Tag: M.W=100-150

Dong, Sanfeng published the artcileOne step stereoselective synthesis of oxazoline-fused saccharides and their conversion into the corresponding 1,2-cis glycosylamines bearing various protected groups, COA of Formula: C6H4N2, the main research area is transition state glycosylamine oxazolinose benzonitrile aminoglycoside synthesis crystal structure.

Herein we disclosed a straightforward synthesis of oxazoline-fused saccharides (oxazolinoses) from peracetylated saccharides and benzonitriles under acidic conditions with stoichiometric amounts of water. The d. functional theory (DFT) calculations have revealed the origin of the stereoselectivity and the key role of water in promoting the departure of the acetyl group at C-2. The resulting oxazolinoses can be concisely converted into the corresponding 1,2-cis glycosylamines bearing various protected groups, allowing the access to schisandrin derivatives

Organic & Biomolecular Chemistry published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Chen published the artcilePalladium-Catalyzed Carbamoyl-Carbamoylation/ Carboxylation/Thioesterification of Alkene-Tethered Carbamoyl Chlorides Using Mo(CO)6 as the Carbonyl Source, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl oxindole preparation; alkene tethered carbamoyl chloride carbamoylation palladium catalyst.

A palladium-catalyzed carbamoyl-carbamoylation/carboxylation/thioesterification of alkene-tethered carbamoyl chlorides such as I [R1 = H, 5-Cl, 7-Me, etc.; R2 = Bn, PMB; R3 = Me, n-Bu, Ph, etc.] using Mo(CO)6 as the carbonyl source was reported. The reactions were typically performed with good functional group compatibility and tolerated different nucleophiles (amines, alcs., phenols, thiols and water), which provided amidated/esterificated/thioesterificated/carboxylated oxindoles or lactams such as II [R4 = Ph, 2-tolyl, 1-naphthyl, etc.; R5 = H, Me] bearing an all-carbon quaternary stereocenter under CO gas-free conditions. Furthermore, natural product mutation and divergent late-stage derivatization were the important practical features.

Advanced Synthesis & Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fukazawa, Yasuaki published the artcileA Mild Method for Electrochemical Reduction of Heterocyclic N-Oxides, Related Products of nitriles-buliding-blocks, the main research area is electrochem reduction heterocyclic amine oxide.

Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chem. or enzymic methods. In this work, we report on an expedient protocol for electrochem. reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring. Thus, e.g., 2-phenylpyridine N-oxide �2-phenylpyridine (89% isolated) by carring out the reaction in an undivided electrochem. cell with two graphite electrodes in 1:1 MeCN/water mixture using LiBF4 as supporting electrolyte.

European Journal of Organic Chemistry published new progress about Chemoselectivity (of electroreduction of amine oxide function group in presence of halogen or nitro groups). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kim, Youyoung published the artcileIr(III)-Catalysed electrooxidative intramolecular dehydrogenative C-H/N-H coupling for the synthesis of N-H indoles, Category: nitriles-buliding-blocks, the main research area is alkenyl arylamine iridium catalyst electrooxidation intramol dehydrogenation coupling; indole preparation.

An iridium(III)-catalyzed electrooxidative intramol. dehydrogenative C-H/N-H coupling of unprotected 2-alkenyl anilines was described. The developed method allowed the synthesis of a variety of 3-substituted N-H indole scaffolds under undivided electrolytic conditions. Mechanistic studies suggested that the reaction proceeds through the electro-oxidation induced reductive elimination pathway.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fu, Zhengjiang published the artcileConversions of aryl carboxylic acids into aryl nitriles using multiple types of Cu-mediated decarboxylative cyanation under aerobic conditions, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl nitrile preparation green chem; malononitrile aryl carboxylic acid decarboxylative cyanation copper catalyst; azodimethylbutyronitrile aryl carboxylic acid decarboxylative cyanation copper catalyst.

Here, used malononitrile or AMBN as a cyanating agent to develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids RC(O)OH (R = 2-nitrophenyl, 2,4,6-trimethoxyphenyl, 3-methyl-1-benzothiophen-2-yl, etc.) bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids. These protocols involved economical methods to synthesize value-added aryl nitriles RCN from simple and inexpensive raw materials. Further diversification of the 2-nitrobenzonitrile product was performed to highlight the practicality of the protocols.

Organic & Biomolecular Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiao, Yan published the artcileRhodium-Catalyzed Reaction of Azobenzenes and Nitrosoarenes toward Phenazines, SDS of cas: 1885-29-6, the main research area is azobenzene nitrosoarene rhodium annulation catalyst; phenazine preparation.

A rhodium-catalyzed annulative reaction between azobenzenes and nitrosoarenes has been developed, leading to a series of phenazines I (R1 = H, 2-Cl, 2-MeO, 2-Me, etc.; R2 = H, 2-Me, 2-t-Bu, 2-Br, etc.) in moderate to good yields. This procedure proceeds with sequential chelation-assisted addition of aryl C-H to nitrosoarenes and ring closure by electrophilic attack of azo group to aryl. During this transformation, the azo group served as not only a traceless directing group but also a building block in the final products.

Organic Letters published new progress about Aromatic compounds, nitroso Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qiu, Di published the artcileVisible Light-Driven, Photocatalyst-Free Arbuzov-Like Reaction via Arylazo Sulfones, Category: nitriles-buliding-blocks, the main research area is visible light Arbuzov reaction arylazo sulfone phosphite; heteroaryl aryl phosphonate preparation.

A visible light-induced formation of Aryl-Phosphorous bonds starting from arylazo sulfones and triaryl (or trialkyl)phosphites in the absence of any photoredox catalyst and any additives was developed. This reaction showed a broad substrate scope and afforded (hetero)aryl phosphonates in good yields and in up to the gram scale.

Advanced Synthesis & Catalysis published new progress about Azo compounds, aromatic Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Asai, Kento published the artcilePalladium-Catalyzed Benzylic Silylation of Diarylmethyl Carbonates with Silylboranes under Base-Free Conditions, Safety of Phthalonitrile, the main research area is palladium catalyzed benzylic silylation diarylmethyl carbonate silylborane; benzylic silane nucleophile preparation reaction carbon electrophile.

A palladium-catalyzed benzylic silylation of diarylmethyl carbonates with silylboranes has been developed. The reaction proceeds smoothly even under external base-free conditions, and the corresponding benzylic silanes are formed in good to high yields. The obtained benzyl silane derivatives can work as the benzylic nucleophiles by the action of a suitable fluoride source and react with some carbon electrophiles to deliver the corresponding benzylic C-C cross-coupled products. Addnl., while still preliminary, the allylic silylation of the isoelectronic allylic carbonates is also achieved.

European Journal of Organic Chemistry published new progress about Carbonates Role: RCT (Reactant), RACT (Reactant or Reagent) (diarylmethyl). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nechausov, S. S. published the artcileDual-curing propargyl/phthalonitrile monomers for composites by vacuum infusion process, Category: nitriles-buliding-blocks, the main research area is propargyl phthalonitrile monomer vacuum curing.

Four different bifunctional monomers were synthesized: two monomers containing N-propargylamine and phthalonitrile groups and two monomers containing O-propargyl ester and phthalonitrile groups. It was shown that only the latter one can be used to obtain composite materials by vacuum infusion (viscosity 40 mPa*s at 120°C). The N-propargylamine containing monomers demonstrated high viscosity of the melts and degradation with allene evolution while curing. Carbon fiber reinforced plastics (CFRP) were successfully obtained from 4-[3-(prop-2-yn-1-yloxy)phenoxy]benzene-1,2-dicarbonitrile by a vacuum infusion molding process. Mech. testing of the composites samples was performed. Influence of end-curing temperature on mech. properties and morphol. of composites was investigated. The curing temperature of 375°C critically affects the properties of the composite due to the high shrinkage. Composites cured at 375°C lost 18% of mech. properties at 300°C but cured at 330 only 10%. LOI for composites with a matrix of propargyl/phthalonitrile dual-curing polymers was equal to 75, which is higher than most materials obtained from thermosets.

IOP Conference Series: Materials Science and Engineering published new progress about Composites. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mihai, Madalina T. published the artcilePara-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is para selective carbon hydrogen bond borylation aniline phenol benzylamine.

The selective functionalization of C-H bonds at the arene para position is highly challenging using transition metal catalysis. Ir-catalyzed borylation has emerged as a leading technique for arene functionalization, but there are only a handful of strategies for para-selective borylation, which operate on specific substrate classes and use bespoke ligands or catalysts. The authors describe a remarkably general protocol which results in para-selectivity on some of the most common arene building blocks (anilines, benzylamines, phenols, benzyl alcs.) and uses standard borylation ligands. The authors’ strategy hinges upon the facile conversion of the substrates into sulfate or sulfamate salts, wherein the anionic arene component is paired with a Bu4N cation. The authors hypothesize that the bulk of this cation disfavors meta-C-H borylation, thereby promoting the challenging para-selective reaction.

Journal of the American Chemical Society published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts