Tag: M.W=100-150

Zhao, Guo-Ying published the artcileCO2 involved synthesis of quinazoline-2,4(1H,3H)-diones in water using melamine as a thermoregulated catalyst, Category: nitriles-buliding-blocks, the main research area is quinazolinedione preparation green chem; aminobenzonitrile carbon dioxide cycloaddition water melamine thermoregulated catalyst.

In this study, pharmaceutically relevant quinazoline-2,4(1H,3H)-diones were synthesized eco-efficiently by cycloaddition of CO2 and 2-aminobenzonitrile in water, catalyzed by melamine as a thermoregulated catalyst. Quinazoline-2,4(1H,3H)-dione was produced selectively with 92% yield at 120 °, 4.2 MPa, and automatically separated from the hot catalytic aqueous solution, which was reused directly for several runs until its activity decreased in an obvious manner. Then, the catalyst melamine was recrystallized from the spent aqueous solution via simple cooling and reused for another several catalytic runs. The efficient valorization of CO2 and the straightforward stepwise recovery of the products and catalyst were important to save energy and minimize process waste for the practical industrial production

Canadian Journal of Chemistry published new progress about Cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yeganeh, Ardeshir Dadgar published the artcileIn situ synthesis and encapsulation of copper phthalocyanine into MIL-101(Cr) and MIL-100(Fe) pores and investigation of their catalytic performance in the epoxidation of styrene, Synthetic Route of 91-15-6, the main research area is copper phthalocyanine encapsulated MOF catalyst styrene epoxidation textural property.

In this work, copper phthalocyanine (CuPc) was encapsulated into mesocages of MIL-101(Cr) and MIL-100(Fe) by assembling CuPc’s constitutional fractions using a deep eutectic solvent. The prepared materials, CuPc@MIL-101(Cr) and CuPc@MIL-100(Fe), were characterized by powder X-ray diffraction (PXRD), FT-IR, UV-vis and diffuse reflectance UV (DR-UV) spectroscopies, SEM (SEM), transmission electron microscopy (TEM), and ICP-OES spectrometry. The prepared materials were used as heterogeneous catalysts for catalytic epoxidation of styrene with mol. oxygen and also tert-Bu hydroperoxide (TBHP) as oxidants in acetonitrile as a solvent. The impact of MOFs and the role of the CuPc complex as the active species in the MOFs’ cages in the epoxidation of styrene were investigated. Among the prepared catalysts, CuPc@MIL-101(Cr) showed the best performance. The heterogeneity of the catalysts was examined by a hot filtration test and ICP-OES of the filtrates after the reaction. Spent catalysts were analyzed by PXRD, FT-IR, UV-DRS, and TEM for reusability investigation and also to further explore the heterogeneous nature of the hybrid materials. Results showed that the prepared catalysts could be recycled and used for several concoctive times without a considerable drop in activity.

Journal of Porphyrins and Phthalocyanines published new progress about Deep eutectic solvents. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ishizaki, Toshiharu published the artcileSynthesis of a Neutral Mononuclear Four-Coordinate Co(II) Complex Having Two Halved Phthalocyanine Ligands That Shows Slow Magnetic Relaxations under Zero Static Magnetic Field, SDS of cas: 91-15-6, the main research area is pseudotetrahedral four coordinate mononuclear Cobalt complex.

Syntheses of a novel pseudotetrahedral four-coordinate mononuclear Co(II) complex that has two halved phthalocyanine moieties as the ligands, [Co(half-Pc)2] (1), and its magnetic properties as a single mol. magnet (SMM) are reported. A one pot reaction of phthalonitrile and lithium methoxide followed by the coordination to a Co(II) ion gave 1 as an orange solid in a moderate yield. X-ray crystallog. on 1 reveals tetragonally distorted coordination geometry around the Co(II) ion. The M-HT-1 plots suggest that 1 has large axial magnetic anisotropy. The ac magnetic susceptibility data of the magnetically diluted 1 (dilute1) clearly show that the complex acts as an SMM even in the absence of the external static magnetic field (Hdc). The influence of intermol. and intramol. interactions for the magnetic relaxation behaviors has been discussed by comparison of the magnetic data of 1 and dilute1. The Orbach process is suggested as the predominant mechanism of magnetic relaxations in the high-temperature range, and the Arrhenius plots provide the effective relaxation energy barrier and pre-exponential factor of Ueff = 54.0 cm-1 and τ0 = 3.17 × 10-10 s, resp. The direct estimation of the axial anisotropic parameter of 1 was successfully performed by high-field, multifrequency ESR measurements up to 55 T and 2.5 THz. The evaluated axial zero-field splitting (ZFS) energy of 57.0 cm-1 is comparable to the Ueff energy, confirming that the magnetic relaxations are initiated by the thermal excitation from the ground |MS〉 = |±3/2〉 states to the |±1/2〉 states in the high-temperature range. The results of the ab initio calculations based on the CAS(7,5) SCF wave functions indicate that the ground states of 1 consist mainly of |MS〉 = |±3/2〉 states, while the first excited states are the mixture of |MS〉 = |+1/2〉 and |-1/2〉.

Inorganic Chemistry published new progress about Ground state, magnetic. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, SDS of cas: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kondoh, Azusa published the artcileFormal umpolung addition of phosphites to 2-azaaryl Ketones under chiral Broensted base catalysis: enantioselective protonation utilizing [1,2]-phospha-Brook rearrangement, Computed Properties of 100-70-9, the main research area is phosphite azaaryl ketone Broensted base enantioselective phospha Brook rearrangement; enantioselective protonation; organocatalysis; organosuperbase; phospha-Brook rearrangement; umpolung.

The formal enantioselective umpolung addition of dialkyl phosphites to 2-azaaryl ketones was developed under Broensted base catalysis. The reaction involved the enantioselective protonation of the transient α-oxygenated (2-azaaryl)methyl anion generated through the 1,2-addition of the anion of dialkyl phosphite to the 2-azaaryl ketone and the subsequent [1,2]-phospha-Brook rearrangement. A chiral bis(guanidino)iminophosphorane organosuperbase efficiently catalyzed the reaction to provide enantio-enriched phosphates in high yields with good to high enantioselectivities. This is a rare example of the catalytic enantioselective protonation of transient carbanions other than enolates, constructing a trisubstituted stereogenic center α to 2-azaarenes.

Chemistry – A European Journal published new progress about 1,2-Addition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Hongpeng published the artcileSynthesis of Silicon-Stereogenic Silanols Involving Iridium-Catalyzed Enantioselective C-H Silylation Leading to a New Ligand Scaffold, Category: nitriles-buliding-blocks, the main research area is crystal structure mol silanol phosphorus silicon heterocycle chiral preparation; iridium catalyst enantioselective carbon hydrogen regioselective silylation stereoselective.

Despite a growing focus on the construction of highly enantioenriched silicon-stereogenic organosilicon compounds, the enantioselective synthesis of silicon-stereogenic silanols through asym. catalysis remains a considerable challenge. Herein, we realized enantioselective construction of silicon-stereogenic diarylsilanols via an Ir-catalyzed C-H silylation of diarylsilanols along with stereospecific substitution or Tamao-Fleming oxidation This strategy gives rise to a class of chiral diol catalyst cores (PSiOLs). Transformation of PSiOLs led to the ligand possessing both Si and P-stereocenters, which is capable of inducing excellent enantioselectivity in the rhodium(I)-catalyzed conjugate 1,4-addition of aryl boronic acids to cyclohexenone.

ACS Catalysis published new progress about 1,4-Addition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yang, Huiyong published the artcileSynthesis of quinazolin-4-ones through an acid ion exchange resin mediated cascade reaction, Formula: C7H6N2, the main research area is quinazolinone preparation green chem; dihydrooxazole amide preparation acid ion exchange resin cascade reaction.

An interesting cascade reaction of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)benzamide I (R1 = Ph, 2-naphthyl, 2-furyl, 2-thiophenyl, adamantan-1-yl, etc.; R2 = H, 3-F, 4-OMe, 5-Me, etc.) in the presence of an acid ion exchange resin is described. In this reaction, a range of substrates bearing various substituent groups are well compatible. This work provides a green and atom-economical alternative approach for the synthesis of quinazolin-4-ones II (R3 = H, 5-F, 6-OMe, 7-Me, etc.) in good yields.

Organic & Biomolecular Chemistry published new progress about Acidic ion exchangers. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Brand, Yaneth M. published the artcileCombretastatin A-4: the antitubulin agent that inspired the design and synthesis of styrene and spiroisatin hybrids as promising cytotoxic, antifungal and antiviral compounds, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is combretastatin A4 antitubulin antifungal antiviral agent cytotoxicity.

The design of a series of styrene and spiroisatin hybrids was based on the structure of combretastatin A-4 1. This library of 20 compounds were synthesized with the pharmacophoric units: 3,4,5-trimethoxy or/and 4-hydroxy-3-methoxy Ph moities in their structure. Thereby, the libraries of beta-nitrostyrenes 10a-10c, spiroisatin-dihydroquinolines 14a-14c, spiroisatinthiazolidinones 17a-17c and spiroisatin-nitropyrrolizidines 20a-20k were evaluated for their in vitro cytotoxic, anti-proliferative, antifungal and antiviral activities. Biol. results revealed that among these compounds, beta-nitrostyrenes 10a-10c exhibited significant cytotoxicity (HeLa and Jurkat tumor cells) and antifungal (T. mentagrophytes) activities. Moreover, the spiroisatindihydroquinoline 14a and 14c showed promising cytotoxicity (U937 cells). 14a-14c mols. were active against human herpesviruses serotypes 1 and 2 (HHV-1 and HHV-2), but only 14a and 14b were effective against dengue virus serotype 2 (DENV-2). The spiroisatin-nitropyrrolizidine 20c exhibited moderate anti-herpetic activity, while 17c spiroisatin-thiazolidinone derivative also reduced the infection of HHV-1 and DENV-2. Finally, the mol. docking showed that these kind of mols. interact with the subunit a/beta-tubulin.

Journal of the Brazilian Chemical Society published new progress about Acute T-cell leukemia. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yuan, Gankun published the artcileNovel Targeted Photosensitizer as an Immunomodulator for Highly Efficient Therapy of T-Cell Acute Lymphoblastic Leukemia, Computed Properties of 91-15-6, the main research area is dasatinib zinc phthalocyanine PDT photosensitizer preparation acute lymphoblastic leukemia.

Dasatinib is a kinase-targeted drug used in the treatment of leukemia. Regrettably, it remains far from optimal medicine due to insurmountable drug resistance and side effects. Photodynamic therapy (PDT) has proven that it can induce systemic immune responses. However, conventional photosensitizers as immunomodulators produce anticancer immunities, which are inadequate to eliminate residual cancer cells. Herein, a novel compound 4 was synthesized and investigated, which introduces dasatinib and zinc(II) phthalocyanine as the targeting and photodynamic moiety, resp. Compound 4 exhibits a high affinity to CCRF-CEM cells/tumor tissues, which overexpress lymphocyte-specific protein tyrosine kinase (LCK), and preferential elimination from the body. Meanwhile, compound 4 shows excellent photocytotoxicity and tumor regression. Significantly, compound 4-induced PDT can obviously enhance immune responses, resulting in the production of more immune cells. We believe that the proposed manner is a potential strategy for the treatment of T-cell acute lymphoblastic leukemia.

Journal of Medicinal Chemistry published new progress about Acute T-cell leukemia. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jaiswal, Anjali published the artcileA convenient synthesis of N-(hetero)arylamides by the oxidative coupling of methylheteroarenes with amines, Quality Control of 1885-29-6, the main research area is heteroarylamide preparation copper acetate elemental sulfur DMSO; methylpyridine methylbenzimidazole amine direct oxidative amidation.

An oxidative amidation of 2-methylpyridines/2-methylbenzimidazole with amines using copper acetate and elemental sulfur in DMSO to afford various N-(hetero)arylamides has been accomplished. Mechanistic studies reveal the intermediacy of N-(pyridin-2-ylmethyl)aniline and confirm the role of DMSO as the oxygen source.

Organic & Biomolecular Chemistry published new progress about Amidation (oxidative). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Brehm, Julian published the artcileIn-depth characterization revealed polymer type and chemical content specific effects of microplastic on Dreissena bugensis, COA of Formula: C7H6N2, the main research area is proteomics microplastics chem composition Dreissena; Filter feeders; In-depth characterization; PET drinking bottles; Proteomics; Real-time valvometry.

In aquatic ecosystems, filter feeders like mussels are particularly vulnerable to microplastics (MP). However, little is known about how the polymer type and the associated properties (like additives or remaining monomers) of MP impact organisms, as the predominant type of MP used for effect studies on the organismic level are micron grade polystyrene spheres, without considering their chem. composition Therefore, we exposed the freshwater mussel Dreissena bugensis (D. bugensis) to in-depth characterized fragments in the same concentration and size range (20-120μm): recycled polyethylene terephthalate from drinking bottles, polyamide, polystyrene, polylactic acid, and mussel shell fragments as natural particle control. Real-time valvometry, used to study behavioral responses via the movement of the mussels valves, showed that mussels cannot distinguish between natural and MP particles, and therefore do not cease their filtration, as when exposed to dissolved pollutants. This unintentional ingestion led to polymer type-dependent adverse effects (activity of antioxidant enzymes and proteomic alterations), related to chems. and residual monomers found in MP. Overall, recycled PET elicited the strongest neg. effects, likely caused by anthranilamide, anthranilonitrile and butylated hydroxytoluene, contained in the fragments, which are toxic to aquatic organisms. As PET is among the most abundant MP in the environment, sublethal effects may gradually manifest at the population level, leading to irreversible ecosystem changes.

Journal of Hazardous Materials published new progress about Amphimedon queenslandica. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts