Tag: M.W=100-150

Naraoka, Asuka published the artcileTransfer Hydration of Dinitriles to Dicarboxamides, COA of Formula: C8H4N2, the main research area is dicarboxamide preparation; dinitrile hydration palladium catalyst acetamide water donor.

A robust method for double transfer hydration of dinitriles to afford diamides was presented. The transfer hydration of 1,n-dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.

Synlett published new progress about Diamides Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, COA of Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hussain, Muhammad Asif published the artcileAn efficient hydration of nitriles with ruthenium-supported heterogeneous catalyst in water under moderate conditions, HPLC of Formula: 100-70-9, the main research area is nitrile hydration ruthenium supported manganese oxide catalyst moderate condition.

A facile eco-friendly heterogeneous catalytic system has been developed for amide synthesis that further utilized in pharmaceutical and organic chem. The Ru/MnO2 catalyst has shown outstanding and unprecedented activity for a wide range of aliphatic and benzylic nitriles in green solvent water at 60°C. The system has also exhibited a remarkable tolerance for selective hydration of heteroatom (e.g. nitrogen, oxygen and sulfur atoms) containing nitriles. Pharmaceutically important nicotinamides and pyrazinamide has been synthesized by hydration of the heteroat. nitriles with appreciable yields and selectivities. Moreover, the Ru/MnO2 catalyst has employed water as a benign solvent, with more than 30,000 TONs and reusability five times after isolation from the reaction mixture by centrifugation and easy workup that established a path for green environmental and technol. acceptable protocol.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Amides Role: IMF (Industrial Manufacture), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mohamed, Asmaa H. published the artcileSynthesis of novel quinazolines via nucleophilic cycloaddition of 2-amino-N’-arylbenzimidamides with dimethyl acetylenedicarboxylate and 2-(dicyanomethylene)indan-1,3-dione, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazoline preparation; amino arylbenzimidamide preparation dimethyl acetylenedicarboxylate cycloaddition; dicyanomethylene indan dione amino arylbenzimidamide preparation cycloaddition.

Synthesis of novel tetrahydroquinazoline-2-carboxylate I (R = H, Me; R1 = H, Cl; R2 = H, Me, Cl; R3 = H, Me) and arylaminoquinazoline-2-carboxylate II in good yields has been established via the nucleophilic cycloaddition of 2-amino-N’-arylbenzimidamides III on di-Me acetylenedicarboxylate. Moreover, the reaction of 2-amino-N’-arylbenzimidamides III with 2-(dicyanomethylene)indan-1,3-dione to give 3,4-dihydroquinazolin derivatives IV is studied. A plausible mechanism for the formation of the products is presented.

Monatshefte fuer Chemie published new progress about Benzamidines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Estruch-Blasco, Manel published the artcileRadical Arylation of Triphenyl Phosphite Catalyzed by Salicylic Acid: Mechanistic Investigations and Synthetic Applications, Formula: C7H6N2, the main research area is phosphonate aryl preparation organocatalytic diazonium arylation triphenyl phosphite; aromatic amine diazotization radical coupling triphenyl phosphite preparation arylphosphonate.

A straightforward and scalable methodol. to synthesize di-Ph arylphosphonates at 20° within 1-2 h is reported using inexpensive salicylic acid as the catalytic promoter of the reaction. Reaction of aromatic amines ArNH2 with P(OPh)3 and Bu nitrite in the presence of 10 mol% of salicylic acid afforded arylphosphonates ArP(O)(OPh)2 with up to 94% yield. Mechanistic investigations suggest that the reaction proceeds via radical-radical coupling, consistent with the so-called persistent radical effect. The reaction tolerated a wide range of functional groups and heteroaromatic moieties. The synthetic usefulness and the unique reactivity of the obtained phosphonates were demonstrated in different one-step transformations.

Journal of Organic Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hussen, Abdulkadir Shube published the artcileAmmonium Chloride Assisted Microwave Mediated Domino Multicomponent Reaction: An Efficient and Sustainable Synthesis of Quinazolin-4(3H)-imines under Solvent Free Condition, HPLC of Formula: 1885-29-6, the main research area is aminobenzonitrile triethyl orthoformate arylamine ammonium chloride multicomponent tandem cyclocondensation; quinazolinimine preparation microwave irradiation green chem.

A novel multicomponent synthesis of quinazolin-4(3H)-imines starting from simple and readily available inputs was described. An efficient and environmentally benign protocol for the synthesis of biol. significant scaffolds from readily available starting materials such as 2-amino benzonitrile, tri-Et orthoformate and mainly aniline derivatives under metal and solvent-free conditions was reported. Owing to its operational simplicity, step and resource economy and broad substrate scope, this robust methodol. is appealing with respect to the previous research findings in this area.

ChemistrySelect published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Krapf, Michael K. published the artcileSynthesis and biological evaluation of quinazoline derivatives – A SAR study of novel inhibitors of ABCG2, HPLC of Formula: 1885-29-6, the main research area is quinazoline derivative preparation ABCG2 inhibitor multi drug resistance; ABC transporter; ABCG2; Inhibitor; Quinazolines; SAR.

Multidrug resistance (MDR) is a major obstacle for effective chemotherapeutic treatment of cancer frequently leading to failure of the therapy. MDR is often associated with the overexpression of ABC transport proteins like ABCB1 or ABCG2 which efflux harmful substances out of cells at the cost of ATP hydrolysis. One way to overcome MDR is to apply potent inhibitors of ABC transporters to restore the sensitivity of the cells toward cytostatic agents. This study focusses on the synthesis and evaluation of novel 2,4-disubstituted quinazoline derivatives regarding the structure-activity-relationship (SAR), their ability to reverse MDR and their mode of interaction with ABCG2. Hence, the inhibitory potency and selectivity toward ABCG2 was determined Moreover, the intrinsic cytotoxicity and the reversal of MDR were investigated. Interaction type studies with the substrate Hoechst 33342 and conformational analyses of ABCG2 with 5D3 monoclonal antibody were performed for a better understanding of the underlying mechanisms. In our study we could further enhance the inhibitory effect against ABCG2 (compound I, IC50: 55 nM) and identify the structural features that are crucial for inhibitory potency, the impact on transport activity and binding to the protein.

European Journal of Medicinal Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lam, Long Yin published the artcileCopper-Catalyzed Synthesis of Functionalized Aryl Sulfonamides from Sodium Sulfinates in Green Solvents, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl sulfonamide preparation green solvent; sodium aryl sulfinate amine coupling reaction copper.

Functionalized aryl sulfonamides are important building blocks in the pharmaceutical industry. A one-step synthesis catalyzed by a copper salt was developed using stable solid commodity chems. in sulfolane or, alternatively, in green solvents such as γ-valerolactone, iPrOAc, or nBuOAc with acetic acid. The method tolerated diverse functional groups commonly presented in current medicines and drug intermediates. The mechanistic study showed a radical coupling pathway between the sulfonyl and anilinium radicals through the use of K2S2O8 and copper catalyst, resp.

Journal of Organic Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Shitao published the artcileSubstituent-controlled chemoselective synthesis of multi-substituted pyridones via a one-pot three-component cascade reaction, Category: nitriles-buliding-blocks, the main research area is arylamine acetylenedicarboxylate ethoxymethylenemalonate cesium carbonate tandem three component cycloaddition; arylpyridone tricarboxylate preparation.

An efficient and concise one-pot strategy for the synthesis of multisubstituted pyridones via a one-pot three-component cascade reaction catalyzed by Cs2CO3 under solvent-free conditions was developed. The substituent-controlled chemoselective cycloaddition process involved steps including a Michael addition/ethanol elimination/intermol. cyclization sequence utilizing anilines, di-Et acetylenedicarboxylate, and di-Et ethoxymethylenemalonate. The synthesis various 2-pyridone and 4-pyridone species (41 examples) were obtained in good to excellent yields.

Organic & Biomolecular Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ielo, Laura published the artcileTelescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines, Formula: C7H6N2, the main research area is chloro halomethyl trifluoromethyl aziridine preparation chemoselective homologation imine; aziridines; carbenoids; chemoselectivity; homologation; lithium.

A conceptually novel, high-yielding, mono- or bis-homologation was realized with lithium halocarbenoids and enables the one-step, fully chemocontrolled assembly of a new class of quaternary trifluoromethyl aziridines. Trifluoroacetimidoyl chlorides (TFAICs) act as convenient electrophilic platforms, enabling the addition of either one or two homologating elements by simply controlling the stoichiometry of the process. Mechanistic studies highlighted that the homologation event, carried out with two different carbenoids (LiCH2Cl and LiCH2F), leads to fluoromethyl analogs in which the first nucleophile was employed for constructing the cycle and the second for decorating the resulting mol. architecture.

Angewandte Chemie, International Edition published new progress about Aziridines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Weiqiang published the artcileSwitchable and efficient conversion of 2-amido-aryl oxazolines to quinazolin-4(3H)-ones and N-(2-chloroethyl)benzamides, COA of Formula: C7H6N2, the main research area is amidophenyloxazoline chemoselective reaction; chloroethylbenzamide preparation; quinazolinone preparation.

Switchable chemoselective conversion of 2-amido-aryl oxazolines to quinazolin-4(3H)-ones or N-(2-chloroethyl)benzamides was achieved. The former reaction was proposed to involve a PIFA-mediated 6π electrocyclization followed by an in situ nucleophilic substitution, while the latter reaction uses aluminum chloride as a halogenated source through a ring-opening reaction. The reactions proceed smoothly under mild conditions and have excellent functional group compatibility.

Organic Chemistry Frontiers published new progress about Benzamides Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts