Tag: M.W=100-150

Wu, Yi published the artcileLigand regulation to prepare an Fe, N, S tri-codoped hollow carbon electrocatalyst for enhanced ORR performance and Zn-air batteries, Synthetic Route of 91-15-6, the main research area is iron nitrogen sulfur carbon electrocatalyst ORR zinc air battery.

It is significant to explore high-efficiency, low-cost, and stable electrocatalysts for the oxygen reduction reaction (ORR) to substitute the precious metal platinum in electrochem. energy conversion devices. Materials with an Fe-Nx center are considered as promising catalysts to achieve this. Herein, a feasible SiO2-ZnCl2 template strategy is used to obtain nitrogen-sulfur-Fe co-doped periodic porous hollow carbon by calcining the Fe-based complexes with different ligands (1,10-phenanthroline, 2,2-bipyridine, and 1,2-dicyanobenzene). Owing to the introduction of the SBA-15 template and pore-forming agent ZnCl2, the as-prepared materials possess a large sp. surface area (SSA) and a well-defined hollow structure. Most importantly, different ligands have a crucial effect on the nitrogen content of the obtained materials, which in turn directly affects the metal active sites of ORR. The appropriate selection of 1,10-phenanthroline as the ligand creates abundant Fe-Nx active sites after the pyrolysis process. Therefore, the optimal hollow carbon (denoted as Z-CNS-Fe) derived from the complex of Fe2+ and 1,10-phenanthroline exhibits better ORR performance with a half-wave potential of 0.880 V, which is 30 mV higher than that of com. Pt/C (0.850 V). Beyond this, Z-CNS-Fe shows long-term stability and superior tolerance to methanol crossover. In addition, when Z-CNS-Fe was applied as the cathode of a primary Zn-air battery, the obtained metal-air cell provided a power d. as high as 141 mW cm-2, which exceeded that of com. Pt/C (114 mW cm-2). The high open-circuit voltage and satisfactory durability also indicate its potential practical applicability.

Sustainable Energy & Fuels published new progress about Electric current-potential relationship Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Cuicui published the artcileBaicalein triazole prevents respiratory tract infection by RSV through suppression of oxidative damage, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Secutellaria baicalein triazole respiratory syncytial virus infection antiviral; Anti-inflammatory; Bronchiolitis; Pneumonia; Tumor necrosis.

Baicalein, an isolate of secutellaria baicalensis is known for its anti-inflammatory activity. In the present study, 12-triazole derivatives of baicalein I (R = 2-OH, 4-Me, 2-Br, etc.) were synthesized and evaluated against RSV infected BEAS-2B cells in vitro and in mice model in vivo. The preventive effect of most active compound I (R = 2-CF3) against RSV infection was studied in detail. The compound I (R = 2-CF3) treatment increased IFN-β1 expression in BEAS-2B cells infected with RSV. In BEAS-2B cells treatment with compound I (R = 2-CF3) inhibited RSV-induced secretion of interleukin-6 and -8 cytokines. It decreased RSV-induced nitric oxide & malondialdehyde production and inhibited the RSV-mediated activation of NF-κB, COX-2, Stat3 and MAPK. RT-qPCR showed that compound I (R = 2-CF3) treatment of the RSV-infected mice significantly (P < 0.05) decreased viral load through reduction in the viral replication. In the mice model of RSV-infection compound I (R = 2-CF3) treatment decreased interleukin-6, -8 and tumor necrosis factor-a expression. In summary, compound I (R = 2-CF3) inhibits RSV-infection and prevents pulmonary airway inflammation through the activation of IFN signalling pathway. Microbial Pathogenesis published new progress about Human cell line BEAS-2B. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Das, Suman published the artcileAn imidazolin-2-iminato ligand organozinc complex as a catalyst for hydroboration of organic nitriles, SDS of cas: 100-70-9, the main research area is bridging imidazoliniminato ethylzinc complex preparation catalyst hydroboration nitrile; crystal structure dinuclear bridging imidazoliniminato ethylzinc complex methylthiophenylmethanammonium chloride; mol structure dinuclear bridging imidazoliniminato ethylzinc complex methylthiophenylmethanammonium chloride; hydroboration kinetics nitrile imidazoliniminatoethylzinc catalyst.

The reaction of diethylzinc with imidazolin-2-imines (ImRNH, R = Dipp (2,6-diisopropylphenyl)), Mes (2,4,6-trimethylphenyl), and tBu (tert-butyl) afforded the corresponding dimeric Zn(II) imidazolin-2-iminato complexes [{(ImRN)ZnEt}2] (R = Dipp, 1a; R = Mes, 1b; R = tBu, 1c). The Zn complexes were characterized using spectroscopic techniques and the mol. structure of complex 1b was established by single-crystal x-ray diffraction anal. Complex 1c was used as a catalyst for the chemoselective hydroboration of organic nitriles with pinacolborane (HBpin) at ambient temperature to obtain diborylamines of a broad substrate scope in high yield. Zn complex 1c exhibits a versatile substrate scope and good functional group tolerance for catalytic hydroboration reactions. A most plausible mechanism is proposed from the kinetic study.

New Journal of Chemistry published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jiao, Jing published the artcileIodine-Promoted Formal [5+1] Annulation of 2-Vinylanilines and Thiurams: A Facile Approach to the Synthesis of 2-Aminoquinolines, Application In Synthesis of 1885-29-6, the main research area is aryl dialkylamino quinoline preparation; vinylaniline tetraalkylthiuram disulfide iodine additive cycloaddition copper triflate catalyst.

A [5+1]-cyclization of 2-vinylanilines RC6H4C(=CH2)(2-NH2C6H3R1) [R = H, 2-Me, 3-Cl, 4-F, etc.; R1 = H, 5-Cl, 4-Me, 3-Et, etc.], 2-(1-naphthalen-1-yl-vinyl)-phenylamine, 2-(1-naphthalen-2-yl-vinyl)-phenylamine with tetraalkylthiuram disulfides (R2)2NC(S)SSC(S)N(R2)2 [R2 = Me, Et, n-Bu] in the presence of iodine and copper(II) triflate was described. This reaction directly employs readily available and low-cost thiuram as both a C1 synthon and a nitrogen source, providing a facile approach to one-step syntheses of a variety of 2-aminoquinolines I [R3 = H, 6-Cl, 7-Me, 8-Et, etc.], N,N-dimethyl-4-(naphthalen-1-yl)quinolin-2-amine, N,N-dimethyl-4-(naphthalen-2-yl)quinolin-2-amine in good to excellent yields.

Synlett published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (vinyl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dai, Bencai published the artcileSustainable and recyclable palladium nanoparticles-catalyzed reduction of nitroaromatics in water/glycerol at room temperature, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is palladium nanoparticle nitroarom catalytic reduction water glycerol temperature.

Palladium nanoparticles with unique catalytic activity and high stability are synthesized. These nanoparticles exhibit excellent catalytic reduction activity for nitroaroms. in green solvents in the presence of H2 at ambient pressure and temperature The prominent advantages of this nanotechnol. include low consumption of catalyst, excellent chemoselectivity, high reusability of the catalyst, and environmentally green solvents.

Journal of Chemical Research published new progress about Catalysis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ogunsipe, Abimbola published the artcileSynthesis, characterization and photostability studies on aluminium phthalocyanine chloride, Safety of Phthalonitrile, the main research area is aluminum phthalocyanine chloride microwave radiation photostability.

The synthesis, characterization and photostability studies of aluminum phthalocyanine chloride are hereby presented. Aluminum phthalocyanine chloride was synthesized by a solvent-free procedure involving microwave irradiation of a mixture of hydrated zinc chloride and 1,2-dicyanobenzene (phthalonitrile); the product was thoroughly purified and dried. The percentage yield was 83.4%. The characterization of the blue product was done via Fourier Transform IR Spectroscopy (FTIR) and UV-Visible spectrophotometry, and the results were satisfactory. In the FTIR spectrum, the formation of zinc phthalocyanine was confirmed by the band due to CN vibrations (around 2100 cm-1) which was present in the phthalonitrile (starting material), but absent in the product (aluminum phthalocyanine chloride). The UV-Visible absorption spectrum showed an intense signal at 672 nm and a weaker one around 350 nm. These bands are taken to be due to π→π* transitions within the phthalocyanine mol. The Beer-Lambert’s plot for the product resulted in a molar extinction coefficient value of 202,118 M-1 cm-1. Photodegradation studies showed that zinc phthalocyanine is very stable towards photoirradiation, with a rather small photodegradation value of 2.73 x 10-8.

Chemistry Research Journal published new progress about Microwave irradiation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Xiaheng published the artcileCopper-mediated synthesis of drug-like bicyclopentanes, Computed Properties of 1885-29-6, the main research area is bicyclopentane preparation copper iridium catalyst propellane nucleophile radical.

Multicomponent reactions are relied on in both academic and industrial synthetic organic chem. owing to their step- and atom-economy advantages over traditional synthetic sequences1. Recently, bicyclo[1.1.1]pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in particular 1,3-disubstituted BCP moieties have become widely adopted in medicinal chem. as para-Ph ring replacements2. These structures are often generated from [1.1.1]propellane via opening of the internal C-C bond through the addition of either radicals or metal-based nucleophiles3-13. The resulting propellane-addition adducts are then transformed to the requisite polysubstituted BCP compounds via a range of synthetic sequences that traditionally involve multiple chem. steps. Although this approach was effective so far, a multicomponent reaction that enables single-step access to complex and diverse polysubstituted drug-like BCP products would be more time efficient compared to current stepwise approaches. Here the authors report a one-step three-component radical coupling of [1.1.1]propellane to afford diverse functionalized bicyclopentanes using various radical precursors and heteroatom nucleophiles via a metallaphotoredox catalysis protocol. This copper-mediated reaction operates on short timescales (five minutes to one hour) across multiple (more than ten) nucleophile classes and can accommodate a diverse array of radical precursors, including those that generate alkyl, α-acyl, trifluoromethyl and sulfonyl radicals. This method was used to rapidly prepare BCP analogs of known pharmaceuticals, one of which is substantially more metabolically stable than its com. progenitor.

Nature (London, United Kingdom) published new progress about Electrochemical redox reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fan, Zhenhua published the artcileMetal-free synthesis of 2-difluoromethylated quinolines via DBU-promoted cascade michael addition / cyclization of methyl-4,4-difluorobut-2-ynoate with 2-aminobenzonitriles, Formula: C7H6N2, the main research area is difluoromethylated quinoline preparation DBU michael cyclization methyl difluorobutynoate aminobenzonitrile.

A facile synthesis of 2-difluoromethylated quinolines via DBU-promoted cascade Michael addition/cyclization between functionalized 2-aminobenzonitriles and Me 4,4-difluorobut-2-ynoate was developed. Various highly functionalized quinolines were assembled in moderate to good yields under mild metal-free reaction conditions.

Tetrahedron published new progress about Crystal structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jankins, Tanner C. published the artcileLow-valent tungsten redox catalysis enables controlled isomerization and carbonylative functionalization of alkenes, Name: Picolinonitrile, the main research area is pyrrolidine dione preparation regioselective; alkene carbon monoxide isomerization hydrocarbonylation tungsten catalyst.

The simple W(0) precatalyst W(CO)6 catalyzed the isomerization of alkenes RNHC(O)R1 [R = pyridin-2-ylmethyl, benzyl, quinolin-8-yl, etc; R1 = but-3-en-1-yl, 3-methylidenecyclobutyl, (3Z)-4-(4-bromophenyl)but-3-en-1-yl, etc.] to inactivated internal positions and subsequent hydrocarbonylation with CO were reported. The six- to seven-coordinate geometry changes that are characteristic of the W(0)/W(II) redox cycle and the conformationally flexible directing group are key factors in allowing isomerization to take place over multiple positions and stop at a defined inactivated internal site that is primed for in situ functionalization.

Nature Chemistry published new progress about Carbonylation catalysts, reductive (regioselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hori, Hiroto published the artcileCobalt-catalyzed cyclization with the introduction of cyano, acyl and aminoalkyl groups, HPLC of Formula: 1885-29-6, the main research area is heterocycle preparation regioselective chemoselective; olefin cyclization cobalt catalyst.

An efficient synthesis of carbo- and heterocycles, e.g., I using C=C, C=O and C=N bonds under cobalt catalysis has been described. The substituents on olefins, e.g., di-Et ((2-[N-(prop-2-en-1-yl)(4-methoxyphenyl)sulfonamido]phenyl)carbonyl)phosphonate are key for controlling the regio- and chemoselectivity in the initial hydrogen atom transfer step and quaternary carbons are efficiently constructed under mild conditions. Cyclopropane cleavage and tandem cyclization give highly functionalized bicyclic skeletons in a single operation.

Organic & Biomolecular Chemistry published new progress about Chemoselectivity. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts