Tag: M.W=100-150

Pieczykolan, Michal published the artcileAn Efficient Method for the Programmed Synthesis of Multifunctional Diketopyrrolopyrroles, Application In Synthesis of 100-70-9, the main research area is aldehyde primary amine nitrile diethyl oxalacetate diastereoselective cyclization fluorescence; diketopyrrolopyrrole preparation; donor-acceptor systems; dyes; fluorescence; heterocycles; lactams.

A new, transformative methodol. for the preparation of diketopyrrolopyrroles from aldehydes, primary amines, nitriles, and di-Et oxalacetate has been developed. It is now possible to prepare diketopyrrolopyrroles, e.g., I, bearing an ordered arrangement of three different substituents from abundant and com. available materials, allowing the independent regulation of all desired physicochem. properties. For the first time very electron-rich (carbazol-3-yl, dimethylaminophenyl, pyrrolo[3,2-b]pyrrolyl), and sterically hindered substituents (naphthalen-1-yl, quinolin-4-yl, acridin-9-yl, imidazo[1,5-a]pyridin-1-yl, 2-bromophenyl etc.) can be appended to the diketopyrrolopyrrole core by condensation of an appropriate nitrile with a pyrrolidin-2-one intermediate. Even greater synthetic possibilities are related to the fact that such demanding substituents as 4-dimethylaminophenyl, indol-3-yl, and 2-methoxyphenyl can be incorporated from aldehyde precursors, bypassing problems with the nitriles reactivity.

Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Das, Asit Kumar published the artcileCu(OAc)2 catalysed aerobic oxidation of aldehydes to nitriles under ligand-free conditions, Safety of Picolinonitrile, the main research area is aldehyde ammonium acetate copper catalyst oxidation reaction green chem; nitrile preparation.

An economically efficient and environmentally benign approach for the direct oxidative transformation of aldehydes to nitriles was developed using com. available non-toxic copper acetate as an inexpensive catalyst and ammonium acetate as the source of nitrogen in the presence of aerial oxygen as an eco-friendly oxidant under ligand-free conditions. The reactions were associated with high yield and various sensitive moieties like allyloxy, benzyloxy, t-butyldimethylsilyloxy, hetero-aryl, formyl, keto, chloro, bromo, methylenedioxy and cyano were well tolerated in the aforesaid method. The kinetic studies showed first order dependency on the aldehyde substrate in the reaction rate. The reaction was faster with the electron deficient aldehydes as confirmed by Hammett anal. Moreover, the present oxidative method was effective on larger scales showing potential for industrial application.

RSC Advances published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Das, Asit Kumar published the artcileCu(OAc)2 catalysed aerobic oxidation of aldehydes to nitriles under ligand-free conditions, Synthetic Route of 1885-29-6, the main research area is aldehyde ammonium acetate copper catalyst oxidation reaction green chem; nitrile preparation.

An economically efficient and environmentally benign approach for the direct oxidative transformation of aldehydes to nitriles was developed using com. available non-toxic copper acetate as an inexpensive catalyst and ammonium acetate as the source of nitrogen in the presence of aerial oxygen as an eco-friendly oxidant under ligand-free conditions. The reactions were associated with high yield and various sensitive moieties like allyloxy, benzyloxy, t-butyldimethylsilyloxy, hetero-aryl, formyl, keto, chloro, bromo, methylenedioxy and cyano were well tolerated in the aforesaid method. The kinetic studies showed first order dependency on the aldehyde substrate in the reaction rate. The reaction was faster with the electron deficient aldehydes as confirmed by Hammett anal. Moreover, the present oxidative method was effective on larger scales showing potential for industrial application.

RSC Advances published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gao, Hongjie published the artcileBioinspired Iron-Catalyzed Dehydration of Aldoximes to Nitriles: A General N-O Redox-Cleavage Method, Recommanded Product: Picolinonitrile, the main research area is nitrile preparation chemoselective; aldoxime dehydration bioinspired iron catalyst; benzoisoxazole kemp elimination bioinspired iron catalyst; dehydration kemp elimination bioinspired iron catalyst.

An efficient iron catalyst, Cp*Fe(1,2-Cy2PC6H4O), which rapidly converts various aliphatic and aromatic aldoximes RCH=NOH [R = Pr, Ph, 2H-1,3-benzodioxol-5-yl, etc.] to nitriles RCN with release of H2O at room temp was reported. The catalysis involves redox activation of the N-O bond by a 1e- transfer from the iron catalyst to the oxime. Such redox-mediated N-O cleavage was demonstrated by the isolation of a ferrous iminato intermediate from the reaction of the ketoxime substrate. This iron-catalyzed acceptorless dehydration approach represents a general method for the preparation of nitriles, and it also delivers salicylonitriles R1CN(2-OH) [R1 = Ph, 3-methoxyphenyl, naphthalen-1-yl, etc.] catalyzing the Kemp elimination reaction.

Journal of Organic Chemistry published new progress about Aldoximes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Uludag, N. published the artcileAn Efficient Synthesis of Nitriles from Aldoximes in the Presence of Trifluoromethanesulfonic Anhydride in Mild Conditions, Computed Properties of 100-70-9, the main research area is aldoxime dehydration reaction; nitrile preparation.

A new and convenient protocol was proposed for the transformation of aldoximes to nitriles using trifluoromethanesulfonic anhydride and triethylamine. The proposed method allowed a range of aldoximes, including aromatic, heterocyclic, aliphatic, and cycloaliphatic aldoximes, to converted to the corresponding nitriles in good to excellent yields.

Russian Journal of Organic Chemistry published new progress about Aldoximes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kooijman, Pieter C. published the artcileA novel dual ionization modality source for infrared laser ablation post-ionization mass spectrometry imaging to study fungicide metabolism and transport, Computed Properties of 1885-29-6, the main research area is ionization modality IR laser ablation postionization MSI fungicide metabolism.

We present a novel probe design for ambient laser-based mass spectrometry imaging combining electrospray ionization (ESI) and atm. pressure chem. ionization (APCI) in a single probe, compatible with a com. laser ablation electrospray ionization (LAESI) instrument. Here we describe the probe design considerations and features, as well as an inhouse developed data processing routine designed to extract accurate mass spectrometry imaging data from ambient laser ablation post-ionization experiments We characterize the probe performance in both APCI and ESI mode on a selection of compounds and show improved pixel-to-pixel repeatability for LA-APCI as compared to LAESI. We apply the dual ionization probe in APCI mode in a time series experiment to monitor agrochems. on tomato plants. We investigate the translocation of fungicide isotianil and one of its metabolites, anthranilonitrile, by mass spectrometry imaging over a period of two weeks after application on a leaf surface. LA-APCI-MSI shows translocation of anthranilonitrile from treated leaves towards non-treated leaves. In summary, we demonstrate that LA-APCI imaging is a valuable addition to the ambient mass spectrometry toolbox, with particular advantages for imaging experiments across a variety of compounds

International Journal of Mass Spectrometry published new progress about Atmospheric pressure chemical ionization mass spectrometry. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qian, Deyun published the artcileChiral Alkyl Amine Synthesis via Catalytic Enantioselective Hydroalkylation of Enecarbamates, Product Details of C6H4N2, the main research area is aryl oxazoline preparation; enecarbamates alkyl halide nickel oxazoline catalyst enantioselective hydroalkylation; alkyl amine preparation.

A nickel-catalyzed hydroalkylation method to assemble a wide range of chiral alkyl amines from enecarbamates (N-Cbz-protected enamines) and alkyl halides with high regio- and enantioselectivity was reported. The method works for both nonactivated and activated alkyl halides and was able to produce enantiomerically enriched amines with two minimally differentiated α-alkyl substituents. The mild conditions led to high functional group tolerance, which is demonstrated in the postproduct functionalization of many natural products and drug mols., as well as the synthesis of chiral building blocks and key intermediates to bioactive compounds

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nasibipour, Mina published the artcileTuning of the redox potential and catalytic activity of a new Cu(II) complex by o-iminobenzosemiquinone as an electron-reservoir ligand, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is preparation crystal mol structure copper iminobenzosemiquinone complex; EPR spectra magnetic property copper iminobenzosemiquinone complex; cyclic voltammetry copper iminobenzosemiquinone complex; alc oxidation catalyst copper iminobenzosemiquinone complex; homocoupling catalyst copper iminobenzosemiquinone complex.

The synthesis and characterization of a new Cu(II) complex, LNIS2CuII (LNIS = o-iminobenzosemiquinone), are reported. X-ray crystallog. studies showed that two o-iminobenzosemiquinone radicals form a distorted square-planar geometry around the Cu(II) center of LNIS2CuII. Magnetic measurements revealed the paramagnetic character of the complex caused by the presence of three unpaired electrons located on the o-iminobenzosemiquinonate ligands and the CuII center. Magnetochem. experiments, and EPR and DFT studies prove that the ground state of the complex is a doublet, which is consistent with the ferromagnetic coupling between Cu(II) and o-iminobenzosemiquinone centers and stronger antiferromagnetic coupling between the iminobenzosemiquinone moieties. The ligand-centered redox reactions of the complex were studied by cyclic voltammetry. Aerobic oxidation of alcs. to aldehydes with TEMPO was studied in the presence of LNIS2CuII. Furthermore, LNIS2CuII is an efficient catalyst in homo-coupling of terminal alkynes.

New Journal of Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Xinyu published the artcileUse of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications, Formula: C7H6N2, the main research area is thiol trifluorodiazoethane iron porphyrin catalyst difluoroalkenylation; alc trifluorodiazoethane iron porphyrin catalyst difluoroalkenylation; amine trifluorodiazoethane iron porphyrin catalyst difluoroalkenylation; unsaturated compound trifluorodiazoethane iron porphyrin catalyst Doyle Kirmse reaction; alkene trifluorodiazoethane iron porphyrin catalyst diastereoselective cyclopropanation.

The development of trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs) as a CF3CHN2 surrogate, which was capable of generating CF3CHN2 in-situ under basic conditions was reported. The reaction conditions employed in this chem. enabled a difluoroalkenylation of X-H bonds (X = N, O, S, Se), affording a wide range of heteroatom-substituted gem-difluoroalkenes, along with Doyle-Kirmse rearrangements and trifluoromethylcyclopropanation reactions, with superior outcomes to approaches using pre-formed CF3CHN2. Given the importance of generally applicable fluorination methodologies, the use of TFHZ-Tfs thus creates opportunities across organic and medicinal chem., by enabling the wider exploration of the reactivity of trifluorodiazoethane.

Nature Communications published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Schreib, Benedikt S. published the artcileRitter reaction for the synthesis of picolinamides, HPLC of Formula: 100-70-9, the main research area is picolinamide preparation; cyanopyridine alc alkene Ritter reaction.

The synthesis of picolinamides through Ritter reaction of 2-cyanopyridine with alcs. and alkenes is reported. Moreover, a range of addnl. heteroaryl nitriles successfully participate in the amidation reaction. Salient features of the reaction include the operational simplicity and the inexpensive reagents used. The synthetic utility of a camphene derived picolinamide is demonstrated through a palladium-catalyzed C-H arylation reaction.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts