-t-butyldiaziridinone to give the indole product.

Organic Letters published new progress about Amination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Batori, Sandor published the artcileSynthetic procedure to pyrido[2,1-f][1,2,4]triazinium salt and related compounds, HPLC of Formula: 100-70-9, the main research area is pyridotriazinium perchlorate preparation; amination cyclocondensation reaction pyridinyl ketone amine.

Pyrido[2,1-f][1,2,4]triazinium perchlorates such as I (R = H, Me, Ph, t-Bu, Cl, 4-morpholinyl, Et2N; R1 = Ph, 4-ClC6H4) were prepared using N-aminations of pyridines and cyclocondensation reactions as key steps. I (R = H; R1 = Ph) formed a hydroxydihydropyridotriazinium perchlorate in the presence of water. 3,4-Dihydropyrido[2,1-f][1,2,4]triazinium perchlorates and a pyrimidotriazinium perchlorate were also prepared using similar methods.

Tetrahedron published new progress about Amination. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Klyamer, Darya published the artcileVanadyl phthalocyanine films and their hybrid structures with Pd nanoparticles: structure and sensing properties, Product Details of C8H4N2, the main research area is vanadyl phthalocyanine film hybrid structure palladium nanoparticle sensing property; ammonia; chemiresistive sensors; hydrogen; palladium nanoparticles; thin films; vanadyl phthalocyanine.

In this work, thin films of vanadyl phthalocyanines (VOPc and VOPcF4) are studied as active layers for the detection of gaseous ammonia and hydrogen. The effect of F-substituents on the structural features of vanadyl phthalocyanine films and their sensor response toward ammonia (10-50 ppm) and hydrogen (100-500 ppm) is investigated by X-ray diffraction (XRD) and chemiresistive methods, resp. It is shown that the sensor response of VOPcF4 films to ammonia is 2-3 times higher than that of VOPc films. By contrast, the sensor response to hydrogen is higher in the case of VOPc films. Apart from this, the hybrid structures of vanadyl phthalocyanine films with Pd nanoparticles deposited on their surface by a chem. vapor deposition method are also tested to reveal the effect of Pd nanoparticles on the sensitivity of VOPc films to hydrogen. Deposition of Pd nanoparticles on the surface of VOPc films leads to the noticeable increase of their sensitivity to hydrogen.

Sensors published new progress about Annealing. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Bor-Yih published the artcileEvaluating the direct CO2 to diethyl carbonate (DEC) process: Rigorous simulation, techno-economical and environmental evaluation, Name: Picolinonitrile, the main research area is cyanopyridine picolinamide annealing diethyl carbonate simulation.

In this work, the plant-wide process to produce di-Et carbonate (DEC) from the direct reaction of CO2 with ethanol, which uses 2-cyanopyridine (2-CP) as an in situ dehydrating agent, is proposed for the first time. Rigorous design, optimization, ability in carbon reduction, techno-economic and feasibility analyses are all performed in this work. The process consists of two sections. The first one is the main section, in which DEC is generated, along with the removal of water using 2-CP to form 2-picolinamide (2-PA). The second one is the regeneration section, where 2-CP is converted back from 2-PA and recycled. Using simulated annealing method, the optimized CO2 reduction rate in the main section is 0.237 (Ton CO2/Ton DEC generated) on an annual basis. We identify that when the regeneration section is operated with a molar ratio of mesitylene to 2-PA being less than 2.05, the overall process can be in net CO2 reduction Under the constraint of 90 % regeneration of 2-CP as reported in available literature, the produced DEC can match the current market price range under 15 % internal rate of return (IRR), if 2-CP can be obtained with a price lower than 2.56 USD/kg (corresponding to DEC price of 1.10 USD/kg and ethanol price of 0.37 USD/kg) to 6.09 USD/kg (corresponding to DEC price of 1.90 USD/kg and ethanol price of 0.56 USD/kg).

Journal of CO2 Utilization published new progress about Annealing. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Leanez, Jacques published the artcileAnti-leishmanial effect of spiro dihydroquinoline-oxindoles on volume regulation decrease and sterol biosynthesis of Leishmania braziliensis, Product Details of C7H6N2, the main research area is Leishmania macrophage spiro dihydroquinoline oxindole sterol antileishmania; Leishmania braziliensis; chemotherapy; parasite internal regulation; spiro dihydroquinoline-oxindoles; squalene epoxidase inhibitors; sterol pathway.

Diverse spiro dihydroquinoline-oxindoles (JS series) were prepared using the BF3·OEt2-catalyzed imino Diels-Alder reaction between ketimine-isatin derivatives and trans-isoeugenol. Ten spiro-oxiindole derivatives were selected and evaluated at different stages of the life cycle of Leishmania braziliensis parasites, responsible for cutaneous leishmaniasis in South America. Among them, the 8-ethyl-4-(4-hydroxy-3-methoxyphenyl)-3-methyl-3,4-dihydro-1H-spiro[indoline-3,2′-quinolin]-2-one called JS87 was able to inhibit the growth of promastigotes without affecting the mammalian cells viability, and to decrease the number of intracellular amastigotes of L. braziliensis. This spiro compound was found to act through the alteration of parasite internal regulation by disrupting the regulatory volume decrease (RVD), and to affect the sterol biosynthetic pathway at level of squalene epoxidase (SE) enzyme. These results revealed that the spiro annulation between quinoline and oxindole scaffolds enhances the anti-leishmanial activity, and could assist in the development of potent quinoline-oxindole hybrids against Leishmania braziliensis, the main etiol. agent of cutaneous leishmaniasis in South America.

Experimental Parasitology published new progress about Apoptosis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Negri, Laisa Bonafim published the artcilePhotobiomodulation combined with photodynamic therapy using ruthenium phthalocyanine complexes in A375 melanoma cells: Effects of nitric oxide generation and ATP production, Application of Phthalonitrile, the main research area is ruthenium phthalocyanine nitric oxide ATP photodynamic therapy melanoma photobiomodulation; Light irradiation therapy; Metal-based drug; Nitrosyl ruthenium-phthalocyanine complex; Photobiomodulation.

Light irradiation has been used in clin. therapy for several decades. In this context, photobiomodulation (PBM) modulates signaling pathways via ROS, ATP, Ca2+, while photodynamic therapy (PDT) generates reactive oxygen species by excitation of a photosensitizer. NO generation could be an important tool when combined with both kinds of light therapy. By using a metal-based compound, we found that PBM combined with PDT could be a beneficial cancer treatment option. This paper used two types of ruthenium compounds, ([Ru(Pc)], Pc = phthalocyanine) and trans-[Ru(NO)(NO2)(Pc)]. The UV-vis spectra of both complexes displayed a band in the 660 nm region. In the case of 0.5 μM trans-[Ru(NO)(NO2)(Pc)], light irradiation at the Q-band reduced the percentage of viable human melanoma (A375) cells to around 50% as compared to [Ru(Pc)]. We hypothesized that these results were due to a synergistic effect between singlet oxygen and nitric oxide. Similar experiments performed with PDT (660 nm) combined with PBM (850 nm) induced more photocytotoxicity using both [Ru(Pc)] and trans-[Ru(NO)(NO2)(Pc)]. This was interpreted as PBM increasing cell metabolism (ATP production) and the consequent higher uptake of the ruthenium phthalocyanine compounds and more efficient apoptosis. The use of metal-based photosensitizers combined with light therapy may represent an advance in the field of photodynamic therapy.

Journal of Photochemistry and Photobiology, B: Biology published new progress about Apoptosis. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts