Tag: M.W=100-150

Tyagi, Aparna published the artcileBroensted acid-catalyzed epoxide ring-opening using amine nucleophiles: A facile access to β-amino alcohols, Quality Control of 1885-29-6, the main research area is amino alc beta synthesis; styrene oxide epoxide ring opening aniline Broensted acid catalyst; ring opening reaction mechanism kinetics Hammett equation; Suzuki Miyaura Cross coupling reaction; aniline; metal-free; phenyl oxirane; β-amino alcohols.

A mild, efficient, and metal-free synthetic protocol for the synthesis of β-amino alcs. is reported. The reaction proceeds at room temperature with only 0.5 mol % catalyst loading and affords β-amino alc. derivatives in excellent yield. This protocol is well-tolerated by a wide range of styrene oxide and aniline derivatives A notably efficacious gram-scale synthesis is also reported with a high TON=842. Further, the Hammett correlation study was also performed to identify the rate-determining step.

Chemistry – An Asian Journal published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jiang, Chenhui published the artcileDirect Transformation of Nitrogen-Containing Methylheteroarenes to Heteroaryl Nitrile by Sodium Nitrite, Application of Picolinonitrile, the main research area is heteroaryl nitrile preparation; methylheteroarene acetyl chloride sodium nitrite cyanation.

The cyanation reaction of methylheteroarenes with acetyl chloride and sodium nitrite via the radical process in high yields is reported. According to the control experiments, the reaction mechanism underwent radical progress. It is very useful in the pharmacy industry due to its metal-free and easy treatment conditions.

Organic Letters published new progress about Benzoxazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yao, Hua published the artcileCyanomethylation of the Benzene Rings and Pyridine Rings via Direct Oxidative Cross-Dehydrogenative Coupling with Acetonitrile, SDS of cas: 1885-29-6, the main research area is arylacetonitrile preparation regioselective green chem; arylamine acetonitrile dehydrogenative coupling cyanomethylation.

A novel and efficient approach for the amine-directed dehydrogenative C(sp2)-C(sp3) coupling of arylamines RNH2 (R = Ph, 5-chloropyridin-2-yl, pyrazin-2-yl, etc.) with acetonitrile was reported by using FeCl2 as the catalyst. Arylamines react with inactive acetonitrile to form the corresponding arylacetonitriles R1CH2CN (R1 = 2-amino-5-chloropyridin-3-yl, 2-aminophenyl, 6-amino-1,3-benzothiazol-7-yl, etc.) in moderate to good yields. This protocol features nontoxic iron catalysis, efficient atom economy, nonprefunctionalized starting materials, good regioselectivity, and excellent compatibility of functional groups and aromatic rings, providing a novel, straightforward, and green approach toward arylacetonitriles.

Organic Letters published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lebedev, Yury published the artcileAsymmetric Hydroboration of Heteroaryl Ketones by Aluminum Catalysis, Recommanded Product: Picolinonitrile, the main research area is heterocyclic ketone enantioselective hydroboration aluminum catalyst; aluminum binol complex catalyst mechanism computational study.

A series of Me aluminum complexes bearing chiral biphenol-type ligands were found to be highly active catalysts in the asym. reduction of heterocyclic ketones (S/C = 100 – 500, ee up to 99%). The protocol is suitable for a wide range of substrates and has a high tolerance to functional groups. The formed 2-heterocyclic-alcs. are valuable building blocks in drug discovery or can be used as ligands in asym. catalysis. Isolation and comprehensive characterization of the reaction intermediates support a catalysis cycle proposed by DFT calculations

Journal of the American Chemical Society published new progress about Enantioselective synthesis. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Hao published the artcileA Strategy to Construct cis-Hydrocarbazole via Nickel/Lewis Acid Dual-Catalyzed Arylcyanation, COA of Formula: C7H6N2, the main research area is cis hydrocarbazole preparation diasteroselective; allylic aniline arylcyanation nickel Lewis acid catalyst.

A strategy for the synthesis of cis-hydrocarbazoles I [R1 = H, 6-Me, 7-F, etc.; R2 = Me, Et, Bn; R3 = H, Me; R4 = H, Me; R3R4 = O(CH2)2O] with a C3 quaternary carbon center was developed through Ni/Lewis acid dual-catalyzed arylcyanation of allylic anilines. A wide array of cis-hydrocarbazoles was accessed with high diastereoselectivities and atom economies in a good yield. The rich chem. of the installed nitrile group was demonstrated in the preparation of tryptamine- and tryptophol-derived cis-hydrocarbazoles.

Journal of Organic Chemistry published new progress about Carbazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dix, Stefan published the artcileRadical C-H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide, SDS of cas: 100-70-9, the main research area is trifluoromethoxylated hetero arene preparation; bis trifluoromethyl peroxide hetero arene radical CH trifluoromethoxylation photochem; (hetero)arenes; TEMPO; fluorine; photocatalysis; trifluoromethoxylation.

Herein, bis(trifluoromethyl)peroxide (BTMP, CF3OOCF3) as a practical and efficient trifluoromethoxylating reagent, which easily accessible from inexpensive bulk chems. was introduced. Using either visible light photoredox or TEMPO catalysis, trifluoromethoxylated arenes could be prepared in good yields under mild conditions directly from unactivated aromatics Moreover, TEMPO catalysis allowed for the one-step synthesis of valuable pyridine derivatives, which was previously prepared via multi-step approaches.

Chemistry – A European Journal published new progress about Photochemistry. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Karges, Johannes published the artcileSynthesis of tetranuclear rhenium(I) tricarbonyl metallacycles, Recommanded Product: Picolinonitrile, the main research area is tetranuclear rhenium tricarbonyl metallacycle preparation structure conformation; crystal structure mol tetranuclear rhenium tricarbonyl metallacycle preparation.

Re(I) tricarbonyl complexes have received much attention due to their attractive photochem., electrochem., and biol. properties. Beyond simple mononuclear complexes, multinuclear assemblies offer greater structural diversity and properties. Despite previous reports on the preparation of di-, tri-, or tetranuclear Re(I) tricarbonyl assemblies, the synthesis of these supramol. structures remains challenging due to overall low yields or tedious purification protocols. Herein, the facile preparation and characterization of tetranuclear Re(I) tricarbonyl metallacycles with a square geometry is reported using a tetrazole-based ligand. The synthesis of the metallacycle was optimized using different metal precursors, solvents, temperatures, and reagent concentrations Finally, the scope of suitable tetrazole-based ligands was explored to produce several tetranuclear Re(I) tricarbonyl-based metallacycles.

Dalton Transactions published new progress about Conformation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xin, Lin published the artcileResearch on the Pollutant Migration Law Based on Large-Scale Three-Dimensional Similar Simulation Experiments of Underground Coal Gasification, HPLC of Formula: 91-15-6, the main research area is pollutant migration coal seam simulation underground gasification.

The potential pollution risk of underground coal gasification (UCG) has become a key factor restricting the development of UCG industrialization. Therefore, studying the migration and diffusion behavior of harmful pollutants is of great significance for preventing UCG pollution. In this paper, a large-scale three-dimensional similar simulation exptl. device for UCG is used to simulate the gasification of Tianjin fat coal under actual working conditions. The rock layer around the simulated coal seam was sampled after the gasification was completed, the contaminants in the samples were examined by XRD, and the changes in the relative content of the contaminants at different sampling points were studied by FTIR. The results showed that benzene, phenols, aldehydes, aromatic hydrocarbons, and aromatic heterocyclic compounds remained after the gasification of Number 7 sampling point in Qianjiang, Tianjin, and that the main pollutants were aromatic hydrocarbons. The migration and enrichment of phenol and aldehyde pollutants were about the same on the east and west sides of the gasification center, while benzene pollutants were more easily migrated and enriched than aromatic heterocyclic compounds The migration distance of phenolic pollutants on the south side of the gasification area is smaller than that of other pollutants and their maximum vertical distance from the gasification reaction area to the south is about 0.7 m. The results can provide a scientific basis for pollutant risk identification and prevention and control in the later UCG field test.

ACS Omega published new progress about Aromatic hydrocarbons Role: PEP (Physical, Engineering or Chemical Process), POL (Pollutant), PROC (Process), OCCU (Occurrence). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rakshit, Amitava published the artcilePd(II)-Catalyzed Synthesis of Furo[2,3-b]pyridines from β-Ketodinitriles and Alkynes via Cyclization and N-H/C Annulation, Computed Properties of 1885-29-6, the main research area is furopyridine preparation; ketodinitrile alkyne annulation palladium catalyst.

A Pd(II)-catalyzed synthesis of furopyridines, e.g., I has been developed from β-ketodinitriles, e.g., 2-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)propanedinitrile and alkynes, e.g., diphenylacetylene via an unusual N-H/C annulation. The participation of both the nitrile groups and the concurrent construction of furan and pyridine rings through the formation of C-C, C=C, C-O, C-N, and C=N bonds are the important features. The synthetic applicability is further demonstrated through a series of postsynthetic alterations.

Organic Letters published new progress about C-C bond formation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shit, Sudip published the artcileSynthesis of Spiro[furan-2,1′-isoindolin]-3′-ones from 2-(4-Hydroxybut-1-yn-1-yl)benzonitriles and Aryl Aldehydes under the Action of Triflic Acid, Quality Control of 1885-29-6, the main research area is spiro furanisoindolinone diastereoselective preparation; hydroxybutynyl benzonitrile aryl aldehyde Prins Ritter ring opening addition.

The synthesis of spiro[furan-2,1′-isoindolin]-3′-ones I [R1 = H, 5-Me, 6-Cl, 6-Br; R2 = H, Me, Et; Ar = Ph, 4-FC6H4, 2-BrC6H4, etc.] from 2-(4-hydroxybut-1-yn-1-yl)benzonitriles and aryl aldehydes was demonstrated. It involved the initial formation of dihydrofuranylideneisoindolinone via intramol. sequential Prins and Ritter reactions, followed by the ring opening of the furanyl moiety to generate N-acyliminium ions and alcs. for the final cyclization reaction, and the spiro-cyclic compounds were produced in moderate to good yields. It was a one-pot, three-component reaction in which one new quaternary carbon, two five-membered rings, one C-N bond, two C-O bonds and one C-C bond are formed. The reaction was carried out with a Bronsted acid from 0°C to room temperature within a short period of time.

Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts