Tag: M.W=100-150

Trivedi, Manoj published the artcileRu(II)- and Ru(IV)-dmso complexes catalyze efficient and selective aqueous-phase nitrile hydration reactions under mild conditions, Application In Synthesis of 100-70-9, the main research area is ruthenium dmso complex catalyst preparation; amide green preparation; nitrile hydration ruthenium catalyst.

New water-soluble ruthenium(II)- and ruthenium(IV)-dmso complexes [RuCl2(dmso)2(NH3)(CH3CN)], [RuCl2(dmso)3(CH3CN)] and [RuCl2(dmso)3(NH3)]·PF6·Cl had been synthesized and characterized using elemental analyzes, IR, 1H and 31P NMR and electronic absorption spectroscopy. The mol. structures of complexes were determined crystallog. The reactivity of complexes had been tested for aqueous-phase nitrile hydration at 60°C in air, and good efficiency and selectivity are shown for the corresponding amide derivatives RC(O)NH2 [R = t-Bu, Ph, 4-BrC6H4, etc.]. Best performance is achieved with complex [RuCl2(dmso)3(NH3)]·PF6·Cl. Amide conversions of 56-99% were obtained with a variety of aromatic, alkyl and vinyl nitriles. The reaction tolerated hydroxyl, nitro, bromo, formyl, pyridyl, benzyl, alkyl and olefinic functional groups. Amides were isolated by simple decantation from the aqueous-phase catalyst. A catalyst loading down to 0.0001 mol% was examined and turnover numbers as high as 990000 were observed The catalyst was stable for weeks in solution and could be reused more than seven times without significant loss in catalytic activity. The gram-scale reaction was also performed to produce the desired product in high yields.

New Journal of Chemistry published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ounkham, Whalmany L. published the artcileAqueous-Phase Nitrile Hydration Catalyzed by an In Situ Generated Air-Stable Ruthenium Catalyst, Category: nitriles-buliding-blocks, the main research area is aqueous phase nitrile hydration air stable ruthenium catalyst; benzamide amide preparation green chem; aqueous-phase catalysis; homogeneous catalysis; nitrile hydration; ruthenium; sustainable chemistry.

RuCl2(PTA)4 (PTA=1,3,5-triaza-7-phosphaadamantane) is an active, recyclable, air-stable, aqueous-phase nitrile hydration catalyst. The development of an in situ generated aqueous-phase nitrile hydration catalyst (RuCl3·3 H2O + 6 equiv PTA) is reported. The activity of the in situ catalyst is comparable to RuCl2(PTA)4. The effects of [PTA] on the activity of the reaction were investigated: the catalytic activity, in general, increases as the pH goes up, which shows a pos. correlation with [PTA]. The pH effects were further explored for both the in situ and RuCl2(PTA)4 catalyzed reaction in phosphate buffer solutions with particular attention given to pH 6.8 buffer. Increased catalytic activity was observed at pH 6.8 vs. water for both systems with turnover frequency (TOF) up to 135 h-1 observed for RuCl2(PTA)4 and 64 h-1 for the in situ catalyst. Catalyst loading down to 0.001 mol % was examined with turnover numbers as high as 22 000 reported. Similar to the preformed catalyst, RuCl2(PTA)4, the in situ catalyst could be recycled more than five times without significant loss of activity from either water or pH 6.8 buffer.

Chemistry – A European Journal published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Uengoeren, S. Hakan published the artcileThe Motifs from Isocytosine and Fused Isocytosine with Quinazoline: Organocatalytic Cascade Reaction of β-Ketoamides, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is isocytosine preparation; ketoamide cyanamide cyclization tandem reaction diazabicycloundecene catalyst.

A method for the synthesis of isocytosine analogs I (R = H, 4-chlorophenyl, pyridin-2-yl, etc.), II, III (R1 = H, Cl) and IV (R2 = H, Cl, Br; R3 = Me, Ph, 4-methoxyphenyl, 3,4-dimethoxyphenyl) from β-ketoamides R4C(O)CH2C(O)NHR5 [R4 = Me, (4-methylphenyl)aminyl, Ph, etc.; R5 = H, 4-chloro-2-cyanophenyl, pyridin-2-yl, etc.] was investigated. Application of the method to β-ketoamides including a 2-cyanoaryl group leads to isocytosine fused quinazolines by the organocatalytic Cascade reaction. 20 Examples of pyrimidone derivatives I, II, III and IV were synthesized in different patterns.

ChemistrySelect published new progress about Amides, oxo Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Barzano, Guido published the artcileTandem Photoredox and Copper-Catalyzed Decarboxylative C(sp3)-N Coupling of Anilines and Imines Using an Organic Photocatalyst, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is photoredox copper catalyzed decarboxylative carbon nitrogen coupling; coupling aniline imine alkyl amine preparation organic photocatalyst.

An organic photoredox catalyst, 4CzIPN, was used in combination with a copper catalyst, CuCl, to effect decarboxylative C(sp3)-N coupling. The coupling worked with both anilines and imines as nitrogen sources and could be used to prepare a variety of alkyl amines from readily available alkyl carboxylic acids.

Organic Letters published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kumar, Gadde Sathish published the artcilePaired Electrolysis for Decarboxylative Cyanation: 4-CN-Pyridine, a Versatile Nitrile Source, Quality Control of 100-70-9, the main research area is cyano pyridine amino acid decarboxylative cyanation electrochem; aniline cyano pyridine regioselective cyanation electrochem; aminoacetonitrile preparation.

A decarboxylative cyanation of amino acids under paired electrochem. reaction conditions was developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic reaction pathway, and the cyanation protocol can be applied to diverse substrates including N,N-dialkyl aniline and indole derivatives

Organic Letters published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Suryawanshi, Manjusha published the artcileSynthesis, characterization and photophysical properties of novel thiazole substituted pyridine derivatives, Name: Picolinonitrile, the main research area is pyridylthiazole preparation photophys property.

Three series of isomeric 2-pyridyl 4-aryl thiazoles were synthesized by reacting 2/3/4-pyridine thioamides derived from the corresponding nitriles with various 4-substituted phenacyl bromides using Hantzsch thiazole synthesis. Amongst the three isomeric series, 2-pyridyl and 4-pyridyl isomers are found to exhibit better photophys. properties than 3-pyridyl series. 4-Pyridyl isomer with methoxy substituent on Ph ring is found to exhibit high luminescence quantum yield. The relationship between the structure and the photophys. properties have been studied using DFT calculations

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Haloketones Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kalogirou, Andreas S. published the artcileSynthesis of 2-Cyanoquinazolin-4-ones from 3′,5′-Dichloro-1H-spiro(quinazoline-2,4′-[1,2,6]thiadiazin)-4(3H)-ones, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is cyanoquinazolinone preparation; dichloro spiroquinazolinone thiadiazine preparation triphenylphosphine catalyst degradation.

A two-step synthesis of five 2-cyanoquinazolin-4-ones I (R = Me, Ph) and II (R1 = H, Me, Ph) starting from 3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine is presented. The latter reacts with 2-aminobenzamides 2-NHR2(C6H4)C(O)NHR3 (R2 = H, Me, Ph; R3 = H, Me, Ph) to give 3′,5′-dichloro-1H-spiro(quinazoline-2,4′-[1,2,6]thiadiazin)-4(3H)-ones III, which can be degraded with either excess polymer bound triphenylphosphine or catalytic amounts of benzyltriethylammonium iodide to give the 2-cyanoquinazolin-4-ones I and II in 46-97% yields. The single crystal X-ray diffraction anal. of 2-cyanoquinazolin-4(3H)-one was also reported.

ChemistrySelect published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Deqiang published the artcileReactivity studies involving a Lewis base supported terminal uranium phosphinidene metallocene [η5-1,3-(Me3C)2C5H3]2U(=P-2,4,6-iPr3C6H2)(OPMe3), Related Products of nitriles-buliding-blocks, the main research area is uranium phosphinidene metallocene lewis base supported reactivity study.

The Lewis base supported terminal uranium phosphinidene metallocene [η5-1,3-(Me3C)2C5H3]2U(=P-2,4,6-iPr3C6H2)(OPMe3) (2) could be isolated from a salt metathesis reaction in toluene at ambient temperature between [η5-1,3-(Me3C)2C5H3]2U(Cl)Me (1) and 2,4,6-iPr3C6H2PHK in the presence of Me3PO, and its structure and reactivity were probed in detail. No reaction of 2 with internal alkynes was observed, but it reacts in the presence of various heterounsatd. mols. such as CS2, isothiocyanates, aldehydes, imines, diazenes, carbodiimides, nitriles, isonitriles, diazoalkane, and organic azides, forming carbodithioates, sulfidos, oxidos, metallaheterocycles, and imido complexes, in good yields. Moreover, on reaction with the diazoalkane derivative Me3SiCHN2 the pseudophosphinimido uranium(III) complex [η5-1,3-(Me3C)2C5H3]2U(N=P-2,4,6-iPr3C6H2)(OPMe3) (20) can be isolated in good yield.

Dalton Transactions published new progress about Aldehydes Role: NUU (Other Use, Unclassified), USES (Uses). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yadav, Kumar Karitkey published the artcileCopper(II) phthalocyanine as an efficient and versatile catalyst for click reactions at room temperature, Recommanded Product: Phthalonitrile, the main research area is copper phthalocyanine catalyst benzyl halide one pot click reaction.

Herein, we report the efficient synthesis of copper(II) phthalocyanines in the presence of DBU as a strong base. These synthesized copper(II) phthalocyanines are utilized as a catalyst for the click reactions of sensitive compounds including metal-free porphyrins under mild reaction conditions at room temperature Further, we have developed a one-pot procedure for the click reactions of benzyl halides with different alkynes in good to excellent yields. The reaction proceeds at room temperature to 40°C and gives 83-99% of products. The reactions are carried out in DMSO solvent. The present reaction condition offers copper(II) phthalocyanines as an efficient and convenient catalyst for different electron-rich and electron-deficient substrates including macrocyclic compounds Electron-deficient substrates and less steric substrates provide a better result. The catalyst is easily separated from the reaction by a simple filtration technique and is reused up to 5 times without significant loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Alkynes Role: IMF (Industrial Manufacture), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Meesa, Siddi Ramulu published the artcileCatalyst and solvent switched divergent C-H functionalization: oxidative annulation of N-aryl substituted quinazolin-4-amine with alkynes, SDS of cas: 1885-29-6, the main research area is indolequinazoline pyridoquinazoline preparation regio chemoselective; aryl quinazolinamine internal alkyne oxidative annulation.

The development of site-selective C-H functionalizations/annulations is one of the most challenging practices in synthetic organic chem. particularly for substrates bearing several similarly reactive C-H bonds. Herein, authors describe catalyst and solvent controlled ortho/peri site-selective oxidative annulation of C-H bonds of N-aryl substituted quinazolin-4-amines with internal alkynes. The ortho C-H selective annulation was observed using Pd-catalyst in DMF to give indole-quinazoline derivatives I (R1 = H, 7-Cl, 6,7-di-OMe; R2 = H, 4-Me, 4-OMe, 4-Cl,etc.; R3 = R4 = Ph, 4-MeC6H4, 2-thienyl, etc.), while, Ru-catalyst in PEG-400 favored the peri C-H bond annulation exclusively to furnish pyrido-quinazoline derivs II.

Organic & Biomolecular Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts