Tag: M.W=100-150

Lai, Calvine published the artcileAdvances in Stereoselective Iron(II)-Catalyzed Synthesis of Sulfilimines with N-Mesyloxycarbamates, HPLC of Formula: 100-70-9, the main research area is sulfilimine preparation enantioselective diastereoselective; thioether mesyloxycarbamate amination iron catalyst stereoselective.

A stereoselective amination of thioethers R1SR2 to access sulfilimines (R)-R1R2SNC(O)OR3 [R1 = Ph, naphthalen-2-yl, thiophen-2-yl, etc., R2 = Me, Et, R3 = (4-methylphenyl)methyl, diphenylmethyl, 2,2,2-trichloroethyl, etc.] using N-mesyloxycarbamates MsOHNC(O)OR3 in a catalytic system composed of iron(II) chloride and a pyridine oxazoline (PyOX) ligand, e.g., (S)-5,5-dimethyl-4-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole, has been developed. The reaction proceeds with modest to good yields and selectivities (up to 86:14 d.r. and 72:28 e.r.). Selectivity was controlled by both the structure of the chiral ligand and the amination reagent.

Helvetica Chimica Acta published new progress about Amination catalysts (stereoselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Malancona, Savina published the artcile5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein, Recommanded Product: Picolinonitrile, the main research area is dihydroxy pyrimidine derivative preparation HIV1 nucleocapsid protein ADME structure.

The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a target of great interest to develop new anti-HIV agents. Moreover, the highly conserved sequence offers the opportunity to escape the drug resistance (DR) that emerged following the highly active antiretroviral therapy (HAART) treatment. On the basis of our previous research, nordihydroguaiaretic acid 1 acts as a NC inhibitor showing moderate antiviral activity and suboptimal drug-like properties due to the presence of the catechol moieties. A bioisosteric catechol replacement approach led us to identify the 5-dihydroxypyrimidine-6-carboxamide substructure as a privileged scaffold of a new class of HIV-1 NC inhibitors. Hit validation efforts led to the identification of optimized analogs, as represented by compound 28, showing improved NC inhibition and antiviral activity as well as good ADME and PK properties.

ACS Medicinal Chemistry Letters published new progress about Anti-HIV agents (anti-HIV-1 agents, Anti-HIV-1 drugs). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Bingqi published the artcileConstruction of a Novel Z-Scheme Heterojunction with Molecular Grafted Carbon Nitride Nanosheets and V2O5 for Highly Efficient Photocatalysis, COA of Formula: C7H6N2, the main research area is grafted carbon nitride nanosheets vanadia efficient photocatalysis; photocatalytic water purification.

Mol. grafted carbon nitride (CN) nanosheets coupled with V2O5 to form a novel Z-scheme heterojunction photocatalyst V2O5/CNX (X is 2-aminobenzonitrile) by a facile in situ growth method was acquired. Its photocatalytic properties were investigated by hydrogen evolution and degradation of rhodamine B under simulated sunlight irradiation It was found that the assembled heterojunction could remarkably enhance photocatalytic activity in contrast to pure CN, V2O5, and previous reported heterojunctions. The great improvement of photocatalytic activity can be attributed to mol. grafting and the formation of the Z-scheme heterojunction, resulting in a remarkable red shift of the optical absorption, a rapid separation of charge carriers, an increase of sp. surface area, and introduction of defects. Moreover, exfoliation of bulk CNX into ultrathin nanosheets increases mobility of charges and sp. surface area. Different wt % ratios of V2O5-loaded heterojunctions were prepared, and 2% of V2O5-loaded heterojunctions were found to display optimal catalytic efficiency. The possible activity enhanced mechanism was proposed. This work reveals that the mol. grafted V2O5/CNX Z-scheme heterojunction can be utilized for highly efficient photocatalysis applied in energy conversion and environmental remediation.

Journal of Physical Chemistry C published new progress about Charge separation (photoinduced, electron-hole pair). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zheng, Dan published the artcileAbsolute control of helicity at the C-termini in quinoline oligoamide foldamers by chiral oxazolylaniline moieties, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is helicity induction quinoline oligoamide foldamer chiral oxazolylaniline.

Absolute one-handed chiral quinoline tetramers and octamers containing different oxazolylanilines at the C-terminus have been synthesized (e.g., I). The absolute one-handed sense and diastereomeric excess values were valued by 1NMR. X-ray crystal diffraction and CD studies reveal that the S-oxazolylaniline always induces a P-handed helicity and the absolute helicity is driven by the stable three-center hydrogen bonding between protons in the amide and N atoms in oxazolylaniline and adjacent quinoline ring. CPL investigations demonstrated that S-CQn-a∼d are CPL active and its glum values are dependent on its length. Interestingly, the sizes of the substituents in the chiral centers are different, however, they exert no effect on the dissym. factors gabs and glum of quinoline oligoamide foldamers.

Chinese Chemical Letters published new progress about Chiral induction (induction of helical chirality). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nguyen, Vu T. published the artcileVisible-Light-Enabled Direct Decarboxylative N-Alkylation, SDS of cas: 1885-29-6, the main research area is visible light decarboxylative alkylation aromatic carbocyclic acid heterocycle amine; acridine catalyst; amination; carboxylic acids; copper catalysis; photocatalysis; visible light.

The development of efficient and selective C-N bond-forming reactions from abundant feedstock chems. remains a central theme in organic chem. owing to the key roles of amines in synthesis, drug discovery, and materials science. Herein, the authors present a dual catalytic system for the N-alkylation of diverse aromatic carbocyclic and heterocyclic amines directly with carboxylic acids, by-passing their preactivation as redox-active esters. The reaction, which is enabled by visible-light-driven, acridine-catalyzed decarboxylation, provides access to N-alkylated secondary and tertiary anilines and N-heterocycles. Addnl. examples, including double alkylation, the installation of metabolically robust deuterated Me groups, and tandem ring formation, further demonstrate the potential of the direct decarboxylative alkylation (DDA) reaction.

Angewandte Chemie, International Edition published new progress about Acridines Role: CAT (Catalyst Use), USES (Uses). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Perevoshchikova, Anna N. published the artcileSynthesis and Prediction of the Ubiquinol-cytochrome c Reductase Inhibitory Activity of 3,4-Dihydroisoquinolines and 2-Azaspiro[4.5]decanes (Spiropyrrolines), SDS of cas: 100-70-9, the main research area is ubiquinol cytochrome c reductase inhibitor hydroisoquinoline azaspirodecane.

Isoquinolines rank as the second largest group among the plant alkaloids. Natural isoquinolines and synthetic isoquinoline derivatives exhibit numerous biol. activities. In this study, the approaches to synthesis of new 3,4-dihydroisoquinoline and 2-azaspiro[4.5]decane (spiropyrroline) derivatives annelated by C(3)-C(4) bonds with a cyclohexyl or cyclopentyl moiety have been developed. In accord with the results of biol. activity prediction by the PASS software, mol. docking was carried out on the ubiquinol-cytochrome c reductase (bc1 complex) model. Compounds 6e and 12a,d (I – III, resp.) were found out as potential Q0 site inhibitors of the bovine bc1 complex.

Journal of Heterocyclic Chemistry published new progress about Drug screening (in silico, using PASS software). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ashraf, Muhammad Aqeel published the artcileFe3O4@L-lysine-Pd(0) organic-inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2+3] cycloaddition synthesis of 5-substituted 1H-tetrazoles, SDS of cas: 100-70-9, the main research area is tetrazole preparation green chem chemo homoselective; aryl nitrile sodium azide cycloaddition reaction palladium nanocatalyst.

An efficient and sustainable synthetic protocol has been presented to synthesis and 5-substituted 1H-tetrazole privileged heterocyclic substructures I (R = Ph, 4-formylphenyl, pyridin-2-yl, etc.). The synthetic protocol involves two-component reaction between aryl nitriles RCN and NaN3 in water using complex of L-lysine-palladium nanoparticles (NPs) modified Fe3O4 nanoparticles as magnetically separable, recyclable, and reusable heterogeneous catalyst. Magnetically retrievable L-lysine-Pd(0) modified Fe3O4 nanoparticles were applied in [2+3] cycloaddition synthesis of 5-substituted 1H-tetrazoles I. The advantages of this strategy include easy recovery and efficient reusability of the expensive Pd NPs, obtaining high yields of [2+3] cycloaddition and short reaction times, and all of the reported synthetic strategies are being performed in water as green solvent for a wide range of substrates.

Applied Organometallic Chemistry published new progress about [3+2] Cycloaddition reaction (chemoselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ashraf, Muhammad Aqeel published the artcileFe3O4@L-lysine-Pd(0) organic-inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2+3] cycloaddition synthesis of 5-substituted 1H-tetrazoles, Recommanded Product: Phthalonitrile, the main research area is tetrazole preparation green chem chemo homoselective; aryl nitrile sodium azide cycloaddition reaction palladium nanocatalyst.

An efficient and sustainable synthetic protocol has been presented to synthesis and 5-substituted 1H-tetrazole privileged heterocyclic substructures I (R = Ph, 4-formylphenyl, pyridin-2-yl, etc.). The synthetic protocol involves two-component reaction between aryl nitriles RCN and NaN3 in water using complex of L-lysine-palladium nanoparticles (NPs) modified Fe3O4 nanoparticles as magnetically separable, recyclable, and reusable heterogeneous catalyst. Magnetically retrievable L-lysine-Pd(0) modified Fe3O4 nanoparticles were applied in [2+3] cycloaddition synthesis of 5-substituted 1H-tetrazoles I. The advantages of this strategy include easy recovery and efficient reusability of the expensive Pd NPs, obtaining high yields of [2+3] cycloaddition and short reaction times, and all of the reported synthetic strategies are being performed in water as green solvent for a wide range of substrates.

Applied Organometallic Chemistry published new progress about [3+2] Cycloaddition reaction (chemoselective). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nagasaki, Yo-hei published the artcileDehydration of Amides to Nitriles over Heterogeneous Silica-Supported Molybdenum Oxide Catalyst, Application of Picolinonitrile, the main research area is silica support molybdenum oxide catalyst preparation surface area; amide silica support molybdenum oxide catalyst dehydration; nitrile preparation.

Silica-supported molybdenum oxide (MoOx/SiO2) with 4.8 wt% Mo (0.5 mmol g-1) was an effective and reusable heterogeneous catalyst for dehydration of 2-furamide to 2-furonitrile (96% yield). The catalyst was applicable to the dehydration of various amides including heteroaromatic, aromatic and alkyl amides, providing the corresponding nitriles in high yields (87-97%). Based on the results of catalyst characterizations (XRD, TEM, UV-vis, Raman) and activity tests, MoOx species are highly dispersed over SiO2, and heptamolybdate anion ([Mo7O24]6-) and isolated dioxo ((O=)2MoO2) were mainly formed on the SiO2 support of the optimal MoOx/SiO2 catalyst. The strong Bronsted acid sites (Mo-OH-Si site) can be formed from the MoOx species and the adjacent silanol group, and the acid-base pair site (Mo(=O)OHSi site) of the strong Bronsted acid site (MoOH-Sisite) and base site (Mo=O) over MoOx/SiO2 catalyst could be themain active site for the dehydration of amides.

ChemCatChem published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hu, Fang-Peng published the artcileBase-promoted Lewis acid catalyzed synthesis of quinazoline derivatives, Quality Control of 1885-29-6, the main research area is quinazolinone preparation; amide oxazoline preparation heterocyclization Lewis acid catalyst.

A one-pot protocol has been developed for the synthesis of quinazolinones I (R = Me, Ph, 2-thienyl, etc.; R1 = H, 7-Me, 6-Cl, 6-Br, 7-Br, 5-F) from amide-oxazolines II (R2 = H, 5-Me, 4-Cl, 4-Br, 5-Br, 3-F) with TsCl via a cyclic 1,3-azaoxonium intermediate and 6π electron cyclization in the presence of a Lewis acid and base. The process is operationally simple and has a broad substrate scope. This method provides a unique strategy for the construction of quinazolinones I.

Organic & Biomolecular Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts