Tag: M.W=100-150

Yamaguchi, Eiji published the artcileOlefin Bifunctionalization: A Visible-light Photoredox-catalyzed Aryl Alkoxylation of Olefins, Product Details of C7H6N2, the main research area is diarylethyl ether photochem preparation; ruthenium photoredox catalyst arylalkoxylation aryl alkene diazonium salt alc; photochem arylalkoxylation aryl alkene diazonium salt alc; alkoxylation; bifunctionalization; olefins; photoredox catalyst; visible light.

Aryl alkenes such as RCH:CH2 (R = Ph, 4-MeCOC6H4, 4-MeO2CC6H4, 4-BrC6H4, 4-ClC6H4, 4-MeC6H4, 3-MeC6H4, 2-MeC6H4, 4-MeC6H4, 1-naphthyl, 2-naphthyl) underwent photoredox arylalkoxylation under visible light with aryldiazonium tetrafluoroborates such as R1N2+BF4- (R1 = 4-O2NC6H4, 3-O2NC6H4, 4-MeCOC6H4, 4-MeO2CC6H4, 4-NCC6H4, 3-NCC6H4, 2-NCC6H4, 4-F3CC6H4, 3-BrC6H4, 2-BrC6H4, 4-ClC6H4, 4-FC6H4) and methanol, ethanol, or 1-propanol in acetonitrile/alc. mixtures in the presence of Ru(bpy)3Cl2 to yield diarylethyl ethers such as R1CH2CH(OMe)R (R = Ph, 4-MeCOC6H4, 4-MeO2CC6H4, 4-BrC6H4, 4-ClC6H4, 4-MeC6H4, 3-MeC6H4, 2-MeC6H4, 4-MeC6H4, 1-naphthyl, 2-naphthyl; R1 = 4-O2NC6H4, 3-O2NC6H4, 4-MeCOC6H4, 4-MeO2CC6H4, 4-NCC6H4, 3-NCC6H4, 2-NCC6H4, 4-F3CC6H4, 3-BrC6H4, 2-BrC6H4, 4-ClC6H4, 4-FC6H4).

Chemistry – An Asian Journal published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yamaguchi, Eiji published the artcileRuthenium polypyridyl complex-catalyzed aryl alkoxylation of styrenes: improving reactivity using a continuous flow photo-microreactor, Related Products of nitriles-buliding-blocks, the main research area is diarylethyl ether preparation photochem; styrene aryldiazonium tetrafluoroborate alc alkoxylation ruthenium polypyridyl complex catalyst.

In this report, an improved protocol for the synthesis of diarylethyl ethers R1C6H4CH2CH(R2)C6H4R3 [R1 = H, 4-Me, 2-CN, etc.; R2 = OMe, OEt, OiPr, OBn, OC(O)H; R3 = 2-Me, 4-MeO, 4-tBu, etc.] via ruthenium polypyridyl complex catalyzed aryl alkoxylation of styrenes with aryldiazonium tetrafluoroborates and alcs. using continuous flow photo-microreactor was described.

Reaction Chemistry & Engineering published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhao, Yiyong published the artcileSO2F2-Promoted Dehydration of Aldoximes: A Rapid and Simple Access to Nitriles, Name: Picolinonitrile, the main research area is nitrile preparation; aldoxime dehydration.

A rapid, simple and mild process for the dehydration of aldoximes RCH=NOH (R = benzyl, 4-fluorophenyl, naphth-1-yl, pyridin-2-yl, etc.) to give the corresponding nitriles RCN, which utilizes SO2F2 as an efficient reagent, has been developed. A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes proceeded with high efficiency to afford nitriles in excellent to quant. yields with great functional group compatibilities in acetonitrile under ambient conditions. Moreover, the eco-friendly conditions of SO2F2/Na2CO3/aqueous methanol were suitable for converting nitrobenzaldoximes R1C6H4CH=NOH (R1 = 2-nitro, 3-nitro, 4-nitro) into nitrobenzonitriles R1C6H4CN. In addition, a one-pot synthetic strategy of obtaining nitrobenzonitriles R1C6H4CN from nitrobenzaldehydes R1C6H4CHO has been confirmed to be feasible.

Synlett published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhao, Yiyong published the artcileSO2F2-Promoted Dehydration of Aldoximes: A Rapid and Simple Access to Nitriles, HPLC of Formula: 91-15-6, the main research area is nitrile preparation; aldoxime dehydration.

A rapid, simple and mild process for the dehydration of aldoximes RCH=NOH (R = benzyl, 4-fluorophenyl, naphth-1-yl, pyridin-2-yl, etc.) to give the corresponding nitriles RCN, which utilizes SO2F2 as an efficient reagent, has been developed. A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes proceeded with high efficiency to afford nitriles in excellent to quant. yields with great functional group compatibilities in acetonitrile under ambient conditions. Moreover, the eco-friendly conditions of SO2F2/Na2CO3/aqueous methanol were suitable for converting nitrobenzaldoximes R1C6H4CH=NOH (R1 = 2-nitro, 3-nitro, 4-nitro) into nitrobenzonitriles R1C6H4CN. In addition, a one-pot synthetic strategy of obtaining nitrobenzonitriles R1C6H4CN from nitrobenzaldehydes R1C6H4CHO has been confirmed to be feasible.

Synlett published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Qingjie published the artcileH2O2-Promoted Inter- and Intramolecular C-N Bond Formation: Synthesis of Quinazoline Derivatives, Product Details of C7H6N2, the main research area is quinazoline preparation one pot; aminobenzylamine aldehyde benzyl bromide toluene nucleophilic amination.

Hydrogen peroxide, a cheap and easily available green oxidant, can not only produce oxygen, but also produce hydroxyl radical by homogenization under the catalysis of metal. Toluene and benzyl halide can be oxidized to benzaldehyde by hydrogen peroxide and participate in the reaction with 2-aminobenzylamine. Through the construction of C-N bond, a series of quinazoline derivatives were synthesized. This reaction allows a broad range of substrates as well as good functional group compatibility.

ChemistrySelect published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pandey, Vipin K. published the artcileSilver-Catalyzed Hydroboration of C-X (X = C, O, N) Multiple Bonds, Synthetic Route of 100-70-9, the main research area is silver catalyst hydroboration carbon oxygen nitrogen multiple bond.

AgSbF6 was developed as an effective catalyst for the hydroboration of various unsaturated functionalities (nitriles, alkenes, and aldehydes). This atom-economic chemoselective protocol works effectively under low catalyst loading, base- and solvent-free moderate conditions. Importantly, this process shows excellent functional group tolerance and compatibility with structurally and electronically diverse substrates (>50 examples). Mechanistic investigations revealed that the reaction proceeds via a radical pathway. Further, the obtained N,N-diborylamines were showcased to be useful precursors for amide synthesis.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Lin published the artcileCopper-Catalyzed Intermolecular Enantioselective Radical Oxidative C(sp3)-H/C(sp)-H Cross-Coupling with Rationally Designed Oxazoline-Derived N,N,P(O)-Ligands, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is cycloalkene alkyne copper catalyst regioselective enantioselective oxidative cross coupling; cycloalkenyl alkyne preparation; alkyne aryl alkene copper catalyst enantioselective oxidative cross coupling; aryl alkyne preparation regioselective; alkynylation; anionic N,N,P(O)-ligands; copper catalysis; oxidative cross-coupling; radical asymmetric chemistry.

Here, a copper-catalyzed asym. C(sp3)-C(sp) cross-coupling of (hetero)benzylic and (cyclic)allylic C-H bonds with terminal alkynes that occurs with high to excellent enantioselectivity was reported. Critical to the success is the rational design of chiral oxazoline-derived N,N,P(O)-ligands that not only tolerate the strong oxidative conditions which were requisite for intermol. hydrogen atom abstraction (HAA) processes but also induce the challenging enantiocontrol. Direct access to a range of synthetically useful chiral benzylic alkynes and 1,4-enynes, high site-selectivity among similar C(sp3)-H bonds, and facile synthesis of enantioenriched medicinally relevant compounds make this approach very attractive.

Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fan, Pei published the artcileNickel/Photo-Cocatalyzed Asymmetric Acyl-Carbamoylation of Alkenes, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is nickel photo cocatalyst asym acylcarbamoylation alkene carbamic chloride; stereoselective indolinone preparation.

An unprecedented asym. acyl-carbamoylation of pendant alkenes tethered on aryl carbamic chlorides with both aliphatic and aromatic aldehydes has been developed via the cooperative catalysis of a chiral nickel-PHOX complex and tetrabutylammonium decatungstate. This reaction represents the first example of merging hydrogen-atom-transfer photochem. and asym. transition metal catalysis in difunctionalization of alkenes. Using this protocol, a variety of oxindoles bearing a challenging quaternary stereogenic center are furnished under mild conditions in highly enantioselective manner.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chandra, Devesh published the artcileMicrowave-Assisted Metal-Free Rapid Synthesis of C4-Arylated Quinolines via Povarov Type Multicomponent Reaction, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aniline aldehyde alkyne camphor sulfonic acid Povarov multicomponent microwave; quinoline metal free preparation.

A rapid microwave assisted, (±) camphor-10-sulfonic acid (CSA)promoted, Povarov type multicomponent synthesis of 4-arylated quinolines fromanilines, alkynes, and paraformaldehyde is described. This reaction proceeds through[4+2] cycloaddition of imine (formed in situ from aniline and paraformaldehyde) andalkynes in the presence of CSA, without any metal catalyst. Mechanistic study revealedthat CSA inhibit the synthesis of Troger’s base and assist the cycloaddition ofimines with alkynes by activating the imine.

European Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gatera, Tharcisse published the artcileOne-Pot, Catalyst-Free Synthesis of Nitriles from Aldehydes Using Aminating Reagent MsONH3OTf, Related Products of nitriles-buliding-blocks, the main research area is nitrile preparation green chem; aldehyde amination.

An eco-friendly protocol to synthesize nitriles RCN (R = naphthalen-2-yl, n-hexyl, 4-bromophenyl, etc.) from their corresponding aromatic and aliphatic aldehydes RCHO in excellent yields has been developed. This is a catalyst-free protocol which employs an aminating reagent (MsONH3OTf) under mild conditions. The hydroxylamine triflic acid salts (MsONH3OTf) acted as the N source for this protocol. The protocol proved to be easy to perform and presented good functional group tolerance.

Synlett published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts