Tag: M.W=100-150

Karaki, Fumika published the artcileCatalyst-free photooxidation reaction from 1,4-dihydropyridazine to pyridazine under air, Related Products of nitriles-buliding-blocks, the main research area is tetrazine strained alkene inverse electron Dielse Alder reaction photooxidation; pyridazine preparation.

In the inverse electron-demand Diels-Alder (iEDDA) reactions between tetrazines and strained alkenes, a mixture of 1,4-dihydropyridazine isomers are formed first, and they are then oxidized to pyridazines. Although the products of these related oxidation processes converge as pyridazines, the oxidation rate was quite low with some substrates. In this study, 1,4-dihydropyridazines formed in the iEDDA reactions were oxidized to pyridazines by simply irradiating with an UV light under an air atm. Exptl. results implied that singlet oxygen was formed in the course of the reactions to oxidize the 1,4-dihydropyridazine mols.

Tetrahedron published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Sheng published the artcileRegioselective umpolung addition of dicyanobenzene to α,β-unsaturated alkenes enabled by electrochemical reduction, Computed Properties of 91-15-6, the main research area is dicyanobenzene unsaturated alkene regioselective electrochem reduction.

An umpolung addition of dicyanobenzene to α,β-unsaturated alkenes has been developed using an electroreductive strategy. This electrochem. protocol is well compatible with a broad range of conventionally challenging substrates, including α,β-unsaturated esters, nitriles and trisubstituted enones. Moreover, good to excellent regioselectivities are observed in the reaction of cinnamates with dicyanobenzene. Synthetic utility of this electrochem. approach is further demonstrated by direct late-stage functionalization of (S)-verbenone and 16-dehydropregnenolone acetate.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Biswas, Sovan published the artcileExpedient Synthesis of Bridged Bicyclic Nitrogen Scaffolds via Orthogonal Tandem Catalysis, Product Details of C6H4N2, the main research area is alkylidenenormorphan preparation diastereoselective regioselective; picolinamide gem dibromoalkene alkenylation amidation tandem palladium copper catalyst; alkenylation; bridged bicyclic nitrogen scaffolds; normorphan; remote functionalization; tandem catalysis.

Bridged nitrogen bicyclic skeletons I (R = t-Bu, Ph, cyclohexyl, 1-(benzenesulfonyl)-1H-indol-5-yl, etc.; R1 = H, methoxycarbonyl; R2 = H, Me; X = O, CH2, Et, (tert-butoxy)-formamidyl; Y = O, CH2, Et) have been accessed via unprecedented site- and diastereoselective orthogonal tandem catalysis from readily accessible reactants in a step economic manner. Directed Pd-catalyzed γ-C(sp3)-H olefination of aminocyclohexanes II (X = Y = CH2, Et) with gem-dibromoalkenes RCH=C(Br2), followed by a consecutive intramol. Cu-catalyzed amidation of the 1-bromo-1-alkenylated product III delivers the interesting normorphan skeleton. The tandem protocol can be applied on substituted aminocyclohexanes (X = Y = CH2) and aminoheterocycles II (X = O, (tert-butoxy)-formamidyl; Y = O), easily providing access to the corresponding substituted, aza- and oxa-analogs I. The Cu catalyst of the Ullmann-Goldberg reaction addnl. avoids off-cycle Pd catalyst scavenging by alkenylated reaction product IV. The picolinamides II directing group stabilizes the enamine of the 7-alkylidenenormorphans I, allowing further product V post functionalizations. Without Cu catalyst, regio- and diastereoselective Pd-catalyzed γ-C(sp3)-H olefination is achieved.

Angewandte Chemie, International Edition published new progress about Alkenylation catalysts, stereoselective (regioselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mo, Xueling published the artcileCopper-Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α-Bromoamides, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is copper catalyst enantioselective Sonogashira coupling alkyne alpha bromoamide; Sonogashira reaction; copper catalysis; enantioselectivety; terminal alkynes; α-bromoamide.

An asym. copper-catalyzed Sonogashira type coupling between alkynes and α-bromoamides was developed. This method represents a facile approach to synthetically useful β, γ-alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylaniline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gajurel, Sushmita published the artcileCuO-NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level, COA of Formula: C6H4N2, the main research area is triazole preparation green chem; arylboronic acid arylacetylene heterocyclization copper nickel dioxide nanocatalyst; benzylhalide arylacetylene heterocyclization copper nickel dioxide nanocatalyst; epoxide phenyl acetylene heterocyclization copper nickel dioxide nanocatalyst; bistriazolyl methane preparation green chem; diazidomethyl methoxybenzene alkyne heterocyclization copper nickel dioxide nanocatalyst; tetrazole preparation green chem; aromatic nitrile heterocyclization copper nickel dioxide nano catalyst.

The unification of CuCl2 ·2H2O and NiCl2·6H2O with the support of graphitic carbon nitride yielded to form an efficient, synergistic, bimetallic nano-catalyst CuO-NiO@g-C3N4. Catalyst with three different molar ratios of Cu and Ni, i.e., Cu75Ni25 (Cu:Ni = 3:1; catalyst-a), Cu50Ni50 (Cu:Ni = 1:1; catalyst-b), and Ni66Cu33 (Ni:Cu = 2:1; catalyst-c), was synthesized, and their catalytic activity was examined The synergistic interaction of one metal with the other on the surface of extremely stable graphitic carbon nitride has enhanced the catalytic performance in the synthesis of triazoles I (R1 = Ph, (4-bromophenyl)methyl, 2-hydroxy-1-phenylethyl, etc.; R2 = H, 4-F, 3-Me, 4-Me, 4-OMe), tetrazoles II (R3 = Ph, pyrazin-2-yl, 4-formylphenyl, etc.), and bis-triazole derivatives III to such a distinguished level (in ppm level), which a monometal fail to possess. The aforementioned statement has been supported by the catalytic activity data provided for both the monometallic and bimetallic catalyst herein. In addition to this, benign reaction conditions, in situ generation of azides, wide reaction scopes, and reusability of the catalyst were also the major advantages leading toward safe and sustainable chem. beyond doubt.

Applied Organometallic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Banerjee, Indrani published the artcileAlkali Metal Catalysed Double Hydrophosphorylation of Nitriles and Alkynes, Category: nitriles-buliding-blocks, the main research area is alkali metal silylamide catalyzed hydrophosphorylation nitrile alkyne; crystal mol structure phosphoryl diphenylphosphinic amide.

Catalytic C-P and N-P bond formation via double hydrophosphorylation of nitriles with diphenylphosphine oxide using alkali metal precatalyst [MN(SiMe3)2] (M = Li, Na, K) is reported. The potassium congener was observed to be the most efficient catalyst for converting aryl nitriles to the corresponding N-((diphenyl-phosphoryl)(aryl)methyl)-P,P-diphenylphosphinic amide [ArCHP(O)-Ph2NHP(O)Ph2] at mild temperature (60°) and with neat reactants. Double hydrophosphorylation of alkynes with HP(O)Ph2 is also very effective when [KN(SiMe3)2] is used as a precatalyst at room temperature and gives the corresponding 1,2-diylbis(diphenyl-phosphine) oxide [RCHP(O)Ph2CH2P(O)Ph2] as the product. A wider substrate scope of both reactions is explored.

European Journal of Inorganic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bhattacharjee, Jayeeta published the artcileN-Heterocyclic Carbene-Phosphinidenide Complexes as Hydroboration Catalysts, Recommanded Product: Picolinonitrile, the main research area is hydroboration catalyst ruthenium osmium NHC carbene phosphinidene half sandwich; crystal structure mol ruthenium osmium NHC phosphinidene half sandwich; ruthenium osmium heterocyclic carbene phosphinidene half sandwich preparation; mechanism kinetics hydroboration ruthenium catalyst NHC phosphinidenide nitrile.

The reactions of the N-heterocyclic carbene-phosphinidene adducts (NHC)PSiMe3 and (NHC)PH with the dinuclear ruthenium and osmium complexes [(η6-p-cymene)MCl2]2 (M = Ru, Os) afforded the half-sandwich complexes [(η6-p-cymene){(NHC)P}MCl] and [(η6-p-cymene){(NHC)PH}MCl2] with two- and three-legged piano-stool geometries, resp. (NHC = IDipp, IMes; IDipp = 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene; IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazolin-2-ylidene). The complexes were initially tested as precatalysts for the hydroboration of benzonitrile, and the most active species, the ruthenium complex [(η6-p-cymene){(IMes)P}RuCl], was further used for the efficient hydroboration of a wide range (ca. 50 substrates) of nitriles, carboxylic esters, and carboxamides in neat pinacolborane (HBpin) under comparatively mild reaction conditions (60-80°C, 3-5 mol % catalyst loading). Preliminary mechanistic and kinetic studies are reported, and stoichiometric reactions with HBpin indicate the initial formation of the monohydride complex [(η6-p-cymene){(IMes)P}RuH] as the putative catalytically active species.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ren, Shishuai published the artcileDehydration of primary amides to nitriles catalyzed by [CNC]-pincer hydrido cobalt(III) complexes, Application In Synthesis of 100-70-9, the main research area is amide nitrile cobalt hydride catalyst dehydration selective safety; nitrile preparation.

The dehydration reactions from primary amides to nitriles were catalyzed by the [CNC]-pincer hydrido cobalt(III) complexes [(ortho-F4C6-CH=N-C10H6)Co(III)(H)(PMe3)2], [(2,5-F2C6H2-CH=N-C10H6)Co(III)(H)(PMe3)2] (I) and [(2,4,5-F3C6H-CH=N-C10H6)Co(III)(H)(PMe3)2] as catalysts with (EtO)3SiH as an efficient reducing agent. These hydrido cobalt(III) complexes as catalysts are suitable for many substrates and have good functional group tolerance. Among the three cobalt hydrides, complex I is the best catalyst. This is the first hydrido cobalt complex-catalyzed dehydration of primary amides to nitriles.

Catalysis Communications published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ruan, Shixiang published the artcileFacile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters, HPLC of Formula: 100-70-9, the main research area is nitrile preparation; primary amide dehydration lead diacetate catalyst.

The synthesis of nitriles RCN [R = n-Pr, 2-MeC6H4, 2-pyridyl, etc.] under mild conditions was achieved via dehydration of primary amides using lead salts as catalyst. The reaction processes were intensified by not only adding surfactant but also continuously removing the only byproduct, water from the system. Both aliphatic and aromatic nitriles could be prepared in this manner with moderate to excellent yields. The reaction mechanisms were obtained with high-level quantum chem. calculations, and the crucial role the anionic ligand played in the transformations were revealed.

Molecular Catalysis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Kai published the artcileEfficient dehydration of primary amides to nitriles catalyzed by phosphorus-chalcogen chelated iron hydrides, Computed Properties of 100-70-9, the main research area is nitrile preparation; primary amide dehydration phosphorus chalcogen chelated iron hydride catalyst.

A series of phosphorus-chalcogen chelated hydrido iron (II) complexes, (o-(R’2P)-p-R-C6H4Y)FeH(PMe3)3I (R = H, Me; R’ = iPr, Ph; Y = O, S, Se) were synthesized. The catalytic performances of I for dehydration of amides to nitriles were explored by comparing three factors: (1) different chalcogen coordination atoms Y; (2) R’ group of the phosphine moiety; (3) R substituent group at the Ph ring. It is confirmed that I (R = H; R’ = Ph; Y = S) with S as coordination atom has the best catalytic activity and I (R = H; R’ = Ph; Y = Se) with Se as coordination atom has the poorest catalytic activity among complexes I (R = H; R’ = Ph; Y = O), I (R = H; R’ = Ph; Y = S) and I (R = H; R’ = Ph; Y = Se). Electron-rich complex I (R = Me; R’ = iPr; Y = O) is the best catalyst among the seven complexes and the dehydration reaction was completed by using 2 mol% catalyst loading at 60° with 24 h in the presence of (EtO)3SiH in THF. Catalyst I (R = Me; R’ = iPr; Y = O) has good tolerance to many functional groups. Among the seven iron complexes, new complexes I (R = H, Me; R’ = iPr; Y = O) were obtained via the O-H bond activation of the preligands o-iPr2P(C6H4)OH and o-iPr2P-p-Me-(C6H4)OH by Fe(PMe3)4. Both I (R = H, Me; R’ = iPr; Y = O) were characterized by spectroscopic methods and X-ray diffraction anal. The catalytic mechanism was exptl. studied and also proposed.

Applied Organometallic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts