Tag: M.W=100-150

Cui, Xian-Chao published the artcileSynthesis of carbinoxamine via α-C(sp3)-H 2-pyridylation of O, S or N-containing compounds enabled by non-D-A-type super organoreductants and sulfoxide- or sulfide HAT reagents, Recommanded Product: Picolinonitrile, the main research area is alkyl oxy aryl methyl pyridine preparation; thio alkyl aryl methyl pyridine preparation; pyridine carbonitrile ether pyridylation catalyst CBZ6 benzenesulfinylbenzene; aryl alkyl pyridinyl methanamine; amine pyridine carbonitrile pyridylation catalyst CBZ6.

In this work, the discovery of a non-donor-acceptor (D-A) type organic photoreductant CBZ6 and sulfoxide/sulfide synergistically catalyzed general α-C(sp3)-H arylation of ethers, thioethers and amines to gave compounds R1R2CHXR3 [R1 = 2-pyridyl, 4-pyridyl, 3-methyl-2-pyridyl, etc.; R2 = Ph, 4-ClC6H4, 4-MeOC6H4, 2-MeC6H4, etc.; R3 = H, Bn, Me, n-Bu, etc.; X = O, S, N, NH, NCH3] was reported. By using as low as 1 mol% of CBZ6 as a recyclable organic photoreductant and sulfoxides or sulfides as a new type of HAT reagent, the 2- or 4-pyridylation of O, N, or S-containing compounds had been accomplished. This was the first base-free version of α-C-H 2-/4-pyridylation of O, N, or S-containing compounds It was the first example of sulfoxides or sulfides working as HAT reagents. It was also the first general method for photocatalytic HAT 2-pyridylation of various ethers, amines or thioethers.

Chemical Science published new progress about Arylation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chandrashekhar, Vishwas G. published the artcileNickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis, Name: Picolinonitrile, the main research area is amine preparation; nitrile amine hydrogenative coupling nickel catalyzed.

A homogeneous nickel catalyst for hydrogenative cross coupling of a range of aromatic, heteroaromatic, and aliphatic nitriles with primary and secondary amines or ammonia to give amines was reported. This general hydrogenation protocol was showcased by straightforward and highly selective synthesis of >230 functionalized and structurally diverse amines including pharmaceutically relevant and chiral products, as well as 15N-isotope labeling applications.

Science (Washington, DC, United States) published new progress about Coupling reaction (hydrogenative). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kamal, Arsala published the artcileVisible Light-Driven Synthesis of Amine-Sulfonate Salt Derivatives: A Step towards Green Approach, Related Products of nitriles-buliding-blocks, the main research area is amine sulfonate salt preparation green chem visible light.

In this work, a novel strategy for the straightforward visible-light-driven synthesis of biol. active, industrially important, and stable amine-sulfonate salts have been reported from p-toluenesulfonic acid and amines, which provide extremely high yield without side product formation. The reaction was performed without catalyst under visible light irradiation and had an excellent functional group tolerance. The structure of the prepared compounds were confirmed through 1H NMR, 13C NMR, and mass spectroscopic studies, and similarly, the mol. structure of compound 3b was established through single-crystal XRD-anal. The advantages of this method meet the requirements of sustainable and green synthetic chem., and it provides a direct way to create valuable amine-sulfonate salt.

Journal of Molecular Structure published new progress about Green chemistry. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mills, L. Reginald published the artcileDesign of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Tertiary Nucleophiles, Application In Synthesis of 91-15-6, the main research area is quaternary aryl nitrile synthesis; benzonitrile ligand nickel catalyzed cross coupling tertiary nucleophile; safety cyanide.

The design of new ligands for cross-coupling is essential for developing new catalytic reactions that access valuable products such as pharmaceuticals. In this report, we exploit the reactivity of nitrile-containing additives in Ni catalysis to design a benzonitrile-containing ligand for cross-coupling involving tertiary nucleophiles. Kinetic and Hammett studies are used to elucidate the role of the optimized ligand, which demonstrate that the benzonitrile moiety acts as an electron-acceptor to promote reductive elimination over β-hydride elimination and stabilize low-valent Ni. With these conditions, a protocol for decyanation-metalation and Ni-catalyzed arylation is conducted, enabling access to quaternary α-arylnitriles from disubstituted malononitriles. Safety: cyanide handling.

Journal of the American Chemical Society published new progress about Arylation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application In Synthesis of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Davies, Alex M. published the artcileValorization of Ethanol: Ruthenium-Catalyzed Guerbet and Sequential Functionalization Processes, SDS of cas: 91-15-6, the main research area is ethanol ruthenium catalyst tandem guerbet alkylation; alc preparation.

A ruthenium-catalyzed tandem Guerbet-alkylation strategy for the valorization of ethanol was reported. The products of ethanol upgrading (higher-order alcs.) undergo subsequent C-C bond forming reactions with four carbon pronucleophiles and one ylide. Studies into catalyst design led to the development of ClRu(5-Mebpi)(PPh3)2 (bpi = 1,3-bis(2′-pyridylimino)isoindolate) as a highly efficient catalyst for producing biofuels and value-added chems. from ethanol via Guerbet and tandem Guerbet reactions. This catalyst affords 65% higher-order alcs. in short reaction times (2 h), providing the highest TON (155,890) and TOF (12,690 h-1) for a homogeneous catalyst reported to date.

ACS Catalysis published new progress about Alkylation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, SDS of cas: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guo, Rui published the artcileDevelopment of Novel Phosphino-Oxazoline Ligands and Their Application in Asymmetric Alkynlylation of Benzylic Halides, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is chiral alkyne preparation enantioselective copper phosphino oxazoline; benzo fused cyclic bromide silyl benzyl coupling.

A new set of stereochem. diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphanyl)benzoic acid were developed. Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical coupling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclic α-halides and α-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions. With multi distinct sites for structural modification, a diverse pool of chiral N,N,P-ligands is readily accessed, allowing for rapid optimization of the ligand structure for a specific substrate. Notably, the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic mols. has also been realized for the first time.

Chinese Journal of Chemistry published new progress about Alkynes, aryl Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Liping published the artcileExperimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is dibenzothiazocine dioxide dibenzoazocinone preparation stereoselective chemoselective regioselective rhodium catalyst; vinyl aryl amide Intramol dehydrogenative cross coupling; benzamide witting reaction vinyl aniline preparation.

Described herein is an unusual Cp*CyRh(III)-catalyzed intramol. site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams I (R1 = H, 9-Me, 7-Cl, etc; R2 = Me, Et, Ph, 4-Br-C6H4; R3 = H, 2-Me, 3-OMe, etc.)and II (X = CO, PO-Ph; Ar = Ph, 2-Me-C6H4, Naph, Py, etc.) with broad substrate/functional group tolerance. Exptl. and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.

Organic Letters published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

de Oliveira Lima Filho, Edson published the artcileMechanochemical Thiocyanation of Aryl Compounds via C-H Functionalization, Quality Control of 1885-29-6, the main research area is aryl thiocyanate mechanochem synthesis ball milling thiocyanation arene; ball milling thiocyanation aniline phenol anisole thioanisole indole.

Aryl thiocyanate compounds are important building blocks for the synthesis of bioactive compounds and intermediates for several functional groups. Reported thiocyanation reactions via C-H functionalization have limited substrate scope and low RME. The ball-milling method reported here uses ammonium persulfate and ammonium thiocyanate as reagents and silica as a grinding auxiliary. It afforded aryl thiocyanates with moderate to excellent yields for a wide variety of aryl compounds (36 examples, 8-96% yield), such as anilines, phenols, anisoles, thioanisole, and indole, thus tolerating substrates with sensitive functional groups. New products such as benzo[d][1,3]oxathiol-2-ones were obtained with C-4 substituted phenols. Thus, to our knowledge, we report, for the first time, aryl thiocyanation reaction by ball-milling at room temperature and solvent-free conditions, with short reaction times and no workup. Anal. of several mass-based green metrics indicates that it is an efficient greener method.

ACS Omega published new progress about Anisoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zeynizadeh, Behzad published the artcileGreen and convenient protocols for the efficient reduction of nitriles and nitro compounds to corresponding amines with NaBH4 in water catalyzed by magnetically retrievable CuFe2O4 nanoparticles, Product Details of C8H4N2, the main research area is reusable copper ferrite magnetic nanoparticle preparation surface area recyclability; benzonitrile sodium borohydride copper ferrite nanocatalyst reduction green chem; benzylamine preparation; nitrobenzene sodium borohydride copper ferrite nanocatalyst reduction green chem; aniline preparation.

Firstly, CuFe2O4 nanoparticles were prepared by a simple operation. The structure of the mentioned nanoparticles was characterized by Fourier transform IR spectroscopy, X-ray diffraction, SEM, transmission electron microscopy, energy-dispersive X-ray spectroscopy, inductively coupled plasma-optical emission spectrometry, vibrating sample magnetometer and also Brunauer-Emmett-Teller and Barrett-Joyner-Halenda analyses. The prepared magnetically copper ferrite nanocomposite was successfully applied as a simple, cost-effective, practicable and recoverable catalyst on the green, highly efficient, fast, base-free and ligand-free reduction of nitriles and also on the affordable and eco-friendly reduction of nitro compounds with the broad substrate scope to the corresponding amines with NaBH4 in water at reflux in high to excellent yields.

Research on Chemical Intermediates published new progress about Aralkyl amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Caiyun published the artcileSynthesis of N-Arylindoles from 2-Alkenylanilines and Diazonaphthalen-2(1H)-ones through Simultaneous Indole Construction and Aryl Introduction, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is indolyl naphthalenol green preparation; alkenylaniline diazonaphthalenone tandem intramol cyclization oxidative aromatization catalyst ruthenium.

In this paper, an efficient synthesis of N-arylindoles I [R1 = H, 5-Me, 6-t-Bu, etc.; R2 = Me, Et, Ph, etc.; R3 = H, Me; R2R3 = (CH2)3, (CH2)4; R4 = H, 6-Me, 7-OEt, etc.] through the cascade reaction of 2-alkenylanilines with diazonaphthalen-2(1H)-ones was presented. Mechanistically, this reaction involved the generation of a Ru-carbene complex from diazonaphthalen-2(1H)-one, followed by carbene N-H bond insertion with 2-alkenylaniline, intramol. cyclization, and oxidative aromatization. In this reaction, the Ru(II) complex acted as a multifunctional catalyst to promote not only the carbene formation but also the intramol. cyclization and the dehydrogenative aromatization. Meanwhile, air acted as a green and cost-effective oxidant. To our knowledge, this was the first example in which N-arylindoles I were synthesized through simultaneous introduction of the N-aryl unit and construction of the indole scaffold. Notable advantages of this method included readily accessible and halide-free substrates, additive-free reaction conditions, good efficiency, excellent atom economy, and compatibility with diverse functional groups. In addition, the utility of the product thus obtained was showcased by its diverse structural transformations.

Journal of Organic Chemistry published new progress about Aromatization (oxidative). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts