Tag: M.W=100-150

Wang, Tengfei published the artcileExploration of catalytic species for highly efficient preparation of quinazoline-2,4(1H,3H)-diones by succinimide-based ionic liquids under atmospheric pressure: Combination of experimental and theoretical study, HPLC of Formula: 1885-29-6, the main research area is quinazoline carbon dioxide absorption ionic liquid catalyst.

Cyclization reaction of carbon dioxide (CO2) and 2-aminobenzonitriles is of significance for the sustainable development, however, the harsh reaction condition especially for the high CO2 pressure is still an obstacle. Herein, a novel ionic liquid benzyltrimethylammonium succinimide ([BzTMA+][Suc-]) is designed and synthesized, in which no active hydrogen atom is included in cation. It displays the excellent catalytic activity achieving the 98.8% yield for quinazoline-2,4(1H,3H)-diones even under the atm. pressure. By combination of NMR spectroscopy (1H NMR and 13C NMR), CO2 absorption measurements, d. functional theory (DFT) calculations, and the frontier MO anal., the real catalytic species and synergistic effect of cation and anion on the catalytic performance are elucidated. The [Suc-] anion affords to introduce the CO2 into the organic phase even under the atm. pressure by formation of [Suc-CO-2]. However, the real catalytic species is [BzTMA+] cation and [Suc-] anion rather than [BzTMA+] and [Suc-CO-2]. If the active hydrogen atom is included in the cation, the CO2 absorption capacity of [Suc-] anion would be weakened by the strong interaction between active hydrogen atom in cation and [Suc-] anion resulting in the inferior catalytic behavior. The cooperation of [BzTMA+] and [Suc-] finally results in the high catalytic activity under the atm. pressure. Involvement of active hydrogen atom in cation is not an insurance to prepare the robust catalyst.

Fuel published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Morozov, Vyacheslav published the artcileMetal-Free Rapid Diastereoselective Construction of Isocryptolepine Core via Electrophilic Dearomatization – Intramolecular Michael Addition Sequence, HPLC of Formula: 1885-29-6, the main research area is methoxyphenyl cyclohexanol aryl nitrile diastereoselective elecrophilic dearomatization Michael addition; indoloacridinone preparation; xanthenoindolone preparation.

A method for rapid construction of indolo[3,2-l]acridin-7-one systems bearing isocryptolepine scaffold was described. Metal-free condensation of (4-methoxyphenyl)cyclohexan carbinols with ortho-amino/hydroxybenzonitriles in concentrated sulfuric acid yielded polyannulated compounds with four new stereogenic centers in a highly diastereoselective manner. The reaction included elecrophilic dearomatization of methoxyarene, formation of spirocyclic intermediate and intramol. 1,4-nucleophilic addition sequence.

ChemistrySelect published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Samim, Sk. Abdus published the artcileCobalt-Catalyzed Tandem Transformation of 2-Aminobenzonitriles to Quinazolinones Using Hydration and Dehydrogenative Coupling Strategy, COA of Formula: C7H6N2, the main research area is cobalt catalyzed hydration dehydrogenative coupling aminobenzonitrile alc quinazolinone synthesis.

A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by using an aliphatic alc.-water system. For this transformation, a cheap and easily available cobalt salt and P(CH2CH2PPh2)3 (PP3) ligand were employed. The substrate scope, scalability, and synthesis of natural products exhibited the vitality of this protocol.

Journal of Organic Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Betori, Rick C. published the artcileReductive Arylation of Arylidene Malonates Using Photoredox Catalysis, Application In Synthesis of 100-70-9, the main research area is diaryl malonate preparation; arylidene malonate reductive arylation photoredox catalysis.

A strategy with arylidene malonates provides access to β-umpolung single-electron species. Reported here is the utilization of these operators in intermol. radical-radical arylations, while avoiding conjugate addition/dimerization reactivity that is commonly encountered in enone-based photoredox chem. This reactivity relies on tertiary amines that serve to both activate the arylidene malonate for single-electron reduction by a proton-coupled electron transfer mechanism as well as serve as a terminal reductant. This photoredox catalysis pathway demonstrates the versatility of stabilized radicals for unique bond-forming reactions.

ACS Catalysis published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jatangi, Nagesh published the artcileBase-catalyzed synthesis of quinazolines in aqueous medium, Application In Synthesis of 1885-29-6, the main research area is quinazoline preparation green chem; ketimine preparation aryl isothiocyanate heterocyclization sodium hydroxide catalyst; aminobenzonitrile magnesium bromide Grignard reaction.

An alternative green and step economy reaction of readily available 2-aminobenzonitriles 2-NH2-5-XC6H3CN (X = H, Cl, OCH3, NO2, etc.) with various organometallic reagents RMgBr (R = Ph, 3-methoxyphenyl, Bu, etc.) led to ortho-aminoaryl NAH ketimine 2-NH2-5-XC6H3C(R)=NH species. The subsequent base catalyzed NAC bond formation with various isothiocyanates ArNCS (Ar = Ph, 4-nitrophenyl, 2,4-difluorophenyl, etc.) afforded quinazoline scaffolds I in aqueous medium. The salient features of this protocol are use of readily available inexpensive precursors, water as a green environmentally benign solvent, short reaction time, operational simplicity, easy workup procedure and good functional group tolerance.

Tetrahedron Letters published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ghadermazi, Mohammad published the artcileIntroduction of Fe into mesoporous MCM-41 for the synthesis of 5-substituted 1H-Tetrazoles from aryl nitriles in water, Related Products of nitriles-buliding-blocks, the main research area is mesoporous supported iron silica catalyst preparation; tetrazole sulfoxide preparation green chem; aryl nitrile sulfide oxidation water.

In this exploration, new recyclable mesoporous-supported iron particles with the ligand and without ligand (MCM-41@ 3,4,5-tri hydroxyphenyl acetic acid @Fe and MCM-41@Fe) have been developed through post-functionalization modification of silica MCM-41. These catalysts were demonstrated to be novel, effective, and green for the synthesis of 5-substituted 1H-tetrazoles from aryl nitriles in water. In these systems, 5-substituted 1H-tetrazoles are produced as the only product. Fe3+ species were identified as active sites. The ordered mesoporous iron-silica catalyst with the ligand displayed better catalytic activity compared to iron-silica catalyst without the ligand, which was ascribed to the improvement of the inter-action of iron with the support. The catalysts can be easily separated using simple recovery and reused several times with consistent activity.

Microporous and Mesoporous Materials published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rina, Yesmin Akter published the artcileDouble Hydrophosphorylation of Nitriles Catalyzed by Rare-Earth-Metal Lanthanum, Safety of Picolinonitrile, the main research area is hydrophosphorylation aromatic nitrile hydrophosphonate preparation phosphono amidophosphate lanthanum catalyst; lanthanum dimethylbenzylamine catalyst double hydrophosphorylation nitrile preparation phosphoryl amidophosphate.

A high-yielding and atom-efficient protocol for the double hydrophosphorylation of aromatic nitriles using a lanthanum-based N,N-dimethylbenzylamine complex (La(DMBA)3) as a precatalyst is reported, giving α-phosphonylated N-benzylphosphoramidates ArCH[P(O)(OEt)2]NHP(O)(OEt)2 (3a-v; Ar = substituted Ph, 2-naphthyl, pyridyl) with high yields and chemoselectivities. This method provides a straightforward and convenient approach for the synthesis of biol. important organophosphorus compounds known as N-(α-phosphoryl)amidophosphates in good to excellent yields. Nitriles with a broad range of addnl. functionality were tolerated, including those with halides, ethers, amines, and pyridyl groups.

Journal of Organic Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Zhuang published the artcileStable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines, Synthetic Route of 1885-29-6, the main research area is aryl nitrile nickel nanocatalyst selective hydrogenation; aromatic primary amine preparation; recyclable silica support nickel catalyst preparation.

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(II)nitrate and colloidal silica under air and subsequent reduction in the presence of mol. hydrogen the optimal catalyst was prepared The prepared supported nanoparticles are stable, was conveniently used and easily recycled. The applicability of the optimal catalyst material was shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

Chemical Science published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Zhuang published the artcileStable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines, Safety of Picolinonitrile, the main research area is aryl nitrile nickel nanocatalyst selective hydrogenation; aromatic primary amine preparation; recyclable silica support nickel catalyst preparation.

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(II)nitrate and colloidal silica under air and subsequent reduction in the presence of mol. hydrogen the optimal catalyst was prepared The prepared supported nanoparticles are stable, was conveniently used and easily recycled. The applicability of the optimal catalyst material was shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

Chemical Science published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chintawar, Chetan C. published the artcileEnantioselective Au(I)/Au(III) Redox Catalysis Enabled by Chiral (P,N)-Ligands, Computed Properties of 1885-29-6, the main research area is oxychroman preparation enantioselective DFT; iodoaryl alkene alc oxyarylation gold catalyst; aminochroman preparation enantioselective DFT; aromatic amine iodoaryl alkene aminoarylation gold catalyst.

The enantioselective Au(I)/Au(III) redox catalysis, enabled by a newly designed hemilabile chiral (P,N)-ligand (ChetPhos) e.g., I was reported. The potential of this concept has been demonstrated by the development of enantioselective 1,2-oxyarylation and 1,2-aminoarylation of alkenes 2-I-3-R1-4-R2-5-R3-6-R4C6OCH2CH=CH2 (R1 = H; R2 = H, F, Me, NO2, etc.; R1R2 = -CH=CHCH=CH-; R3 = H, OMe, C(O)OMe, CF3; R4 = H, Me, OMe) which provided direct access to the medicinally relevant 3-oxy- and 3-aminochromans II [R5 = H, Me, Et, i-Pr, (2-bromophenyl)methyl] III (R6 = 4-nitrophenyl, 4-bromo-2-nitrophenyl, 3-cyanothiophen-2-yl, etc.) (up to 88% yield and 99% ee). DFT studies were carried out to unravel the enantiodetermining step, which revealed that the stronger trans influence of phosphorus allows selective positioning of the substrate in the C2-sym. chiral environment present around nitrogen, imparting a high level of enantioselectivity.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (iodoaryl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts