Tag: M.W=100-150

He, Dandan published the artcileSynthesis of Densely Substituted Pyridine Derivatives from 1-Methyl-1,3-(ar)enynes and Nitriles by a Formal [4+2] Cycloaddition Reaction, Synthetic Route of 100-70-9, the main research area is pyridine preparation regioselective chemoselective; isoquinoline preparation regioselective chemoselective; benzothienopyridine preparation regioselective chemoselective; aryl alkyne nitrile cycloaddition.

An attractive method for assembling densely substituted pyridine derivatives I [R = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = H, 6-Me, 6-Ph, 7-Ph, 8-F; R2 = H, Me, CN, Ph; R3 = Ph, 4-FC6H4, 2-pyridyl, etc.], II [R4 = Ph, 4-MeOC6H4, 3-ClC6H4, etc.; R5 = Ph, 2-naphthyl, 2-pyridyl, etc.; Y = O, S], III [R6 = H, 3-Me, 4-MeO, etc.] from 1-methyl-1,3-(ar)enynes and nitriles via a formal [4+2] cycloaddition had been established. The well-balanced affinities of two alkali metal salts enabled C(sp3)-H bond activation and excellent chemo- and regioselectivities. Exptl. studies revealed that nitrile functioned only as a partial nitrogen source for pyridine synthesis, and the addition of a metalated imine intermediate to an intramol. alkyne was the rate-limiting step.

Organic Letters published new progress about [4+2] Cycloaddition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hamsath, Akil published the artcileIntramolecular tetrazine-acryloyl cycloaddition: chemistry and applications, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is coumarin dihydropyridazine preparation; acryloyl ester amide tetrazine intramol cycloaddition.

An unprecedented intramol. [4 + 2] tetrazine-olefin cycloaddition with α,β-unsaturated substrates was discovered. The reaction produces unique coumarin-dihydropyridazine heterocycles that exhibited strong fluorescence with large Stokes shifts and excellent photo- and pH-stability. This property can be used for reaction anal. The rate of cycloaddition was found to be solvent dependent and was determined using exptl. data with a kinetic modeling software (COPASI) as well as DFT calculations (k1 = 0.64 ± 0.019 s-1 and 4.1 s-1, resp.). The effects of steric and electronic properties of both the tetrazine and α,β-unsaturated carbonyl on the reaction were studied and followed the known trends characteristic of the intermol. reaction. Based on these results, authors developed a “”release-then-click”” strategy for the ROS triggered release of methylselenenic acid (MeSeOH) and a fluorescent tracer. This strategy was demonstrated in HeLa cells via fluorescence imaging.

Chemical Science published new progress about [4+2] Cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xu, Liguo published the artcileMulticomponent Polymerizations of Alkynes, Sulfonyl Azides, and 2-Hydroxybenzonitrile/2-Aminobenzonitrile toward Multifunctional Iminocoumarin/Quinoline-Containing Poly(N-sulfonylimine)s, Application In Synthesis of 1885-29-6, the main research area is multicomponent polymerization alkyne sulfonylazide hydroxybenzonitrile aminobenzonitrile; multifunctional polysulfonylimine iminocoumarin quinoline sensor antibacterial agent.

Multicomponent polymerizations (MCPs) of diynes, disulfonyl azides, and 2-hydroxybenzonitrile or 2-aminobenzonitrile were reported with the catalysis of CuCl and Et3N, generating iminocoumarin/quinoline-containing poly(N-sulfonylimine)s with high mol. weights (up to 37700 g/mol) and high yields (up tp 96%). MCPs enjoyed a wide monomer scope and high atom economy, releasing N2 as the only byproduct. The fluorescent poly(N-sulfonylimine) was utilized for sensitive and selective detection of Ru3+. The fluorescent poly(N-sulfonylimine) also had antibacterial properties.

ACS Macro Letters published new progress about Aggregation-induced emission. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Riazimontazer, E. published the artcileDesign, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Alzheimer antiAlzheimer tacrine isatin Schiff base acetylcholinesterase butyrylcholinesterase; beta amyloid metal chelation; Acetylcholinesterase; Alzheimer’s disease; Amyloid-beta aggregation; Butyrylcholinesterase; Cholinesterase inhibitors; Isatin Schiff base; Metal chelation; Tacrine.

A series of novel tacrine-isatin Schiff base hybrid derivatives (7a-p) were designed, synthesized and evaluated as multi-target candidates against Alzheimer’s disease (AD). The biol. assays indicated that most of these compounds displayed potent inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) and specific selectivity for AChE over BuChE. It was also found that they act as excellent metal chelators. The compounds 7k(I) and 7m(II) were found to be good inhibitors of AChE-induced amyloid-beta (Aβ) aggregation. Most of the compounds inhibited AChE with the IC50 values, ranging from 0.42 nM to 79.66 nM. Amongst them, I, II and 7p(III), all with a 6 carbon linker between tacrine and isatin Schiff base exhibited the strongest inhibitory activity against AChE with IC50 values of 0.42 nM, 0.62 nM and 0.95 nM, resp. They were 92-, 62- and 41-fold more active than tacrine (IC50 = 38.72 nM) toward AChE. Most of the compounds also showed a potent BuChE inhibition among which 7d(IV) with an IC50 value of 0.11 nM for BuChE is the most potent one (56-fold more potent than that of tacrine (IC50 = 6.21 nM)). In addition, most compounds exhibited the highest metal chelating property. Kinetic and mol. modeling studies revealed that I is a mixed-type inhibitor, capable of binding to catalytic and peripheral site of AChE. Our findings make this hybrid scaffold an excellent candidate to modify current drugs in treating Alzheimer’s disease (AD).

Bioorganic Chemistry published new progress about Amyloid formation inhibitors. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zivkovic, Kristina published the artcileChiral tridentate bis(oxazol-2-ylimino)isoindoline-based pincer ligands: isolation and characterization via deligation from in situ prepared Cd-ligand complexes, Product Details of C8H4N2, the main research area is chiral tridentate oxazolylimino isoindoline pincer cadmium palladium complex preparation; crystal mol structure oxazolylimino isoindoline pincer cadmium palladium complex.

The first isolation and structural characterization of a series of chiral trinitrogen 1,3-bis(4,5-dihydrooxazol-2-ylimino)isoindoline-based pincer ligands are reported. Cadmium complexes, isolated as Cd(L2X)2 where L2X is the deprotonated form of L2XH = 1,3-bis(4,5-dihydro-4-(R)-phenyloxazol-2-ylimino)-isoindoline ((R,R)-5H) or 1,3-bis(4,5-dihydro-4-(S)-iso-propyloxazol-2-ylimino)isoindoline ((S,S)-6H) were prepared in situ via traditional or microwave-based techniques with the latter being more efficient but less able to be scaled up at this time. Ligands (R,R)-5H and (S,S)-6H were isolated via deligation from their resp. cadmium complexes using a thiol-based ligand exchange protocol. The characterization of ligands and their resp. cadmium complexes, in both the solid (x-ray crystallog.) and solution (NMR spectroscopy) states are reported. Pd((S,S)-6)(OAc) is reported as a proof-of-concept of the ability to prepare 1 : 1 ligand to metal ratio complexes that are believed to be necessary as potential enantioselective catalysts.

Dalton Transactions published new progress about Catalysts (enantioselective). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kato, Yoshimi published the artcileDevelopment of Pseudo-C2-symmetric Chiral Binaphthyl Monocarboxylic Acids for Enantioselective C(sp3)-H Functionalization Reactions under Rh(III) Catalysis, Application of Picolinonitrile, the main research area is dioxazolone alkylpyridine carboxylic acid rhodium catalyst enantioselective amidation; pyridinylpropyl carboxamide preparation.

Herein, pseudo-C2-sym. tunable chiral carboxylic acids with a binaphthyl backbone and their application to enantioselective C(sp3)-H amidation reactions of 2-alkylpyridines and related heteroaromatic substrates were reported. The fixed cyclic structure and pseudo-C2-symmetry of the developed chiral carboxylic acids reduced the conformational flexibility and ambiguity. The combination of an optimal chiral carboxylic acid and a sterically hindered rhodium catalyst (Cp*tBuRhIII) exhibited high enantioselectivity (up to 96:4 er).

ACS Catalysis published new progress about Amidation (stereoselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Cheng published the artcileA Design Principle for Polar Assemblies with C3-Sym Bowl-Shaped π-Conjugated Molecules, Safety of Phthalonitrile, the main research area is crystal structure chiral resolution homochiral boron subphthalocyanine complex preparation; C3-sym; bowl-shaped π-conjugated molecule; crystal engineering; polar assembly.

Polar materials attract wide research interest due to their unique properties, such as ferroelectricity and the bulk photovoltaic effect (BPVE), which are not accessible with nonpolar materials. However, in general, rationally designing polar materials is difficult because nonpolar materials are more favorable in terms of dipole-dipole interactions. Here, we report a rational strategy to form polar assemblies with bowl-shaped π-conjugated mols. and a mol. design principle for this strategy. We synthesized and thoroughly characterized 12 single crystals with the help of various theor. calculations Furthermore, we demonstrated that it can be possible to predict whether polar assemblies become more favorable or not by estimating their lattice energies. We believe that this study contributes to the development of organic polar materials and their related studies.

Angewandte Chemie, International Edition published new progress about Chromatographic chiral resolution. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Molaei, Somayeh published the artcileSynthesis of CoFe2O4 @Amino glycol/Gd nanocomposite as a high-efficiency and reusable nanocatalyst for green oxidation of sulfides and synthesis of 5-substituted 1H-tetrazoles, HPLC of Formula: 91-15-6, the main research area is cobalt spinel ferrite magnetite nanoparticles immobilized covalently amino glycol; gadolinium nanocomposite preparation; nickel ferrate magnetite nanoparticles supported on silica immobilized covalently; amino glycol gadolinium nanocomposite preparation; sulfinyl green preparation; tetrazole green preparation.

In this study, a novel gadolinium 2-amino-2-methyl-1,3-propanediol (amino glycol) complex immobilized covalently on CoFe2O4 magnetite nanoparticles was synthesized. The nanocatalyst was characterized thoroughly using thermogravimetric analyzes (TGA), FT-IR spectroscopy, SEM (SEM), energy dispersive X-ray (EDX), inductively coupled plasma optical emission spectroscopy (ICP-OES), vibrational sample magnetometry (VSM), and powder X-ray diffraction (PXRD). CoFe2O4 @amino glycol/Gd was found to be efficient for the oxidation of sulfides to sulfinyl R1S(O)R2 [R1 = Et, Ph, Bn, etc.; R2 = Me, Et, Ph, etc.] and synthesis of 5-substituted 1H-tetrazoles I [R3 = Ph, Bn, 4-HOC6H4, etc.] at mild reaction conditions in the green medium. The influences of reaction temperature, solvent, and the amount of catalysts were studied. The best results were obtained in water and without organic solvent condition for 5-substituted 1H-tetrazoles and oxidation of sulfides, resp. The catalyst was easily collected via an external magnetic field and further reused at least 6 times without a significant decrease in catalytic activity. The wide applicability of the catalyst, ease of catalyst separation, its reusability capacity, and importantly reaction operation in a green medium and elimination of hazardous organic solvents were the advantages of this catalyst.

Journal of Organometallic Chemistry published new progress about Functional groups, sulfinyl group. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Marchese, Austin D. published the artcileNickel-Catalyzed Enantioselective Carbamoyl Iodination: A Surrogate for Carbamoyl Iodides, COA of Formula: C7H6N2, the main research area is iodooxindole preparation enantioselective; styrene carbamoyl chloride carboiodination nickel catalyst.

This work reports the enantioselective formal transfer of a carbamoyl iodide across 1,1-disubstituted styrenes 2-N(C(O)Cl)R-3-R1-4-R2-5-R3-6-R4-C6C(=CH2)R5 (R = Me, prop-2-en-1-yl, 4-methoxybenzyl; R1 = H, F; R2 = H, F, Cl, OMe, CF3; R3 = H, Cl, OMe, C(O)OCH3; R4 = H, F, OMe; R5 = Me, Ph, cyclopropyl, etc.) using Ni-catalysis. Employing an air-stable Ni(II) precatalyst and a com. available chiral ligand ((S)-tBuPHOX), enantioenriched 3,3-disubstituted iodooxindoles I were obtained in up to 90% yield and up to 97:3 e.r. This methodol. was applied to the total synthesis of (-)-esermethole and (-)-phenserine.

ACS Catalysis published new progress about Carbamoylation (stereoselective). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Deng, Guobo published the artcileAssembly of Furazan-Fused Quinolines via an Expeditious Metal-Free [2+2+1] Radical Tandem Cyclization Process, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is oxadiazoloquinoline preparation; arylketimine benzonitrile tertbutyl nitrite radical tandem heteroannulation.

A [2+2+1]-NO-segment-incorporating heteroannulative cascade is described. This versatile method, particularly using modular cyanoarylated ketimine substrates 2-CN-3-R-4-R1-5-R2C6HN=C(Me)Ar (Ar = 3-methylphenyl, 4-bromophenyl, thiophen-2-yl, etc.; R = H, Br; R1 = H, Br; R2 = H, Me, F, Cl, Br, MeO, CF3), allows efficient access to structurally diversified quinolines embedded with an oxadiazole core I. This metal-free protocol proceeds smoothly at 30°C, offers easy manipulation of substituents on the quinoline moiety, and tolerates a spectrum of functional groups. D. functional theory calculation revealed that the cyano moiety is crucial to facilitate the early cyclization step in this heteroannulation process and is different from the previously established late cyclization mechanistic interpretation.

Organic Letters published new progress about Density functional theory, B3LYP. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts