Tag: M.W=100-150

Du, Huang-Chi published the artcileSynthesis of 5-substituted tetrazoles via DNA-conjugated nitrile, Computed Properties of 269411-71-4, the main research area is nitrile DNA conjugated sodium azide zinc cycloaddition; tetrazole substituted DNA conjugated preparation.

A zinc bromide-catalyzed synthesis of 5-substituted tetrazoles via DNA-conjugated nitriles using sodium azide has been developed. The protocol offered moderate to excellent yields of tetrazoles with a broad range of substrates, including a variety of functionalized aromatic, heterocyclic, and aliphatic nitriles. In addition, the electronic effect within the substrate scope was evaluated. DNA fidelity was assessed by ligation efficiency and amplifiability anal. The ability to generate tetrazoles expands the diversity of heterocycles in the preparation of DNA-encoded chem. libraries.

Organic & Biomolecular Chemistry published new progress about 1,3-Dipolar cycloaddition catalysts. 269411-71-4 belongs to class nitriles-buliding-blocks, name is 3-Amino-5-methoxybenzonitrile, and the molecular formula is C8H8N2O, Computed Properties of 269411-71-4.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Carpentier, Florian published the artcileSynthesis of 5-Substituted 1H-Tetrazoles from Nitriles by Continuous Flow: Application to the Synthesis of Valsartan, Formula: C6H4N2, the main research area is tetrazole preparation; nitrile trimethylazide continuous flow polymer supported organotin catalyst; valsartan preparation angiotensin II receptor.

An efficient continuous flow process for the synthesis of 5-substituted 1H-tetrazoles I [R = n-Bu, Ph, 2-thienyl, etc.] was described. The polymer-supported organotin azide, which was in situ generated with a polystyrene-supported triorganotin alkoxide and trimethylsilylazide and immobilized in a packed bed reactor. The process involved the reaction between a polymer-supported triorganotin azide, trimethylazide and organic nitriles. The process was also applied for the synthesis of valsartan an angiotensin II receptor antagonist II. This approach was simple, fast (it took from 7.5 to 15 min), and guaranted a low concentration of tin residues in the products (<5 ppm). Organic Process Research & Development published new progress about Angiotensin II receptor antagonists. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Martin, James S. published the artcileCharacterising covalent warhead reactivity, Safety of Picolinonitrile, the main research area is NMR covalent drug warhead kinetics; Covalent drug; Reactivity; Warhead.

Many drugs currently used are covalent inhibitors and irreversibly inhibit their targets. Most of these were discovered through serendipity. Covalent inhibitions can have many advantages from a pharmacokinetic perspective. However, until recently most organizations have shied away from covalent compound design due to fears of non-specific inhibition of off-target proteins leading to toxicity risks. However, there has been a renewed interest in covalent modifiers as potential drugs, as it possible to get highly selective compounds It is therefore important to know how reactive a warhead is and to be able to select the least reactive warhead possible to avoid toxicity. A robust NMR based assay was developed and used to measure the reactivity of a variety of covalent warheads against serine and cysteine – the two most common targets for covalent drugs. A selection of these warheads also had their reactivity measured against threonine, tyrosine, lysine, histidine and arginine to better understand our ability to target non-traditional residues. The reactivity was also measured at various pHs to assess what effect the environment in the active site would have on these reactions. The reactivity of a covalent modifier was found to be very dependent on the amino acid residue.

Bioorganic & Medicinal Chemistry published new progress about Covalent bond (covalent inhibitors). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

El-Mahdy, K. M. published the artcileConvenient Methodology for Some Heterocyclization Reactions with Thioxopyrimidine Derivatives, Application In Synthesis of 91-15-6, the main research area is fused pyrimidine heterocyclic preparation; thioxopyrimidine dimedone benzaladehyde phthalonitril eelectrophilic substitution nucleophilic reaction.

A simple and efficient method for derivatization of the pyrimidine nucleus is developed. The readily available 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one has been used as a versatile building block for the synthesis of thioxopyrimidine derivatives A variety of novel fused pyrimidines has been prepared via nucleophilic and/or electrophilic reactions of thioxopyrimidine derivatives

Russian Journal of Organic Chemistry published new progress about Electrophilic substitution reaction. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application In Synthesis of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, Lei published the artcileFabrication of Nanoreactors Based on End-Functionalized Polymethacrylate and Their Catalysis Application, Safety of Picolinonitrile, the main research area is end functionalized polymethacrylate nanoreactor catalysis application.

Polymer-based nanoreactor, which can be achieved by self-assembling of amphiphilic polymers in water, has attracted more and more attention in recent years. In this study, a kind of Pd-nanoreactor was fabricated by self-assembling of chiral palladium complex-containing amphiphilic polymers in water. Firstly, chain transfer reagent (CTA) CEPA-PyOx was obtained by condensation reaction of (S,S)-4-hydroxymethyl-5-phenyl-2-(2′-pyridinyl)-1,2-oxazoline (PyOx) and 4-cyano-4-[((ethylthio)carbonothioyl)thio] pentanoic acid (CEPA) in the presence of EDC·HCl. Next, polymethacrylate with a terminal chiral oxazoline ligand (CEPA-POEGMA36-PyOx) was synthesized through Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization After removal of the thioester bond and coordination with palladium trifluoroacetate, the polymer self-assembled in water affording Pd-nanoreactor, which possess core-shell structure and with chiral palladium complex in the core. At last, the nanoreactor was successfully applied in the asym. catalytic synthesis of flavanone in aqueous phase, and the catalyst loading was greatly reduced compared to unsupported palladium complex. In the presence of low palladium loading (0.5 mol%), flavanone was successfully synthesized with excellent yield (98%) and high enantioselectivity (82%).

Journal of Inorganic and Organometallic Polymers and Materials published new progress about Lower critical solution temperature. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Evtushok, Vasilii E. published the artcileSynthesis of pyrazolo- and [1,2,4]triazolo-[1,5-a]quinolin-9-ols by cycloaddition to 8-hydroxyquinoline N-imide, Product Details of C8H4N2, the main research area is amino hydroxyquinolinium mesitylenesulfonate internal alkyne cycloaddition; alkene amino hydroxyquinolinium mesitylenesulfonate cycloaddition; pyrazoloquinolinol preparation; nitrile amino hydroxyquinolinium mesitylenesulfonate cycloaddition; triazoloquinolinol preparation.

The reaction of 1-amino-8-hydroxyquinolinium mesitylenesulfonate with alkenes and alkynes containing electron-withdrawing substituents was performed in MeCN-K2CO3 system and gave the resp. 9-hydroxypyrazolo[1,5-a]quinolines I [R = H, CO2Me, Ph; R1 = Ac, CO2Me, CO2Et, COPh]. The reaction with acetonitrile and aromatic nitriles in aqueous 2N KOH solution gave the resp. 9-hydroxy[1,2,4]triazolo[1,5-a]quinolines II [R = Me, C6H5, 2-NCC6H4, 3,4-(MeO)2C6H3].

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 1,3-Dipolar cycloaddition reaction. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kaur Gulati, Harmandeep published the artcileDesign, Synthesis, biological investigations and molecular interactions of triazole linked tacrine glycoconjugates as Acetylcholinesterase inhibitors with reduced hepatotoxicity, Category: nitriles-buliding-blocks, the main research area is click alkyne azide triazole cycloaddition catalyst human HePG2 aminoglycoside; triazole glycoconjugate acetylcholinesterase inhibitor hepatotoxicity; mol dynamics tacrine glycoconjugate acetylcholinesterase inhibitor alzheimer docking; Enzyme Kinetics; Glyco-conjugates; Hepatotoxicity; Molecular docking; Molecular dynamics.

Tacrine is a known Acetylcholinesterase (AChE) inhibitors having hepatotoxicity as main liability associated with it. The present study aims to reduce its hepatotoxicity by synthesizing tacrine linked triazole glycoconjugates via Huisgen’s [3 + 2] cycloaddition of anomeric azides and terminal acetylenes derived from tacrine. A series of triazole based glycoconjugates containing both acetylated, e.g. I, and free sugar hydroxyl groups at the amino position of tacrine were synthesized in good yield taking aid from mol. docking studies and evaluated for their in vitro AChE inhibition activity as well as hepatotoxicity. All the hybrids were found to be non-toxic on HePG2 cell line at 200μM (100% cell viability) as compared to tacrine (35% cell viability) after 24 h of incubation period. Enzyme kinetic studies carried out for one of the potent hybrids in the series I (IC50 0.4μM) revealed its mixed inhibition approach. Thus, compound I can be used as principle template to further explore the mechanism of action of different targets involved in Alzheimer’s disease (AD) which stands as an adequate chem. probe to be launched in an AD drug discovery program.

Bioorganic Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shakeel-u-Rehman published the artcileClick chemistry inspired facile synthesis and bio-evaluation of novel triazolyl analogs of D-(+)-pinitol, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is structure activity enzyme inhibiting antitumor inositol triazole preparation human; click cycloaddition alkyne azide glucosidase inhibitory triazole inositol preparation; glucosidase inhibitory alkyne azide cycloaddition triazole cyclitol antitumor preparation.

Cu(I)-catalyzed alkyne-azide cycloaddition was carried out for the preparation of novel 1,4-disubstituted 1,2,3-triazoles of D-(+)-pinitol. All the analogs were screened for cytotoxicity against promyelocytic leukemia (HL-60), colorectal carcinoma (HCT 116) and pancreatic carcinoma (Mia-Paca-2) cancer cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay. Compounds, e.g. I, showed the best activity with IC50 of 19.2, 17.5 and 16.4μM against leukemia (HL-60), colorectal carcinoma (HCT 116) and pancreatic carcinoma (Mia-Paca-2) cell lines resp. All the triazolyl analogs were further evaluated for β-glucosidase inhibitory activity, wherein, the deprotected derivatives, e.g. II, showed better activity with IC50 of 148.5, 139.2 and 142.4μM resp. The structure activity relationship (SAR) studies revealed that the analogs with bromo, nitro or Me groups (substituted Ph moiety attached to 1,2,3-triazole) moiety exhibited better cytotoxicity, while as, the analogs with N-substituted long chain aliphatic hydrocarbon R moieties displayed effective β-glucosidase inhibition.

Arabian Journal of Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vorob’ev, Aleksey Yu. published the artcile1,3-Dipolar cycloaddition of cyanopyridines to heterocyclic N-imines: experimental and theoretical study, SDS of cas: 100-70-9, the main research area is triazolopyridine preparation; triazolophenanthroline preparation; triazoloquinolinol preparation; cyanopyridine heterocyclic imine dipolar cycloaddition.

A series of 2-pyridyl[1,2,4]triazolo[1,5-a]azines I [R = H, 4-pyridyl; R1 = H, 2-pyridyl; R2 = 2-pyridyl, 3-pyridyl, 4-pyridyl], II [R3 = 2-pyridyl, 3-pyridyl, 4-pyridyl], and III [R4 = 2-pyridyl, 3-pyridyl, 4-pyridyl] was synthesized by cycloaddition of cyanopyridines with N-aminoazinium mesitylenesulfonates under basic conditions (KOH/H2O). An improved protocol for pyridyl-substituted [1,2,4]triazolo[1,5-a]pyridines synthesis based on addition of H2O2 as internal oxidant had been suggested. In the case of quinolinium and isoquinolinium salts, only dimerization of the corresponding N-imines had been observed, while pyrazinium-N-imine had not shown any reactivity toward cycloaddition DFT studies showed that the cycloaddition proceeded through concerted mechanism.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 1,3-Dipolar cycloaddition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Qiang-Qiang published the artcileSynthesis of π-Extended Imidazoles by 1,3-Dipolar Cycloaddition of Polycyclic Aromatic Azomethine Ylides with Nitriles, Quality Control of 100-70-9, the main research area is polycyclic aromatic azomethine ylide nitrile dipolar cycloaddition reaction; tertbutyl aryl tribenzoimidazoquinolizine preparation; aryl tertbutyl tribenzoimidazoquinolizine palladium catalyst cyclization; diazadibenzocyclopentapentaphene preparation UV fluorescence.

Dipolar cycloaddition of polycyclic aromatic azomethine ylides with nitriles to produce highly fused imidazole derivatives, i.e., tribenzo[b,g,ij]imidazo[2,1,5-de]quinolizine was reported. The advantages of this transformation were the broad substrate scope and the good functional group compatibility. The subsequent palladium-catalyzed intramol. cyclization provided an efficient approach to further π-extended imidazoles, i.e., 14b1,15-diazadibenzo[fg,ij]cyclopenta[rst]pentaphene.

Organic Letters published new progress about 1,3-Dipolar cycloaddition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts