Tag: M.W=100-150

Moghaddam, Firouz Matloubi published the artcileAn advancement in the synthesis of nano Pd@magnetic amine-Functionalized UiO-66-NH2 catalyst for cyanation and O-arylation reactions, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is palladium magnetic amine MOF UiO66 NH2 preparation thermal stability; benzonitrile preparation; phenyl aryl ether preparation.

The magnetic MOF-based catalytic system has been reported here to be an efficient catalyst for synthesis of benzonitriles and diarylethers of aryl halides under optimal conditions. The MOF catalyst was built based on magnetic nanoparticles and UiO-66-NH2 which further modified with 2,4,6-trichloro-1,3,5-triazine and 5-Ph tetrazole at the same time and the catalyst structure was confirmed by various techniques. This new modification has been applied to increase anchoring palladium into the support. Furthermore, the products’ yields were obtained in good to excellent for all reactions under mild conditions which result from superior activity of the synthesized heterogeneous catalyst containing palladium. Also, the magnetic property of the MOF-based catalyst makes it easy to sep. from reaction mediums and reuse in the next runs.

Scientific Reports published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vishwakarma, Niraj K. published the artcileConverting CO2 into heterocyclic compounds under accelerated performance through Fe3O4-grafted ionic liquid catalysts, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is heterocyclic compound preparation ferric oxide grafted ionic liquid catalyst.

Solid supported catalysts such as amines are in high demand for the chem. fixation of CO2 into commodity chems. Here, we demonstrate an accelerated platform for 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-ionic liquid (IL) catalyzed CO2 fixation via the grafting of DBU-ILs over magnetically separable Fe3O4 nanoparticles (MNPs). The DBU-ILs were covalently immobilized over Fe3O4 MNPs utilizing the thio-ene reaction of allyl-DBU with -SH modified Fe3O4 MNPs. The DBU-IL-grafted Fe3O4 (Fe3O4@DBU-ILs) materials were characterized by Fourier-transform IR spectroscopy, field-emission SEM, transmission electron microscopy, XPS, thermogravimetric anal. and vibrating-sample magnetometry. TEM revealed that the MNPs have a spherical structure with a particle size of 12-20 nm. VSM showed the gradual decrease in magnetization after stepwise grafting from Fe3O4 to Fe3O4@DBU-ILs. The efficacy of the two different Fe3O4@DBU-ILs, Fe3O4@[HDBU+][TFE-] and Fe3O4@[HDBU+][AcO-] prepared by neutralization of Fe3O4@DBU with 2,2,2-trifluoroethanol (TFE) and acetic acid (AcOH), was investigated by simultaneous fixation of CO2 into the important heterocyclic compounds quinazoline-2,4(1H,3H)-dione and benzimidazolone. This approach shows excellent recyclability with a nominal decrease (2-3%) in product yields after each cycle. In particular, the energy-dispersive X-ray spectroscopy mapping of Fe3O4@[HDBU+][TFE-] used for five cycles demonstrated significant leaching of TFE. Interestingly, after retreatment with TFE, Fe3O4@[HDBU+][TFE-] showed a similar yield to that of a fresh catalyst.

New Journal of Chemistry published new progress about Benzimidazoles Role: IMF (Industrial Manufacture), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Samanta, Partha Kumar published the artcileMesoporous silica supported samarium as recyclable heterogeneous catalyst for synthesis of 5-substituted tetrazole and 2-substituted benzothiazole, Name: Picolinonitrile, the main research area is mesoporous silica supported samarium catalyst tetrazole benzothiazole synthesis.

Synthesis of nitrogen-containing heterocycles such as tetrazoles and benzothiazoles gains immense importance as they are omnipresent structural modules often utilized in pharmaceuticals. In the present study, well ordered MCM-41 type mesoporous silica with large pore (l-MSN) was synthesized and impregnated with samarium nitrate (Sm@l-MSN). Due to high abundance of samarium relative to many catalytically active transition metals (e.g. Ru, Ir, Pt), it may offer an opportunity to develop sustainable catalysts for organic conversions. The synthesized materials were characterized using nitrogen sorption, SEM, energy-dispersive X-ray, elemental mapping and transmission electron microscopy. The catalytic efficiency of the materials was explored for the synthesis of tetrazoles and benzothiazoles, two very important heterocyclic moieties in medicinal chem. and biol. The catalyst was readily recovered and recycled up to five consecutive runs without noteworthy loss of activity or leaching.

Journal of Porous Materials published new progress about Benzothiazoles Role: IMF (Industrial Manufacture), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Samanta, Partha Kumar published the artcileMesoporous silica supported samarium as recyclable heterogeneous catalyst for synthesis of 5-substituted tetrazole and 2-substituted benzothiazole, Quality Control of 91-15-6, the main research area is mesoporous silica supported samarium catalyst tetrazole benzothiazole synthesis.

Synthesis of nitrogen-containing heterocycles such as tetrazoles and benzothiazoles gains immense importance as they are omnipresent structural modules often utilized in pharmaceuticals. In the present study, well ordered MCM-41 type mesoporous silica with large pore (l-MSN) was synthesized and impregnated with samarium nitrate (Sm@l-MSN). Due to high abundance of samarium relative to many catalytically active transition metals (e.g. Ru, Ir, Pt), it may offer an opportunity to develop sustainable catalysts for organic conversions. The synthesized materials were characterized using nitrogen sorption, SEM, energy-dispersive X-ray, elemental mapping and transmission electron microscopy. The catalytic efficiency of the materials was explored for the synthesis of tetrazoles and benzothiazoles, two very important heterocyclic moieties in medicinal chem. and biol. The catalyst was readily recovered and recycled up to five consecutive runs without noteworthy loss of activity or leaching.

Journal of Porous Materials published new progress about Benzothiazoles Role: IMF (Industrial Manufacture), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hu, Pengfei published the artcileQuaternary-centre-guided synthesis of complex polycyclic terpenes, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is terpene polycyclic synthesis quaternary center guided; conidiogenone synthesis quaternary center guided.

The presence of a quaternary center-a carbon with four other carbons bonded to it-in any given mol. can have a substantial chem. and biol. impact. In many cases, it can enable otherwise challenging chem. For example, quaternary centers induce large rate enhancements in cyclization reactions-known as the Thorpe-Ingold effect-which has application in drug delivery for mols. with modest bioavailability. Similarly, the addition of quaternary centers to a drug candidate can enhance both its activity and its metabolic stability. When present in chiral ligands, catalysts and auxiliaries, quaternary centers can guide reactions toward both improved and unique regio-, stereo- and/or enantioselectivity. However, owing to their distinct steric congestion and conformational restriction, the formation of quaternary centers can be achieved reliably by only a few chem. transformations. For particularly challenging cases-for example, the vicinal all-carbon8, oxa- and aza-quaternary centers9 in mols. such as azadirachtin, scopadulcic acid A and acutumine-the development of target-specific approaches as well as multiple functional-group and redox manipulations is often necessary. It is therefore desirable to establish alternative ways in which quaternary centers can pos. affect and guide synthetic planning. Here we show that if a synthesis is designed such that each quaternary center is deliberately leveraged to simplify the construction of the next-either through rate acceleration or blocking effects-then highly efficient, scalable and modular syntheses can result. This approach is illustrated using the conidiogenone family of terpenes as a representative case; however, this framework provides a distinct planning logic that is applicable to other targets of similar synthetic complexity that contain multiple quaternary centers.

Nature (London, United Kingdom) published new progress about Cyclic terpenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Han published the artcileCatalytic oxidative conversion of aldehydes into nitriles using NH3·H2O/FeCl2/NaI/Na2S2O8: A practical approach to febuxostat, Product Details of C8H4N2, the main research area is oxidative cyanation aldehyde nitrile synthesis febuxostat synthesis.

A novel approach to convert aldehydes into nitriles using NH3·H2O/FeCl2/NaI/Na2S2O8 has been developed. Both alkyl and aryl nitriles were obtained in good to excellent yields. Electron-withdrawing and electron-donating groups, such as fluoro, chloro, bromo, nitro, ester, cyano, trifluoromethyl and alkoxy were tolerated. Notably, febuxostat (I) and its intermediate, Et 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylate, were obtained in excellent yields.

Tetrahedron Letters published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reidl, Tyler W. published the artcileLewis Basic Salt-Promoted Organosilane Coupling Reactions with Aromatic Electrophiles, Application of Phthalonitrile, the main research area is arylalkane preparation; organosilane aromatic electrophile coupling Lewis basic salt promoted.

Lewis basic salts promoted organotrimethylsilane coupling with (hetero)aryl nitriles, sulfones and chlorides as a new route to 1,1-diarylalkanes. This method combined the substrate modularity and selectivity characteristic of cross-coupling with the practicality of a base-promoted protocol. In addition, a Lewis base strategy enabled a complementary scope to existing methods, employed stable and easily prepared organosilanes and achieved selective arylation in the presence of acidic functional groups. The utility of this method was demonstrated by the synthesis of pharmaceutical analogs and its use in multicomponent reactions.

Journal of the American Chemical Society published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation) (aryl). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Menglan published the artcileIron-promoted construction of indoles via intramolecular oxidative C-N coupling of 2-alkenylanilines using persulfate, COA of Formula: C7H6N2, the main research area is indole preparation; alkenylaniline intramol oxidative coupling iron catalyst.

Without N-protection, readily prepared 2-alkenylanilines were transformed into indoles I [R1 = H, Me, 3-MeC6H4, etc.; R2 = H, Me, Et; R3 = H, 5-Me, 5-Cl] in good yields via intramol. oxidative C-N coupling using K2S2O8 as oxidant in the presence of catalytic amounts of FeF2. The K2S2O8/FeF2 system offered direct and benign synthetic route to compounds I and it is applicable to wide range of substituted indoles including drug intermediates. The advantages of this protocol were cheap reagents, no N-protection, mild conditions and good group tolerance.

Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (alkenyl-). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Yueyue published the artcileDirect Arylation of α-Amino C(sp3)-H Bonds by Convergent Paired Electrolysis, Category: nitriles-buliding-blocks, the main research area is tertiary amine benzonitrile TEMPO catalyst electrochem arylation; benzylic amine preparation regioselective; C−H activation; arylation; cross-coupling; electrocatalysis; tertiary amines.

A metal-free convergent paired electrolysis strategy to synthesize benzylic amines through direct arylation of tertiary amines and benzonitrile derivatives at room temperature was developed. This TEMPO-mediated electrocatalytic reaction made full use of both anodic oxidation and cathodic reduction without metals or stoichiometric oxidants, thus showing great potential and advantages for practical synthesis. This convergent paired electrolysis method provided a straightforward and powerful means to activate C-H bonds and realize cross-coupling with cathodically generated species.

Angewandte Chemie, International Edition published new progress about Aralkyl amines Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ding, Yi published the artcileAlkylaluminum Complexes as Precatalysts in Hydroboration of Nitriles and Carbodiimides, HPLC of Formula: 100-70-9, the main research area is aluminum diketiminate alkyl complex preparation hydroboration nitrile carbodiimide catalyst; crystal structure aluminum diketiminate alkyl complex; mol structure aluminum diketiminate alkyl complex.

The metathesis reaction of aluminum(III) dihydride β-diketiminate LAlH2 (1, L = (DippN:CMe)2CH, Ar = 2,6-iPr2C6H3) with BuLi and Bu2Mg, resp., resulted in di-Bu aluminum complex LAlBu2 (2). Meanwhile 1 reacted with MeLi producing di-Me aluminum LAlMe2 (3). Complexes 2 and 3 were characterized by NMR and elemental anal., and 2 was addnl. studied by single-crystal X-ray diffraction. The reported synthesis allows for access of dialkylaluminum complexes from aluminum(III) dihydride compound (1) with excellent yields. The chemoselective double hydroboration of nitriles or single hydroboration of carbodiimides was studied with pinacolborane (HBpin) using LAl(n-Bu)2 (2) as the precatalyst to afford bis(boryl)amines (4a-4m) and N-borylamines (6a-6d) under solvent-free and mild conditions (60 °C). The records show that the catalytic reactions proceed in quant. yields and short time. Moreover, nearly quant. yield of di(boryl)(silyl)amine (5) was obtained, when cyanobenzene was reacted with equal amounts of HBpin and phenylsilane in the presence of precatalyst 2. A comparison of the previously reported hydroboration reactions with nitriles in the literature and our results in the presence of the precatalyst LAl(n-Bu)2 show convincingly the better results of short reaction time, mild reaction conditions, and quant. yields.

Organometallics published new progress about Aralkyl amines Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts