Tag: M.W=100-150

Vidyacharan, Shinde published the artcileContinuous-Flow Visible Light Organophotocatalysis for Direct Arylation of 2H-Indazoles: Fast Access to Drug Molecules, COA of Formula: C7H6N2, the main research area is aryldiazonium indazole arylation visible light continuous flow; arylindazole regioselective preparation; visible light arylation promotor; continuous flow micro reaction technol; C−H activation; drug synthesis; flow chemistry; organocatalysis; photocatalysis.

A continuous-flow homogeneous photocatalytic method has been devised for the direct arylation of 2H-indazoles. This visible-light-promoted approach directly accesses a wide range of structurally diverse C3-arylated scaffolds of biol. interest in a fast (1 min), single-step reaction by using eosin Y as an organophotocatalyst. Furthermore, a microreactor technol. is also employed for the fast synthesis of liver X receptor inhibitor drugs with very good yields under metal-free conditions, whereas the reported methods required multiple steps and much longer reaction times (18-24 h).

ChemSusChem published new progress about Arylation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Yamei published the artcileSilica supported potassium oxide catalyst for dehydration of 2-picolinamide to form 2-cyanopyridine, Synthetic Route of 100-70-9, the main research area is picolinamide cyanopyridine silica potassium oxide catalyst dehydration.

The dehydration of 2-picolinamide to produce 2-cyanopyridine was investigated thoroughly using silica supported potassium oxide as a heterogeneous catalyst. Both large sp. surface area and pore size of SiO2 (B) contributed to the favorable catalytic performance for the synthesis of 2-CP. In addition, the yield of 2-CP showed the linear relationship with the amounts of medium basicity of the catalysts, demonstrating that medium basic sites were the active sites of silica supported potassium oxide catalysts. The catalysts were further characterized by XRD and FT-IR to clarify the active species. The results indicated the Si-O-K group produced by the reaction of K2CO3 with Si-OH was the active species, which was further evidenced by the adjustment of the amount of Si-OH by silylation and hydroxylation procedure.

Chinese Chemical Letters published new progress about Catalysis. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kalita, Gauravjyoti D. published the artcileBimetallic Au-Pd nanoparticles supported on silica with a tunable core@shell structure: enhanced catalytic activity of Pd(core)-Au(shell) over Au(core)-Pd(shell), Recommanded Product: Picolinonitrile, the main research area is gold palladium nanoparticle silica coreshell structure catalytic activity.

A facile ligand-assisted approach of synthesizing bimetallic Au-Pd nanoparticles supported on silica with a tunable core@shell structure is presented. Maneuvering the addition sequence of metal salts, both Aucore-Pdshell (Au@Pd-SiO2) and Pdcore-Aushell (Pd@Au-SiO2) nanoparticles were synthesized. The structures and compositions of the core-shell materials were confirmed by probe-corrected HRTEM, TEM-EDX mapping, EDS line scanning, XPS, PXRD, BET, FE-SEM-EDX and ICP anal. The synergistic potentials of the core-shell materials were evaluated for two important reactions viz. hydrogenation of nitroarenes to anilines and hydration of nitriles to amides. In fact, in both the reactions, the Au-Pd materials exhibited superior performance over monometallic Au or Pd counterparts. Notably, among the two bimetallic materials, the one with Pdcore-Aushell structure displayed superior activity over the Aucore-Pdshell structure which could be attributed to the higher stability and uniform Au-Pd bimetallic interfaces in the former compared to the latter. Apart from enhanced synergism, high chemoselectivity in hydrogenation, wide functional group tolerance, high recyclability, etc. are other advantages of our system. A kinetic study has also been performed for the nitrile hydration reaction which demonstrates first order kinetics. Evaluation of rate constants along with a brief investigation on the Hammett parameters has also been presented.

Nanoscale Advances published new progress about Catalysis. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Yu published the artcileRoom-temperature conversion of CO2 into quinazoline-2,4(1H,3H)-dione using deep eutectic solvents at atmospheric pressure with high efficiency, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is carbon dioxide quinazoline dione DES pressure high efficiency temperature.

Highly efficient and sustainable conversion of CO2 into quinazoline-2,4(1H,3H)-dione at room temperature and atm. pressure is challenging. Deep eutectic solvents (DESs) are considered as the green solvents of the 21st century, which are also designable with high tunability and high atom efficiency. Here, DESs are for the first time used to catalyze the CO2 conversion into quinazoline-2,4(1H,3H)-dione at room temperature and atm. pressure with high efficiency and nearly 100% yield. This work provides a sustainable way for the efficient conversion of CO2 into quinazoline-2,4(1H,3H)-dione by DESs at room temperature and atm. pressure.

Reaction Chemistry & Engineering published new progress about Catalysis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chan, Chieh-Kai published the artcileEnvironmentally Friendly Nafion-Catalyzed Synthesis of Substituted 2-Ethyl-3-Methylquinolines from Aniline and Propionaldehyde under Microwave Irradiation, HPLC of Formula: 1885-29-6, the main research area is nafion quinoline environmentally microwave irradiation cyclization.

Herein, we report a facile synthetic methodol. for the preparation of 2,3-dialkylquinolines from anilines and propionaldehydes. This cyclization involved environmentally friendly Nafion NR50 as an acidic catalyst with microwave irradiation as the heating source. A series of substituted 2-ethyl-3-methylquinolines were prepared from various anilines and propionaldehyde derivatives through this protocol with good to excellent yields. Some new chem. structures were confirmed by X-ray single-crystal diffraction anal. and the related data were provided. The plausible reaction mechanism studies are also discussed.

Catalysts published new progress about Catalysts. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fan, Linbing published the artcileConversion of chenodeoxycholic acid to cholic acid by human CYP8B1, Related Products of nitriles-buliding-blocks, the main research area is chenodeoxycholic cholic acid human CYPB; S. pombe; bile acid; cytochrome P450; fission yeast; liver; steroid hydroxylation.

The human cytochrome P 450 enzyme CYP8B1 is a crucial regulator of the balance of cholic acid (CA) and chenodeoxycholic acid (CDCA) in the liver. It was previously shown to catalyze the conversion of 7α-hydroxycholest-4-en-3-one, a CDCA precursor, to 7α,12α-dihydroxycholest-4-en-3-one, which is an intermediate of CA biosynthesis. In this study we demonstrate that CYP8B1 can also convert CDCA itself to CA. We also show that five derivatives of luciferin are metabolized by CYP8B1 and established a rapid and convenient inhibitor test system. In this way we were able to identify four new CYP8B1 inhibitors, which are aminobenzotriazole, exemestane, ketoconazole and letrozole.

Biological Chemistry published new progress about Catalysts. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Revuelta-Maza, Miguel A. published the artcileSynthesis and Aggregation Studies of Functional Binaphthyl-Bridged Chiral Phthalocyanines, HPLC of Formula: 91-15-6, the main research area is zinc phthalocyanine chiral complex preparation CD spectra fluorescence.

We describe the preparation of a battery of chiral Zn(II) phthalocyanines with an AABB substitution pattern through cross-condensation of different chiral, binaphthyloxy-linked bisphthalonitriles and (non)functionalized single phthalonitriles. All the compounds are endowed with reactive groups (halogen and/or ethynyl moieties) that will allow us to prepare customized amphiphilic phthalocyanines. Preliminary self-assembly studies in solution have been performed by UV-vis and CD experiments

Organic Letters published new progress about Chirality. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vogt, Natalja published the artcileThe equilibrium molecular structure of 2-cyanopyridine from combined analysis of gas-phase electron diffraction and microwave data and results of ab-initio calculations, Synthetic Route of 100-70-9, the main research area is cyanopyridine electron diffraction microwave rotational constant equilibrium mol structure.

The gas-phase electron diffraction study of 2-cyanopyridine was carried out for the first time. Results of ab-initio structure calculations performed at the CCSD(T) level of theory agree well with the equilibrium structure determined by the electron diffraction method in combination with vibrational spectroscopy data and microwave rotational constants The deviations between them are only a few thousandths of Å units and a few tenths of degree in the bond lengths and bond angles, resp. The structure in the solid state is more different from that in the gas phase. The observed discrepancies between these structures are up to 0.02 Å and 2° in the bond lengths and bond angles, resp. The influence of the ortho-, meta- and para-cyano substituents on the geometry of pyridine ring is discussed. The pyridine ring is noticeably distorted due to cyano substituents. The Cipso-N and/or Cipso-C bond lengths are elongated both in 2-CNP and 4-CNP by 0.004 Å in comparison to those in pyridine, whereas the Cipso-C bond lengths are increased by 0.005 and 0.009 Å in 3-CNP.

Structural Chemistry published new progress about Bond angle. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Fusheng published the artcileEfficient One Pot Capture and Conversion of CO2 into Quinazoline-2,4(1H,3H)-diones Using Triazolium-Based Ionic Liquids, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is CO quinazolinedione triazolium ionic liquid.

CO2 capture and utilization (CCU) have aroused much attention. In this paper, several novel triazolium-based ionic liquids (ILs) were developed for highly efficient transformation of CO2 into quinazoline-2,4(1H,3H)-diones. The catalytic behaviors such as the effects of IL structures and reaction parameters, catalyst recyclability, and scope of substrates were studied in detail. As compared to the reported homogeneous and heterogeneous catalysts, the [HTMG][Triz] with a tetramethylguanidine cation and a triazole anion exhibited an exceptional activity at 50°C and 1 atm CO2 without any organic solvents. On the basis of the CCU strategy, we first studied the equimolar CO2 capture by the [HTMG][Triz] and one pot conversion of activated CO2 into various quinazoline-2,4(1H,3H)-diones, and good to excellent product yields were obtained. In addition, the catalytic performance for synthesis of quinazoline-2,4(1H,3H)-dione under low concentration of CO2 using a simulated flue gas was studied. The developed triazolium-based ILs could realize simultaneous activation of CO2 and the substrates under ambient conditions, which also have been demonstrated to support the reaction mechanism well. The integrative protocol here shows great significance in the practical synthesis of quinazoline-2,4(1H,3H)-dione and their derivatives from captured CO2 waste under mild conditions. Triazolium-based ionic liquids show exceptional performance for equimolar CO2 capture and subsequent conversion into quinazoline-2,4(1H,3H)-diones under mild conditions.

ACS Sustainable Chemistry & Engineering published new progress about Flue gases. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gong, Zi-Jie published the artcileDirect copolymerization of carbon dioxide and 1,4-butanediol enhanced by ceria nanorod catalyst, Safety of Picolinonitrile, the main research area is carbon dioxide butanediol direct copolymerization ceria nanorod catalyst.

Direct copolymerization of CO2 and 1,4-butanediol to yield poly(butylene carbonate) oligomers has been recently realized using CeO2 as a catalyst and 2-cyanopyridine as a dehydrating agent. In this study, CeO2 nanorod and nanocube were synthesized, characterized, and compared their catalytic activities with com. CeO2 nanoparticle and submicronparticle. Reaction testing reveals that CeO2 nanorod exhibits a much higher yield of polycarbonate oligomer than other CeO2 catalysts. Surface characterizations indicate that CeO2 nanorod displays a significantly higher CO2 uptake and stronger interactions with CO2, properties that could be beneficial to activate stable CO2 mol. In-situ IR spectroscopy suggests that bidentate carbonate, i.e., CO2 adsorbs over the CeO2 surface with an oxygen atom and an oxygen vacancy coordinated with a cerium atom, is the key intermediate associated with the observed catalytic activities. These results manifest the importance of surface oxygen vacancy of CeO2 for activating CO2 to proceed non-reductive conversion.

Applied Catalysis, B: Environmental published new progress about Grain size. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts