Tag: M.W=100-150

Grytsai, Oleksandr published the artcileArylbiamidines: synthesis and structural studies en route to anticancer applications, Product Details of C6H4N2, the main research area is thiazolyl bromophenyl biamidine synthesis anticancer.

Biamidines are a unique and poorly studied class of nitrogenous compounds prone to tautomerization and H-bonding. Four series of heteroaryl diarylbiamidines were synthesized and the antimelanoma activity and physicochem. properties of the resulting 37 new compounds were evaluated. The dimethylthiazolyl 3-bromophenyl biamidine derivative B6 (I) inhibits the growth of six different melanoma cell lines, having higher activity than the pos. control drug, the B-RAF inhibitor PLX4032. This study introduces diarylbiamidines as promising frameworks for drug discovery.

New Journal of Chemistry published new progress about Addition reaction (addition reaction of thiazolylguanidines onto aryl nitriles). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Xia published the artcileAnticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with Amines, HPLC of Formula: 100-70-9, the main research area is heteroaryl alkyl ether amine nucleophilic amination; amine heteroaryl preparation anticancer activity green chem.

A mild amination protocol of N-heteroaryl alkyl ethers with various amines is described. This transformation is achieved by utilizing simple and readily available base as promoter via C-O bond cleavage, offering a new amination strategy to access several anticancer-active compounds This work is highlighted by the excellent functional group compatibility, scalability, wide substrate scope, and easy derivatization of a variety of drugs.

Organic Letters published new progress about Alkyl aryl ethers Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaryl). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Denekamp, Ilse M. published the artcileA simple synthesis of symmetric phthalocyanines and their respective perfluoro and transition-metal complexes, Product Details of C8H4N2, the main research area is phthalocyanine transition metal complex preparation.

The authors report a simple synthesis protocol for making phthalocyanines (Pcs) starting from phthalonitriles. This method is general and requires no specialized equipment. The complexes are isolated and characterized using x-ray diffraction, NMR, FTIR and Raman spectroscopy and high-resolution mass spectrometry. First, the authors study and present a 1-step synthesis route to a metal-free Pc (H2PcH16), as well as to the corresponding MPcH16 complexes of Mn, Fe, Co, Ni, Cu and Zn. Then, this route can also be used to make the fluorinated Pc analogs (MPcF16). Finally, the authors present a new and useful procedure for inserting a metal ion into a metal-free H2PcH16 ring, by direct metalation, yielding the corresponding MPcH16 complex. This last method is especially useful if you want to make different MPcH16 complexes.

Applied Organometallic Chemistry published new progress about Phthalocyanines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Smith, Cameron J. published the artcile2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety, Quality Control of 34133-58-9, the main research area is CETP inhibitor arylbenzoxazole preparation structure activity.

A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure-activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the 5- and 7-positions of the benzoxazole moiety was beneficial for CETP inhibition. Compound 47 was the most potent inhibitor in this series and inhibited CETP with an IC50 of 28 nM.

Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Quality Control of 34133-58-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aleshkevich, V. V. published the artcileC/C composites developed from phthalonitrile based composites, Recommanded Product: Phthalonitrile, the main research area is carbon fabric phthalonitrile composite reinforced plastic porosity.

Carbonization of carbon fabric reinforced plastics (CFRPs) with phthalonitrile matrixes at 1000°C was investigated. Four different carbonization modes were tested. It was explored, that a mode with step heat rate is most beneficial. Two different phthalonitrile resins were investigated. Elemental anal. of final carbon-carbon composite (C/C) matrix was carried out and the results showed up to 88.5 mass% carbon presence. Final C/C d. reached 1.5991 after only one cycle of impregnation-carbonization. Final porosity of samples reached 9.2%. These results allow to consider phthalonitriles as a prospective carbon precursor for C/Cs manufacturing Mech. testing of the C/C samples was performed (Compressive strength P = 72.2MPa, E = 11.8 GPa). Tribol. data was received (coefficient of friction = 0.31, wear rate = 30μ/min). Thermal anal. was carried out (χ = 72.94 W/m*K, α = 85.8 cm2/s).

IOP Conference Series: Materials Science and Engineering published new progress about Carbonization. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiao, Xiao published the artcileHHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator, Related Products of nitriles-buliding-blocks, the main research area is breast cancer cell proliferation HHQ4 anticancer agent GRP78; Breast cancer cells; Glucose deprivation; Glucose-regulated protein 78; HHQ-4; Unfolded protein response.

As a central regulator for endoplasmic reticulum (ER) stress, glucose-regulated protein 78 (GRP78), controls the activation of ER-transmembrane signaling mechanisms by inducing unfolded protein response (UPR) in response to ER stress. Based on this premise, we investigated the mol. mechanisms of a synthetic quinolone derivative, 2-hexyl-3-methyl-4(1H)-quinolinone (HHQ-4), in regulating the GRP78 expression and UPR transcriptional program under glucose deprivation or 2-deoxy-D-glucose (2-DG)-stressed conditions. We found that HHQ-4 suppressed the transcriptional and translational expression of GRP78 gene in glucose-deprived breast cancer cells. Constitutive expression of GRP78 completely prevented breast cancer cells from HHQ-4-mediated proliferation inhibition during glucose starvation, stressing the important role of suppression of the GRP78 in HHQ-4-mediated cell proliferation inhibition. HHQ-4 was also found to exert inhibitory activity against breast cancer cell proliferation by suppressing three survival arms of the UPR, including PERK/eIF2a/ATF4, IRE1/XBP1, and ATF6, which orchestrate an intricate signaling network to modulate GRP78 gene transcription under glucose-deprived stress. Our findings show HHQ-4 could be a promising candidate, alone or in combination with 2-DG, for selectively inhibiting breast cancer cell proliferation by down-regulating the transcription and expression of GRP78 under stressful microenvironments.

Toxicology and Applied Pharmacology published new progress about Activating transcription factor 6α Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sojka, Martin published the artcileBifurcated hydrogen bonds in platinum(II) complexes with phosphinoamine ligands, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is platinum phosphinoamine chloro complex preparation conformational energy DFT; crystal structure platinum phosphinoamine chloro.

In this work we report an investigation of the influence of bifurcated intramol. hydrogen bonds on conformations of platinum(II) complexes with phosphinoamine ligands. The series of new cis and trans-PtCl2L2 complexes with phosphinoamine ligands was synthesized and characterized by 1H, 31P, 195Pt NMR, IR, and mol. structures of 8 complexes were determined by X-ray crystallog. The hydrogen bonds are observed between NH···ClPt and NH···R (R = COOCH3, C(O)CH3, F, CN) moieties of the ligands and Pt core. The structural data from X-ray diffraction are linked to calculated conformational energies from d. functional theory (DFT) and topol. anal. results obtained from quantum theory of atoms in mols. (QTAIM) calculations The most prominent NH···ClPt interactions are found in the cis complexes with para substituted phosphinoamine ligands, which show delocalization indexes (DI) up to 0.09. The ortho substituted phosphinoamine ligands decrease the DI values down to zero for C(O)OCH3 and C(O)CH3 moieties.

Polyhedron published new progress about phosphinoamines). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lesuisse, Dominique published the artcileDevelopment of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson’s disease, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Parkinson’s disease NURR1 NOT agonist hits HTS SAR neuroprotective.

In the course of a program aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson’s disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and stringent structure activity relationship. A comprehensive program of optimization led to a potent and safe candidate drug displaying neuroprotective and anti-inflammatory activity in several in vitro and in vivo models.

Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lioret, Vivian published the artcilePyrene/coumarin-subphthalocyanine conjugates as light harvesting systems with intramolecular energy transfer, Related Products of nitriles-buliding-blocks, the main research area is pyrene coumarine subphthalocyanine photoinduced intramol energy transfer.

A series of subphthalocyanine-antenna dyads have been successfully designed, synthesized and characterized by 1H NMR, 13C NMR, high-resolution mass spectroscopy and X-ray diffraction for some of them. Pyrene and coumarin have been appended at the axial position of the subphthalocyanine scaffold using different types of linkers. Photophys. properties of the new compounds have been measured in toluene, THF, chloroform, DMSO and methanol. Energy transfer efficiencies between antenna and the subphthalocyanine platform have been investigated and almost quant. energy transfer occurs in the antenna-platform 5.

Dyes and Pigments published new progress about Crystal structure. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tomishige, Keiichi published the artcileCO2 Conversion with Alcohols and Amines into Carbonates, Ureas, and Carbamates over CeO2 Catalyst in the Presence and Absence of 2-Cyanopyridine, Related Products of nitriles-buliding-blocks, the main research area is carbonate urea carbamate catalyst cyanopyridine cerium oxide; Carbamate; Carbon dioxide; Cerium oxide; Organic carbonate; Urea.

Recent progress on the CeO2 catalyzed synthesis of organic carbonates, urea, and carbamates from CO2+alcs., CO2+amines, and CO2+alcs.+amines, resp., is reviewed. The reactions of CO2 with alcs. and amines are reversible ones and the degree of the equilibrium limitation of the synthesis reactions is strongly dependent on the properties of alcs. and amines as the substrates. When the equilibrium limitation of the reaction is serious, the equilibrium conversion of the substrate and the yield of the target product is very low, therefore, the shift of the equilibrium reaction to the product side by the removal of H2O is essential in order to get the target product in high yield. One of the effective method of the H2O removal from the related reaction systems is the combination with the hydration of 2-cyanopyridine to 2-picolinamide, which is also catalyzed by CeO2.

Chemical Record published new progress about Amines Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts