Tag: M.W=100-150

Chlupaty, Tomas published the artcileReversible addition of tin(II) amides to nitriles, Related Products of nitriles-buliding-blocks, the main research area is tin silylamide reaction nitrile dinitrile trinitrile; amidotin amidinate preparation crystal mol structure; magnesium lanthanum benzamidinate preparation; crystal mol structure amidotin amidinate.

Lappert’s stannylene (Sn[N(SiMe3)2]2) has been reacted with various nitriles, dinitriles and trinitriles with the formation of heteroleptic amidotin(II) amidinates of the general formulas [RC(NSiMe3)2]SnN(SiMe3)2, R'{[C(NSiMe3)2]SnN(SiMe3)2}2 and R”{[C(NSiMe3)2]SnN(SiMe3)2}3, where R = Ph (1), 2-(CN)-C6H4 (2), 3-(CN)-C6H4 (3); R’ = 1,3-C6H4 (4), 1,4-C6H4 (5) and R” = 1,3,5-C6H3 (6). The reactions of amidotin(II) benzamidinate 1 with an excess of benzonitrile proceed to homoleptic tin(II) bis(benzamidinate) [PhC(NSiMe3)2]2Sn, which reversibly eliminates benzonitrile and 1 when warmed. The premise of reversibility has been supported by a multinuclear time-dependent NMR study and a theor. (DFT) description. On the other hand, magnesium(II) bis(benzamidinate) [PhC(NSiMe3)2]2Mg (8) and lanthanum(II) tris(benzamidinate) [PhC(NSiMe3)2]3La (7) have been synthesized from appropriate metal hexamethyldisilazides and benzonitrile.

Dalton Transactions published new progress about Crystal structure. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kalogirou, Andreas S. published the artcileSynthesis and Reactivity of 3′,5′-Dichloro-1H-spiro(quinazoline-2,4′-[1,2,6]thiadiazin)-4(3H)-ones, Formula: C7H6N2, the main research area is chloro spiro quinazoline thiadiazine derivative synthesis reactivity.

A three-step synthesis of 3′,5′-dichloro-1H-spiro(quinazoline-2,4′-[1,2,6]thiadiazin)-4(3H)-ones starting from 3,4,4,5-tetra-chloro-4H-1,2,6-thiadiazine (I) is presented. The latter reacts with 2-aminobenzonitriles to give 2-[(3,5-dichloro-4H-1,2,6-thiadiazin-4-ylidene)amino]benzonitriles [e.g., I + 2-aminobenzonitrile → II (86%)] , which affords, after hydration, the resp. benzamides [II → III (84%)]. Upon heating at reflux in EtOH or HFIP, the benzamides intramolecularly cyclize onto the thiadiazine C4 position to give 3′,5′-dichloro-1H-spiro(quinazoline-2,4′-[1,2,6]thiadiazin)-4(3H)-ones [III → IV (95% in EtOH, 97% in HFIP)]. Single crystal X-ray crystallog. supports the structure of two analogs. The chloride displacement of these new spiroquinazolinones was demonstrated by Stille coupling, and by reaction with methoxide to afford both the mono and bis-methoxy derivatives

European Journal of Organic Chemistry published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (anthranilonitriles → [(dichlorothiadiazinylidene)amino]benzamides). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zheng, Ye published the artcileAsymmetric Transfer Hydrogenation of o-Hydroxyphenyl Ketones: Utilizing Directing Effects That Optimize the Asymmetric Synthesis of Challenging Alcohols, SDS of cas: 1885-29-6, the main research area is arylmethanol arylmethanamine enantioselective preparation; arylpropyldiamine ruthenium catalyst enantioselective transfer hydrogenation hydroxyphenyl aryl ketone.

The enantioselective transfer hydrogenation of diaryl ketones in the presence of nonracemic tethered areneruthenium diamine complexes to give benzylic alcs. was studied. When o-hydroxyphenyl ketones with bulky aryl moieties were used as substrates in the presence of nonracemic phenylpropyldiamine ruthenium complexes, diarylmethanols were formed enantioselectively. The enantioselective reduction of aryl benzyl and diaryl ketimines was also studied.

Organic Letters published new progress about Aralkyl amines Role: ARU (Analytical Role, Unclassified), SPN (Synthetic Preparation), ANST (Analytical Study), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Recommanded Product: 4-Ethynylbenzonitrile.

Zhang, Zhansong;Song, Qingmin;Feng, Chengjie;Wang, Zikun;Zhao, Wanjun;Ning, Yongquan;Wu, Yong research published 《 The sulfinylsulfonation of alkynes for β-sulfinyl alkenylsulfone》, the research content is summarized as follows. Here the sulfinylsulfonation of alkynes to afford β-sulfinyl alkenylsulfone products RS(O)C(R¹)=C(R²)SO₂R [R = Me, Ph, 4-MeC₆H₄, etc.; R¹ = n-Bu, cyclohexyl, Ph, etc.; R² = H, Me, Br, etc.] with a broad substrate scope, excellent functional group compatibility and high yield was reported. Moreover, the sulfinylsulfonation reaction of enyne could also be realized for constructing functionalized carbo- and heterocycles, e.g., I through a radical cascade cyclization process.

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Application of C9H5N.

Zhang, Zhen;Li, Jie;Chen, Hao;Huang, Jing;Song, Xiaojuan;Tu, Zheng-Chao;Zhang, Zhang;Peng, Lijie;Zhou, Yang;Ding, Ke research published 《 Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors》, the research content is summarized as follows. Aberrant FGF19/FGFR4 signaling is an oncogenic driver force for the development of human hepatocellular carcinoma (HCC). A series of 2-formyl tetrahydronaphthyridine urea derivatives I (R = 2-phenylethynyl, 2-(pyridin-2-yl)ethynyl, 2-(3-methoxyphenyl)ethyl, etc.; R¹ = F, propan-2-yloxidanyl, cyclopentylaminyl, etc.) and II was designed and synthesized as new covalently reversible inhibitors of FGFR4. The representative compound II (R = 2-(pyridin-3-yl)ethynyl) (III) exhibited an IC₅₀ value of 5.4 nM against FGFR4 and demonstrated extraordinary kinome selectivity. Compound III also exhibited good oral pharmacokinetic properties with an AUC_(0-t) value of 38 950.06 h*ng/mL, a T_1/2 value of 3.06 h, and an oral bioavailability of 50.97%, at an oral dose of 25 mg/kg in Sprague-Dawley (SD) rats. Furthermore, compound III induced significant tumor regressions in a xenograft mouse model of Hep3B2.1-7 HCC cancer cells without an obvious sign of toxicity upon 30 mg/kg oral administration. Compound III may serve as a promising lead compound for further anticancer drug development.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Application of C9H5N

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Reference of 3032-92-6.

Zheng, Changge;Ma, Mingyu;Huang, Shuai;Jiang, Chao;Liu, Yang;Fu, Yingying;Zhao, Kui;Feng, Ruilong;Hong, Jianquan research published 《 Stereoretentive trifluoromethylthiolation of (E)-styrylboronic acid with AgSCF₃ or N-trifluoromethylthiosuccinimide》, the research content is summarized as follows. A stereoretentive trifluoromethylthiolation of styrylboronic acids with AgSCF₃ or N-trifluoromethylthiosuccinimide has been developed under mild reaction conditions. This synthetic method for vinyl trifluoromethyl thioethers possesses good functional group tolerance, high yield and excellent stereoselectivity with AgSCF₃ as the SCF₃ source. The stereospecificity of the reaction could been achieved through the trifluoromethylthiolation of β-styrylboronic acids with N-trifluoromethylthiosuccinimide.

Reference of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Formula: C9H5N.

Zheng, Zhipeng;He, Jiali;Ma, Qianru;Zhang, Yumeng;Liu, Yan;Tang, Guo;Zhao, Yufen research published 《 Photoredox/copper-catalyzed coupling of terminal alkynes with P(O)SH compounds leading to alkynyl phosphorothioates》, the research content is summarized as follows. The direct construction of a C(sp.)-S-P(O) moiety from unactivated terminal alkynes remains highly challenging. Alkynyl phosphorothioates are obtained by coupling terminal alkynes and P(O)SH. Using com. available and inexpensive Ru(bpy)₃Cl₂ and copper as a catalyst, this cross dehydrogenative coupling reaction is first performed under photoirradiation Direct use of stable P(O)SH and terminal alkynes without the need to prepare unstable S-X and P-X derivatives represents a prominent advantage of this method. More attractively, this operationally simple reaction avoids the use of odorous thiols and poisonous alkynyl bromides.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Formula: C9H5N

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Formula: C9H5N.

Yusuf, Mohammad;Hira, Shamim Ahmed;Park, Kang Hyun research published 《 Light-Harvesting Novel Hierarchical Porous Cu₉S₅-MnWO₄ Hybrid Structures in Photocatalytic Oxidative Homocoupling of Alkynes and Amines》, the research content is summarized as follows. The discovery of light-harvesting materials for use in photocatalytic organic reactions has recently attracted attention, indicating the potential for utilizing renewable energy sources. A hybrid semiconductor (SC)-SC structure, Cu₉S₅-MnWO₄, was synthesized using a simple, efficient method. The novel hierarchical porous Cu₉S₅-MnWO₄ hybrid structures were then applied in the photocatalysis of oxidative homocoupling of alkynes and amines. The design of a heterogeneous catalyst based on a porous, SC-SC hybrid structure and low-cost Cu should generate interest in the fabrication and modification of photocatalysts for a wide range of applications.

Formula: C9H5N, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Electric Literature of 3032-92-6.

Zeng, Jiajun;Li, Jianying;Huang, Bin;Li, Jiajia;Cai, Mingzhong research published 《 A practical access to 1,2-dicarbonyls via oxidation of alkynes catalyzed by gold(I) immobilized on MCM-41》, the research content is summarized as follows. The heterogeneous gold(I)-catalyzed oxidation of alkynes was achieved by using 2,3-dichloropyridine N-oxide as oxidant and MCM-41-anchored diphenylphosphine-gold(I) complex [MCM-41-Ph₂P-AuNTf₂] as the catalyst under mild and acid-free conditions, yielding diverse 1,2-dicarbonyls in good to excellent yields with easy recycling of the gold catalyst. The developed method is applicable to a wide variety of alkynes including internal or terminal alkynes, alkynyl ethers or thioethers and ynamides, and can tolerate a wide range of functional groups.

Electric Literature of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Electric Literature of 3032-92-6.

Zeng, Meng-Qiang;Feng, Ke-Xin;Hu, Bo-Lun;Tu, Hai-Yong;Zhang, Xing-Guo research published 《 Ni-Catalyzed Reductive Arylalkenylation of Alkynes for the Selective Synthesis of Polysubstituted Naphthalenes》, the research content is summarized as follows. A Ni-catalyzed reductive arylalkenylation of alkynes with 1-bromo-2-(2-chlorovinyl)arenes in the presence of zinc powder has been developed. This base-free cyclization provides a novel protocol for the selective synthesis of 2-trifluoromethyl naphthalenes and Et 2-naphthoates from simple starting materials in moderate to good yields with excellent tolerance of functional groups.

Electric Literature of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts