Tag: M.W=100-150

Rammal, Fatima published the artcilePhotochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms, Computed Properties of 100-70-9, the main research area is silyl hydroxymethyl pyridine preparation; methoxy pyridinium methylsulfate tert butyldimethylsilane silylation photochem.

Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation The synthetic importance of the developed reactions is demonstrated by the synthesis of biol. relevant compounds ESR spectroscopy, quantum yield measurements, and d.-functional theory calculations allowed to understand reaction mechanisms of both photocatalytic reactions.

ACS Catalysis published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhong, Long-Jin published the artcileBenzylic C-H heteroarylation of N-(benzyloxy)phthalimides with cyanopyridines enabled by photoredox 1,2-hydrogen atom transfer, Safety of Picolinonitrile, the main research area is pyridinyl diarylmethanol preparation; benzyloxy phthalimide cyanopyridine benzylic heteroarylation iridium photoredox catalysis.

A visible light initiated α-C(sp3)-H arylation of N-(benzyloxy)phthalimides with cyanopyridines for the construction of highly valuable pyridinyl-containing diarylmethanols, including bioactive motif-based analogs, is reported. This method enables arylation of the C(sp3)-H bonds adjacent to an oxygen atom through alkoxy radical formation by O-N bond cleavage, 1,2-hydrogen atom transfer (HAT), arylation and C-CN bond cleavage cascades, and offers a means to exploit 1,2-HAT modes to incorporate functional groups for constructing functionalized alcs.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Huan published the artcileBurn Intensity Drives the Alteration of Phenolic Lignin to (Poly) Aromatic Hydrocarbons as Revealed by Pyrolysis Gas Chromatography-Mass Spectrometry (Py-GC/MS), Synthetic Route of 91-15-6, the main research area is phenolic lignin polyaromatic hydrocarbon PyGC MS; alkyl side chain; black carbon/nitrogen; forest fuel reduction; prescribed fire; wildfire.

High-intensity wildfires alter the chem. composition of organic matter, which is expected to be distinctly different from low-intensity prescribed fires. Herein, we used pyrolysis gas chromatog./mass spectrometry (Py-GC/MS), in conjunction with solid-state 13C NMR and Fourier transform IR (FT-IR) spectroscopy, to assess chem. alterations from three wildfires and a long-term frequent prescribed fire site. Our results showed that black ash formed under moderate intensity burns contained less aromatic (ArH), polyaromatic hydrocarbon (PAH), and nitrogen-containing compounds (Ntg) but more lignin (LgC) and phenol compounds (PhC), compared to white ash formed under high intensity burns. Both 13C NMR and FT-IR confirmed a higher relative percentage of carboxyl carbon in white ash, indicating the potential for higher water solubility and more mobile carbon, relative to black ash. Compared to wildfires, ash from low-intensity prescribed fire contained less ArH, PAH, and Ntg and more LgC and PhC. Controlled laboratory burning trials indicated that organic matter alteration was sensitive to the burn temperature, but not related to the fuel type (pine vs. fir) nor oxygen absence/presence at high burn temperatures This study concludes that higher burn temperatures resulted in higher (poly)aromatic carbon/nitrogen and lower lignin/phenol compounds

Environmental Science & Technology published new progress about Aromatic hydrocarbons Role: NUU (Other Use, Unclassified), USES (Uses). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Uchida, Ko published the artcileTransformation of aromatic bromides into aromatic nitriles with n-BuLi, pivalonitrile and iodine under metal cyanide-free conditions, Synthetic Route of 100-70-9, the main research area is aromatic nitrile preparation.

Various aromatic nitriles ArCN [Ar = Ph, 4-BrC6H4, 5-ethyl-2-furyl, etc.] were obtained in good yields by the treatment of aryl bromides with n-butyllithium and then pivalonitrile, followed by the treatment with mol. iodine at 70 °C, without metal cyanides under transition-metal-free conditions. The present reaction proceeded through the radical β-elimination of imino-nitrogen-centered radicals formed from the reactions of imines and N-iodoimines under warming conditions.

Tetrahedron published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

McConnell, Danielle L. published the artcileSynthesis of Bench-Stable N-Quaternized Ketene N,O-Acetals and Preliminary Evaluation as Reagents in Organic Synthesis, Recommanded Product: Picolinonitrile, the main research area is ethoxyvinyl pyridinium salt preparation; acetylenic ether pyridine Bronsted Lewis acid substitution reaction.

In this report, a general synthetic approach to a variety of bench-stable N-quaternized ketene N,O-acetals I (R = H, 2-Ph, 4-Me, 2,6-Cl2, etc.; X = OTf, NTf2) via treatment of pyridine II or aniline bases with acetylenic ethers R1CC (R1 = OEt, 4-methoxyphenyl) and an appropriate Bronsted or Lewis acid (triflic acid, triflimide, or scandium(III) triflate) have been described. The resulting pyridinium I and anilinium salts C6H5N+((CH3)CH2)C(=CH2)R1 X- can be used as reagents or synthetic intermediates in multiple reaction types. For example, N-(1-ethoxyvinyl)pyridinium or anilinium salts can thermally release highly reactive O-Et ketenium ions for use in acid catalyst-free electrophilic aromatic substitutions. N-(1-ethoxyvinyl)-2-halopyridinium salts I (R = 2-Cl, 2-Br) can be employed in peptide couplings as a derivative of Mukaiyama reagent (2-chloro-1-methylpyridinium iodide) or react with phenylmethanamine in nucleophilic aromatic substitutions under mild conditions. These preliminary reactions illustrate the broad potential of these currently understudied compounds in organic synthesis.

Journal of Organic Chemistry published new progress about Acetals, ketene Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wolinska, Ewa published the artcileChiral pyridine oxazoline and 1,2,4-triazine oxazoline ligands incorporating electron-withdrawing substituents and their application in the Cu-catalyzed enantioselective nitroaldol reaction, Product Details of C7H6N2, the main research area is nitro alc preparation enantioselective diastereoselective; aldehyde nitromethane nitroaldol pyridine triazine oxazoline copper catalyst.

Eight pyridine-containing and four 1,2,4-triazine-containing chiral oxazoline ligands incorporating electron-withdrawing substituents have been oxazolines I (R1 = Ph, t-Bu; R2 = H, F; R3 = H, Cl; R4 = H, F, Cl, nitro; R5 = H, Br), II and III synthesized by two-step route including Buchwald-Hartwig amination. Enantio-inducing activity of the ligands has been assessed in the copper-catalyzed asym. nitroaldol reactions and the influence of the electron-withdrawing substituents on the ligands’ activity has been investigated.

Monatshefte fuer Chemie published new progress about Alcohols, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Watanabe, Koh published the artcileReductive Cross-Coupling between Arylaldehydes and (Hetero)aryl Electrophiles Using Silylboronate Reductant, HPLC of Formula: 91-15-6, the main research area is diarylmethanol preparation; arylaldehyde heteroaryl electrophile cross coupling reaction.

A catalytic reductive cross-coupling between arylaldehydes ArCHO (Ar = Ph, 2-methylphenyl, naphthalen-2-yl, thiophen-2-yl, etc.) and aryl electrophiles RX (R = pyridin-2-yl, 3-methylpyridin-2-yl, 1,3-benzothiazol-2-yl, etc.; X = F, Cl, CN) using a silylboronate Si(Et)3(B)C(Me)2C(Me)2 as a terminal reductant is described. The reaction involves a copper-catalyzed silylboration of aldehydes affording the O-borylated α-silyl alcs. ArCH(R)OSi(Et)3 (I) followed by a nucleophilic aromatic substitution reaction with aryl electrophiles. This protocol offers a new opportunity to access 1,1-diarylmethanol derivatives (I) without rare metals or highly basic organometallic reagents.

European Journal of Organic Chemistry published new progress about Alcohols, silyl Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Wanting published the artcileEnantioselective Oxidative Coupling of β-Ketocarbonyls and Anilines by Joint Chiral Primary Amine and Selenium Catalysis, Product Details of C7H6N2, the main research area is enantioselective nitroso aldol oxidative coupling ketocarbonyl aniline; chiral primary amine selenium catalyzed enantioselective nitroso aldol.

An enantioselective primary amine-catalyzed total N-selective nitroso aldol reaction (N-NA) was achieved through the oxidation of primary aromatic amines to the corresponding nitrosoarenes catalyzed by selenium reagents and 30% H2O2. This protocol provides a facile and highly efficient access to α-hydroxyamino carbonyls bearing chiral quaternary centers under exceedingly mild and green reaction conditions with high chemo- and enantiocontrol.

Organic Letters published new progress about Aldol addition catalysts, stereoselective (N-selective nitroso aldol). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Yuliang published the artcilePhotoinduced Cross-Coupling of Aryl Iodides with Alkenes, Recommanded Product: Phthalonitrile, the main research area is aryl iodide alkene photoinduced cross coupling UV absorption.

A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes was developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes was proposed. The method enabled iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.

Organic Letters published new progress about Aralkyl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kalaus, Hubert published the artcileA Kinetic Photometric Assay for the Quantification of the Open-Chain Content of Aldoses, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is kinetic photometric quantification aldehyde selective conformation aldose aminobenzamidoxime; Aldehydes; Analytical methods; Carbohydrates; Kinetics; UV/Vis spectroscopy.

Aldoses exist predominantly in the cyclic hemiacetal form, which is in equilibrium with the open-chain aldehyde form. The small aldehyde content hampers reactivity when chem. addresses the carbonyl moiety. This low concentration of the available aldehyde is generally difficult to ascertain. Herein, we demonstrate a new kinetic determination of the (minute) open-chain content (OCC) of aldoses. This kinetic approach exploits the aldehyde-selectivity of 2-aminobenzamidoxime (ABAO), which furnishes a strongly UV-active adduct. Simple formation curves can be measured in a photometer or plate reader for high-throughput screening. Under pseudo-first order kinetics, these curves correlate with a prediction model yielding the relative OCC. The OCCs of all parent aldoses (pentoses and hexoses) were determined referencing against the two tetroses with exceptionally high OCCs and were in very good agreement with literature data. Addnl., the assay was extended towards higher-carbon sugars with unknown OCC and also applied to rationalize a lack of reactivity observed in a recent synthetic investigation.

European Journal of Organic Chemistry published new progress about Aldoses Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts